Science Interviews


Wed, 13th Aug 2014

Gene of the Month - Pax6

Kat Arney

Listen Now    Download as mp3 from the show Genes for Sore Eyes

Kat - And finally it’s time for our gene of the month, and in keeping with our theme of vision it’s Pax6. Known as PAX6 in humans and eyeless in fruit flies - but found in a wide range of different animals including mammals, insects and fish - the gene is a ‘master controller’ telling a developing embryo exactly where to grow an eye. Impressively, the Pax6 gene from mice can be put into fruit flies, and can direct them to grow fruit fly eyes. And as might be expected, any faults in such an important gene lead to major problems with eye development, so researchers are studying the gene in detail to gain insights into why some children are born blind.


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Pax6 is a neurogenesis controlling factor. During embryonic development, Pax6 is necessary for retinal neurons proliferation and self-renewal. tkadm30, Fri, 29th Apr 2016

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