Science Interviews


Thu, 9th Aug 2012

Gene of the month - Tribbles

Kat Arney

Listen Now    Download as mp3 from the show Genes and genomes

Our gene of the month may be familiar to any Star Trek fans who are listening - itís none other than Tribbles.

It was first discovered in 2000 by Thomas Seher and Maria Leptin, who found that cells in fruit flies with mutations in the gene multiply uncontrollably, much like the furry critters in Star Trek. Since then, Tribbles has turned up in many other organisms, including humans, where thereís a large family of related proteins that help to control fatty acid production, insulin resistance, cholesterol levels and more.

Unsurprisingly, some of these Tribbles proteins have been implicated in conditions such as type 2 diabetes and the formation of atherosclerotic plaques - the fatty deposits that can block blood vessels and cause heart attacks. Unusually high levels of Tribbles have also been found in leukaemia cells, which fits with the proteinís other role in driving cell growth, although I should point out that it doesnít make the cancer cells furry.


Subscribe Free

Related Content

Not working please enable javascript
Powered by UKfast
Genetics Society