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The Naked Scientists: Science Radio & Science Podcasts

30th Jun 2007 < Previous Show | Next Show >

The Naked Scientists Q & A Show


Chris Smith

Phil Rosenberg

This week, playing bingo on an inflatable space station, a new way to attack the cause of Alzheimer's and mending a broken heart with stem cells.  Also, using bananas to speed up fruit ripening, leeches out of water and chemical tricks to stop smoking and iron out wrinkles.  Plus, in Kitchen Science we vibrate our way to a fountain in a cup!

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Bouncy Space Station

Las Vegas based space company Bigelow Aerospace have just this week successfully launched their second inflatable spacecraft into Earth orbit.

Bigelow Aerospace intend to launch the worlds first commercial inflatable space station by the year 2010 called Sundancer which will hold a crew of three and in 2012 they intend to launch an add on module called BA330 which will make the whole Bigelow station larger than the current International Space Station.

The International Space StationThe recently launched module is called Genesis 2 and is the second test mission using the ultra tough inflatable design. The craft includes 22 cameras, both inside and outside and also contains a number of personal items sent up to space by the public. Mostly people paid to send photos and memorabilia and the first images sent back show these items floating around inside the cabin.

Genesis 2 also carries a bingo ball selector which will be activated in the coming weeks so that people can play space bingo on the Bigelow web page


1st Jul 2007


New Alzheimer's Drug goes on Trial

A new class of drug designed specifically to combat Alzheimer's Disease has entered clinical trials in the US this week. Dubbed CTS-21166, the drug was the brain child of Purdue researcher Professor Arun Ghosh. Unlike existing treatments for Alzheimer's, most of which aim to boost levels of the neurotransmitter acetyl choline, CTS-21166 blocks an enzyme called beta-secretase, which is thought to be responsible for the pathological build-up in the brain of aggregates called beta-amyloid.An assortment of drugs

These are a neuropathological hallmark of the disease and are thought to provoke the death and dysfunction of nerve cells, which is what triggers the disease. Scientists suspect that if the formation of these amyloid plaques can be prevented then the progression or even the onset of the disease might be delayed. The trial, which is being run by San Francisco-based pharmaceutical company CoMentis Inc., has enrolled 48 healthy volunteers in a phase 1 trial to assess the safety and tolerability of the new drug, with phase 2 trials involving patients with Alzheimer's starting in 2008. Ghosh is optimistic. "The molecule is both highly potent and highly selective, meaning it does not appear to affect other enzymes important to brain function or cause harmful side effects".

1st Jul 2007


Galaxy Zoo

Ever wanted to take part in astronomy research, but don’t have a telescope? Well now you can get a chance to look through some of the most beautiful astronomical images taken and make a contribution to science in a project called galaxy zoo.The Andromeda Galaxy

A galaxy is a cluster of billions of stars swirling through our universe. Our sun for example is part of a galaxy called the Milky Way. These galaxies come in a number of varieties. Our Milky way for example is a spiral galaxy, which is flattened like a pancake and has spiral arms containing bright young stars, hence the name a spiral galaxy. But there are other types too large amorphous galaxies with no spirals arms are called elliptical galaxies for example.

A robotic telescope called the Sloan Digital Sky Survey has been automatically taking photos of one million galaxies and these now need categorising. Unfortunately computers have turned out to be incredibly bad at doing this, which is where the Galaxy Zoo project comes in. Members of the public get to be the first human eyes to look at some of these galaxies in return for telling scientists what kind of galaxy you think it is. But don’t worry if you think you’re not up to the task, full instructions are on the site and initial testing has actually shown that members of the public are better at it than scientists.

So if you’re keen then log on to www.galaxyzoo.org to sign up.

30th Jun 2007


Stem cells get to the heart of angina

Researchers in the US have found that patients with angina who received injections of their own stem cells into the diseased heart muscle showed considerable improvements in their symptoms. Cardiologist Douglas Losordo and his colleagues recruited 24 patients aged 48-84 with severe (grade 3 or 4) angina; on enrollment the patients were symptomatic upon mild exertion; even brushing their teeth was sufficient to provoke chest pain. The team harvested stem cells from the patients by injecting them with a hormone called G-CSF. This encourages bone marrow stem cells to grow and spill over into the bloodstream from which they can easily be collected.Mouse embryonic stem cells

The team used a molecular marker known as CD34 to single out the stem cells, which were then injected into the heart muscle in some of the patients. Others received a placebo. The injections were placed at sites in the heart known as "hibernating myocardium", which are regions of the muscle revealed by scans to contain viable muscle which is largely shut down (asleep) due to poor oxygen and glucose supply. Three to six months after the therapy the patients given stem cell injections had improved significantly. Some of them went from barely being able to make it to the toilet to managing two flights of stairs. The team suspect that the injected stem cells promote the formation of new blood vessels within the muscle, helping to boost the supply of oxygen and therefore increasing the workload that the heart can handle.

"Our goal is to reconstitute the microcirculation, get the blood back into the tissue and alleviate the symptoms," says Losordo.

1st Jul 2007


What prevents venomous animals from being knocked off by their own venom? For example, while the venom is being made in the glands? If I inject cobra venom into a cobra, would it die?

The reason that snakes, scorpions or other venomous creatures don’t poison themselves is because it’s kept in a very special compartment in the body, specifically designed not to let the venom out and not to be sensitive to the effect of the venom.  In a snake’s poison glands, there are specialised cells which have genes activated which tell them how to make the cocktail of proteins (snake venom is a protein) which makes up the venom.  The venom is then squirted out into a special system of ducts, lined with cells designed not to be sensitive to the venom.  The venom is produced, it trickles down these ducts and into a special bag which holds it and keeps it safely away from the rest of the snake’s body until it’s needed.

A snake’s teeth are hollow and, in the case of the cobra, curved.  This means that when the snake wants to bite something, it can lock on to its prey and hook its teeth in.  Muscles around the venom bag then contract, squirting the venom out through the hollow teeth and inside the tissue of the victim.

Normal tissue lacks the specialist defences found in the venom producing glands of the snake.

This is very similar to the human stomach.  We make digestive juices in the stomach including acid and enzymes which could break down our body’s tissues.  They are stopped from doing this by the stomach’s special lining, which protects it from the effects of the digestive juices.

If you were to inject cobra venom into the normal tissue of a cobra, it would have the same effect at it would on you!

July 2007


What is the surface of the Sun made of? Does it even have a surface? Andy, Harwich

The sun itself is made of gas, mostly hydrogen and helium, and so does not have a solid surface like you would find on Earth or Mars.  However, if you look at a photo of the sun you can see it has a definite edge to it. This is not because the gas stops at this point, it actually carries on diffusely for thousands of kilometres.  The Sun is hotter in the centre and cooler towards the outside, and there is a point where the hot gas becomes cool enough to become transparent, so this point is what we see as the surface of the Sun.

The surface of the Sun is about 5000 degrees Celsius, but inside its millions of degrees.  Nuclear fusion reactions occur inside the Sun, much like nuclear bombs going off all the time.

There is also material streaming off the surface of the Sun all the time, which forms the “Solar Wind”.

July 2007


Why does tea leave a stain in a cup only in a ring around where the surface of the tea was? Why doesn’t it stain the cup evenly? Cai, Manchester

In hard water areas, the water contains quite a lot of calcium in the form of ‘temporary hardness’ – calcium hydrogen carbonate Ca(HCO3)2.  When this is heated, the temporary hardness breaks down into calcium carbonate, which is chalk, and water. 

These calcium salts can bind to tannins in the tea and form an insoluble precipitate - a scum.  These particles float to the top of the tea, and stick to the side of the cup.  Tannins contain some of the colour of the tea, and so this ring of particles will be dark, and stain your cup!

July 2007


Cup Fountain

Make a fountain, and some fascinating patterns with a polystyrene cup and a piece of carpet.

What you need

A Polystyrene Cup

A polystyrene cup, full of water

A carpet

A carpet - office type carpets definitely work well. Make sure it doesn't matter if it gets wet...

 

 

What to Do

Pushing the cupPush the cup across the carpet, slowly, do you notice anything about the cup?

Speed up your pushing until you see some strange effects


What may Happen

 

 

Disturbed water 1

Disturbed water 2

As you start the water will start to vibrate

It will form waves of different shapes and patterns

Disturbed Water 3

Fountain

It will get more and more disturbed as you speed up.

Until it forms spouts fountaining out of the cup.

Here is a video of the effect.


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