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The Naked Scientists: Science Radio & Science Podcasts

31st May 2008 < Previous Show | Next Show >

Naked Science Question and Answer show


Dave Ansell

Kat Arney

Chris Smith

Footballs in space, mind-controlled machines and long-lasting bubbles join your questions on this week's Naked Scientists Question and Answer show. We discover the feminine side of prostate cancer and the robot that can walk up walls, and also hear how a computer has designed the next generation of mosquito repellents. Plus, we revisit the Phoenix mission on Mars, and also find out how surfing the internet can contribute more carbon to climate change than surfing the skies in an aeroplane! Plus, in Kitchen Science, Dave demonstrates a psychedelic effect with some milk.

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Wall climbing robots

Robots are becoming more and more important in war zones, disaster areas, and in every day life, in order to view places people cant access easily or safely. At the moment flying robots can't last for very long because they use so much power, and ground based robots are constrained to fairly flat surfaces.

SRI International's Wall Climbing RobotVarious groups have tried to make wall climbing robots based on suction pads, or reusable gecko adhesive, but none of them work on loose surfaces. Researchers from SRI international have invented a really elegant way to make robots climb walls, using the same principle as how you can rub a balloon on your hair and then stick a balloon to a wall.

This works by a process called electro-adhesion, the balloon sticks because when you rub it, you build up a large negative charge. When this is near the wall, the part of the wall close to the balloon will become positive and attract the balloon, this attraction is large enough for friction to hold it up. But on a conducting wall the charge will escape and the balloon will fall off quickly.

Harsh Prahlad and collegues have built a robot on the same principle, it has a series of electrodes insulated form the wall by a thin layer of flexible rubber. The robot charges up these electrodes to several thousand volts which then attract the wall in the same way as the balloon, and because the electrodes are insulated it will work on metal surfaces as well.

The robot will climb walls which are dusty, and can support between 20 and 140g per square cm of clamping area. But the researchers are still working on walls that are wet, as unfortunately the robot sticks to the water rather better than the wall...!

1st Jun 2008


Bacterial basis of "good bugs" and probiotics

Scientists have found convincing evidence for the basis of "good bacteria" and how they contribute to health.  Caltech researcher Sarkis Masmanian and his colleagues, writing in this week's Nature, have shown that a common friendly gut inhabitant, an anaerobic bacterium called Bacteroides fragilis, produces a sugary chemical called PSA, short for polysaccharide A, that can damp down inflammation.

Bacteroides biacutisFirst the team raised animals in sterile conditions to prevent them from becoming colonised with any gut bugs.  Apart from being less healthy from the outset compared with control animals, when these animals were challenged with a bacterial species called Helicobacter hepaticus they developed gut ulceration and inflammation.  But a prior dose of Bacteroides fragilis prevented the inflammation, as did giving just the PSA molecule in the diet.

On the other hand, giving the animals modified B. fragilis, which was unable to make PSA, made no difference, proving that the PSA was responsible for the effect.  PSA works by blocking the production of inflammatory signals including one called IL17, whilst at the same time promoting the production of regulatory T cells and other hormones like IL10, which keep the immune response in check.

The key question to address now is whether PSA can alter the situation for patients with established inflammatory intestinal disorders, like Crohn's Disease and ulcerative colitis.  Encouragingly, giving these patients doses of worms, which are thought to have similar chemical effects to PSA, can damp down the disease, suggesting that PSA could be the key to future therapies.  Until it's proven though, it'll remain a gut feeling!

1st Jun 2008


Prostate cancer discovers its female side

Prostate cancer affects more than 670,000 men worldwide, and researchers have known for a long time that the disease is fuelled by the male sex hormone testosterone.  Men with prostate cancer are often given drugs that block the production or actions for testosterone in the body, and these treatments are often successful to start with, but their cancer eventually develops resistance and starts growing again.

A Prostate Cancer CellNow scientists at the New York Presbyterian Hospital and the Weill Cornell Medical Centre have made a surprising discovery that could make a big impact on the way that men are treated, if the results hold true.

Led by Dr Mark Rubin, the scientists analysed the activity levels of more than 6,000 genes in 455 prostate cancer samples.  They found that samples from more aggressive cancers appeared to be driven by a receptor for oestrogen, the female sex hormone.  

To get a bit more detailed, around half of all aggressive prostate cancers are driven by a fusion protein, created when two important genes get spliced together.  The researchers found that oestrogen can boost the activity of this fusion protein, fuelling the cancer growth.

But what does this mean for men with prostate cancer? We know that oestrogen plays an important role in fuelling breast cancer, and there are a number of very successful therapies for this disease that target the hormone.  So this discovery raises the possibility that similar drugs could be used to treat men with aggressive prostate cancer.  And, more speculatively, there’s the possibility that oestrogen or oestrogen mimics in the environment might be helping to increase the risk of prostate cancer, or fuelling its growth.

1st Jun 2008


Footballs could be the answer to the exploration of planets

Orbiters around planets such as Mars have given us an unprecedented view of the whole surface, but sometimes you actually have to go down and have a look. Last week the Mars Polar Lander touched down and will be digging holes and studying the chemistry, but only in one place. Rovers like Spirit and Opportunity can travel further, but in over 4 years they have only travelled a few km which isn't far on a whole planet.

A footballResearchers from Angstrom Aerospace in Sweden may have a solution to this problem. Their design involves putting the rover in what is basically a football.  You put an axel across an inflatable sphere and then hang all the batteries and electronics below it, a bit like a pendulum.  By moving this pendulum the robot can twist the axle and make the ball roll, and if it wants to steer it moves the pendulum to one or other side. The idea is to attach cameras and probes at the ends of the axle and if the robot wants to take a sample it can just tip over onto it's side.

As the robot is inflatable it will take up about half of the space of an equivalent robot, and because it is fundamentally a football, it rolls really efficiently and you are much less worried about bumping into things. So it should be able to get up to about 30km/hr and travel about 100km on a battery charge, Then it would have to recharge it's batteries from flexible solar panels build into its skin.

The researches propose using these small robots as scouts for larger wheeled robots which would carry more sophisticated sensors

1st Jun 2008


Movement by the power of thought

US researchers have developed a system which translates brain activity into movements of a prosthetic arm, a discovery which could help patients paralysed by strokes, injuries and other diseases to regain their independence.


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