Plant Sugars Provide PetrolWe all know that the days of fossil fuels are limited, so researchers are trying to find alternative fuels. Biofuels have risen in popularity in recent years – fermenting plant material to make ethanol is already being used to produce fuel in several countries around the world. But ethanol is a long way, chemically speaking, from the petrol (or gasoline for our US listeners) and diesel that are currently used in car engines.
21st Sep 2008 Fungi are world's fastest fliersScientists have discovered the fastest fliers in nature and, somewhat surprisingly, they're fungi!
Writing in this weeks PLoS ONE the team have successfully made fungal ballistic measurements of spore trajectories to reveal that these organisms are firing their microscopic projectiles, which measure just a fraction of a millimetre across, at speeds exceeding 25 metres per second and at rates corresponding to 180,000 times the acceleration due to gravity. This is sufficient to propel the spores up to 2.5 metres away from the parent dung pile. The team were also able to get a handle on how the organisms achieve their fungal feat. A concentrated mixture of sugars, alcohols and other metabolites inside the fungus and its fruiting body pulls in water by osmosis, priming the gun at a pressure about four times that of the atmosphere. At the right moment the structure ruptures and the pressure drives out the spores. According to the researchers the images of these fungal ejaculations are so pretty that they've set them to music and plan to post them on YouTube!
21st Sep 2008 ‘Baby’ Fat may Beat ObesityIt’s something that many of us struggle with – fat. But where does it come from? Researchers in Dallas have finally tracked down the location of immature fat cells, which hide out waiting for the extra calories that turn them into flab.
21st Sep 2008 Stem Cells Muscle InScientists have shown that, contrary to prevailing wisdom, muscles contain stem cells that can repair, replace and strengthen injured tissue. Writing in Nature Stanford researcher Helen Blau and her colleagues have identified a collection of chemical markers that can be used to identify a population of muscle stem cells.
The team made the discovery by genetically labelling the cells with a coloured marker protein before injecting them into mice with damaged leg muscles. This technique enabled the researchers to follow the progress of the same mouse over a period of time by using a sensitive camera that could pick up the increasing intensity of the coloured stem cells as they grew. "We were able to show that the injected cells increased their own numbers, contributed to existing muscle and also produced entirely new muscle in these mice," points out Blau. The results are very exciting because now researchers are able to readily identify the muscle stem cells they can turn their attention to discovering ways to activate them in people with muscle-wasting diseases, or use them to repair muscles in trauma patients. "That's the next step," says Blau.
21st Sep 2008 Surprise Attack - Stopping Bacteria from Sensing your Immune ResponseVanessa Sperandio, Southwestern Medical Centre, University of TexasChris - Some bacterial infections, like E. coli 0157 which is a cause of food poisoning and can also damage your kidneys, seem to get a lot worse when you give patients antibiotics, instead of getting better. It seems that this is because the bacteria enter a sort of high-alert state in response to the treatment. They fight back by becoming a lot more virulent. Researchers at the Southwestern Medical Centre, University of Texas have come up with a drug that can stop the bacteria from sensing the chemicals in your body that tell the bacteria your body’s gearing up to fight them. Dr Vanessa Sperandio is in Dallas and she joins us to tell us a bit about this research. Hello... Vanessa - Hello Chris.
Vanessa - They sense two stress hormones that you have: adrenaline and noradrenaline, and they use those two hormones as cues to know they are inside of you. When they sense that through a receptor in the bacteria they activate production of the virulence trait. By doing that they can actually make you sick and turn on everything that will cause disease. Chris - It’s intriguing to think that these bacteria are eaves-dropping on our own inflammatory signals. They’ve learned or evolved, I should say, to detect the signals our body uses to fight them. Vanessa - Yes, and those are very primal types of signals. That’s at the core of your immune system and it’s the core of gauging how well – how healthy or not you really are and how stressed you are. Chris - How did you get a handle on what the bacteria were doing and then try to work out how to stop them? Vanessa - We figured out many years ago that they were using the signals and then in 2006 we were able to identify one of the bacterial receptors for this signal. What we’ve done now is to develop drugs that will bind to the bacteria receptors and prevent the receptors from seeing the host’s stress hormones. In this way the bacteria passes blindly through the host without being able to know where it is and activate it virulence traits. Chris - So you’ve managed to come up with a drug molecule that can block up the ability of the bacteria to see adrenaline or noradrenaline so the bacteria don’t effectively know they’re in the body. Vanessa - Yes. Chris - How could this molecule be used and is it safe? Vanessa - So far the molecule is safe. Of course, this is in the lab of proof of principle. We did do some preliminary toxicology in mice and so far it looks to be safe. It also does not signal to human adrenergic receptors, which is important. It can be used either to treat infections or hopefully we want to try to use this to prevent infections.
Vanessa - It can be very useful for something like E. coli 0157 which, right now, has no treatment. We also did look at this drug to treat salmonella infections which can cause gastroenteritis and typhoid fever. We looked into tularaemia which is a bioterror agent. In between these bacteria there are several important pathogens that have this sensor. This could be used hopefully to treat some of the communal infections especially for patients in ventilators. Bacteria like klebsiella, acinetobacter, pseudomonas who are important in this class of patient s which do not have a lot of treatments and antibiotics against and are quite resilient to the biotic treatments. They all posses this signalling system. Chris - When do you think that we might be seeing this going into humans in clinical trials? Vanessa - We’ve got money from the National Institute of Health to develop this drug to pre-clinical in five years which means in five years we want to be able to have everything pre-clinically, toxicology and safety done. Hopefully in five years we’ll start the first safe trials in humans. Chris - Thank you Vanessa. September 2008 |
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