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14th May 2006

BSE, Cervical Cancer and Toxoplasmosis


Helen Scales

Chris Smith

As the ten-year ban on British beef exports is lifted, Professor Tony Minson from Cambridge University joins us to discuss what causes BSE, how it is spread and why it is such a problem. With another example of how animal diseases can be passed to humans is Dr Joanne Webster from Imperial College London who describes the life cycle of Toxoplasma gondii, how it makes mice as mad as hatters and a possible link to schizophrenia in humans. But it's not all doom and gloom as Professor Margaret Stanley from Cambridge University reveals how a cervical cancer vaccine is proving highly successful in clinical trials, and Derek Thorne has fun with food colouring in Kitchen Science.

 

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Questions

 

Do TV and radio signals travel vertically, and if they do, do they disappear or travel off into space forever? If so, does that mean that a signal from the 1950s is still in space somewhere?


 

I was listening to my radio one night and I noticed that when I turned on my desk light there was a little blip of noise on the radio. I repeated this and I noticed that when I was on the border of completing the circuit, such that when the bulb was flickering, I got severe interference on my radio. My radio was running on batteries. Why does this happen?


 

As far as I know, mammals do not use the colours blue or green, but most other animals and plants do. Is there a reason for this?


 

Have we got a time bomb in the population with mad cow disease?


Interviews

 

Science Update - Monopoly and Lung Cancer

Chelsea Wald and Bob Hirshon From Aaas
 

What Is Bse And How Is it Spread?

Professor Tony Minson, University of Cambridge
 

When Rats Chase The Cats

Dr Joanne Webster, Imperial College London
 

Human Papilloma Virus And a Cervical Cancer Vaccine

Professor Margaret Stanley, University of Cambridge

Fact or Fiction

US Pentagon staff get through 1000 rolls of toilet paper a day
TrueTrue
Acetylsalicylic acid is the chemical name for aspirin
TrueTrue

BSE, Cervical Cancer and Toxoplasmosis - More about this podcast

BSE - Bovine Spongiform Encephalopathy, commonly known as "mad cow disease" was first recognised in the UK in 1986 and became an epidemic; peaking in 1992 as 37,000 cases were reported that year. To date over 183,000 cases have been confirmed, altough the number of new cases is now at its lowest since records began. And at the beginning of May (2006) the EU lifted the worldwide ban on British beef exports, ten years after it was introduced to prevent the spread of BSE. (source: Defra)

So why is it called "mad cow disease"? - BSE occurs in adult animals of both sexes, usually in animals aged over 5 years. It is a neurological disease in which affected animals show signs that include: changes in mental state, abnormalities of posture, movement and sensation .The clinical disease usually lasts for several weeks and is invariably progressive and fatal.

BSE has been linked to CJD - Creutzfeld - Jakob disease; this is a disease which causes paralysis and death in humans. Over 140 people have been diagnosed since it first appeared in the UK and most of them have died.
How does it spread between cows? What is the link to humans? Why did it take so long to eradicate the disease? Is British beef now safe? To answer these questions and any others you may have, two eminent Cambridge professors in pathology, both of whom have acted in an advisory capacity in relation to this disease, will appear on the Naked Scientists this week. Here's a bit of background to their work...

Professor Minson specialises in herpesviruses which are amongst the largest and most complex viruses. Different members of the herpes virus are responsible for different human diseases ranging from chicken pox, glandular fever, cold sores and genital herpes, as well as economically important infections in domestic animals - such as BSE. All herpesviruses are composed of at least 30 different proteins of which ten or more are inside the membrane which surrounds the virus particle. Interactions between these membrane proteins and the host cell are the first step in the infection process; this causes the fusion of the virus and host membranes which releases the virus core into the cell. All enveloped viruses can induce membrane fusion but the herpesviruses are special because membrane fusion and the entry of the virus into the host cell is achieved by the action of four different viral membrane proteins. Minson's research attempts to define how the membrane proteins are assembled into the virus particle and how they function together to create membrane fusion.

Professor Margaret Stanley specialises in HPV - human papillomavirus. These are a large group of pathogens which infect skin and mucus membranes, which can cause a variety of disorder from warts to cancer. Certain types of HPV particularly HPV 16 and HPV 18 are closely connected with the development of some human cancers, particularly cervical cancer. Margaret has been a key player in the development of the world's first cervical cancer vaccine which is currently showing extremely promising results in trials that are on-going. Cervical cancer is one of the leading causes of death amongst women worldwide, and especially in the 3'rd world where countries lack the infrastructure and funding to implement a screening programme.



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