Science News
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The holy grail of finding extraterrestrial life has been the discovery of an Earth-sized planet with just the right temperature for liquid water to exist on the surface... |
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Researchers in America at the Ohio State University Medical Centre, led by neurologist Yousef Mohammad, have found that a quick zap to the head with a magnet can stave off a migraine attack. Character... |
Questions

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Is there any scientific reason why a key suspended from a length of string held over food always seems to indicate correctly whether I can eat a particular food? If I eat anything containing MSG (monosodiumglutamate) in any form, I get a very severe migraine. If it rotates clockwise then the food is taboo, but if it rotates anticlockwise then the food is ok for me to eat. I really can't believe that this is true.
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Sorry Mary, but we can't believe it's true either. I imagine that any spinning is more to do with the twist of the cotton that you hang the key on than anything else. There's probably a bit of gambler's fallacy kicking in there. You're expecting the right answer and therefore the result happens.
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I tend to get awful headaches that fall under the migraine classification but I notice that they're weather related. Why is it that weather should have these effects?
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I don't know whether there is a direct relationship between pressure and headaches. If anyone listening knows anything about a link between migraines and weather, I'd be very interested to hear about it. My email is chris@thenakedscientists.com. One thing that does occur to me is that if you have high pressure, then usually that's associated with a warm day. When people get very hot, they get dehydrated and a fierce headache. That could be possible.
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How cold is it in outer space and how do you protect satellites from extreme cold?
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It's a bit of a fallacy that outer space is really cold. It actually depends on how close you are to the sun. One problem is that it doesn't feel cold like it does on the Earth. There's no air around you to conduct heat away from you or towards you; everything is done by radiation, passing light from one object to another. Light from the sun falls on a body and heats it up. For satellites up in space around Earth, we actually cover then in reflective material to keep them cool, and insulating material to keep them hot. If they're in the sunlight, they actually overheat so we put reflective material on there to reflect the light away. When they're in the Earth's shadow, we can use heaters to keep it warm. When you get further and further away from the sun, it gets really cold. The outer space around Earth is around 20 degrees Centigrade. If you go out to Pluto, you're probably looking at around minus 220 degrees Centigrade. So it depends on exactly where you are.
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Why do we assume that life on other planets would be a carbon-based Homo erectus type of being that breathes oxygen? Could it not breathe hydrogen or methane or be based on a different element?
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I completely agree with you, John. The point is that here on Earth we see organisms the breathe methane. We see organisms that breathe and produce hydrogen as a waste product, and we see organisms that produce hydrogen sulphide as a waste product. In fact some of the first organisms on Earth were methanogenic bacteria. They produced methane by taking simple carbon building blocks from the environment, jamming them together with four hydrogens and making methane. Some scientists from Japan found some of the world's oldest bacteria locked away inside tiny bubbles inside quartz. Life can come in all shapes and sizes, and evolution can pattern us and puts pressure on us to become adapted to our environment. On a different planet, things could be completely different and we have no reason to assume that alien life would look or even metabolise anything like we do.
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If as a human I share 98% of my genes with a chimpanzee and 60% of my genes with a banana, how come I only share 50% of my genes with my own daughter?
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I would say that you actually share more than 98% of your genes with a chimpanzee. I suspect that virtually all of the genes in the human genome also have counterparts in the chimpanzee genome. The most likely explanation for the fact that we are so obviously different from chimpanzees is the way in which these genes are controlled and the way they are switched on and off, and the length of time for which genes are active. You share 50% of your genes with your daughter because she's obviously inherited one genome from you and one genome from her mother. We all have two genomes in our bodies: one from our mother and one from our father, but there are counterparts to all of your genes in the genome that your daughter has inherited from her mother. If you compare a banana with a human, just over half the genes in a banana will do the same job in a banana as they do in a human. However, the genes themselves will not be the same letter for letter; they just perform the same function. In contrast, when you are talking about the genes you share with your daughter, you are not asking how many of the genes have the same function (which is 100%), you are asking how many of those genes are absolutely identical, letter for letter. The probability that any one of those genes came from the father is 50%, and the probability that a gene has come from the mother is also 50%. This is why you share 50% of your genes with your daughter.
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Why do people go bald?
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I should make it plain from the outset that I don't really understand why people go bald. I'd probably be very rich if I understood that! Baldness is what is described as a sex limited condition rather than a sex linked condition, which means it tends to affect one sex more than the other. In this case it's obvious: it affects males more than females. But it's not a straight forward inheritance of a gene on the Y-chromosome, for example, that leads to baldness. The genetics and inheritance patterns are more complex than that, otherwise people would have been able to follow these inheritance patterns through families and understand more about the genetics of baldness. So we're not there yet, but we have some useful information.
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I'd like to hear about recessive genes and why they say that blondes and ginger people have more of these genes and will become extinct. Why will the genes only kick in now and not before and have there been genes in the past that have timed out? Is it possible for genes like green hair to start up and replace them?
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I'm not sure I can comment on the idea that blonde and ginger people will become extinct, as it's the first time I've heard that. But interestingly, some people have speculated that the Y-chromosome that we were talking about earlier may disappear completely. The Y-chromosome has degenerated during the evolution of the sex chromosomes. Some people have speculated that in 10 million years it will have disappeared altogether. Obviously that is of some concern to males, but suffice to say that natural selection will act against anything that prevented there being males within the population. So for the Y-chromosome to disappear, another gene would have to arise to make a male sex. But I really can't comment on the extinction of blonde and ginger people.
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Why is it, that despite all this talk of evolution going on, humans have not evolved for the last 4000 years?
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There are obviously different components to evolution. There's a component of genetic change and genetic change is still going on. There's also the component of natural selection whereby certain adaptations are selectively advantageous or disadvantageous. There's an argument that we've stopped evolving as humans because we've removed those elements of natural selection. Other people are speculating that we're evolving in different ways; psychologically and so on rather than physically. But it's an open question.
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Do scientists have any understanding of the mechanisms that skills, that animals such as humans, learn and pass to their offspring via their genetic code?
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That's a very difficult question to answer. I'm not aware of there being any evidence for learning of particular skills then becoming hard wired in the DNA. This was a theory that was quite popular in the early twentieth century that perhaps things could get hard wired into the DNA, but I'm not sure there is a mechanism for that to occur.
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| Interviews
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Chelsea Wald and Bob Hirshon from AAAS, the science society
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Dr Mark Ross, the Sanger Institute, Cambridge
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Dr Michael Traugott, University of Innsbruck and University of Cardiff
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Kitchen Science

You've heard about DNA, but have you ever seen any? This week Derek and Lucy extract DNA from Kiwi fruit using just simple kitchen items.
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| Sex Chromosomes, Genetics and Food Webs - More about this podcast
| Figure 1: The larger X (on the right) and Y (left) chromosomes magnified 15000 times by an electron microscope. |
Ever wondered why there is an 'x' in 'sex'? Or indeed why you are the sex you are? The answer lies in your DNA… This week on the Naked Scientists Dr Mark Ross, an Investigator at the Wellcome Trust Sanger Institute (part of the International Human Genome Sequencing Consortium), will be on the show to tell us about all about the X chromosome. Mark Ross has co-authored publications on the map and sequence of the human genome as a whole, and led the team that sequenced and analysed the human X chromosome. His major research interests lie in studying the sequence for clues to the evolution and biology of what he considers the most interesting of human chromosomes.straight-forward chromosomes, but at one point X became touched by magic and developed special powers that allowed it to determine sex. Chromosomes are made up of DNA, which is a chain of chemical building blocks known as nucleotides. There are four types of nucleotide; adenine (A), cytosine (C), guanine (G) and thymine (T). Last year the X-chromosome's DNA sequence was published by a team led by Dr Mark Ross. 115 million As, Ts, Cs and Gs later the X chromosome is giving clues to how sex chromosomes evolved, and the role of X-linked genes in human disease.
Humans have 23 pairs of chromosomes; 22 of those come in identical pairs, this allows them to swap DNA with their partner. One pair of chromosomes has non-identical partners, they are X and Y and they don't like to share. Once upon a time, (roughly 300 million years ago, to be a bit more specific) there lived an animal which was the ancestor of mammals, birds and reptiles. Sometime later (a bit less specific as this is still only a theory) mammals and birds went their separate evolutionary ways, each with a different pair of chromosomes responsible for determining sex. In mammals this pair was X and Y, in birds it was W and Z.

| Figure 2: The Sanger Institute's Mark Ross, who is trying to answer fundamental questions about where the X chromosome came from, and how the genes encoded within it are controlled. |
For mammals the sex determination trigger was pulled by the emergence of the Y-chromosome SRY gene - this is the master switch in male development. Over time most of the Y chromosome's DNA lost the ability swap with X, without a partner it could use as a template to repair damage, Y has gradually become a shrunken stump and lost most of its DNA. The X chromosome has 1100 genes and Y only 76. This can be seen in figure 1. See there is a reason your mother told you to share your toys!
Generation X: Mark Ross is comparing the human chromosome sequence with the X chromosome of other mammals. From this study is seems that the X chromosome has gained pieces of DNA at various stages of mammalian evolution, the leading change occurred when a large region from another chromosome was added during the evolution of the placental mammals. Other changes have been more subtle. Chunks of DNA have been acquired by the X and Y chromosomes simultaneously, so there would have been two active copies. Over time the Y chromosome segment has decayed and the X copies have been recruited into X chromosome inactivation gradually.
X chromosome inactivation: X spent so much time evolving into the ultimate cool chromosome, so why is there a need for inactivation? The answer lies in the role of X and Y in mammalian sex determination; females are XX and males are XY. To prevent females with their two X chromosomes receiving a double dose of male gene products, one of the X chromosomes is shut down early in the development of the female embryo. Originally it was thought that the inactivated human X would be completely inert, however using the genome data from the Sanger Institute and its collaborators; this is not the case at all. Looking at activity levels of hundreds of genes on the inactive X, it was found that about 15% escape from inactivation. A further 10% of supposedly inactive genes are actually active in some women but not in others. Of all the 40 women used in the study, each had a unique pattern of gene activity.
So why do some genes become inactive whilst others choose to carry on as normal and what does this mean for the individual? At the moment it is too early to say, preliminary studies however, show that inactivation escapees may underlie the effects of sex chromosome anomalies. Mark is currently investigating the differences between regions of X chromosome inactivation and regions of escape. He wants to find out whether the genes that escape form domains or whether they escape on a gene by gene basis. |
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