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27th Jan 2008

Flu and Viruses


Dave Ansell

Chris Smith

In this week's not-to-be-sniffed-at infectious episode of the naked scientists, we find out the facts of flu, including how the virus hijacks your cells, how new strains of the virus emerge to trigger epidemics and pandemics, and how scientists can combat the threat with vaccines.  Also under the microscope is a new technique to identify viruses within just 2 hours, providing patients with a fast track to the right treatment!  Also, how bone marrow transplants can overcome organ rejection, how to stop a terrorist with a mobile phone, and the new material 30 times blacker than our current blackest black! Plus, in kitchen science, we'll be pouring cold water on claims of centrifugal force...

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Science News

Organ Transplants without Rejection

Four out of five patients participating in a recent kidney transplant trial in America have been able to stop using immune-suppressing drugs. The patients, aged 22-46 years old, had all developed kidn...

Cell phones to Detect Nuclear Terrorism

One of the biggest nightmares of the police and security services is a dirty bomb, this is where a terrorist blows up a conventional bomb surrounded with radioactive material. This is not a real nucle...

Pregnancy-Caffeine Combo Bad Idea

Researchers have shown that caffeine exposure is linked to an increase risk of miscarriage. De-Kun Li, from Californian health insurer Kaiser-Permanente, followed 1063 women during the first twenty we...

Grass could be the fuel of the future

Transport systems have been powered by grass for hundreds of years in the form of horses, but it looks like it will be a fuel of the future as well. Farmers in Nebraska and the Dakotas have been taki...

Kitchen Science

Inverted Bucket


Have a bucket full of water upside down over your head, and stay dry!

Question of the Week

Treadmill runway?

Could a plane take off on a 'treadmill' runway?


How funny - thanks for telling us!

Chris...
- chris - 31st Jan 08

FYI: http://www.edcp.org/influenza/Influenza_serv.html if you want to know how flu is going on this side of the Atlantic. I keep tabs on how things ar...
- RenRen - 1st Feb 08

Thank you, we're very grateful for your feedback. And if you'd like to write an article for us about what you do, that would be wonderful!- chris - 1st Feb 08

I would be honored to write something up. There are two options, however... I could write as an epidemiologist and just talk about how we go about inv...
- RenRen - 1st Feb 08
Whole Thread | Post Reply

Interviews

The Blackest Black

Professor Pulickel Ajayan, Rensselaer Polytechnic

Rising Stars - The Brain and the temptation of Cake

Yvonna Reekie

Influenza - Flu Facts

Ed Hutchinson, Cambridge University

Finding Flu Fast

Martin Curran and Tim Wreggitt, Addenbrookes Hospital

Virus Vaccination

Dr John Wood, NIBSC

Questions

Fluorescent lights are already efficient when they’re running but I’ve heard that it takes a lot of energy to turn a fluorescent light tube on. So is it more efficient to turn off a fluorescent tube immediately when you’ve finished using it or is it better to leave it on and then wait until you’re more likely to not use it again for a while? This question was first asked in last week's show.


I recently bought some tiny magnets from a hardware store to stick things up on my wall. I bought these magnets called rare earth magnets. They’re so strong that now I can’t unstick them from each other. It’s amazing, can you tell me how these tiny magnets that’re about 1.5cm in diameter, different from other magnets that don’t have the same kind of power?


My wife and I are expecting our first child and we’ve been using a Doppler machine to listen to the baby’s heartbeat. It’s very fast, at least 150bpm whereas ours is about 70. Why is this? Does an elephant have a very slow heartbeat and does it take longer for the blood to circulate in bigger animals, for example?


 

I’ve been in contact with someone who’s had the flu quite badly but I didn’t catch it. Why would that be?


Since viruses aren’t technically living organisms, where did they come from and how were they formed how have they evolved?


If you suffer from coldsores, can you pass on the virus even when you don't have a coldsore showing?


Flu and Viruses - More about this podcast

If you've spent this winter curled up in bed, running a high temperature and sipping hot lemon, then you've probably had a brush with 'flu.  This week on the Naked Scientists, we're looking into the science of flu, viruses and the vaccines that could keep us out of bed!

Who's Virus it it Anyway?

PCR tubesWhen your feeling achy or coughing hysterically, it can be frustrating when the doctor sends you for various time-consuming tests to find out what's wrong with you, and in many cases you often feel better by the time they find out what was wrong!

But now a new technique in use at Addenbrookes hospital in Cambridge is revolutionising diagnosis of flu and the common cold. Real-time PCR is a new sampling procedure that can tell you all the bugs you've got in your system within 2 hours!

Meera speaks to Dr Martin Curran about how this analysis works and the benefits associated with it.

If the genes don't fit...

Every so often, new strains of the influenza virus appear and cause devastating pandemics, which can kill millions of people.  One way for these new strains to appear is when two different viruses, used to growing in different host species, infect a cell at the same time.  The viruses produced from this cell will get some genes from one parent virus, and some from the other.

Influenza Virus

Influenza can do this as its genes are not all on a single strand but are divided between eight, physically separate, segments.  These segments are a bit like chromosomes, and as well as allowing the virus to swap genes they also cause it problems.  A new virus must include at least one copy of each of the eight segments, from whatever source, otherwise it will be missing genes.  We know that influenza has evolved a mechanism to make sure that all eight segments are included when a new virus is put together, but we don’t know what it is or how it works.

Cambridge University researcher Ed Hutchinson is using a range of genetic techniques to identify the bits of segments involved in making sure influenza includes all its genes – something we need to know both to understand this deadly virus, and to design vaccines against it.

Virus Vaccines

VaccinationHere in the UK, once you're collecting your pension you're also encouraged to collect a 'flu vaccination every year.  But how are these vaccines made?  If viruses are constantly mutating, how can we tell if a vaccine is any good?  Will a winter flu jab keep you safe from other viruses, even bird flu?

Dr John Wood, Principal Scientist in the Division of Virology at the National Institute for Biological Standards and Control (NIBSC) in the UK, will be coming into the studio to tell us about his work.  Dr Wood sits on the World Health Organisation advisory panel on influenza vaccine development, and is working on vaccinations that will protect across a broad range of viruses, including H5N1 bird flu.




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