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23rd May 2010
Transmissible Tumours
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Cancers you can catch go under the Naked Scientists microscope this week. We find out how a transmissible facial tumour is devastating devil populations in Tasmania and also hear how the Human Papilloma Virus (HPV) causes cancer. Also, Meera looks into the science of cervical screening, and Ben and Dave reveal how carrots can help us to spot cancer cells. Plus, biofuel hope from the burning bush plant, the battle between Staphylococcus species, and the introduction of Synthia - the first microbe with a genuinely synthetic genome.
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News
Researchers at Michigan State University have made a discovery that could help turn the burning bush into the saviour of future biofuels, according to their paper in PNAS this week...
Researchers in Japan have discovered that the key to killing MRSA may lie with one of its own relatives - Staphylococcus epidermidis
An international team of scientists, writing in the journal PNAS this week, have found a way to reactivate dormant egg cells. This could have big benefits for infertile women, or those who have had their ovary tissue frozen before treatment for diseases such as cancer...
Questions

Can you catch cancer?
Kat - I get asked that a lot. As far as we know, the only cancers that are contagious are these Tasmanian Devil facial cancers and this dog venereal cancer. There’s no need to worry that you can catch cancer from another person with cancer.
Chris - Well having said that Kat, what about organ transplants because obviously, if there is a cancer that we don't know about lurking inside the donor organ, there’s a possibility you could transmit that, couldn’t you?
Kat - There is a possibility and also, interestingly, in patients who have had organ transplants, they're often on immunosuppressive drugs to stop their immune system attacking the cancer, and in fact, this can lead to an increase in certain types of cancer in a patient. But you shouldn’t be worried if one of your relatives is affected by cancer. You can't catch it off them so that’s important to point out.

What are the consequences of HPV infection in males?
We posed this question to Margaret Stanley from the University of Cambridge:
HPV is transmitted from skin to skin. So it’s very important to emphasize that you don't have to have full sexual intercourse, penetrative intercourse. Foreplay, kissing is an easy way of transmitting. Now, more men than women get cancer of the anus, the back passage. Men get cancer of the head and neck and it looks as though more men than women get cancer there as well. So yes, there are men who get HPV from women, women who get it from men, men get it from other men if they have sex with them, and it’s the same for women with women.

How are translocations related to cancers?
We posed this question to Elizabeth Murchison from the Wellcome Trust Sanger Institute...
Elizabeth - Well cancer happens when genes called tumour suppressor genes and oncogenes are mutated and cause the cell to start dividing abnormally. And this can happen when you get single point mutations in your DNA which mutate an oncogene or a tumour suppressor gene, but they can also occur when two genes can come together abnormally in a translocation and what this can often do is to drive a gene which is not normally active in a particular cell type up to an abnormal level of activity which can sometimes cause the cell to become cancerous.
Chris - I get it. So by the chromosomes rearranging themselves, the gene which would normally be off in a cell can end up being put next to a gene which is normally on in that cell, so the cancer causing gene also gets turned on abnormally and makes the cell misbehave.
Elizabeth - That type of thing, yes.
Kitchen Science
How grated carrot and some ink can teach us about staining cells
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Interviews
This week the J Craig Venter Institute announced the creation to huge fanfare of a brand new synthetic microorganism dubbed, “Synthia.” This has prompted lots of excitement but also lots of controversy. Some people have argued that Synthia isn’t entirely synthetic. So to tell us more here’s Craig...
2010 is the International Year of Biodiversity, and as part of that, BioBlitz events will be going on across the country. Their aim is to get the public to come and help catalogue all the biodiversity in that area. Ed Drewitt from the Bristol Natural History Museum tells us more about the Bristol ev...
An iconic animal, the Tasmanian Devil is under threat from a type of cancer that can be transmitted between individuals. Elizabeth Murchison from the Wellcome Trust Sanger Institute has been studying the genetics of the cancer.
Human Papillomavirus or HPV is the main cause of the majority of cases of cervical cancer. Professor Margaret Stanley from the Department of Pathology at Cambridge University explains more about what we know about the virus and the newly-introduced HPV vaccine.
Cervical screening helps to catch cancers before they become a problem, but what actually happens to a sample after it’s been taken? Meera Senthilingam has been finding out...
QotW
Despite external similarities, Donkeys and Horses sound very different. We find out why, as well as ask what noise a Zebra makes...
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