Science Questions

'Smart Drug' side effects?

Thu, 24th Jan 2013

Part of the show Smart Drugs, Anyone?


Teo Gibson and Ryan Chown asked:

What effect do these cognitive enhancer drugs have on the teenage brains?Ē


Barbara -   Yes, well thatís an extremely important point because I'm very concerned about the use of these drugs in healthy children. 

So for instance, if you have attention deficit hyperactivity disorder ADHD, itís very important if you got severe ADHD that you get a treatment thatís effective like methylphenidate or Ritalin because if you donít, it will impact on your ability to perform well at school and have a good normal education.  So, you do need a treatment in order to do well at school and to obviously also make friends behaviourally, and so forth.  So, itís really important that if youíve got severe ADHD, you get a treatment. 

But then we have to ask, ďWell, what are these effects when healthy people are taking these drugs on the developing brain?Ē 

Really elegant work at the National Institute of Mental Health led by Jay Giedd and others - it shows that our brains are still in development well into late adolescence, early young adulthood, so even up to the age of 25 years.  So, we have to ask the question, what are the effects of these drugs on a healthy developing brain?  What is the influence?  Will we be tampering with something thatís already set to function really well and normally and will we have a disadvantage later on? 

So, I think we really have to be concerned about young people who are healthy, taking these drugs.  And in particular, the frontal lobes are in development later on, and so, they're very important for our cognitive control and executive function, memory, various forms of working memory, and also for planning and executive functions such as problem solving.  So, we donít want to tamper with something thatís already functioning quite well.


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