Science Questions

Why do we get fatty lumps?

Mon, 4th Jul 2016

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Question

Valerie McLaren asked:

My Mother in law has quite a few (fatty lumps) Lipomates all over her body. She has had 10 previously removed and they just seem to re-appear. They are not painful in any way but they are quite large and some of them noticeable through her clothing. Could you please supply some info on the causes of these fatty deposits?

Answer

Kat Arney put this to fellow Naked Scientist Chris Smith...Lipoma

Chris - It sounds to me like these are what we call a lipoma or when you have more than one, they are lipomata which are benign tumours or benign growths of fat. They may also be fibromas because thatís fibrous tissue, but they sound like the fatty equivalent Ė fibro and lipomas. There is a condition and itís called familial lipomatosis. Itís very rare. About 0.002 per cent of people have this. Itís caused by a gene which is usually a dominant gene Ė as youíve just heard what that is from Kat Ė and that means you usually see this running in families. But because with every generation, you pass on 30 to 50 new genetic changes or mutations from parents to offspring, these changes can arise sometimes de novo. In other words, out of the blue. And so, there may be no obvious family connection because this is a new mutation. We donít know why it happens but we know itís twice as common in men as women. It tends to occur on the trunk or on the limbs. It tends to spare the shoulders and the head. It is not harmful really and most of the time, these things, despite being a bit unsightly, won't do you harm, they can be shelled out or removed. But because they are growing from a preponderance of the fat cells to form these little benign tumours or growths, they do recur. And so, just because you take one out, you may get another one somewhere else.

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The lipomas and/or benign mesenchymal-tissue neoplasms are common in obesity and evidence suggests they are often the result of HMGI-C gene mutation.
exothermic, Tue, 5th Jul 2016

In addition to what Chris mentioned regarding the genetic link to lipomas i.e. familial multiple lipomatosis, patients with Gardner syndrome are prone as well.

Overall though I'd say the link to obesity via HMGI-C gene mutation is the most plausible cause for the prevalence of lipomatosis. exothermic, Tue, 5th Jul 2016

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