Adrian Lisecki asked:
How is Morphine is a painkiller?
Since I smashed my ankle the pain is terrible, I have been put back on
Thank you.......... Adrian
Morphine is one of the most famous painkillers. Itís an opioid drug which means itís a cousin of the ancient drug opium, which has been used socially and in medicine thousands of years. These drugs bind to the opioid receptors which are on the surface of nerve cells and that sets off a chain of chemical reactions inside the cell which ultimately causes the cell membrane to be less excitable. this means that nerve cells become sluggish and don't fire so many impulses. Morphine can dull pain by silencing nerves in the spine that carry pain signals, but it also has complex effects in the pain processing areas in the brain and morphine receptors are found on nerves all over the body. So the problem is that putting a damper on all of these nerves can do more than just kill the pain. So if you take one example, the nerves that supplied the muscles in the gut are slowed down by morphine, causing constipation and then all the other side effects are due to sluggish nerves basically.
Morphine works by blocking the morphine receptors in the central nervous system. I've never seen it not work in acute trauma unless in renal colic (kidney stones)--and I've seen a whole lot of acute trauma.
Actually different morphine analogs have differing strengths as analgesics. There are analogs which are as much as 12,000 times as "strong" as morphine sulfate. Those agents would not be 12,000 times as good at stopping pain- it's just that 12,000 times smaller dose would have a similar effect as a quarter grain (15 mg.) dose of morphine sulfate.
Dang! You little old British people's conception of manners is so damned cute. Have we met or are you just naturally like that?
It is indeed unfortunate that this Gentleman's simple request for help with his affliction can't be addressed without a load of nonsense from kibitzers with a secondary agenda popping in to show off their useless and pointless knowledge .
Martin, you are clutching at straws and being unnecessarily abusive. You are commenting on multiple areas which are demonstrably beyond your knowledge and flaming anyone who dares to offer a contrary opinion. The fact that you offer a clinical opinion at the same time as typing arrant nonsense is particularly galling.
Morphine is indeed an agonist-it binds and activates MORs which is turn affect the inhibition of GABA.
Adrian Lisecki asked the Naked Scientists: How is Morphine is a painkiller? Since I smashed my ankle the pain is terrible, I have been put back on oral morphine. Thank you.......... Adrian What do you think? Adrian Lisecki, Mon, 27th Jun 2011
British people talk in an intelligent way because they know other Brits will understand them and expect them to be generous enough not to simplify things. It is not our fault if people from other countries think we are condescending when actually we are only assuming people will be intelligent enough to understand us. Sorry if that sounded a little condescending. Relative, Fri, 8th Mar 2013
Opioids look like chemicals in your brain and body that attach to tiny parts on nerve cells called opioid receptors. Scientists have found three types of opioid receptors: mu, delta, and kappa (named after letters in the Greek alphabet). Each of these receptors plays a different role. For example, mu receptors are responsible for opioidsí pleasurable effects and their ability to relieve pain. Opioids act on many places in the brain and nervous system, including: the limbic system, which controls emotions. Here, opioids can create feelings of pleasure, relaxation, and contentment. the brainstem, which controls things your body does automatically, like breathing. Here, opioids can slow breathing, stop coughing, and reduce feelings of pain. the spinal cord, which receives sensations from the body before sending them to the brain. Here too, opioids decrease feelings of pain, even after serious injuries. brianjones978, Sat, 15th Nov 2014