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Nuclear bombs mark newborn neurons

Thu, 6th Jun 2013

Chris Smith

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Radioactivity released into the air by Cold War nuclear tests has enabled Swedish scientists to probe how adult brains produce new nerve cells and whether they Mushroom Cloudsurvive for any length of time.

The discovery in the 1990s that certain parts of the human brain retain the ability to produce new nerve cells into adulthood rocked the neuroscience world which had, prior to then, been firmly of the opinion that adult brains don't regenerate.

But although it became clear that new nerve cells could be produced, it wasn't known whether these cells survived for any appreciable length of time and therefore whether they had any important purpose or were just an anomaly.

Surprisingly, the Cold War has come to the rescue. The proliferation and testing of nuclear weapons in the 1950s and 60s increased the levels of radioactive carbon (carbon-14) in the atmosphere.

Taken in by growing plants and then channelled along the food chain, this radioactive blip has found its way into the brain cells of people alive both at the time and subsequently, date-stamping their DNA with an indelible marker.

Kirsty Spalding, from the Karolinska Institute in Sweden, has now used this radioactive label to carbon date nerve cells to discover - to within an accuracy of 1.5 years - how long these newborn neurones can live for, and how many of them there are.

Working on donated post-mortem brain samples from patients aged 19-92, the team isolated nerve cells from the hippocampus, one of three regions where new nerve cells were found to appear during adulthood.

The DNA was extracted from these cells and the amount of carbon-14 contained within them was quantified enabling them to be retrospectively birth-dated.

The team worked on the premise that, if a baby is born with a complement of brain cells that are to last it a lifetime, then the amount of carbon-14 in the DNA of the cells, which are not dividing, should fall over time.

But subjects the team studied, one of whom was 92 at the time of death, had nerve cell DNA levels of carbon-14 that were far higher than the levels of carbon-14 that would have been around when the person was born. This proves that they must have been adding new nerve cells to their hippocampi well into adulthood.

The results also show that, on average, 700 new nerve cells are added to the adult hippocampus each day which, over a year, amounts to just under 2% of the hippocampal nerve cells being replaced. Over a lifetime that means that about one third of the cells in this part of the brain turnover.

These newly-added cells aren't as long-lived as the neurones a person is born with, the team found. Models run by the Karolinska team show that they die off 7-10x faster than the starting cells.

As to the role of these replacement cells, the researchers speculate in their paper in Cell that they might be important in new memory formation, and specifically the separation of new from existing experiences. They also highlight the importance of exploring the part played by these nascent cells in psychiatric diseases, particularly depression which might affect their longevity...


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I'm not sure if that study tells one anything.
We already know that nerve cells make new dendritic and axonal connections throughout their lives.  One would expect cell walls and various proteins to be replaced throughout the life cycle of the cells.

The approach, however, is interesting.

A much better study would be to isolate the neurons from the glia cells.
Then isolate the DNA from the neurons.
Then carbon date just the DNA as current theory would indicate that the DNA would be one molecule that would not be replaced during the life of the cells. CliffordK, Thu, 6th Jun 2013

I disagree, Clifford. The fact that new nerve cells were being born was known; but what was contentious was whether any of those newborn neurones actually survived for any appreciable length of time. Being born is one thing, but if you die a neuronal death a day later, arguably you are going to make very little contribution to brain function. But if you persist for a significant period of time, then other observations such as the link between the birth rate of these cells and conditions like depression, begin to make a lot more sense; moreover, new avenues open up in terms of important research questions.

Also, to address you final point, they did indeed isolate the neurones from the glia and do the carbon-dating experiment on both cell types individually. chris, Fri, 21st Jun 2013

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