Getting high from marathons
Thu, 8th Oct 2015
Cannabis-like chemicals may be the cause of the so-called "runners' high" experienced by athletes, new research has revealed this week.
Traditionally, a surge of endorphines, the body's own morphine-like chemicals, triggered by exercise were thought to account for the sense of calm elation experienced by runners.
Instead, a paper published this week in PNAS shows that cannabinoids, nerve chemicals that act on the same parts of the brain that are sensitive to the effects of cannabis, are the cause.
Unlike endorphins, which cannot cross over into the brain from the bloodstream, cannabinoids are able to move between the two. And so even though running and exercise do lead to the release of endorphins around the body, they cannot penetrate the brain.
To investigate these effects, researchers from the University of Heidelberg worked with mice, which also appear to experience a runners' high. Given wheels in their cages, the mice chose to run up to six or seven kilometres a day.
After letting the mice run for five hours, Johannes Fuss and his team studied their behaviour.
"We found that both the pain and the anxiety were reduced after running," he said.
Meanwhile, he also found that the levels of endocannabinoids in the blood had risen.
By blocking the receptors for both endorphins and cannabinoids, they were able to see how these chemicals affected the behaviour of the mice.
It was only if their cannabinoid receptors were blocked that the mice did not have reduced pain and anxiety. If their endorphin receptors were blocked, the mice still got their runnersí high.
As well as reduced pain and anxiety, runnersí high also gives people feelings of euphoria and relaxation. Although these canít be measured in mice, Fuss is confident that ďthe same mechanism in humansĒ is occurring.
That said, some people just donít get that samr buzz from running. This could be because their bodies donít produce cannabinoids when they run, or that their bodies respond to them in a different way...