Science News

Getting to the heart of coronary risk prediction

Wed, 28th Sep 2011

Chris Smith

Part of the shows Tweeting the Mood of the World and Would a Siphon Work in Space?

An analysis of electrical heart tracings from thousands of patients has ECG - electrocardiographyrevealed a new way to spot those at risk of repeat heart attacks.

University of Michigan scientist Zeeshan Syed and his colleagues, writing in Science Translational Medicine, used a computer to marry up clinical outcomes with the features present in long-term electrocardiogram (ECG) recordings of over 4500 people who had undergone a recent heart attack.

They were able to define three characteristic "biomarkers" that could be used to predict an individual patient's risk of further heart problems. These they have called Morphological variability (MV), which looks at how the shape of the ECG tracing changes over time, the Symbolic Mismatch (SM), which compares an individual patient's ECG trace with those of other patients with a similar clinical history, and the Heart Rate Motif (HRM), which looks at how often "risky" patterns of heart rate activity crop up in an individual's recordings.

Incorporating these assessments into the existing protocols used to calculate a patient's risk could, they say, enable doctors to better identify those patients most in need of close monitoring or more intensive drug therapies; on the flip side, it could also potentially spare patients who are actually at a lower risk than first thought from having more rigorous interventions that they don't require. Moreover, as the scientists point out in their paper, "these biomarkers can be extracted from data that are already routinely captured from patients with acute coronary syndrome and will allow for more accurate risk stratification and potentially better patient treatment."



Subscribe Free

Related Content


Make a comment

According to my doc (who actually experienced a heart attack), ECGs are a waste of time. He said something about a much more expensive test that the insurance companies don't like to pay for, but I can't remember exactly what it was! Geezer, Fri, 30th Sep 2011

Was this just before he recommended a new cardiac test to you? imatfaal, Fri, 30th Sep 2011

No - I don't remember exactly how we got on the subject. It would not benefit him. He would not be able to run the test.

I think it might have involved some sort of MRI? It's pretty spendy, so the insurance companies try to discourage it. Geezer, Fri, 30th Sep 2011

See the whole discussion | Make a comment

Not working please enable javascript
Powered by UKfast
Genetics Society