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12th Dec 2004
Superbugs, MRSA, Phages & Bdellovibrio.
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This week the world of bacteria, fungi, viruses and superbugs goes under the microscope. Microbiologist Dr Mark Farrington discusses the worsening issue of antibiotic resistance and the MRSA problem. He is joined by Nottingham University bacteriologist Dr Liz Sockett who works on Bdellovibrio, a predatory bacterium that hunts down other bacteria and might be useful as a 'living' antibiotic, and Professor Nick Mann, from Warwick University, who is developing bacteriophages (viruses that can attack bacteria including MRSA) that can safely be applied to wounds, in a dressing or as a nose-spray, to eliminate the carriage of bacteria, or infection.
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Science News
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Questions

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Is it normal for you to have a body temperature lower than 36.7celsius ?
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Normal body temperature is 37?C. This is set by part of your nervous system and the hypothalamus, which is found in the brain stem. The hypothalamus monitors your body temperature and changes it if it becomes too hot or too cold. Your body temperature doesn't have to be exactly 37?C: exercise can make you hotter, while going outside on an icy day can make you cooler. The place in which you measure your temperature is very important. Putting a thermometer under your armpit will show you your peripheral temperature, and this can be quite a bit lower than your 'real' body temperature called your core temperature, or the temperature at the centre of your body. This varies very little at all in day to day life. It can best be measured by putting a thermometer in your bottom! You have to get very cold to change your core temperature, such as being stuck in freezing weather for a long time. People who have a drop in core body temperature have what is known as hypothermia. This makes them drowsy, and if left untreated, they will eventually become unconscious. When the body is cold, the chemical reactions that provide your cells with energy don't work as well. This makes cells function abnormally and, if prolonged, can be fatal.
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Some roofs have clean lines across them caused by copper cables that have been lain across them in the past, and I've also heard that to kill a tree, you can drive a copper nail in to the trunk. In both cases, copper seems to have bad effects on living organisms, including trees and algae. Are the copper water pipes we have in our houses likely to have a similarly bad effect on humans, just as lead pipes did ?
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Plants make food for themselves via photosynthesis. This process involves a number of chemicals, enzymes and pigments, including green chlorophyll. Copper stops the photosynthetic process from working, which is why copper is toxic to plants and algae. The lines on the roof are likely to have been caused by copper: some builders purposely build copper strips into roofs to stop them going green. As for killing a tree with a copper nail, I'm not sure that that is true. Trees are very large and contain lots of water to dilute any copper particles put into it. Therefore, lots of copper would be needed to kill a tree. Metallic copper (which a nail would be made from) does not go into solution easily and would find it hard to get into the tree's food and water transport systems. In terms of humans, I think copper poisoning is unlikely in this area. The east of England has very hard water, which makes the water pipes fur up. This makes it hard for our drinking water to come into contact with the pipes. Copper in small amounts is actually important for humans as it helps some of our enzymes work. Only in the genetic 'Wilson's disease' can copper be a problem where sufferers accumulate too much of the metal in their brains.
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I have a thyroid problem and have to take thyroxin. What causes thyroid problems?
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Thyroxin is given to people with an under-active thyroid that can't make enough thyroxin by themselves. People with low levels of thyroxin in their blood often have a slower heart rate, have a tendency to put on weight, and feel lethargic. Interestingly, only one in five of all cases of thyroid under-activity will be in men. Doctors tailor the amount of thyroxin given to patients to ensure that the patient's body is working at the right level. Without knowing exactly what is wrong with your thyroid, it is hard to say what caused it to become under-active. Sometimes its caused by insufficient iodine in the diet. Historically underactive thyroids were common in Derbyshire causing people to develop a neck 'goitre' (swollen thyroid) - termed 'Derbyshire neck' - because their diets were deficient in iodine. However, most cases are caused by an autoimmune response, whereby the body starts attacking its own tissues. The reasons for thyroid problems can therefore be partly genetic, and partly environmental.
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What ingredients go into antibiotics, and how do they work ?
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Tablets taken by mouth contain a lot of the actual antibiotic. They also contain lots of other substances which enable the manufacturer to produce a tablet that can be kept in packets and are easy to swallow. For example, the smooth outer coatings of some tablets are often made out of vegetable products. Once the tablet is in your stomach, the active bits distribute around the body through the bloodstream, reach the site(s) of infection, and kill the offending bacteria. There are three different ways antibiotics kill bacteria. Some stop bacteria from growing by stopping their protein production; others stop them from making chromosomes; and the third type stop bacteria from making cell walls. Without a proper cell wall, the bacteria explode and die.
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Which bacteria or viruses cause ear infections ?
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The ears have the same linings and are connected to the nose and throat through the eustacian tube. This means that any of the viruses that cause colds and sore throats can get through into your ears. Viruses are the main invaders, but bacteria can cause secondary infection. They seize the opportunity to invade after a virus has caused the initial problem - such as damaging the protective lining of the airway, or blocking up the eustacian tubes in your ears with mucus
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| Interviews
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Dr Mark Farrington Chris - We are told that MRSA kills 5000 people per year. What is MRSA and where did it come from?
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Bdellovibrio are natural, tiny predatory bacteria that have other bacteria as their main food. Their strategy is to break into bacterial cells, close up the hole behind them suck their guts out! Having dissolved the inside of
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Professor Nick Mann
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Fact or Fiction
50% of guide dogs are short-sighted
 
It's False - Luckily for their
blind handlers who rely on their dogs to lead them around, only 13% of
dogs are short sighted.
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The planet Saturn has 10 rings
 
It's False - Saturn has at least 7,
possibly 8, rings. The newest ring to join the family, if confirmed, will
be the first ring discovered for 25 years. It was picked up by the Cassini
spacecraft which following its launch in 1997 arrived and began to explore
the Saturnian system in mid 2004.
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A red blood cell can travel around your entire body and get back to
where it started in less than 20 seconds
 
It's True - A red cell can circumnavigate
the entire body in under 20 seconds.
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Sunlight takes roughly 60 seconds to reach the earth from the sun
 
It's False - The sun is about 96 million miles away and light travels
at about 12 million miles a minute. So sunlight reaches earth roughly
8 minutes after it leaves the sun.
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The Japanese have the longest life-expectancy in the world
 
It's False
- In fact people in Norway live the longest, lasting an average 78.9 years.
We Brits are currently 12th on the list, making it to 78 years, whilst
the Americans are managing only 77.
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Doctors have come up with a condition called "exploding head
syndrome"
 
It's True - It's a rare condition that affects mainly
adults. Sufferers describe being woken up suddenly by a frighteningly
loud noise like a gunshot going off inside their heads, but without any
pain or headache. Attacks usually happen 1 to 2 hours after nodding off,
come with varying frequency over weeks to months, and then stop. It's
poorly understood, but doctors think that it may be down to brain-alerting
pathways not switching off when they should do, after you fall asleep.
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