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The last paragraph sounds exaggerated, unless I missed a lot of action.
I'm gonna try to find whats wrong with me without waiting for [proposals, clinical trials, etc.]
studies take a lot of time. You have to develop a proposal, get it approved by an ethics committee, apply for funding, plan the technicalities, run it, analyze, publish, etc.
We could end up [with] an endocrinologist who likes the idea and wants to investigate more about it. Its good to have a plan B, if my plan A fails.
NORD (National Organization of Rare Disorders) is willing to take that on for us (see previous posts on NORD). But they want $30,000 minimum, which we don't have.
Looking_for_answ, i like your energy about solving pois, if you can get a prolactin antagonist and take it before an orgasm, that would be the biggest help in drug experimentation since limejuice and i ran out to our doctors and got progesterone. i need to let my doctors have a few months off before i push another drug on them.
Quote from: demografx on 27/01/2009 16:43:02Quote from: mister_z on 27/01/2009 16:24:42would toco-8 be tocopherol aka vitamin E ? Yes your right.mister_z, your guess is as good as mine! Unless "anonymous sufferer" comes forward we won't know. But don't worry, mister_z, this is the first time in 2 years since the forum started that this type of anonymous posting has occurred. Hi all,I report back now after several months of no symptoms of POIS that I have fully cured my POIS by reimbalancing my hormone and neurotransmitter levels.No more depression, mood swings, headaches/mirgraines/foggy brain/muscle and joints pain, exhaustion, inflammation of the eyes, stomach bloating, indigestion, diaheera, stomach pain & cold,flu like symptoms after an orgasm.You can check in my last few posts that I said I was getting furthur hormone bloodwork, saliva and urine neurotransmitter tests done and would take the action necessary to reach optimal hormone levels.The short version :Low total+Free/Bio testosterone levelsLow Cortisol & Dhea levels = Adrenal fatigueLow-Mid range Thyroid (Free T3)Very High prolactin levelsHigh Estriol+Estrone levelsHigh Progesterone levelsLow Dht levelsVery Low Serotonin levels Very Low Gaba levelsI made a big mistake by going on testosterone cypionate shots but i was lucky I did not completely shut down my HPTA and desensitise my testes Lh signals as I was shooting HCG* E2D to keep the natural production of T from completely shutting down.I then had to use HCG+HMG/FSH+Toco8 to fully restart natural t production to optimal levels as I did not want to stay on T shots for life.I found that by eating more red meats, eggs and in general more protein and less carbs helped with the restart.It was not a easy process though alot of ups and downs.I burnt my adrenals out in my late teens by overtraining in boxing and mixing that with overdrinking spirits(straight bottles of vodka, brandy etc) and taking too many stimulants and partying with very little sleep for a few years.I didnt notice the adrenal fatigue till around age 21 in my trip to New York.Iam using 6mg of Medrol, 5mg Dhea sublingual+15mg dhea cream, Maca, Pantothenic Acid and Vitamin C to heal my adrenals. I also had a period where I would sleep in for 10-12 hours and take naps often in the day.The cortisol from the medrol is used from the body and that shuts down the bodies own production of cortisol which gives the adrenal glands time to recover.After starting on Medrol for around 4-6 weeks, I then startedon Armour 1/2 grain and increased 1/4 to 1/2 grain every 2 weeks too 2 grains. I understand I will need to wean of both Medrol and Armour after 6-24 months depending on the individual.I had very high prolactin levels which is the cause of crap libido and very slow refractory periods after an orgasm and also can cause headaches/migraines and an overall foggy, drained feeling.I used Cabaser/Dostinex/Cabergoline(All same drug) to lower to 1/4 of the lower range which is perfect.Now I sometimes use the USP supplement Powerfull when I want to go more than once which has scientifically been proven to reduce prolactin levels and increase testosterone and dopamine levels.I improved my good to bad estrogen ratio by taking calcium glutarate and Broccoli extract to lower the high estrone and estriol.The very low serotonin and gaba levels which caused me anxiety, depression, mood swings and often in the past heart palpitations was cured easily by taking gaba and 5htp.I had to drink a glass of orange juice everytime I took a 5htp tablet to make sure the 5htp would pass the brain barrier and also I found that gaba sublingually was more effective than standard oral tablets.I was stumped on the high progesterone levels and low dht levels for a while. I looked everywhere on how to lower progesterone directly but the only sources I found proven to lower progesterone was to increase dht levels. Luckily for me that by increasing my testosterone levels, some of the increased testosterone converted to dihydrotestosterone and then lowered my progesterone levels I guess when you sort one thing out it will reach to the rest. Once my DHT+Test levels were near the top of the range, E2 mid range and Prolactin was within 1/4 of the lower range this is when I feel my best for libido, overall physically feeling a hell of a lot stronger and very confident mentally.I do still monitor my hormone levels every month or 2 as sometimes I get lazy with supplements and diet or I have a period of eating crap junk food .. loloh ... I solved my stomach bloating and indigestion by taking Hydrochloride Betaine, Q-Zyme Digestive Enzyeme blend and primal defense Ultra probiotic formula.I recommend everyone to have their hormones and neurotransmitter checked either through their local gp/dr or through an independant lab, ZRT, Quest etcHormones:Total+Free/Bio Test, LH+FSH, Estradiol(E2), SHBG, Prolactin, Cortisol(Saliva, morning, noon, evening, night), Dhea, IGF-1, Progetesterone, Dht, Free T3 (Free T4,TSH if possible), You will know exactly what is wrong and there would be no more second guessing Remember even if you have already had hormone tests done and your doctor says you are fine or normal. It usually isnt the case as they do go by ranges only and not age to range.For example :A 70 year old male could have a Total testosterone level of350 with ranges of 250-850but a 21 yr old could have the same level yet most drs will say you are normal because you are within range.The dont tell you that 250-350 test level is normal for a 70-80 yr old and the upper range 800+ is normal for a late teenager or early 20s. Obviously we feel the best when our t levels are higher than lower.A good doc would do furthur tests like E2, Prolactin, Cortisol, Free T3, SHBG and others to check what is causing the low t levels even if it is within "range".It happened to me and I let it go for years thinking there was nothing wrong with my hormone levels until I started to do my own research and studying many Anti Aging Specialists posts on the anabolic and metaphorsis forums.I did all my tests at home even the blood tests (just a simple pr.ick of the finger) and did them the morning after an ejaculation. This way it showed me exactly what was going wrong in my body during the symptoms of POIS.I kind of knew I had low testosterone as I had no drive for life, no libido and felt like sh1t in general and lost a ton of strength and muscle and gained alot of weight in fat.I also guessed I had adrenal fatigue due to having no energy all day and night dispite sleeping 10-12 hours. I didnt want to speak to people and even had social anxiety due to the crap adrenal fatigue but the good thing is that I have it no more I had no idea about the high prolactin, low DHT, high Progesterone, High estrone & Estriol(Bad estrogens) so it is best to get everything checked as much as possible. hmmm ... i think thats all for now, any questions please fire away.Michael*HCGBenefits of HCG supplementation:1. Aesthetic maintenance of testicular size2. Maintaining activity of testicular Leydig cells - promoting natural testosterone production - preventing primary hypogonadism3. Improving sex drive greatly (perhaps more so than just with testosterone replacementHCG acts like LH (Luteinizing Hormone).LH has several actions, such as:1. It stimulates testosterone production from the testes2. It stimulates the production of aromatase enzyme3. It stimulates the production of Cytochrome P450sc enzymeWritten by a Physician, Psychiatrist, Behavioral Neuroendocrinology, Immunology, and Nutrition = Psychiatry in Dr Romeo B. Mariano.The above was taking from my posts made several months back.
Quote from: mister_z on 27/01/2009 16:24:42would toco-8 be tocopherol aka vitamin E ? Yes your right.mister_z, your guess is as good as mine! Unless "anonymous sufferer" comes forward we won't know. But don't worry, mister_z, this is the first time in 2 years since the forum started that this type of anonymous posting has occurred.
would toco-8 be tocopherol aka vitamin E ? Yes your right.
my progesterone was high, i am going to do a bunch more tests on Friday.
Has anyone ever tried Piracetam (a nootropic) for POIS?
The semen would literally pour out when no contractions (orgasm) occur, quite odd to watch!I still could keep going (erection) and feel fairly energetic.In terms of POIS, this had no severe effects anymore than if I had not ejaculated (some tiredness but simply being turned on had always previously caused some pois anyway).It was the contractions of the orgasms that caused the real fatigue problems.
Quote from: RhythmSpring on 30/03/2010 15:00:20Has anyone ever tried Piracetam (a nootropic) for POIS?no, but it seems has powerfull as using cerebrolysin. Do you think it is something almost all neurologist will know about.
Quote from: lauracostis on 30/03/2010 03:12:54my progesterone was high, i am going to do a bunch more tests on Friday.could ldn affect your results..