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Thanks for the encouragement demografx, fenugreek really does seem to have nailed POIS for me!
Theory: Depletion and replacement problems. Several have mentioned this on this forum and to me this seems the most likely candidate. From an evolutionary perspective it is important for men to replace sperm relatively quickly once it is lost. Most can do so but this requires the endocrine system to work hard and take "resources" away from other activities (like brain function and physical fitness). POIS sufferers may have more problems than others because their body is not as efficient in replacing sperm. One example may be those with low testosterone production or tolerance.
I certainly used to believe that the body's desperation to replenish lost fluids was key to POIS. I still have a lot of success with eating a large protein-heavy meal following orgasm.However, when I wake up aroused in the morning (no fluids involved), it usually leads to a mild POIS episode (brain-fog for 1-2 days). So a mere erection can cause me problems.Does this mean that POIS and fluid-loss are unconnected? I don't think it does, but I do think there is more than one factor that throw the brain into POIS - possibly several.
Quote from: hurray on 08/02/2009 04:09:31I certainly used to believe that the body's desperation to replenish lost fluids was key to POIS. I still have a lot of success with eating a large protein-heavy meal following orgasm.However, when I wake up aroused in the morning (no fluids involved), it usually leads to a mild POIS episode (brain-fog for 1-2 days). So a mere erection can cause me problems.Does this mean that POIS and fluid-loss are unconnected? I don't think it does, but I do think there is more than one factor that throw the brain into POIS - possibly several.Hurray, I hope you're still doing well on fenugreek. Like you and with the recent developments I think there could be several causes to pois. (For many reasons I still believe fluids are involved.) I can't explain why a simple erection could cause pois symptoms for 1-2 days. I don't think this has been reported before, but I find this interesting. Perhaps something with relaxation. When I'm aroused there is usually a small loss of fluids but I understand it's not your case.Concerning the heavy meal it seems to be a constant, a lot of pois sufferers including me are reporting a faster recovery with enhanced nutrition. (Unfortunately this is not a proof that fluid loss is involved.) On an other side my experience is that anything that can give you energy will eventually exhaust you after a while. That's why when I don't try to stimulate my body I can have more energy ultimately.I'm sometimes wondering if pois could be caused by excessive intake of food.(enlarged digestive organs...)
In each study sexual arousal and erection correlated positively with noradrenaline concentration. Interruption of arousal in roughly the middle of each study is reflected consistently by a decrease in plasma noradrenaline levels.
Demo, let's keep our fingers crossed that you get continued positive responses during this POIS episode---
To help me with my personal experimentation and theories, are there any others out there who have classical inflammatory responses to POIS or anxiety flare up?...Demo has fingertips flare ups, etc.
Quote from: Plasma Noradrenaline and Dopamine-Beta-Hydroxylase DuringSexual ActivityIn each study sexual arousal and erection correlated positively with noradrenaline concentration. Interruption of arousal in roughly the middle of each study is reflected consistently by a decrease in plasma noradrenaline levels.
I've added some things, added things are green:POIS catecholamines theory
I submit that various POIS theories are not mutually exclusive e.g. depletion, catecholamine and autoimmune etc. In all of these we're still dealing with the Hypothalamus, Pituitary, Adrenal Axis--They all involve, somehow, responses to and by hormones, whether we identify them as "hormones" (e.g. prolactin, cortisol), catecholamines (e.g. noradrenaline, dopamine) or immune messengers (e.g. prostoglandins, cytokines). To help me with my personal experimentation and theories, are there any others out there who have classical inflammatory responses to POIS or anxiety flare up? I have back and hip flare ups, Rob has arthritis and tendon flare ups, Demo has fingertips flare ups, etc. Any burning eyes? other myalgias? sneezing? skin issues? I'm asking these questions because I might see a connection between our regularly discussed neurotransmitters and the inflammatory messengers that modulate them (e.g. prostoglandins). Until last night, I never looked at GAD as a possible autoallergic reacation. Now I do, and now I look at POIS and GAD as possibly being both an autoallergic and hormone imbalance together. It may give me TWO methods to attack each problem, OR are they both really part of the same imbalances in ME (and some of us)?
Girlwind--I'm sorry that you are having a down mood right now. I am also in that roller coaster car right behind you. For the last 21 months, the longest I have felt really great is approx. 18-24 hours; very cyclical. I'm trying to work on getting over that hump. If I can get over that hump, I'll have hard info. to share.
Has anybody tried 5 hour energy? I would say it releives a bit of the pois, i tried some yesterday, but only a couple sips not even half of the bottle.
demografx I was just wondering while symptoms improving is recovery period reducing.