Hi Igor,
...the second hypothesis is more correct:
quote:
Or does the infarction cause surrounding tissue, including blood vessels, to die,
i.e. is necrosis responsible for the haemorrhage?
Igor
...but before cells death (necrosis) you should simply consider hypoxia as initial damage to the tissue that normally receive oxigen from blood flow.
Septic (bacteria) or thrombotic (clots) microembolism (or both) stop regular blood circulation.
Hypoxia makes cells shift to anaerobic glycolysis for energy production and excessive and toxic accumulation of lactate and pyruvate leading to 'capillary leakage', i.e. extravasation of plasma proteins and white and red cells into the surrounding tissue (petechiae, splinter haemorrhages).
Necrosis of part of the hypoxic tissue comes later, after prolonged hypoxia, leading to permanent damage.
Skin petechial haemarrhages and splinter haemorrhages
(https://www.thenakedscientists.com/forum/proxy.php?request=http%3A%2F%2Fwww.medibyte.com%2Fcme%2Ftutorial08%2Ffig1.jpg&hash=add5e346d69970bba0803c8a10f72fcb)
http://www.medibyte.com/cme/tutorial08/fig1.jpg
Here you can find more details from:
INFECTIVE ENDOCARDITIS
by Sam Firoozi, Dept. of Cardiological Sciences, St. Georges Hospital, edited by Sanjay Sharma copyright 2001 Medibyte.com
http://www.medibyte.com/cme/tutorial08/tutiend.htm
ikod