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Throughout all the years that I've had POIS it has changed a lot. The most notable change is that I have a lot less brain fog. I think this happened after taking relora. After my brainfog-less POIS episode while on relora, I haven't had the same brain fog that I always had. When I say brain fog, I'm referring mostly to derealization. This "brain fog", to me, was like an actual "pseudo-physical" thing, like an actual fog in my head, not just a loss of concentration. It is the thing that would make me pick up an actual physical object and say "Is this real?", "Is this actually there?". I felt entirely detached from the world around me, like i couldn't reach out and touch someone. That doesn't happen anymore, but I think it has kind of screwed up my gauge of what is normal. Now out of POIS I don't know if I have just a little brainfog, or If that's just "baseline" for me. Things aren't completely clear, visually, to me, even out of POIS. The question I ask myself when holding an object now is "How close am I supposed to feel to this?"If I rub my eyes, It gets a little better, so I'm thinking it might be physical. Perhaps its my glasses...I don't know.Another note is that, compared to when I was a freshman in highschool, my POIS episodes are now less "desperate" than they were back then. I'm going to go ahead and attribute that to having had it longer and being "jaded", but mostly to having found this forum, putting a name to it and knowing that there is some hope for a cure. Thank you to John, who started this thread and everyone that works to keep it going. I don't know what would have done without it even for only 2 years!
Although the information gathered in these 200+ thread pages is invaluable, the webmasters should really consider organising it a bit better. Lots of info is buried in an endless frustrating pile of posts...it's nearly impossible to read everything in a row unless I bookmark each time the last page where I stopped reading.
spermatogenesis:after ejaculation, or when sperm levels fall below 20 million, "activin" stimulates the hormone "FSH" which starts sperm production. when sperm levels reach desired amount by testis, inhibin is released shutting off "fsh". its possible that either fsh or activin may be responsible for pois symptoms. activin and fsh are both proteins, so they could be the most likely culprit if the auto immune system is the problem. the more O's you have the greater the sperm deficit, and the more activin and fsh you will have in your system. as sperm count gradually rises activin will start to taper off, and inhibin will start taking over and block release of "fsh". there will always be small amounts of activin in your system because sperm storage life in testis is about 90 days, after that they are destroyed and need to be replaced. in a 24 hour period (without ejaculation)small amounts of activin and fsh are released to replace 1/90th of sperm. this could be the reason why we never totally recover from pois.
I'm really hesitant to fill my body with dopamine, testosterone, serotonin, melatonin, DHEA, GABA, Acetylcholine and the rest, in fear of causing further irrecoverable damage to my health due to unknown side effects of mixing all these things together
Although the information gathered in these 200+ thread pages is invaluable, the webmasters should really consider organising it a bit better.
sometimes I feel similar symptoms to a much less lesser degree from time to time, even with no O. For example if some hottie walks by and my mind wanders a bit too much- no O but it seems to activate some process regardless.
spermatogenesis:after ejaculation, or when sperm levels fall below 20 million, "activin" stimulates the hormone "FSH" which starts sperm production. when sperm levels reach desired amount by testis, inhibin is released shutting off "fsh". its possible that either fsh or activin may be responsible for pois symptoms. activin and fsh are both proteins, so they could be the most likely culprit if the auto immune system is the problem. the more O's you have the greater the sperm deficit, and the more activin and fsh you will have in your system. as sperm count gradually rises activin will start to taper off, and inhibin will start taking over and block release of "fsh". there will always be small amounts of activin in your system because sperm storage life in testis is about 90 days, after that they are destroyed and need to be replaced. in a 24 hour period (without ejaculation)small amounts of activin and fsh are released to replace 1/90th of sperm. this could be the reason why we never totally recover from pois.Activin and inhibin are two closely related protein complexes that have opposing biological effects. Activin enhances FSH biosynthesis and secretion,Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis,[1] metabolism, homeostasis, immune response, wound repair,[2] and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.[3]
Has any body put more thought into this chemo brain thing, their symptoms match to closely with pois. and the way the patients describe their situation it resembles to much of what we are going through. When i looked at science daily it talked about different activity in brain.The PET scans show a link between chemo-brain symptoms and lower metabolism in a key region of the frontal cortex," explained Silverman, a member of UCLA's Jonsson Comprehensive Cancer Center. "We found that the lower the patient's resting brain metabolism rate was, the more difficulty she had performing the memory test."The scans revealed that blood flow to the frontal cortex and cerebellum spiked as the chemotherapy patients performed the memory tests, indicating a rapid jump in these brain regions' activity level."The same area of the frontal lobe that showed lower resting metabolism displayed a substantial leap in activity when the patients were performing the memory exercise," said Silverman. "In effect, these women's brains were working harder than the control subjects' to recall the same information."Finally, the researchers discovered that women who underwent hormonal therapy in addition to chemotherapy displayed changes to their basal ganglia, a part of the brain that works to bridge thought and action. On average, these women showed an 8 percent drop in resting metabolism in this brain region.