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Author Topic: collagen and serotonin  (Read 5900 times)

Offline Donnah

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collagen and serotonin
« on: 02/04/2003 22:24:11 »
Is there a link between collagen and serotonin in the body?  What foods can we eat (or what else can we do) to boost seratonin and/or collagen?:D
« Last Edit: 17/05/2004 06:42:52 by NakedScientist »


 

Offline NakedScientist

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Re: collagen and serotonin
« Reply #1 on: 03/04/2003 23:32:41 »
The only link I can think of is that they are both derived, initially, from amino acids - collagen because it is a protein used to form structural components including cartilage, skin and organ capsules for example, and serotonin because it is derived, by de-amination, from the amino acid tryptophan. Serotonin is a neurotransmitter and predominantly localised to the central nervous system. Collagen is widely distributed throughout the body.

Therefore, eating a diet deficient in tryptophan can induce a state of low serotonin and low mood (in some individuals), whilst vitamin C (ascorbate) is needed to synthesise mature collagen and hence a diet deficient in fruit and vegetables produces scurvy.

Hope that helps,

TNS
« Last Edit: 03/04/2003 23:35:44 by NakedScientist »
 

Offline cuso4

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Re: collagen and serotonin
« Reply #2 on: 29/04/2003 08:16:55 »
This might be a stupid question but is serotonin the chemical released at the end of a synapse?

AG
 

Offline NakedScientist

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Re: collagen and serotonin
« Reply #3 on: 29/04/2003 09:16:56 »
Quite right, Serotonin, or 5-hydroxytryptamine (5-HT), is a neurotransmitter in the brain and spinal cord, but it is also found elsewhere in the body including in blood 'platelets'. Platelets assist in blood clotting and when a platelet is 'activated', by meeting some collagen for instance (interesting parallel to how this question got started !) it discharges its store of serotonin which activates other nearby platelets, making them become 'sticky', and causes blood vessels to constrict (to limit bleeding).

In the brain serotonin has a powerful influence on mood and arousal and drugs like amphetamines, including ecstasy, work by elevating brain serotonin levels. These drugs cause the nerve terminals which store serotonin to pump out far more of the transmitter than normal, accounting for the 'buzz' experienced by users.

Of course there is no such thing as a free lunch and the hefty 'come down' experienced after using amphetamines is caused by a relative reduction in brain serotonin whilst the affected nerve cells recover after the drug has left the body.

Worringly there is growing evidence that at least some of the affected nerve fibres never do recover, leading to permanent brain damage and the threat of depression later in life. Women may also be at greater risk of this happening than men :

http://www.thenakedscientists.com/HTML/Shows/2001.12.02.htm
http://www.thenakedscientists.com/HTML/Guestfile/johnhenry.htm

TNS
 

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Re: collagen and serotonin
« Reply #3 on: 29/04/2003 09:16:56 »

 

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