The Naked Scientists

The Naked Scientists Forum

Author Topic: Why shouldn't asthmatics use ibuprofen or ephedrine?  (Read 5174 times)

Offline DoctorBeaver

  • Naked Science Forum GOD!
  • *******
  • Posts: 12656
  • Thanked: 3 times
  • A stitch in time would have confused Einstein.
    • View Profile
A few times when I've bought Ibuprofen from a chemist (drug store to you Americans), I've been asked if I suffer from asthma.

The same is true of ephedrine. I sometimes buy tablets containing ephedrine when my chest is congested, but on the blurb inside the packet it says not to take them if asthmatic.

So what is the problem with these medications and asthma?


 

Offline chels

  • Jr. Member
  • **
  • Posts: 10
  • comin' in a mess, goin' out in style ;)
    • View Profile
Why shouldn't asthmatics use ibuprofen or ephedrine?
« Reply #1 on: 22/01/2008 23:26:54 »
The ibuprofen - would be because even low doses of ibuprofen can cause bronchospasms and bronchocontricion, which could in turn be because of the inhibition of prostaglandin synthesis by the ibuprofen.....the degree of enzyme inhibition is enough to cause bronchocontriction and subsequent onset of asthmatic symptoms.
it can also be noted - the onset of asthmatic symptoms in conjunction with ibuprofen use is more prevalent in people who are also sensitive to aspirin...
As for the ephedrine, im not sure why they would ask about asthma, possibly because ephedrine used to be used to treat asthma and maybe it would have a synergistic or additional effect with the medication you are prescribed for asthma (if you had it), im really not 100% sure on this though - maybe something to do with heart irregularities and the fact it increases your blood pressure....possible trigger for bronchospasms again?

maybe..
 

Offline DoctorBeaver

  • Naked Science Forum GOD!
  • *******
  • Posts: 12656
  • Thanked: 3 times
  • A stitch in time would have confused Einstein.
    • View Profile
Why shouldn't asthmatics use ibuprofen or ephedrine?
« Reply #2 on: 24/01/2008 23:23:07 »
Thank you, Chels.
 

The Naked Scientists Forum

Why shouldn't asthmatics use ibuprofen or ephedrine?
« Reply #2 on: 24/01/2008 23:23:07 »

 

SMF 2.0.10 | SMF © 2015, Simple Machines
SMFAds for Free Forums