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Author Topic: Tell me about Doxycycline???  (Read 9594 times)

Offline Karen W.

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Tell me about Doxycycline???
« on: 02/02/2008 21:02:05 »
I have a user sheet and also directions on bottle that confuse me and sort of contradict each other..One says take without food the other says with food but no iron or iron rich food or dairy products 1 hour before or After.. And I am not supposed to lie down within 2 to three hours of taking it, but I can't stay on my feet more then about ten minutes so how shall I do this. Is sitting up OK??

I am confused!
« Last Edit: 03/02/2008 14:00:28 by Karen W. »


 

Offline JnA

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Tell me about Doxycycline???
« Reply #1 on: 03/02/2008 13:41:25 »
I would go with what the insert says.. making sure it *is* for the drug that is in the box.

Doxycycline is an antibiotic, so usually they are best taken with food.

I would suggest that sitting up would be fine.. as opposed to standing. But I am not a doctor, so you're probably better off asking one or taking to a pharmacist.

good luck.
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #2 on: 03/02/2008 13:58:33 »
Yeah, Thank you.. I know its an antibiotic, but the bottle says to take it one way and the insert says two or three ways to take it. The insert is definitely the same as the bottle as far as it being the correct product! Thanks for that ! Thats a good idea to double check that, as I have not been very clear in thought lately!

I am also taking 1/4 teaspoon of baking yeast in 1/8 cup water twice a day , with each dose of the antibiotic doses, to keep the good bacteria in my tummy healthy..
« Last Edit: 03/02/2008 14:01:22 by Karen W. »
 

Offline iko

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Tell me about Doxycycline???
« Reply #3 on: 03/02/2008 14:49:46 »
Hi Karen,

I am sorry to be late replying to your question.
Doxy is irritant to the mucosa (esophagus) and should go directly to the stomach with water and some cracker to keep the tablet 'moving around' while it is dissolving in gastric juice.
Better moving than laying down for 1-2hours.
As far as I know, calcium and iron bind doxy and impair proper adsorption.
So you shouldn't have milk, yogurt or cheese two hours before and two hours after having taken your tablet:


-Doxycycline is an antibiotic used to treat bacterial infections.

-Swallow doxycycline tablets whole (not crushed or chewed), with plenty of water, while sitting or standing - this will stop them from sticking in the throat and causing irritation.

-The most common side effects are nausea, vomiting and diarrhoea.




Please read the whole recommendation sheet by Patient.co.uk.
(Do you prefer italian instructions?) ;D
You'll make it.
It's a bit of a problem for thousands of people around the world.

ikoD


« Last Edit: 07/02/2008 18:30:13 by iko »
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #4 on: 03/02/2008 15:02:42 »
Thanks IKo.. I will read it now. Mine was confusing.. Thats why so much water.. I wonder if any of my other meds have any of those things in it! It says not to lie down for 2 to 3 hours after taking the pill! So I assume sitting up and of course moving as much as possible would be a good thing!

Thank- you so much... BTW Yesterday not any side effects but today had some tummy issues and the later of the side effects.. pretty bad.. I also forgot a dose of the yeast and the water.. I must take that she said it will help my stomach.
 

Offline iko

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Tell me about Doxycycline???
« Reply #5 on: 03/02/2008 15:09:43 »
Yes.

You may get lost between problems and side effects with doxycycline on the wwweb: forums, chats, medical reports.
You should find your own way and tricks to tolerate it: don't be too fussy about it.
Hope you'll see some improvement soon.
It's almost time, don't you think?
Take care.

ikoD
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #6 on: 03/02/2008 15:14:09 »
Ok Iko I read it and thank you.. different yet then mine.. but more explanation on why so much water..YAYYYYY thanks IKO.

By the way if I were to eat say a steak within that hour before or after, does that qualify for iron suppliment or do they just mean like a real iron tablet.. as I quit taking my iron because of impossible bowel problems..

Boy howdy is it time.. I hope something improves.. She sure has drug her feet.. I am so worn out I feel like I have been drug through a knot hole several times!


Thanks IKO!
 

Offline iko

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Tell me about Doxycycline???
« Reply #7 on: 03/02/2008 15:20:21 »
Take it easy.
You deserve some 'random' positive hint from Oulu, Finland!
Do you remember T.Timonen's vitamin D & Leukemia connections? They came from Oulu too!


Use of doxycycline to decrease the growth rate of abdominal aortic
aneurysms: a randomized, double-blind, placebo-controlled pilot study.


Mosorin M, Juvonen J, Biancari F, Satta J, Surcel HM, Leinonen M, Saikku P, Juvonen T.
Department of Surgery, University of Oulu, Finland.

OBJECTIVE: Eradication of Chlamydia pneumoniae infection and inhibition of elastolytic matrix metalloproteinases with doxycycline have been suggested to reduce the growth rates of small abdominal aortic aneurysms (AAA). We designed a study to investigate the efficacy of doxycycline in reducing the expansion of small AAAs.
SUBJECTS AND METHODS: This was a prospective, double-blind, randomized, placebo-controlled study that was set in a university referral hospital. The study group consisted of 32 of 34 initially eligible patients who had an AAA diameter perpendicular to the aortic axis of 30 mm or more in size or a ratio of infrarenal to suprarenal aortic diameter of 1.2 or more and a diameter less than 55 mm. Patients were randomly assigned to receive either doxycycline (150 mg daily) or placebo during a 3-month period and underwent ultrasound surveillance during an 18-month period. Outcome measures included aneurysm expansion rates, the number of patients who had AAA rupture or repair, C pneumoniae antibody titers, and serum concentrations of C-reactive protein.
RESULTS: The aneurysm expansion rate in the doxycycline group was significantly lower than that in the placebo group during the 6- to 12-month (P = .01) and the 12- to 18-month periods (P =.01). Five patients (41%) in the placebo group and 1 patient (7%) in the doxycycline group had an overall expansion of the aneurysm of 5 mm or more during the 18-month follow-up. Among the placebo group patients, a higher expansion rate was observed in those with enhanced C pneumoniae immunoglobulin G antibody titers (> 128) than in those with lower titers (P = .03). Doxycycline treatment had no clear effect on antibody titers. However, at 6-month follow-up, C-reactive protein levels in the doxycycline group were significantly lower than the baseline levels (P = .01).

CONCLUSIONS: The results of this small pilot study suggest that doxycycline may favorably alter the outcome of patients with small AAA. However, because of the small size of this randomized study and of the potentially confounding effect of pretreatment risk factors, doxycycline-based treatment cannot be justified only on the ground of the current results. Because of the high prevalence of this disorder and its clinical, social, and economic relevance, a multicenter study should be performed to further investigate whether there is any place for medical treatment of small AAAs.

J Vasc Surg. 2001 Oct;34(4):606-10.


« Last Edit: 03/02/2008 21:30:01 by iko »
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #8 on: 03/02/2008 15:35:12 »
WOW!!! That would be cool if it indeed does help the aneurysm... Thanks Iko.. That is a very good article with good hope on the horizon.. Very cool indeed..

So because I have these bacterias I am getting the doxy, which may inadvertently slow the growth of the aneurysm. in the overall scheme of things. They need to do some more studies!
 

Offline iko

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Tell me about Doxycycline???
« Reply #9 on: 08/02/2008 15:34:26 »
WOW!!! That would be cool if it indeed does help the aneurysm... Thanks Iko.. That is a very good article with good hope on the horizon.. Very cool indeed..

So because I have these bacterias I am getting the doxy, which may inadvertently slow the growth of the aneurysm. in the overall scheme of things. They need to do some more studies!


They are doing more studies!


Role of matrix metalloproteinase inhibitors in preventing abdominal aortic aneurysm.

Aziz F, Kuivaniemi H.
Department of Surgery, New York Medical College, Valhalla, NY, USA.

Abdominal aortic aneurysm (AAA) is a significant health problem in the United States, with approximately 30,000 repair operations annually. Treatment of AAA is associated with more than 150,000 hospital admissions per year. The development of AAA is characterized by destruction of the elastic media of the aortic wall. A large body of evidence suggests that a group of enzymes called matrix metalloproteinases (MMPs) plays a significant role in the destruction of extracellular matrix in the aortic wall. MMP inhibition has, therefore, been viewed as an alternative pharmacotherapeutic approach to slow down the development and progression of small AAAs, thus reducing the need for surgical intervention.

Ann Vasc Surg. 2007 May;21(3):392-401.



Oooops! Me forgot to mention that doxycycline has anti-MMP activity!
« Last Edit: 24/02/2008 11:19:24 by iko »
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #10 on: 08/02/2008 16:36:35 »
That would sure be nice!

Hey, since starting this medication, I am experiencing fever like heat. I feel extemely warm, and it is 32 degrees F. Quite unusual for me to be hot like that!

 

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Tell me about Doxycycline???
« Reply #11 on: 08/02/2008 17:11:01 »
That would sure be nice!

Hey, since starting this medication, I am experiencing fever like heat. I feel extemely warm, and it is 32 degrees F. Quite unusual for me to be hot like that!



Hey, didn't they ever tell you, you are one hot lady ;D
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #12 on: 10/02/2008 16:43:10 »
That would sure be nice!

Hey, since starting this medication, I am experiencing fever like heat. I feel extemely warm, and it is 32 degrees F. Quite unusual for me to be hot like that!



Hey, didn't they ever tell you, you are one hot lady ;D

OHHHH...No They didn't ... LOL ,,:) Thanks George!  [:I] [:I] [:I]
 

Offline Karen W.

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Tell me about Doxycycline???
« Reply #13 on: 12/02/2008 01:38:14 »
Ok Iko.. I have had two good days except I seem to be running a fever of about 102. and just under that for two days off and on. Seems to spike and hour or so after I take the medication.. I called the doctors office with no response back yet! When it hits it I am just really drug out.. find myself back in bed with absolutely no energy,,,barely made it to the loo once a day from Thursday night to Saturday ....


I was up yesterday with only one nap period and today had to lay back down for a bit this afternoon much earlier this afternoon. Nausiated and fever again.

I will wait and see what the doctor says..
 

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Tell me about Doxycycline???
« Reply #13 on: 12/02/2008 01:38:14 »

 

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