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Author Topic: Are you aware of this ? A magnetic stimulation device for migraine.  (Read 3802 times)

Offline bill

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A lightweight, handheld device helps migraine sufferers zap away pain, sometimes within two hours, according to a new study.
Called a transcranial magnetic stimulation device (TMS), it transmits magnetic pulses that interrupt the "hyper-excitability" of neurons in the brain, which some experts believe is to blame for launching the migraine.

can someone explain how it works ?


 

Offline Karen W.

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see wiki..

http://en.wikipedia.org/wiki/Transcranial_magnetic_stimulation

Transcranial magnetic stimulation
From Wikipedia,

Transcranial magnetic stimulation (TMS) is a noninvasive method to excite neurons in the brain: weak electric currents are induced in the tissue by rapidly changing magnetic fields (electromagnetic induction). This way, brain activity can be triggered with minimal discomfort, and the functionality of the circuitry and connectivity of the brain can be studied.

Repetitive transcranial magnetic stimulation is known as rTMS and can produce longer lasting changes. Numerous small-scale pilot studies have shown it could be a treatment tool for various neurological conditions (e.g. migraine, stroke, Parkinsons Disease, dystonia, tinnitus) and psychiatric conditions (e.g. clinical depression, auditory hallucinations).


   
The principle of inductive brain stimulation with eddy currents has been noted since the 19th century. The first successful TMS study was performed in 1985 by Anthony Barker et al.[1] in Sheffield, England. Its earliest application was in the demonstration of conduction of nerve impulses from the motor cortex to the spinal cord. This had been done with transcranial electrical stimulation a few years earlier, but use of this technique was limited by severe discomfort. By stimulating different points of the cerebral cortex and recording responses, e.g., from muscles, one may obtain maps of functional brain areas. By measuring functional imaging (e.g. MRI) or EEG, information may be obtained about the cortex (its reaction to TMS) and about area-to-area connections.
TMS publications.
TMS publications.

Pioneers in the use of TMS in neuroscience research include Anthony Barker, Vahe Amassian, John Rothwell of the Institute of Neurology, Queen Square, London, Mark S. George, MD of the Medical University of South Carolina, David H. Avery, MD of the University of Washington at Seattle, Charles M. Epstein of Emory University, Drs. Mark Hallett, Leonardo G. Cohen, and Eric Wassermann of the National Institutes of Health, and Alvaro Pascual-Leone of Harvard Medical School. Currently, thousands of TMS stimulators are in use. More than 3000 scientific publications have been published describing scientific, diagnostic, and therapeutic trials.

[edit] How TMS affects the brain

The exact details of how TMS functions are still being explored. The effects of TMS can be divided into two types depending on the mode of stimulation:

    * Single or paired pulse TMS. The pulse(s) causes a population of neurons in the neocortex to depolarise and discharge an action potential. If used in the primary motor cortex, it produces a motor-evoked potential (MEP) which can be recorded on electromyography (EMG). If used on the occipital cortex, 'phosphenes' (flashes of light) might be detected by the subject. In most other areas of the cortex, the participant does not consciously experience any effect, but his or her behaviour may be slightly altered (e.g. slower reaction time on a cognitive task), or changes in brain activity may be detected using Positron Emission Tomography or fMRI. These effects do not outlast the period of stimulation. A review of TMS can be found in the Handbook of Transcranial Magnetic Stimulation.[2]

    * Repetitive TMS (rTMS) produces effects which last longer than the period of stimulation. rTMS can increase or decrease the excitability of corticospinal or corticocortical pathways depending on the intensity of stimulation, coil orientation and frequency of stimulation. The mechanism of these effects is not clear although it is widely believed to reflect changes in synaptic efficacy akin to long-term potentiation (LTP) and long-term depression (LTD). A recent review of rTMS can be found in Fitzgerald et al, 2006[3].

As such, it is important to distinguish TMS from repetitive TMS (rTMS) as they are used in different ways for different purposes.

[edit] TMS and rTMS techniques in research

One reason TMS is important in cognitive psychology/neuroscience is that it can demonstrate causality. A noninvasive mapping technique such as fMRI allows researchers to see what regions of the brain are activated when a subject performs a certain task, but this is not proof that those regions are actually used for the task; it merely shows that a region is associated with a task. If activity in the associated region is suppressed (i.e. 'knocked out') with TMS stimulation and a subject then performs worse on a task, this is much stronger evidence that the region is used in performing the task.

For example: subjects asked to memorize and repeat a stream of numbers would likely show activation in the prefrontal cortex (PFC) via fMRI, indicating the role of this brain region in short-term memory. If the researcher then interfered with the PFC via TMS, the subjects' ability to remember numbers would decline, and the researcher would have evidence that the PFC is important for short-term memory, because reducing subjects' PFC capability led to reduced short-term memory.

This ‘knock-out’ technique (also known as virtual lesioning) can be done in two ways:

    * Online TMS: where subjects perform the task and at a specific timepoint (usually in the order of 1-200ms) of the task, a TMS pulse is given to a particular part of the brain. This should affect the performance of the task specifically, and thus demonstrate that this task involves this part of the brain at this particular time point. The advantage of this technique is that any positive result can provide a lot of information about how and when the brain processes a task, and there is no time for a placebo effect or other brain areas to compensate. The disadvantages of this technique is that in addition to the location of stimulation, one also has to know roughly when the part of the brain is responsible for the task so lack of effect is not conclusive.

    * Offline repetitive TMS: where performance at a task is measured initially and then repetitive TMS is given over a few minutes, and the performance is measured again. This technique has the advantage of not requiring knowledge of the timescale of how the brain processes. However offline repetitive TMS is very susceptible to the placebo effect due to the contribution of dopamine to the placebo effect[4]. Additionally, the effects of repetitive TMS are variable between subjects and also for the same subject. A variant of this technique is the ‘enhancement’ technique, where repetitive TMS is delivered to enhance performance. This is even harder to achieve than the ‘knock-out’ technique.

[edit] Risks of TMS and rTMS

As it induces an electrical current in the human brain, TMS and rTMS can produce a seizure. The risk is very low with TMS except in patients with epilepsy and patients on medications. The risk is significantly higher, but still very low, in rTMS especially when given at rates >5Hz at high intensity.
The only other effects of TMS which are reported in most subjects are:

    * Discomfort or pain from the stimulation of the scalp and associated nerves and muscles on the overlying skin
    * Hearing from the loud click made by the TMS pulse

[edit] Clinical uses of TMS and rTMS

The uses of TMS and rTMS can be divided into diagnostic and therapeutic uses.

[edit] TMS for diagnostic purposes

TMS is used currently clinically to measure activity and function of specific brain circuits in humans. The most robust and widely-accepted use is in measuring the connection between the primary motor cortex and a muscle (i.e. MEP amplitude, MEP latency, central motor conduction time). This is most useful in stroke, spinal cord injury, multiple sclerosis and motor neuron disease. There are numerous other measures which have been shown to be abnormal in various diseases but few are validated or reproduced and more importantly, no one knows the significance of these measures. The most famous is short-interval intracortical inhibition (SICI) which measures the internal circuitry (intracortical circuits) of the motor cortex described by Kujirai et al. in 1993.[5]

Plasticity of the human brain can also be measured now with repetitive TMS (and variants of the technique, e.g. theta-burst stimulation, paired associative stimulation) and it has been suggested that this abnormality of plasticity is the primary abnormality in a number of conditions.

[edit] TMS for therapeutic purposes

A large number of studies with TMS and rTMS have been conducted for a variety of neurological and psychiatric conditions but few have been confirmed and most show very modest effects, if any. Some conditions which have been reported to be responsive to TMS-based therapy are:

    * Stroke
    * Nonfluent aphasia [6]
    * Tinnitus
    * Parkinson’s Disease
    * Dystonia
    * Amyotrophic lateral sclerosis
    * Epilepsy
    * Migraine[7]
    * Dysphasia
    * Hemispatial neglect
    * Clinical depression (rTMS therapy for drug-resistant depression has been approved by Health Canada for clinical delivery since 2002).
    * Phantom limb
    * Chronic pain
    * Obsessive-compulsive disorder (ongoing study)
    * Auditory Hallucinations associated with Schizoaffective Disorders

It is important to stress that in a vast majority of these studies, no adequate control of placebo effect was possible and thus it is tempting to wonder if this effect is placebo.

[edit] TMS equipment

The major manufacturers for general purpose TMS and repetitive TMS equipment are:

    * The Magstim Company, UK
    * Medtronics, USA
    * Nexstim, Finland
    * Cadwell, USA
    * Dantec, Denmark
    * Schwarzer, Germany
    * Neuronetics,Inc., USA

Several TMS/rTMS devices are approved by the US Food and Drug Administration (FDA) for stimulation of peripheral nerve and, therefore, can be used "off label" by individual physicians to treat brain disorders, essentially in any way they believe appropriate, analogous to the off label use of medications. However, most legitimate use of TMS in the USA and elsewhere is currently being done under research protocols approved by hospital ethics boards and, in the US, often under Investigational Device Exemption from the FDA. The requirement for FDA approval for research use of TMS is determined by the degree of risk as assessed by the investigators, the FDA, and the local ethics authority. An application for clearance of TMS Therapy as a treatment for depression was submitted to the FDA in 2006. The FDA convened its Neurological Devices Panel on January 26, 2007 to review the TMS Therapy application. The results of this panel meeting were mixed with no concerns regarding the safety of this treatment, however, there was clear questioning of the efficacy of this treatment.[8] A final decision from the FDA in regard to approving TMS as a treatment for depression is expected in the first half of 2008. As regulated medical devices, TMS devices are not sold to the general public. They are also expensive (US$25,000-100,000 for basic equipment; US$500,000 for state-of-the-art targeting and recording instruments). In Europe, TMS devices that have been manufactured according to the Medical Device Directive have been granted the CE mark and can thus be freely marketed within the EU.

[edit] Technical information on TMS

TMS is simply the application of the principle of induction to get electrical current across the insulating tissues of the scalp and skull without discomfort. A coil of wire, encased in plastic, is held to the head. When the coil is energized by the rapid discharge of a large capacitor, a rapidly changing current flows in its windings. This produces a magnetic field oriented orthogonally to the plane of the coil. The magnetic field passes unimpeded through the skin and skull, inducing an oppositely directed current in the brain that flows tangentially with respect to skull. The current induced in the structure of the brain activates nearby nerve cells in much the same way as currents applied directly to the cortical surface. The path of this current is complex to model because the brain is a non-uniform conductor with an irregular shape. With stereotactic MRI-based control, the precision of targeting TMS can be approximated to a few millimeters (Hannula et al., Human Brain Mapping 2005).

Typical data: [9]

    * magnetic field: often about 2 tesla on the coil surface and 0.5 T in the cortex
    * current rise time: zero to peak, often around 70-100 microseconds
    * wave form: monophasic or biphasic
    * repetition rate for rTMS: below 1 Hz (slow TMS), above 1 Hz (rapid-rate TMS)

[edit] TMS coil types

A number of different types of coils exist, each of which produce different magnetic field patterns. Some examples:

    * round coil: the original type of TMS coil

    * figure-eight coil (i.e. butterfly coil): results in a more focal pattern of activation

    * double-cone coil: conforms to shape of head, useful for deeper stimulation

    * Deep TMS (or H-coil): currently being used in a clinical trial for the treatment of patients suffering from clinical depression.[10]

[edit]
 

Offline chris

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I wrote up a news story based on a trial of this in the US recently.

Here's the link:

http://www.thenakedscientists.com/HTML/content/news/news/315/
 

Offline Karen W.

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WOW Chris! That is really cool. Migrains really suck!  Have you heard if there is any validity to it really helping sufferers of depression as myself.....or even the pain..etc as mentioned in the wiki article?
 

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