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Author Topic: 4-fluorobenzoic acid?  (Read 3213 times)

Offline Limpet chicken

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4-fluorobenzoic acid?
« on: 24/12/2004 22:10:51 »
I have searched online, for information, but I can't find anything regarding synthesis or suppliers or natural plant sources of 4-halobenzoic acids, in particular the 4-fluoro and 4-chloro derivatives.

Does anyone have any information on synthesis procedures, safety, or suppliers, that sell to the public? all I can find are the likes of sigma-aldrich and fluorochem, but they don't sell to the public.


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Offline Ylide

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Re: 4-fluorobenzoic acid?
« Reply #1 on: 25/12/2004 10:16:01 »
I don't think that you can synthesize it with easily accessible materials.  The easiest synthesis of it would be to start with benzoic acid (can be bought legally, I think, as it's a food additive) and chlorinate the ring, as the carboxylic acid group is both activating and ortho/para directing.  I forget the name of the reaction, but it's in any basic organic chemistry text... the reagents would be FeCl3 (not sure if that's easily purchasable but can't be too hard to make) and Cl2.  (probably not easy to purchase but not hard to make)  

As for plant sources, I have no idea.

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The Naked Scientists Forum

Re: 4-fluorobenzoic acid?
« Reply #1 on: 25/12/2004 10:16:01 »


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