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Author Topic: What role does serotonin play in mood disorders?  (Read 5359 times)

Graham

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What role does serotonin play in mood disorders?
« on: 16/10/2008 09:01:59 »
Graham asked the Naked Scientists:

What happens when one's serotonin levels are unstable? I was told, and this happens to me, that I start experiencing panic attacks. I have been taking Ciprimal combined with Rivitrol but this seems to be effective for a very short period eg. approx 2 hours and then it seems to wear off.

Can you help?

What do you think?


 

Offline Chemistry4me

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What role does serotonin play in mood disorders?
« Reply #1 on: 25/12/2008 08:55:07 »
This neurotransmitter is present in many tissues, particularly blood platelets, the lining of the digestive tract, and the brain. Serotonin was first thought to be involved in high blood pressure because it is present in blood and induces a very powerful contraction of smooth muscles. In the brain, serotonin has been implicated in sleep, mood, depression, and anxiety. Because serotonin controls the different switches affecting various emotional states, scientists believe these switches can be manipulated by analogs, chemicals with molecular structures similar to that of serotonin. Drugs that alter serotoninís action,such as fluoxetine (Prozac), have relieved symptoms of depression and obsessive-compulsive disorder.
 

Offline DoctorBeaver

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What role does serotonin play in mood disorders?
« Reply #2 on: 25/12/2008 09:05:36 »
Cipramil is a SSRI (Selective Seratonin Re-uptake Inhibitor). This class of medication allows the level of seratonin to stay higher.

Rivotril (Clonazepam) is a benzodiazepine. These drugs are used to regulate the amount of GABA on the brain. GABA helps keep you calm and lack of it can cause anxiety. You're not an apileptic, are you?
 

Offline Chemistry4me

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What role does serotonin play in mood disorders?
« Reply #3 on: 25/12/2008 09:08:32 »
Most antidepressants affect norepinephrine or serotonin in the brain, apparently by correcting the abnormal signals that control mood, thoughts, and other sensations. The tricyclic antidepressants, such as imipramine, primarily block the reabsorption and inactivation of serotonin and norepinephrine to varying degrees. Another class of antidepressant medications is the monoamine oxidase inhibitors (MAOIs). These agents inhibit monoamine oxidase,(an enzyme that breaks down serotonin and norepinephrine), allowing these chemicals to remain active.
 

Offline Chemistry4me

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What role does serotonin play in mood disorders?
« Reply #4 on: 25/12/2008 09:09:08 »
Thanks Doc.
 

Offline Chemistry4me

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What role does serotonin play in mood disorders?
« Reply #5 on: 25/12/2008 09:14:17 »
The SSRIs, the serotonin-norepinephrine reuptake inhibitors (SSRNs), cognitive behavior therapy, or a combination of these are now the first-choice treatments of most anxiety disorders. Tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and high-potency benzodiazepines are also effective for many of these disorders.
 

Offline DoctorBeaver

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What role does serotonin play in mood disorders?
« Reply #6 on: 25/12/2008 09:16:42 »
Tri-cyclics aren't used so much these days. The same is true of MAOIs as they can react with some foodstuffs and cause severe side-effects if taken with other medicines.
 

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What role does serotonin play in mood disorders?
« Reply #7 on: 25/12/2008 09:18:23 »
CBT would be my choice as I think medication should be a last resort except in some circumstances where it is obviously required immediately.
 

Offline tkadm30

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Re: What role does serotonin play in mood disorders?
« Reply #8 on: 27/02/2016 20:57:21 »
Is hippocampal neurogenesis upregulated by serotonin/BDNF signaling? If so, does antidepressants increase neurogenesis?

 
 

Offline chris

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Re: What role does serotonin play in mood disorders?
« Reply #9 on: 28/02/2016 09:38:02 »
Yes; fluoxetine as well as certain neurotrophins including BDNF are linked to neurogenesis.

http://www.cell.com/neuron/fulltext/S0896-6273%2808%2900541-2
 

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Re: What role does serotonin play in mood disorders?
« Reply #9 on: 28/02/2016 09:38:02 »

 

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