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Author Topic: What is infectious mononucleosis?  (Read 6431 times)

Offline chenrko420

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What is infectious mononucleosis?
« on: 13/07/2009 04:54:58 »
Anyone experiencing or have experienced it in the past? My doctors tells me that there really isn't a cure for it...
« Last Edit: 04/09/2009 22:13:06 by chris »


 

Offline Karen W.

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What is infectious mononucleosis?
« Reply #1 on: 11/10/2009 14:20:24 »
It is otherwise known as the kissing disease..
I am under the understanding that it is treated with antibiotics but that it does reoccur as you stated.. I am not a doctor but someone will come along and correct me and give you a better answer... Good luck and welcome to the forum!
 

Offline Nizzle

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What is infectious mononucleosis?
« Reply #2 on: 13/10/2009 09:30:32 »
It's caused by a virus: Cytomegalovirus.

There is indeed not really a cure for it, only meds to ease the symptoms.
You'll have to let your own body overcome the virus.
 

Offline iko

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What is infectious mononucleosis?
« Reply #3 on: 14/10/2009 15:21:27 »
It's caused by a virus: Cytomegalovirus.

There is indeed not really a cure for it, only meds to ease the symptoms.
You'll have to let your own body overcome the virus.

Nah!  CMV is from the same family (Herpes viridiae), but mononucleosis is caused by EBV.
Epstein-Barr Virus is a bad beast sometime, but in most cases infection is asymptomatic.
Find plenty of information at medical websites...

ikod
« Last Edit: 14/10/2009 15:26:36 by iko »
 

Offline Karen W.

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What is infectious mononucleosis?
« Reply #4 on: 14/10/2009 16:15:00 »
So Iko, if one has Mono, does that mean they also have Epstein-Barr Virus? OR does that mean they have been exposed to Epstein_Barr?
I was under the impression that it was not catchy Epstein_Barr but Mono was? Am I wrong about that?
 

Offline iko

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What is infectious mononucleosis?
« Reply #5 on: 15/10/2009 08:50:04 »
Hi Karen!   :)

Yes, EBV - or HHV4 Human Herpes Virus 4 - is the infectious agent
responsible for mononucleosis.
Most people get it before 30yrs, only few have symptoms of 'mono'.
Herpes viruses are DNA viruses able to 'hide' indefinitely in our
body and come out when immune defenses are low (prolonged steroid
treatments, immune suppression for organ/marrow transplant, AIDS, etc.)


Enjoy a good reading at:    http://emedicine.medscape.com/article/963894-overview
« Last Edit: 15/10/2009 08:52:24 by iko »
 

Offline Nizzle

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What is infectious mononucleosis?
« Reply #6 on: 15/10/2009 09:15:23 »
Nah!  CMV is from the same family (Herpes viridiae), but mononucleosis is caused by EBV.
Epstein-Barr Virus is a bad beast sometime, but in most cases infection is asymptomatic.
Find plenty of information at medical websites...

ikod


I did some more digging and we're both correct ;)
Mononucleosis can be caused by either CMV or EBV

The Mono caused by CMV is more acute than the EBV variant.
« Last Edit: 15/10/2009 09:19:36 by Nizzle »
 

Offline Karen W.

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What is infectious mononucleosis?
« Reply #7 on: 15/10/2009 09:35:50 »
Thanks you guys.. nice link  iko.. thank you.
 

Offline iko

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What is infectious mononucleosis?
« Reply #8 on: 15/10/2009 09:46:14 »
Nah!  CMV is from the same family (Herpes viridiae), but mononucleosis is caused by EBV.
Epstein-Barr Virus is a bad beast sometime, but in most cases infection is asymptomatic.
Find plenty of information at medical websites...

ikod


I did some more digging and we're both correct ;)
Mononucleosis can be caused by either CMV or EBV

The Mono caused by CMV is more acute than the EBV variant.

Well, I've seen just one 'mononucleosis'- like reaction in a kid, years ago. It was a tricky case, and CMV infection came from a blood transfusion after an accident and following surgery (splenectomy).
Most cases (>95%?) of mononucleosis come from EBV infection.
The well known 'kiss disease' as Karen properly reminded.
Both clinical presentations can be more or less acute.
CMV should be considered a 'variant', not EBV mononucleosis!
« Last Edit: 15/10/2009 14:29:56 by iko »
 

Offline Nizzle

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What is infectious mononucleosis?
« Reply #9 on: 15/10/2009 09:53:43 »
I follow...

Maybe this is due to the fact that EBV is far more widespread in human population than CMV, and thus propagates faster as well throughout the (kissy kissy) population.

The funny thing is that i have a friend who had Mono last month, caused by CMV.
That's why i didn't do any further digging on the subject before my first post in this thread ;)

Quote
Causes

Numerous etiologies exist.

    * In more than 90% of cases, infectious mononucleosis is secondary to Epstein-Barr virus (EBV) infection.
    * Other infectious causes include the following:
          o Adenovirus
          o Cytomegalovirus (CMV)
          o Group A beta-hemolytic streptococci
          o Hepatitis A
          o Human herpes virus
          o Human immunodeficiency virus (HIV)
          o Rubella
          o Toxoplasma gondii
    * Noninfectious causes of heterophile negative infectious mononucleosis like syndrome include medications (eg, phenytoin, sulfas) and malignancy (eg, lymphomas, leukemias).
    * Risk factors include the following:
          o Being a college or high school student
          o Kissing
          o Blood transfusion
source: http://emedicine.medscape.com/article/784513-overview

« Last Edit: 15/10/2009 09:55:58 by Nizzle »
 

Offline iko

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What is infectious mononucleosis?
« Reply #10 on: 15/10/2009 14:07:17 »
Quote
Causes

Numerous etiologies exist.

    * In more than 90% of cases, infectious mononucleosis is secondary to Epstein-Barr virus (EBV) infection.
    * Other infectious causes include the following:
          o Adenovirus
          o Cytomegalovirus (CMV)
          o Group A beta-hemolytic streptococci
          o Hepatitis A
          o Human herpes virus
          o Human immunodeficiency virus (HIV)
          o Rubella
          o Toxoplasma gondii
    * Noninfectious causes of heterophile negative infectious mononucleosis like syndrome include medications (eg, phenytoin, sulfas) and malignancy (eg, lymphomas, leukemias).
    * Risk factors include the following:
          o Being a college or high school student
          o Kissing
          o Blood transfusion


We agree for a >95% EBV etiology in mononucleosis.
This table is not accurate, because CMV and EBV are both Human Herpes Viruses, like Herpes Simplex (cancre sore) and Varicella/zoster. Furthermore EBV may be responsible for some leukemia, certainly for Burkitt's lymphoma and post-transplant lymphomas.
In some genetically predisposed children (very rare condition!), the simple 'contact' with EBV unleashes a lethal proliferation of B-lymphs, leading to a massive lymphoma.
To understand more about EBV-related phenomena, finding practical applications means...
just being in the number for the next Nobel Prize for Medicine or Physiology!
« Last Edit: 15/10/2009 14:34:54 by iko »
 

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What is infectious mononucleosis?
« Reply #10 on: 15/10/2009 14:07:17 »

 

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