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Author Topic: How does alcohol affect your Antibiotic Cousre?  (Read 13100 times)

lyner

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How does alcohol affect your Antibiotic Cousre?
« on: 26/07/2009 16:10:20 »
You frequently read that antiboitics should not be taken along with alcohol. Is this just because alcohol affects the absorption of the drug?
If the dose is one tablet a day, taken in the morning, is the alcohol (not a skin full!) yIou would like to have with my evening meal going to affect the efficacy of the course?

The drug in question is Doxycycline and seems to have some very stringent instructions - like not to take it laying down but stand or sit. It is an irritant, apparently. My sinusitis is very persistent, having taken five days to respond significantly. I wouldn't like to undo all the good work but I am going to be socialising for two evenings and you know how it is. . . .


 

Offline RD

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How does alcohol affect your Antibiotic Cousre?
« Reply #1 on: 26/07/2009 16:53:30 »
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Chronic alcohol consumption may enhance the elimination of doxycycline. The mechanism is induction of hepatic microsomal enzymes by alcohol. In one study, the half-life of doxycycline in six alcoholics was 10.5 hours, compared with 14.7 hours in six control patients.
http://www.drugs.com/drug-interactions/doxycycline_d00037_alcohol_d03162.html

Quote
Alcohol may reduce the effectiveness of Doxycycline – drink in moderation only, or avoid alcohol, while taking this treatment

http://www.plymouthpct.nhs.uk



So it depends what you mean by socialising, e.g. socialised as a newt  :)
« Last Edit: 26/07/2009 17:00:02 by RD »
 

Offline Variola

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How does alcohol affect your Antibiotic Cousre?
« Reply #2 on: 26/07/2009 17:05:49 »
You frequently read that antiboitics should not be taken along with alcohol. Is this just because alcohol affects the absorption of the drug?
If the dose is one tablet a day, taken in the morning, is the alcohol (not a skin full!) yIou would like to have with my evening meal going to affect the efficacy of the course?

The drug in question is Doxycycline and seems to have some very stringent instructions - like not to take it laying down but stand or sit. It is an irritant, apparently. My sinusitis is very persistent, having taken five days to respond significantly. I wouldn't like to undo all the good work but I am going to be socialising for two evenings and you know how it is. . . .
-


I personally have only seen that warning in relation to metronidazole, but I believe that not drinking alcohol is advised for the whole amibicede class of antibiotic.
Doxycycline is a tetracycline, and as far as I am aware, there is no alcohol interactions with tetracyclines. The warnings come mainly from the idea that if you over indulge in alcohol and make yourself ill, it will decrease the effectivity of the antibiotic, as would any other stomach upset. I have not heard the advice to take it while standing or sitting either! But I guess that makes sense to not be rushing about or have an over-active digestion, such as after a big meal. Some antacids can causes a reduction in the effectiveness of a tetracyline too as it binds to it and prevents absorption, but check with your pharmacist which ones.
 

Offline Variola

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How does alcohol affect your Antibiotic Cousre?
« Reply #3 on: 26/07/2009 17:10:25 »
Hmmmmm.

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Tetracycline should be taken on an empty stomach. Avoid cheese, yogurt, milk, ice cream, iron-fortified cereals and supplements, and meats for 2 hours before or after taking this drug. There is no interaction with alcohol.

http://gicare.com/MEDICATIONS/Medications.aspx?CID=1&ID=4

I think the confusion maybe arising from what an 'interactions' is as opposed to 'reducing the effectiveness'. Without going into the biochemistry of the drug, I don't know the answer, to me, stating that there is no interation between alcohol and a tertracyline means that it is not affected biochemically, but perhaps I am being too simplistic.
 

lyner

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How does alcohol affect your Antibiotic Cousre?
« Reply #4 on: 26/07/2009 18:49:06 »
The leaflet just says
"You should not drink alcohol whilst taking Doxycycline capsules, speak to your doctor if you have questions"
Are they just covering their arses?
I only intend to have a couple of pints or glasses of wine, max.
(Anyone else, other than Max, can answer)

It also says "It is important not to lie down for at least 30 minutes after taking Doxycycline capsule"
 

Offline Bored chemist

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How does alcohol affect your Antibiotic Cousre?
« Reply #5 on: 26/07/2009 21:27:06 »
Are you having difficulty with the second clause in this "You should not drink alcohol whilst taking Doxycycline capsules, speak to your doctor if you have questions"?

I think they probably are just covering themselves but I'm not a doctor.
It's my understanding that they tell you to avoid alcohol because the combination of drug and alcohol; is more likely to upset your stomach and also an upset stomach from drinking may mess up the absorbtion of the drug. (It certainly will if you treat it with a calcium containing antacid).
On the other hand you would be better asking someone who knows more about it than me; preferably someone who knows about your own particular circumstances. Your doctor might be a reasonable choice.
 

Offline Variola

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How does alcohol affect your Antibiotic Cousre?
« Reply #6 on: 26/07/2009 21:50:07 »
Are you having difficulty with the second clause in this "You should not drink alcohol whilst taking Doxycycline capsules, speak to your doctor if you have questions"?

I think they probably are just covering themselves but I'm not a doctor.
It's my understanding that they tell you to avoid alcohol because the combination of drug and alcohol; is more likely to upset your stomach and also an upset stomach from drinking may mess up the absorbtion of the drug. (It certainly will if you treat it with a calcium containing antacid).
On the other hand you would be better asking someone who knows more about it than me; preferably someone who knows about your own particular circumstances. Your doctor might be a reasonable choice.


I agree. On the Amibicedes they make is crystal clear not to drink alcohol and inform you that you will feel sick, dizzy and a fast heart rate if you do. If it was a similar result for the tetracycline then it would be the same.
 

lyner

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How does alcohol affect your Antibiotic Cousre?
« Reply #7 on: 26/07/2009 23:31:40 »
BC
If one is told not to do something, it is very reasonable to want to know why. The information on the leaflet was about as minimal as you could get and, unlike what they say about 'how' to take the capsules, gives you no clue about the 'why no alcohol'. For all I know, the producers may be Methodists and are just peddling propaganda.
Quote
Your doctor might be a reasonable choice.
"your doctor" is a concept that, I think, went out with Doctor Finlay.
'A doctor' would be a better phrase. When I go down to my health centre I see one of about half a dozen and they're very pleasant and competent. How much they 'know me' is open to question, however as they come and go fairly frequently, by my timescale, at least.  They certainly don't have time to discuss, in detail the (very) small print on all the medicines they prescribe me.  The fact that he didn't mention it may indicate that it isn't a vital piece of information and, as I suggested, just arse covering by the manufacturer.
I look upon this forum as a useful source of general (and sometimes even specialised) knowledge about such matters. Asking enthusiastic contributors to this site a trivial question about an indulgence of mine  is probably less misuse of resources than wasting a GP's time. That was the reason for my question. You aren't forced to answer!  (Do I ever appear as cross as you, BC?  :-\)
I have already had more information from this thread (thank you all) than I could have expected from that nice young man down the road.
 

Offline Bored chemist

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How does alcohol affect your Antibiotic Cousre?
« Reply #8 on: 27/07/2009 20:15:52 »
Well, I have a doctor. I can't remember his name and last I heard he was off sick anyway. OTOH I work with a few doctors so if I wanted to know I'd bother one of them. Would you like me to ask one on your behalf?
Incidentally, if you choose to explicitly disregard the instructions with your medication it's not that shocking if someone point it out.
 

lyner

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How does alcohol affect your Antibiotic Cousre?
« Reply #9 on: 28/07/2009 10:43:10 »
Thanx for the offer but I thought that this site would have the expertise that I needed. There was some useful info, in fact.
I think it's optimistic to expect one's doctor to know all that's necessary about everything. Even the best ones will have their limits and it's a good idea to cast the net as wide as poss for information. As with all scientific matters.
I have come across some very limited GPs in my time!
Otoh I have met some with whom I'd readily trust my life.

Btw, would you advise me to stick to plumbers for plumbing advice?
 

Offline Bored chemist

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How does alcohol affect your Antibiotic Cousre?
« Reply #10 on: 28/07/2009 19:24:44 »
Define plumbing.

"There once was a plumber from Lee
Who was plumbing his girl by the sea
She said “Stop your plumbing,
There's somebody coming!”
Said the plumber still plumbing... “It's me!”

"
 

lyner

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How does alcohol affect your Antibiotic Cousre?
« Reply #11 on: 29/07/2009 00:00:37 »
You are plumbing the depths with that one.
Here's another:

There was a young girl from Cape Cod
Who dreamed she was sleeping with God.
'Twas not the Almighty
who lifted her nightie
'TWas Roger the Lodger the sod.
 

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How does alcohol affect your Antibiotic Cousre?
« Reply #11 on: 29/07/2009 00:00:37 »

 

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