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Author Topic: Statin study model  (Read 6843 times)

Offline srinivasan

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Statin study model
« on: 25/08/2003 16:21:39 »
Hi everyone,
  I'm new to this group. I have a doubt. Why rodents are not good model to study the efficacy of statins? Is it due to the very low level of LDL in rodents? Then which animal species is the good model for studying the pleiotropic effect of statins?

with regards

Dr.Srinivasan M. Rajaram MVSc
Research Associate
Pharmacology
Zydus Research Centre
N.H.No.8A, Moraiya,
Ahmedabad, Gujarat, India


 

Offline Exodus

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Re: Statin study model
« Reply #1 on: 26/08/2003 16:33:30 »
welcome to the forum!

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Offline srinivasan

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Re: Statin study model
« Reply #2 on: 28/08/2003 14:32:14 »
Hi all,
 can anyone tell me is it ok to take high fat diet during statin treatment? is it diet restriction is so important during statin treatment? if yes Why? if no Why?


Dr.Srinivasan M. Rajaram MVSc
Research Associate
Pharmacology
Zydus Research Centre
N.H.No.8A, Moraiya,
Ahmedabad, Gujarat, India
 

Offline Quantumcat

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Re: Statin study model
« Reply #3 on: 28/08/2003 14:37:06 »
Um, what's a statin?

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Offline chris

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Re: Statin study model
« Reply #4 on: 28/08/2003 16:07:17 »
Dear Srinivasan

good question. Remember that statins, as a class, lower cholesterol by inhibiting HMG-CoA-reductase, the rate-limiting step in endogenous cholesterol bio-synthesis. Diet is a poor modifier of cholesterol levels because eliminating cholesterol from food merely leads to up-regulation of the body's own synthesis.

However, whilst they can lower cholesterol levels, they will not stop you absorbing fats (and cholesterol) from the food you eat and hence there will still be an elevation in serum lipids after meals which will presumably antagonise the problem for which you need a statin in the first place. Therefore you should always eat sensibly and live healthily (low saturated fat, >2:1 monounsaturates to saturates ratio, less than 30% daily calories from fat, low salt, avoid red meats, at least 5 portions fruit or vegetables per day, weight reduction if too large), modest exercise).

Hope this helps

Chris



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Offline Ray hinton

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Re: Statin study model
« Reply #5 on: 02/02/2006 21:39:11 »
I have to take simvastatin,why must i avoid grapefruit whilst taking statin ?.

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Offline ukmicky

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Re: Statin study model
« Reply #6 on: 02/02/2006 21:57:27 »
quote:
I have to take simvastatin,why must i avoid grapefruit whilst taking statin ?.


https://secure.pharmacytimes.com/lessons/200303-02.asp

see sometimes i can actually be helpful;)

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Offline Ray hinton

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Re: Statin study model
« Reply #7 on: 03/02/2006 02:17:32 »
typical,,,WEB PAGE UNAVAILABLE ah well.bacon buttie anyone?

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ROBERT

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Re: Statin study model
« Reply #8 on: 03/02/2006 10:22:32 »
"" Statins Revolutionize Heart Disease Care:
Article Created: 2003-05-13 ""
http://healthlink.mcw.edu/article/1031002246.html

"" Statins may help treat Multiple Sclerosis, Alzheimer’s and Ostoeporosis:
Category: Statins News
Article Date: 14 May 2004 ""
http://www.medicalnewstoday.com/medicalnews.php?newsid=8307

""Source: John Wiley & Sons, Inc.
Posted: January 30, 2006
Using Statins To Potentially Treat Rheumatoid Arthritis""
http://www.sciencedaily.com/releases/2006/01/060130030451.htm

""A CHOLESTEROL-CONTROLLING DRUG COULD STRIKE A BLOW AGAINST INSULIN RESISTANCE
Type 2 diabetes is now an epidemic. Simvastatin could be key for prevention against this deadly disease. April 9, 2003""
From this forum's "latest medical discoveries".



Call me a cynic, but I believe that medications purported to "cure-all" usually cure nothing.
« Last Edit: 03/02/2006 17:18:48 by ROBERT »
 

Offline Ray hinton

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Re: Statin study model
« Reply #9 on: 03/02/2006 22:22:42 »
this seems to not be the case with me,my cholesterol was 8.5,i had a heart attack because of it,due to the statin ive been having,my cholesterol is 4.5,hope i can maintain that low level.

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ROBERT

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Re: Statin study model
« Reply #10 on: 08/02/2006 16:53:41 »
quote:
Originally posted by Ray hinton

this seems to not be the case with me,my cholesterol was 8.5,i had a heart attack because of it,due to the statin ive been having,my cholesterol is 4.5,hope i can maintain that low level.



Ray, are you sure that your lowered cholesterol was not due to changes in your diet & lifestyle
 which you presumably made after your heart attack ?.
« Last Edit: 08/02/2006 16:56:00 by ROBERT »
 

ROBERT

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Re: Statin study model
« Reply #11 on: 08/02/2006 17:02:45 »
"" 17 May, 2005, 11:43 GMT 12:43 UK  
 
Med journals 'too close to firms'  

Ex-BMJ editor Dr Smith is critical of industry influence on journals
Medical journals are an extension of the marketing arms of drug firms, says an ex-British Medical Journal editor.
Dr Richard Smith, who edited the BMJ for 13 years, criticised the journals' reliance on drug company advertising.

Writing in Public Library of Science Medicine, he also said journals were undermined by relying on clinical trials funded by the drugs industry.""

http://news.bbc.co.uk/1/hi/health/4552509.stm
« Last Edit: 08/02/2006 17:05:40 by ROBERT »
 

Offline Ray hinton

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Re: Statin study model
« Reply #12 on: 19/02/2006 01:09:54 »
my attack was in december 05 i havent changed my diet much as i ate quite healthy in the first place,but i have stopped smoking.
 

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Re: Statin study model
« Reply #12 on: 19/02/2006 01:09:54 »

 

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