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Author Topic: Do human reproductive cells deteriorate when vitrification occurs in zero g?  (Read 7475 times)

Offline CliffordK

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DNA Damage by cosmic rays?

Ahhh...  Wikipedia has a good section on cryopreservation, as well as a summary of Vitrification and the formation of small ice crystals.

http://en.wikipedia.org/wiki/Cryopreservation#Main_methods_to_prevent_risks

While you would still need to do the experiments, it should be safe at temperatures lower than that of liquid Nitrogen, for example cooling it to Liquid Helium temperatures.

And, it also says that Oocytes can also be vitrified using similar methods.

http://en.wikipedia.org/wiki/Oocyte_cryopreservation

As well as cryopreservation of ovarian tissue.

http://en.wikipedia.org/wiki/Ovarian_tissue#Cryopreservation  and even implanting the ovarian tissue in mice or rats for maturation and harvesting of the eggs.

There is a note in the first Wikipedia article:
When having reached the frozen stage, the preserved material is relatively safe from further damage. However, estimates based on the accumulation of radiation-induced DNA damage during cryogenic storage have suggested a maximum storage period of 1000 years.

I don't see any sources for that note.

But...
If you consider DNA damage caused by radiation as ongoing.  It wouldn't make a difference whether the organism is frozen or not.  In fact, a frozen organism would be at a disadvantage because it would not be able to rely on cellular DNA repair mechanisms.

So, for example, you get broken links, or slow changes from Carbon Atoms changing to Nitrogen atoms (or visa-versa), then you would eventually get critical damage whether or not it is cryo-preserved.

In fact, assuming your DNA has some 14C, 3H, then one could just get time based damage.  But, it is likely to be sped up in a high radiation environment.

A large portion of our 14C & 3H is considered to be of cosmic/solar origin.  That could cause unforeseen issues with harvesting local elements from planets & moons with high solar flux, and limited atmosphere or magnetosphere such as the Moon, Venus & Mars.
 

Offline RD

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The standard speed of revolution for extraterrestrial phonograph records is ...
Quote
16⅔ revolutions per minute.
http://en.wikipedia.org/wiki/Voyager_Golden_Record#Contents


Although ET will have to be seriously geeky to work that out ...
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Written around [the record] in binary arithmetic is the correct time of one rotation of the record, 3.6 seconds, expressed in time units of 0.70 billionths of a second, the time period associated with a fundamental transition of the hydrogen atom.
  http://en.wikipedia.org/wiki/Voyager_Golden_Record#Playback
« Last Edit: 12/01/2011 06:38:11 by RD »
 

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