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Author Topic: Can transplant patients be made immune to organ rejection?  (Read 2214 times)

Offline thedoc

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Scientists have found a way to selectively shut down the components of the immune system responsible for triggering autoimmune diseases and rejecting transplanted organs.

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« Last Edit: 24/05/2011 13:29:08 by _system »


 

Offline CliffordK

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Can transplant patients be made immune to organ rejection?
« Reply #1 on: 22/05/2011 17:53:24 »
Interesting.

I like the highly targeted approach.

When I read this, I started thinking about bone marrow transplants, which I believe eventually lead to recognition of both host and donor tissue.

And, in fact, there have been studies of transplanting bone marrow along with the transplanted organ.

I suppose what this study indicates is that rather than transplanting all the bone marrow from the donor, one may only need to select the treg cells if they could be isolated, and thus have less risk of Graft-versus-host disease.
 

Offline chris

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Can transplant patients be made immune to organ rejection?
« Reply #2 on: 22/05/2011 22:56:50 »
In the case of allogeneic bone marrow transplant, actually it's slightly complicated because there is a desire to achieve a degree of graft-versus-leukaemia activity, to help to suppress the existing disease state. Care would be needed to ensure that this activity wasn't compromised.
 

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Can transplant patients be made immune to organ rejection?
« Reply #2 on: 22/05/2011 22:56:50 »

 

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