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Offline thedoc

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How might fatty acids disrupt viruses?
« on: 01/08/2013 12:30:02 »
"ottarstensvold asked the Naked Scientists:
   
Biochemistry of viruses treating HIV/AIDS and other viral infections.

Viruses contain a lot of proteins in their capsids and envelopes.

These protein chains are densely packed. They can be dissolved by short-chain fatty acids, e.g. the four-carbon butyric acid: C-C-C-COOH, the caproic acid or the caprylic acid.

These acids are small enough to creep in between the protein chains, they will intermingle and get locked between the R-groups in the protein chains. The acids will act as soap molecules, make fractures and fringe, puncture/implode the viruses. Beside acting as amphipathic soap molecules in the fat/protein-intersection, the butyric acid and its related molecules could neutralize the viruses.

The stuff will prod the viruses and break them up like millions of tiny wedges in concerted action. Butterfat contains a broad range of fatty acids of varying lengths, which are bound up in triglycerides. Maybe around 10% have less than 12 carbon atoms.

Butyric acid alone constitutes 3-4%. When butter is boiled in base (HO-) the fatty acids get released (saponification). When I boiled butter in sodium bicarbonate (NaHCO3 - baking soda - natron) and water, I got a cocktail of water-soluble, short-chain, free fatty acids. The emulsion showed very promising features in dissolving stacked proteins. When drinking this in sufficient amounts, some of the free fatty acids will avoid getting built into chylomicrons in the enterocytes. Thus they will be interspersed in blood and lymph, and possibly they will help dissolve the viruses.

A possible side-effect is water retention in interstitial fluid as a result of Gibbs-Donnan effect and osmolarity. Delayed blood clotting/anti-thrombosis effect and increased bleeding tendency due to dissolving of coagulation factors and cholesterol is maybe another considerable aspect.

PS Virus infections and cancers are often correlated, with stacked-proteins-pathogenesis as a common trait, so it should be tried in cancer therapy too. Even in Alzheimer`s disease there is a protein (amyloid) plaques syndrome, so this approach can be far-reaching!

Recipe: one spoon of butter, two spoons of baking soda and three spoons of water boiled to the top in a small pot will do the trick.

Invented and written by Ottar Stensvold

Molde
Norway


Some relevant links:

This article shows the virucidal effect of lipids after only 30 minutes of incubation:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174645/

Inactivation of enveloped viruses in human bodily fluids by purified lipids: http://www.ncbi.nlm.nih.gov/m/pubmed/8030973/

Virucidal effect of lipids on visna virus, a lentivirus related to HIV: http://www.ncbi.nlm.nih.gov/m/pubmed/16388394/? i=4&from=/8030973/related

Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies: http://www.sciencedirect.com/science/article/pii/S0024320598002793

Protective activity of monoacetone glucose 3-butyrate, prodrug of n-butyric acid, against the fatal effect of encephalomyocarditis virus in mice: http://www.ncbi.nlm.nih.gov/m/pubmed/1313734/

Electron-microscopic studies show that the envelope of vesicular stomatitis virus (VSV) is completely destroyed by linoleic acid (18:2): http://books.google.no/books? id=6ZepRgMaa2gC&pg=PT143&lpg
Butter contains linoleic acid: http://en.m.wikipedia.org/wiki/Linoleic_acid#section_1

http://en.m.wikipedia.org/wiki/Butterfat#section_1

http://en.m.wikipedia.org/wiki/Sunflower_butter#section_3

Butyrate strains viruses in action within days: http://www.ncbi.nlm.nih.gov/m/pubmed/2986799/

Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides:http://www.ncbi.nlm.nih.gov/m/pubmed/8030974/

Clostridia produce butyric acid and degrade proteins, for instance in silage: http://www.biomin.net/cz/centrum-vzdelavani/clanky/articles-details/article/prevention-of-contaminations-with-clostridia-in-silages-using-inoculants/

http://ag.udel.edu/anfs/faculty/kung/articles/analyzing_silages_for_fermentati.htm

Butyric acid destroys the protein-laden erythrocytes: http://www.ncbi.nlm.nih.gov/m/pubmed/1810341/(working for 60 minutes and with mechanical stress/centrifugation)

The old butyric acid test for syphilis shows turbidity when butyric acid binds to serum proteins:http://archive.org/stream/39002010637842.

Degradation of tobacco mosaic virus with acetic acid: http://www.sciencedirect.com/science/article/pii/0042682257900387

Degradation of influenza viruses with acetic acid: http://www.indianjournals.com/ijor.aspx? target=ijor:ijps&volume=45&issue=1&article=021

http://www.ncbi.nlm.nih.gov/m/pubmed/19439628/? i=2&from=/18459307/related

Acetic acid as a solvent for erythrocyte membrane proteins:http://www.sciencedirect.com/science/article/pii/0005273671900290

Red blood cells are lysed with 2% acetic acid: http://www.ncbi.nlm.nih.gov/m/pubmed/8513697/

The effect of pH on the inhibition of bacterial growth by physiological concentrations of butyric acid: implications for neonates fed on suckled milk: http://ukpmc.ac.uk/abstract/MED/9717513/

Inactivation of avian influenza virus using common detergents and chemicals: http://www.ncbi.nlm.nih.gov/m/pubmed/18459307/

Breastmilk found to destroy HIV:

http://www.naturalnews.com/036382_breast_milk_AIDS_HIV.html


What do you think?
« Last Edit: 01/08/2013 12:30:02 by _system »


 

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How might fatty acids disrupt viruses?
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