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Author Topic: Could we make a drug to stop jetlag?  (Read 1786 times)

Offline thedoc

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Could we make a drug to stop jetlag?
« on: 03/10/2013 21:50:43 »
Mice that don't suffer jetlag have been developed by scientists in Japan...

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« Last Edit: 03/10/2013 21:50:43 by _system »


 

Offline CliffordK

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Re: Could we make a drug to stop jetlag?
« Reply #1 on: 03/10/2013 21:35:21 »
I could imagine any drug to reduce jetlag would also have wide applications for shift workers and rotating shift workers.  Although I fear it may also have abuse potential.  How does it affect overall drowsiness?
 

Offline chris

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Re: Could we make a drug to stop jetlag?
« Reply #2 on: 04/10/2013 09:01:51 »
It's not so much the drowsiness but what else AVP signalling does in the brain. This transmitter system is involved in partner bonding; individuals with certain AVP receptor polymorphisms are more likely to have affairs and to get divorced! The molecule is also an important systemic signal for regulation of blood pressure and blood volume.

Although the mice in the present study were biologically normal, the situation was artificial, the systems and behaviours described above were not probed (to my knowledge).

Developing a "clean" drug capable of acting selectively within the SCN and without impacts on the other brain centres would be necessary, and I'm not sure how simple that will be, as I am not aware of the distribution of V1a and V1b receptors elsewhere in the brain.
 

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Re: Could we make a drug to stop jetlag?
« Reply #2 on: 04/10/2013 09:01:51 »

 

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