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Author Topic: Vitamin D deficiency in Leukemia?  (Read 233782 times)

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #225 on: 29/03/2009 02:04:20 »
I got two hours of that beautiful sunshine today and it makes me feel so much better!!
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #226 on: 08/12/2009 15:06:41 »
Long time, no see... ;)
No discussion anymore, >70k viewers in over 3 years, ≈100 a day.

Is vitamin D3 good for the bone(marrow)?

Vitamin D Metabolism and Action in Human Bone Marrow Stromal Cells.


Zhou S, Leboff MS, Glowacki J.

Departments of Orthopedic Surgery (S.Z., J.G.) and Medicine (M.S.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Vitamin D metabolites are important effectors of bone and mineral homeostasis. Extrarenal conversion of 25-hydroxyvitamin D (25OHD) to the biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1,25(OH)2D] is catalyzed in several cell types by the 1alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones. We examined whether human bone marrow stromal cells (hMSCs, also known as mesenchymal stem cells) participate in vitamin D metabolism and whether vitamin D hydroxylases in hMSCs are influenced by the vitamin D status of the individual from whom the hMSCs were obtained. We also investigated the effects of vitamin D metabolites on osteoblast differentiation and the role of IGF-I in the regulation of CYP27B1. In a series of 27 subjects, vitamin D hydroxylases in hMSCs were expressed at different levels and were correlated with serum 25OHD, 1,25(OH)2D, and PTH. In vitro treatment with 25OHD up-regulated CYP27B1 and IGF-I in hMSCs; IGF-I also up-regulated CY27B1 expression and stimulated osteoblast differentiation. When hydroxylation of 25OHD was blocked by ketoconazole, a cytochrome P450 inhibitor, 25OHD was no longer able to induce CYP27B1 expression.

 In summary, these findings show that human bone marrow stromal cells have the molecular machinery both to metabolize and respond to vitamin D. We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)2D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I.

Endocrinology. 2009 Dec 4. [Epub ahead of print]


« Last Edit: 09/12/2009 21:57:05 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #227 on: 12/12/2009 10:04:24 »
 Iko what is osteoblast differentiation?
 

Offline Chemistry4me

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Re: Vitamin D deficiency in Leukemia?
« Reply #228 on: 13/12/2009 05:05:04 »
An osteoblast is a cell from which bone develops, differentiation here means to specialise and form different types of cells with different functions, for example, some specialise to become the periosteum on the outside of the bone and others the marrow on the inside.
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #229 on: 14/12/2009 14:37:53 »
Thank you Chem4me,

...I have been looking for some pic&link to post for Karen:




...and here is the text:  http://www.sigmaaldrich.com/life-science/stem-cell-biology/mesenchymal-stem-cells.html

Bone marrow is a complex 'system', and to fix its defects and failures even more difficult sometime!
I'll look for other nice pictures and links in a while.

ikod

...Location of active bone marrow in an adult:


« Last Edit: 14/12/2009 16:35:15 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #230 on: 19/02/2010 16:05:02 »
Say someone is diagnosed as being severely deficient in vitamin D. Would that person Possibly be suffering, extreme exhaustion, weakness in the legs, arms etc. Maybe general feelings of un-wellness, or perhaps heaviness of limbs, degenerating bones, fractures,and unusual wear and tear on bones? Maybe even aches in the joints and such problems..etc? Perhaps short stabbing pains in toes and bottom of feet and legs also? Could a deficiency of"D" cause any of these symptoms...?
What concerns should one have when having severe deficiencies of "D".
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #231 on: 19/02/2010 22:00:24 »
Say someone is diagnosed as being severely deficient in vitamin D. Would that person Possibly be suffering, extreme exhaustion, weakness in the legs, arms etc. Maybe general feelings of un-wellness, or perhaps heaviness of limbs, degenerating bones, fractures,and unusual wear and tear on bones? Maybe even aches in the joints and such problems..etc? Perhaps short stabbing pains in toes and bottom of feet and legs also? Could a deficiency of"D" cause any of these symptoms...?
What concerns should one have when having severe deficiencies of "D".

Hi Karen,

Today vitamin D deficiency is diagnosed by testing 25OHvitamin D levels in a blood sample.
Levels <20 ng/mL are defined as 'vitamin D deficiency'. Symptoms may be totally absent or many and severe. We are all different, with different capabilities to cope with a temporary condition of deficiency (lack of sun exposure during winter months).
Treatment is easy: 50,000 I.U vitamin D3 per week, orally for 6 weeks (300,000 I.U total), then 50,000 I.U. per month. Blood levels may be rechecked after 6-12 months.
Half-life of vitamin D should be around 90 days.
Improvement in symptoms of deficiency (bone pain, weakness etc.) may be expected not before 10-15days.  See Professor Michael Holick's videos for details! ...and for the fun of it: he is treating zoo's patients...waiting for his turn in the Nobel Prize race!





What my mind is made up about is the assertion that "vitamins can do magic" is crap.

Vitamin D is unique amongst vitamins because it's a pre-hormone and is part of the endocrine system.  Genetic research from the last 10-20 years has revealed that vitamin D (as calcitriol) regulates many important functions throughout the body, including immunity, inflammation and cell propagation.  These functions are linked to a number of morbidities.

Ecological studies link latitude and skin colour to 'vitamin D' morbidities; cohort studies link low vitamin D levels with 'vitamin D' morbidities; epidemiological studies show high levels of vitamin D deficiency by latitude and by skin colour; the few RCTs involving large dose supplementation show that vitamin D significantly reduces 'vitamin D' morbidities.

Not "vitamins", just vitamin D; not magic, just science.


You are exactly right Kevan,

but we have to tell the whole story:
why such a simple and cheap remedy is coming so late in modern medicine?
I can give you some good reasons to 'justify' such a delay:
- Vitamin D is not a vitamin, but a steroid hormone acting on specific cell receptors.
- The dosage in serum is tricky and expensive: large studies are coming out only now.
- Normal levels are expressed in ng/mL or nmol/ml, just for the fun of it...
- The active form, calcitriol, has been improperly used instead of replenishing 25-OHvitD pool.
- Toxicity has been overestimated: 400U/day failed where 2000U/day are making the trick.
- Cholecalciferol or vitamin D3 is a 'generic' drug, too cheap to support clinical trials.

Do you want to play the doctor?
Just read this amazing case report, free-fulltext from Canada:



Now look for a chronic-back-pain patient, get a history of lack of sunlight exposure, no cod liver oil or vitamin D supplements and suggest her/him to have 25-OHvitaminD tested.
If the result is below 20 ng/ml...Bingo!  Send her/him to a doctor for a 50kU/week x 8weeks prescription.  A clinician will exclude any condition of vitD toxicity or intolerance and monitor calcium levels if necessary.
The following two-three weeks might be really magic for that patient...
Unbelievable? On my part, I don't think so anymore!  ;)



Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series.

Schwalfenberg G.

Department of Family Medicine, University of Alberta, Canada. gschwalf@telus.net

This article reviews 6 selected cases of improvement/resolution of chronic back pain or failed back surgery after vitamin D repletion in a Canadian family practice setting. Pub Med was searched for articles on chronic back pain, failed back surgery, and vitamin D deficiency. Chronic low back pain and failed back surgery may improve with repletion of vitamin D from a state of deficiency/insufficiency to sufficiency. Vitamin D insufficiency is common; repletion of vitamin D to normal levels in patients who have chronic low back pain or have had failed back surgery may improve quality of life or, in some cases, result in complete resolution of symptoms.

J Am Board Fam Med.2009 Jan-Feb;22(1):69-74.

« Last Edit: 19/02/2010 22:40:59 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #232 on: 20/02/2010 02:17:00 »
ok Iko.. My blood tests=vitamin "D" test came back at 12 WHICH she said was very very low.. supplements have been added 1 a week at 1.25mg for a 12 weeks. Only she said it shouldn't be that low while I am taking huge doses of omega 3, Vitamin "D," and my thyroid screwed up, so I am  now taking 175mcg levoxyl instead 150.Feel like crap and hurt everywhere especially in my bones etc...
« Last Edit: 06/06/2010 07:19:20 by Karen W. »
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #233 on: 20/02/2010 11:50:54 »
ok Iko.. My tests vitamin "D" test came back at 12 and she said it was very very low.. supplements have been added 1 a week at 1.25mg for a 12 weeks. Only she said it shouldn't be that low while I am taking huge doses of omega 3 Vitamin. "D" and my thyroid screwed up now taking 175mcg levoxyl instead 150.Feel like crap and hurt everywhere specially in my bones etc...


1 a week at 1.25mg...

...of WHAT? D2, D3, Dx?
Ergocalciferol, Cholecalciferol, Calcitriol, Whateverol?  ;)

1.25mg per week of D2(ergocalciferol) or D3(cholecalciferol) are 50,000 I.U.(International Units).
Just fine for a good replenishing of the sunshine hormone avoiding toxicity.
Improvement expected in 10-15 days: sometimes referred as magic, all of a sudden.
Fingers crossed.

How low were your very very low low values...in digits?



20-30min. of proper sunlight exposure,
the so called "suberythemal dose"
should give us 10-20,000 I.U. of Vit.D!!!


I got two hours of that beautiful sunshine today and it makes me feel so much better!!


« Last Edit: 20/02/2010 12:11:13 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #234 on: 20/02/2010 14:18:57 »
in digits....12

She said she wants to get me back up to around 50 or 60 can't recall which one.
« Last Edit: 20/02/2010 14:38:43 by Karen W. »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #235 on: 20/02/2010 14:29:05 »
The bottle says: TAKE ONE CAPSULE WEEKLY
                 
                 VITAMIN D 1.25MG
                 
                 GREEN OVAL PA140

THEY ARE GREEN OVAL LIQUID FILLED CAPSULES.
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #236 on: 20/02/2010 15:02:03 »
Yap! Got it!


It is vitamin D2(ergocalciferol)...It seems that you don't have D3 in the States, poor things  :D.
But you have prof. Michael Holick!
It is the right stuff and the proper dosage.
See you in 10days (after the second pill!).
Wish you all the best,

ikod
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #237 on: 20/02/2010 15:04:27 »

in digits....12
 

...I'm so sorry! and ignorant: I thought 'back at 12' was the TIME!!!  ;D

You seem to be in the right range to benefit from this type of treatment.
Today values <20 nanograms/milliliter are considered as vitamin D deficiency.
In the few patients I heard of, from relatives and friends (I don't practice):
a 6ng/mL, over 80yrs was in very bad shape and got better quickly,
a 9ng/mL, around 70yrs had chronic back pain and  bony aches(mostly hips): fine after 10days.
a 17ng/mL, 60yrs with back pains in the morning got better in weeks.
It's called osteomalacia from vitamin D deficiency...and it has been neglected for long.
Vitamin D dosages started to be commonly available only in the '90s.
For fear of toxicity, vitamin supplements usually have 200 I.U. only (1400 per week!).
I hope this is your case and you'll find other 'deficient' patients in your neighbourhood to tell your happy end...in just two weeks!

« Last Edit: 22/02/2010 14:32:12 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #238 on: 21/02/2010 02:34:36 »
Thank you IKO I
Yap! Got it!


It is vitamin D2(ergocalciferol)...It seems that you don't have D3 in the States, poor things  :D.
But you have prof. Michael Holick!
It is the right stuff and the proper dosage.
See you in 10days (after the second pill!).
Wish you all the best,

ikod
LOL...LOL..I sure hope it works well. Will be good to feel better!
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #239 on: 21/02/2010 02:46:04 »
Thanks IKO..
Yap! Got it!


It is vitamin D2(ergocalciferol)...It seems that you don't have D3 in the States, poor things  :D.
But you have prof. Michael Holick!
It is the right stuff and the proper dosage.
See you in 10days (after the second pill!).
Wish you all the best,

ikod
Ten days from thursday day before yesterday! YAYYYYYYYYY!!!!
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #240 on: 21/02/2010 13:27:02 »
ok Iko.. My blood tests=vitamin "D" test came back at 12 WHICH she said was very very low.. supplements have been added 1 a week at 1.25mg for a 12 weeks. Only she said it shouldn't be that low while I am taking huge doses of omega 3 Vitamin. "D" and my thyroid screwed up now taking 175mcg levoxyl instead 150.Feel like crap and hurt everywhere specially in my bones etc...


Instead of tons of omega-3(fish oil), you could have taken
Liver fish oil, rich of omega-3 plus vitamin A and D;)
« Last Edit: 21/02/2010 13:30:24 by iko »
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #241 on: 21/02/2010 15:07:23 »
WELL THAT WOULD HAVE BEEN GOOD lol... WHAT THE HECK IS A LIVER FISH? LOL...
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #242 on: 21/02/2010 16:12:59 »
WELL THAT WOULD HAVE BEEN GOOD lol... WHAT THE HECK IS A LIVER FISH? LOL...

Fish liver oil...mostly cod liver oil!!!  ;D
(I learned English from a book!)
Hugs

ikod
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #243 on: 21/02/2010 19:40:49 »
LOL...LOL. Basically cod liver oil.... OK then.. Thanks Iko.. Your English is fine like mine... Sometimes, I need to explain myself, too!

Thank you!

Hugs you back!
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #244 on: 06/06/2010 07:31:27 »
update...I am now in my second round of 12 weeks of Vitamin D supplementation. I do feel some better but still having some problems.. She checked my Vitamin d level and felt it necessary to   continue for another 12 weeks on 50,000 units a week. 
 

Offline ericcarter13

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Re: Vitamin D deficiency in Leukemia?
« Reply #245 on: 18/06/2010 14:37:05 »
"There is much we still need to learn about the roles of diet and physical activity in protecting against cancer: We are confident these new studies will add to our understanding in this vital field,"
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #246 on: 18/06/2010 17:54:34 »
Do we need more than vitamin D 200-400 I.U. per day recommended in the past century?
Maybe:

Are commonly recommended dosages for vitamin D supplementation too low?
Vitamin D status and effects of supplementation on serum 25-hydroxyvitamin D levels
-an observational study during clinical practice conditions.


Leidig-Bruckner G, Roth HJ, Bruckner T, Lorenz A, Raue F, Frank-Raue K.
Gemeinschaftspraxis für Endokrinologie, Nuklearmedizin und Humangenetik, Brückenstr. 21, 69120, Heidelberg, Germany, thomas.bruckner@t-online.de.

Abstract
Vitamin D deficiency is associated with increased fracture risk. The observational study aimed to investigate vitamin D status and supplementation in ambulatory patients. Only 20% of patients had optimal serum 25-hydroxyvitamin D [25(OH)D] levels. Commonly recommended dosages were insufficient to achieve clinically relevant increase of 25(OH)D levels. Higher dosages were safe and effective under clinical practice conditions.
INTRODUCTION: Vitamin D deficiency is associated with adverse health outcome. The study aimed to investigate vitamin D status and supplementation in ambulatory patients.
METHODS: Nine hundred seventy-five women and 188 men were evaluated for bone status from January 2008 to August 2008 within an observational study; 104 patients (n = 70 osteoporosis) received follow-up after 3 months. Dosage of vitamin D supplementation was documented and serum 25(OH)D and parathyroid hormone (PTH) determined.
RESULTS: In all patients (age, 60.4 +/- 14.1 years), distribution of 25(OH)D was 56.3 +/- 22.3 nmol/L (normal range, 52-182 nmol/L) and PTH 53.8 +/- 67.5 ng/L (normal range, 11-43 ng/L). The proportion of patients with 25(OH)D < 25, 25 to <50, 50 to <75, >/=75 nmol/L was 7.5%, 33.3%, 38.9% and 20.2% in the total group and 20.1%, 38.5%, 30.8%, 10.6% at baseline in the follow-up group, respectively. After 3 months, 3.9% had still 25(OH)D < 25 nmol/L; only 12.5% achieved 25(OH)D >/= 75 nmol/L. In osteoporosis patients, 25(OH)D increased more in those taking >/=1,500 (median, 3,000) IU vitamin D per day (33.1 +/- 14.7 nmol/L) compared with </=1,000 (median, 800) IU/day (10.6 +/- 20.0 nmol/L) (p < 0.0008). PTH decreased more in patients taking >/=1,500 IU/day (-13.2 +/- 15.2 ng/L) compared with </=1,000 IU/day (-7.6 +/- 19.2 ng/L; p = 0.29). 25(OH)D was negatively correlated to PTH (r = -0.49, p < 0.0001). An increase of 25(OH)D >/= 75 nmol/L resulted in normalised PTH.

CONCLUSION: Supplementation with higher vitamin D dosages (2,000-3,000 IU/day) is required to achieve a relevant increase of 25(OH)D and normalisation of PTH.

Osteoporos Int. 2010 Jun 17. [Epub ahead of print]






A promise is a promise... ;)
so here you find D-vitamin safety limits:

Risk assessment for vitamin D.


Hathcock JN, Shao A, Vieth R, Heaney R.
Council for Responsible Nutrition, Washington, DC 20036-5114, USA. jhathcock@crnusa.org

The objective of this review was to apply the risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D. New data continue to emerge regarding the health benefits of vitamin D beyond its role in bone. The intakes associated with those benefits suggest a need for levels of supplementation, food fortification, or both that are higher than current levels. A prevailing concern exists, however, regarding the potential for toxicity related to excessive vitamin D intakes. The UL established by the FNB for vitamin D (50 microg, or 2000 IU) is not based on current evidence and is viewed by many as being too restrictive, thus curtailing research, commercial development, and optimization of nutritional policy. Human clinical trial data published subsequent to the establishment of the FNB vitamin D UL published in 1997 support a significantly higher UL. We present a risk assessment based on relevant, well-designed human clinical trials of vitamin D.
Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL.

Am J Clin Nutr. 2007 Jan;85(1):6-18.




Free full text to enjoy real Science!  http://www.ajcn.org/cgi/reprint/85/1/6
« Last Edit: 24/06/2010 14:11:04 by iko »
 

Offline Jimy blue

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    • vitamin D deficiency symptoms
Re: Vitamin D deficiency in Leukemia?
« Reply #247 on: 18/06/2010 18:55:57 »
he doctor should be called if the parent notices that the child has any signs of vitamin D
take care people
 

Offline Karen W.

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Re: Vitamin D deficiency in Leukemia?
« Reply #248 on: 19/06/2010 12:13:42 »
Jimmy Blue do you mean if the child has any sign of vitamin "D" deficiency?
 

Offline iko

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Re: Vitamin D deficiency in Leukemia?
« Reply #249 on: 24/06/2010 10:20:19 »

D-vitamin newsletter!  ;D ;D ;D



Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults.

Sabetta JR, Depetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML.

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Abstract
BACKGROUND: Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections. This study was done to determine if serum 25-hydroxyvitamin D concentrations correlated with the incidence of acute viral respiratory tract infections. METHODOLOGY/FINDINGS: In this prospective cohort study serial monthly concentrations of 25-hydroxyvitamin D were measured over the fall and winter 2009-2010 in 198 healthy adults, blinded to the nature of the substance being measured. The participants were evaluated for the development of any acute respiratory tract infections by investigators blinded to the 25-hydroxyvitamin D concentrations. The incidence of infection in participants with different concentrations of vitamin D was determined. One hundred ninety-five (98.5%) of the enrolled participants completed the study. Light skin pigmentation, lean body mass, and supplementation with vitamin D were found to correlate with higher concentrations of 25-hydroxyvitamin D. Concentrations of 38 ng/ml or more were associated with a significant (p<0.0001) two-fold reduction in the risk of developing acute respiratory tract infections and with a marked reduction in the percentages of days ill.
CONCLUSIONS/SIGNIFICANCE: Maintenance of a 25-hydroxyvitamin D serum concentration of 38 ng/ml or higher should significantly reduce the incidence of acute viral respiratory tract infections and the burden of illness caused thereby, at least during the fall and winter in temperate zones. The findings of the present study provide direction for and call for future interventional studies examining the efficacy of vitamin D supplementation in reducing the incidence and severity of specific viral infections, including influenza, in the general population and in subpopulations with lower 25-hydroxyvitamin D concentrations, such as pregnant women, dark skinned individuals, and the obese.

PLoS One. 2010 Jun 14;5(6):e11088



 

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Re: Vitamin D deficiency in Leukemia?
« Reply #249 on: 24/06/2010 10:20:19 »

 

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