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Author Topic: Could we engineer humans to reduce Type 2 Diabetes, metabolic syndrome and Gout?  (Read 1095 times)

Offline evan_au

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Most species of mammals have an enzyme in the liver called Uricase; it breaks down uric acid.

However, humans and most apes have a corrupted genetic pathway to synthesise Uricase. This leads to a buildup of Uric Acid in the bloodstream. This directly causes gout in some people, but has been implicated in the explosion of fatty liver, metabolic syndrome and Type 2 diabetes in the worlds richest countries.

Could we restore the genetic pathway to produce Uricase, reducing the impact of these non-contagious diseases?

As both Uric Acid and Abscorbic Acid are both powerful antioxidants, Abscorbic acid synthesis would probably need to be restored before restoring Uricase functionality.


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