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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 3377928 times)

John21

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Post Orgasmic Illness Syndrome (POIS)
« on: 18/02/2007 17:40:40 »
(After writing this post and registering I noticed that the forum rules specify no sexual content. I was going to stop, but I did a search and found another post about it. I hope this type of discussion won't be deemed inappropriate.)


Hi. I would like to relate my very personal story of an unusual condition that I have been plagued with. Ever since puberty I have had serious problems in the days immediately following ejaculation. My first symptom was acute back pain in the days following, at whatever age it was, perhaps around 14. After a few years it changed to an impaired cognitive condition, which I would describe as definite mental illness, in which thinking becomes very difficult, and it feels horrible in a way that can not be described. I'm sure specific neurotransmitters are depleted or something, but the cause of such a reaction is what I have never been able to understand. This has occurred following both nocturnal emissions and sexual activity. To minimize the problem I am not sexually active and try to avoid nocturnal emissions.


John 
« Last Edit: 07/05/2011 14:18:52 by John21 »

paul.fr

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #1 on: 18/02/2007 19:28:55 »
Hi John.

i personally have never heard or known of anyone with your symptoms. You may find some usefull information here:
http://www.issm.info/prod/system/main/index.asp

an example of their work:
Post-Orgasmic Cognitive Symptoms
Dr. John Dean presented a case of a man in his mid fifties complaining of lifelong transient loss of memory and irritability that occurs after every orgasm. Otherwise the patient has no other sexual complaints, and no neurological disorders diagnosed by a neurologist. Dr. Dean considered asking the patient to masturbate and to have an orgasm whilst he was having his EEG. Dr. Charles Moser reported seeing two similar cases and forwarded an abstract by Dr. Waldinger Ėpublished in J Sex Marital Therapy- describing a post-ejaculatory syndrome in two men with spontaneous ejaculations. The syndrome consists of severe fatigue, intense warmth, and a flu like state, with generalized myalgia.

Dr. Gorm Wagner advised in-depth technical and psychological evaluation and considering simple measures such as post-coital blood pressure evaluation. Dr. Giuseppe La Pera advised a 24-hour Holter test, and reported a similar case with post coital elevated blood pressure, where symptoms resolved with beta blockers.

Dr. David Rabinowitz advised a full battery of investigations, and raised the possibility of a dissociative state, or a variant of Transient Global Amnesia. Dr. Ganesh Adaikan forwarded an article from the lancet where a woman with similar symptoms was cured with the antiepileptic, carbamazepine. Dr. Broderick also advised ruling out arrhythmias and blood pressure disorders by an ambulatory halter monitor and Blood Pressure cuff, then proceeding with considering dissociative states.

Paul

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #2 on: 18/02/2007 21:33:46 »
John,

Just acknowledging to you that your post is welcomed and definitely appropriate,

I sincerely hope that in addition to Pauls post above that some helpful comments arrive here soon.!!

B_Jim

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3 on: 06/06/2007 08:55:17 »
Hi John,

I have the same problem.  I contacted Dr Waldinger and he told me that Post-Orgasmic Illness Syndrome is characterized by a general myalgia (that i don't have, only knee pains sometimes). Anyway most cases of POIS are about 40-50 years old. The auto-immmune hypothesis is possible(after orgasm the body release something and fight against it, as it was a virus or stranger => severe sweets, severe tiredness... )

EDIT 2011  : Some of my posts are obsolete after 2nd and 3rd paper of M.Waldinger. The auto-allergic hyposthesis was the good one. But we keep one eye on hormones theory because some of us have succes with testsosterone for example.




Quote
Tired and sweaty after sex? A Dutch doctor said on Friday he is studying a rare new syndrome among middle-aged men who complain of flu-like symptoms for up to a week after having an orgasm.

Marcel Waldinger, head of the department of psychiatry and neurosexology at Leyenburg Hospital in the Hague said he planned to publish a report on "post-orgasmic illness syndrome" in the US Journal of Sex and Marital Therapy this month. Waldinger has seen five Dutch men in as many years in his surgery complaining of a range of flu-like symptoms, including a sore throat, sweating, extreme fatigue and eye irritation after sex.

"Men developed influenza-like symptoms within minutes of having an orgasm. It is like having a serious flu. This happens as soon as they have an orgasm," said Waldinger. "It is a new syndrome or a syndrome which is old but has not been looked at properly." The syndrome could be a physical disorder caused by an allergic reaction or the immune system in direct response to the release of chemicals in the body after sex. The symptoms lasted between three and seven days, he said. "We know that during orgasm and ejaculation very specific compounds like hormones are released into the nervous system. One hypothesis is that they might have had an allergic reaction to one of those compounds," Waldinger said.

http://cat.inist.fr/?aModele=afficheN&cpsidt=13719471

Quote
We describe the symptoms of a postejaculatory syndrome in two men with spontaneous ejaculations. The syndrome consists of severe fatigue, intense warmth, and a flulike state, with generalized myalgia. These symptoms occur rapidly after ejaculation and only disappear after 4 to 7 days. The symptoms are so severe that sexual activity is avoided. The cluster of symptoms is named postorgasmic illness syndrome (POIS). To date, no explanation has been offered for the etiology and pathogenesis of the symptoms, and the prevalence is unknown. Both cases are presented to draw attention to this syndrome for further research regarding etiology, pathogenesis, and treatment.

ISSM Links :
http://www.issm.info/prod/system/main/index.asp?page=/prod/data/issirlist/digest13.htm

http://www.issm.info/prod/system/main/index.asp?page=/prod/data/issirlist/digest16.htm#Post%20Orgasmic%20Illness%20Syndrome


Quote
Post Orgasmic Illness Syndrome

Dr. Mulhall presented a case of a 48 year old man complaining of crashing upon ejaculation for 2 days. He feels flu like symptoms, extremely achy, heavy, very sluggish cognitively, and sometimes even sore throat. He avoids ejaculation. Apart from that he is cardiac free with normal testosterone and cortisol. He suffers from hypothyroidism. His libido is normal.
Dr. Mulhall found nothing in literature except a single paper (case report on 2 patients) by Dr. Marcel Waldinger and hence was asking about any ideas as regards the pathophysiology and management of this problem.
Dr. Kevan tried for such cases a number of analgesics including gabapentin and pregabalin as well as many of the classic treatments for 'prostatitis'. Distraction techniques and other non ejaculatory (but orgasmic) Taoist type sexual activity, he thought might be useful. He also added that for some cultures and many couples, there are a number of psychosomatic or relational factors to considered.
Dr. Moser suggested success with Buproprion having anti-anxiety properties with no negative effects on sexual functioning. Dr. Ashour had success with Tramal 50mg PRN. Dr.Dave wrote about a study which tried an opioid antagonist (Naloxone ) given to a group of atheletes having similar symptoms post exercising and questioned if this syndrome could be related to endorphin deficit.
Dr. Krishnamurti stated that in some countries some guys believe that loss of semen (vital fluid) causes weakness. Many of these develop post-ejaculatory symptoms to varying degrees, sometimes severe.
Detailed discussion

Dear ISSM Members:

Please read below an email from a man who seems to have
post-orgasmic illness syndrome. other than a single paper
(case report on 2 patients) by marcel waldinger I have not
found any other useful literature. I would value your thoughts
as to the pathophysiology and management of this problem.


"My symptoms became apparent about 8 years ago. They are
very simple really. Upon ejaculation I crash. By that I
mean, completely (and I mean completely) drained of energy
for about 2 days. I feel flu-ish, extremely achy, heavy,
very sluggish cognitively, sometimes even sore throat.
Needless to say, I avoid ejaculation. Other than that I am
(according to my doctor) a normal, healthy, 48 year old male
although I have hypothyroidism. I just had a physical and all
blood tests and heart are normal. I have had testosterone
and cortisol tested and those are normal. Also, libido is
normal."

I am currently seeing a client with the same syndrome. I
recommend contacting Marcel D. Waldinger,

He was able to give me some insights into my case. He is
currently
conducting another study on this topic but his results have
not been
published yet.
Annette Owens, MD PhD

Dear John & Annette

I am currently trying to help another man with these symptoms in my andrology clinic who avoids ejaculation at all costs. To date he has tried a number of analgesics including gabapentin and pregabalin after trails of many of the classic treatments for 'prostatitis'. Other men I have treated with similar symptoms are often resistant to medical interventions.

Distraction techniques and Ďprescribingí non-ejaculatory (but orgasmic) Taoist type sexual activity may be useful but the aftermath of loss of ejaculatory control for many of these men is too overwhelming and they cannot be persuaded to become sexually active again.
Of course for some cultures and many couples there are a number of psychosomatic or relational factors to consider.Kevan.

Dear folks,
I have had several patients like this as well. I have also noted that they are resistant to medical interventions. My best success is with buproprion XL, but patients often choose to discontinue it, even after it has ďhelped.Ē
Take care,
Charles Moser, PhD, MD, FACP

Charles
what is the rational for Wellbutrin?????
Pierre Assalian

I saw this as an anxiety disorder, at least in my patient.
Buproprion does
have anti-anxiety properties (though many people do not
believe the data)and it has no negative effects on sexual functioning. It
also tends to energize people, so I thought it might help the feelings of
fatigue after orgasm.

The patient was seen back 2 in weeks; he took 150 mg QD for
a week then 300 mg QD for a week. He felt his fatigue was less severe
after orgasm and his girlfriend thought everything was better in their
relationship. He was seen after another month on 300 mg a day and reported that the
fatigue and other symptoms were better and were still improving, but were not
yet resolved. He then decided to travel for 6 months and did not want to
take the pills with him. Also of note, he broke up with his girlfriend.
Pt was lost to follow-up at that point. Take care, Charles Moser

Dear All:

Is it possible to prove that this syndrome is NOT functional in etiology ? What is the scientific explanation for this symptom complex ? In this part of the world, there are millions of guys who believe that loss of semen (vital fluid) causes weakness. Many of these develop post-ejaculatory symptoms to varying degrees, sometimes severe.
If there's conjecture about possible organic etiology, it has to be established unambiguously.

Sudhakar Krishnamurti

It is possible, but the patients I have seen did not seem preoccupied with semen loss or overly worried about it. They just noted this response.
See reference below.
Take care,

Charles Moser, PhD, MD, FACP
Dear Annette and all
i had one case of the same symptoms who failed any treatment but what found of geat help is to use Tramadol-Tramal 50 mg as PRN thrapy.
Shedeed Ashour Shedeed

Dear colleagues,
The syndrome described is reminiscent of a study I recall in which physically fit volunteers were given an opioid antagonist (Naloxone I think) and then asked to exercise. Rather than experiencing the "high" well known to exercisers after an aerobic session they experienced a response similar Ėit seems to me- to that described in the post-ejaculatory syndrome: fatigue, anhedonia, etc. So the question: could this be a syndrome of endorphin deficit??
Dave



"Composition of Semen
According to Sandor Gardos, Ph.D, the former About Sexuality Guide, it
contains very modest quantities of the following substances...

ascorbic acid, blood-group antigens, calcium, chlorine, cholesterol,
choline, citric acid, creatine, deoxyribonucleic acid, fructose,
glutathione, hyaluronidase, inositol, lactic acid, magnesium,
nitrogen, phosphorus, potassium, purine, pyrimidine, pyruvic acid,
sodium, sorbitol, spermidine, spermine, urea, uric acid, vitamin B12,
and zinc."


440 POIS cases

Congratulation to Dr Waldinger's team : they have found the gene of premature ejaculation.

Very important doc : neuroendocrine response to orgasm



Please answer the questionnaire :
http://pois.olympe-network.com
Ejaculation and testosterone

New Pois Site ! :
http://sites.google.com/site/poiswebsite/

2nd scientific study : (february2010) !
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short
Thank you vey much Thisisme and CCconfucius for this excellent link.
Named as coital headaches but symptoms described in complete article are definitly Pois symptoms (3 days duration, cognitive, fatigue...).
The information was given just some days after publication and we really enjoyed this help.

3rd scientific study ! (Thanks Demo)
http://www3.interscience.wiley.com/journal/123304654/abstract?CRETRY=1&SRETRY=0


News 2011 :

Dr Waldinger published 2 new papers :
- Confirmation of auto-immune cause.
- Experimental cure

Videos on Pois :
http://www.youtube.com/watch?v=7c2xmD9yq4A
http://www.youtube.com/watch?v=3oRsqHe_4Fw
http://www.youtube.com/watch?v=1_kqIpGUYpI&context=C4685843ADvjVQa1PpcFPtj6SqqT-_CSu69uM0joq7jnxafsz81gU=


« Last Edit: 18/04/2012 06:40:00 by B_Jim »

B_Jim

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #4 on: 06/06/2007 09:05:06 »


6/ ISSM Update :
http://www.issm.info/v4/data/issmlist/digest21.asp#Post_Orgasmic_Illness_Syndrome

Quote
Post Orgasmic Illness Syndrome (Dr. Sarah Ashworth)

Dr. Ashworth had a case of an 18 years old male complaining of post orgasmic illness syndrome in the form of cognitive symptoms associated with anxiety and depression. Flouxetine was prescribed which had some effect with regard reducing the amount of nocturnal emissions he experiences but has had little effect regarding his other symptoms post orgasm. Dr. Moser had tried SSRI and Bupropion with limited success. Dr. Ashour suggested the trial of cymbalta or tramal. Dr. Boul thought it might be a form of General Anxiety Disorder (GAD) with the depersonalisation experienced in Panic Attacks which might be related to a past traumatic sexual experience.

I am wondering whether it would be possible to post a query on your list or if you could provide me with any further information - particularly practitioners who know something about Post-Orgasmic Illness Syndrome.

I am about to conduct a mental health assessment on an 18 year old young man who has given me prior information that he believes that he suffers from POIS. Certainly the symptoms he describes seems to fit with the examples I have just read on your forum. The symptoms he lists are as follows:

Lack of concentration
Lack of cognition
Disorientation
Brain fog <-- most important
Absentmindedness
Confusion
Shortened attention span
Depersonalization
De-realization
Exhaustion (physically and mentally)
Word finding difficulties
Tongue tied
Inability to comprehend/retain what is read
Impairment of speech and/or reasoning (forming thoughts into words)
Inability to calculate numbers
Depression
Anxiousness

Any advice I could give him about how to get help would be appreciated. He finds his symptoms so troublesome that he has abstained from sexual behavior including masturbation for some time and states, "If I did not have a single orgasm in the rest of my life I would be so happy."

He tells me he has seen two GPs, neither of whom had heard of the syndrome and has subsequently been prescribed Fluoxetine 20mg which has had some effect with regard reducing the amount of nocturnal emissions he experiences but has had little effect regarding his other symptoms post orgasm.

Hope you can help and best wishes, Sarah

Sarah Ashworth

I do believe POIS exists, but there is no data on what the underlying problem is or how to treat it. Many of the individuals are quite disturbed about it (understandably), but it is not clear how to help them. I have used SSRIís to help decrease sexual urges. I have had some limited success with Bupropion. I am also interested in what others have tried.

Sincerely,

Charles Moser, PhD, MD, FACP

Dear all

Yes it exists But the symptoms vary beteen patients. I do believe its a sort of neurotransmitters depletion??? but regarding this case it points to an AD or ADHD background of the pt. Pls check and if not; trial of Dual action anti depressants may help Cymbalta 60 mg. or Tramal 50 mg PRN in very limited range.

Shedeed Ashour

Dear Sarah

The symptoms of post orgasmic illness syndrome, and the ones you describe for your young clients, sound very much like most of the symptoms of General Anxiety Disorder (GAD) with the depersonalisation experienced in Panic Attacks.

My immediate thoughts, particularly with a young inexperienced client, would be around potential past traumatic sexual experiences i.e., early masturbatory trauma - being caught in the act, being ridiculed by a partner, or abused. Indeed, it could be a form of PTSD but it would appear that there havenít been any long term studies to identify if the episodes intensify or change. The client could also have fears of such things as losing control, sexually transmitted diseases, inadequacy, and there is also a possibility of confusion over sexual identity.

Medication for the physical symptoms will assist your client in engaging in therapy and exploring any underlying psychological issues.

Hope this is of assistance.

Lori Boul PhD



EDIT Some of my post are obsolete since 2011 and new papers on Pois.





« Last Edit: 17/03/2014 07:38:20 by B_Jim »

lyner

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5 on: 08/06/2007 22:53:27 »
There  is also the risk of stress and depression due to lack of  sexual release. It seems you just can't win.

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #6 on: 24/06/2007 21:00:06 »
Hi John,

I'm really happy that you posted (and others replied).I've had POIS symptoms (no myalgia)for decades! I thought testosterone injections would help, but that turned out to only work very modestly (and exacerbating the need to have sex!).

I'm lost and extremely disappointed having this problem. I don't want to curtail sex, even though I know it creates this awful 4+ days misery.

Let's keep in touch!
« Last Edit: 18/10/2008 22:17:32 by demografx »

B_Jim

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #7 on: 26/06/2007 08:43:50 »
sophiecentaur : Yes you right. Without sexual activities you feel more nervous and depressed, that's why i try to have it once a month. But the exhaustion is  so severe that you need to slow down the frequency.

You post is interesting. Yes, testosterone injections seems to have a low effect on our state. You talked about POIS : have you described these symptoms with a doctor ? Very very few doctors know what pois is. As i said,  POIS refer to myalgia. I don't have myalgias but cleraly intense muscle tremors  and nervous system agitated in the 15-20 hours following orgams and strange cold/hot sensations (ill state as POIS). Then severe fatigue and brain fog start.

« Last Edit: 18/10/2008 22:24:12 by demografx »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #8 on: 27/06/2007 18:07:05 »
Hello B_Jim!............MANY thanks for your reply, I've contacted numerous physicians, sex researchers and many others over the years with my symptoms....and I usually get blank stares..."Gee, I never heard of THAT!" Thank you, Dr. send me a bill. Sorry to be so sarcastic, but I'm beyond desperate! (I'm 61 and actively hunting a solution for 25+ years)

I tried to contact you, Jim_B, but I can't figure out those crazy codes to copy (I haven't a clue how I finally made it here to TNS!)

Getting in touch with Dr Waldinger has been enormously frustrating. I succeeded once, then the email kept changing.

As you asked me to note, my most recent post-orgasmic symptoms just ended, and included 4 days of extreme exhaustion, depression, foggy cognition, burning FINGERTIPS - all 10 (this has included dermatitis, numbness and heat).

JIM_B AND EVERYONE: Since I'm unable to contact you here because I can't copy those cryptic messages (UdHk?)I would love to start a correspondence: let's gang up on this crazy syndrome!!
« Last Edit: 18/10/2008 22:18:26 by demografx »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #9 on: 27/06/2007 18:08:51 »
B_Jim   not Jim_B    MY APOLOGIES.
« Last Edit: 18/10/2008 22:19:07 by demografx »

paul.fr

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #10 on: 27/06/2007 19:33:24 »

There is another similar discussion here: http://www.thenakedscientists.com/forum/index.php?topic=2734.0
You may find it interesting.
« Last Edit: 18/10/2008 22:22:42 by demografx »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #11 on: 01/07/2007 03:42:01 »
MY "POST ORGASMIC ILLNESS CURE-SEARCH" BREAKTHROUGH?

For obvious reasons, I just took Levitra (similar to Viagra) for the very first time and lo! The Post Orgasmic symptoms I described - in an earlier post above - are _today_ (the first day after sex) but a small fraction of the usual debilitating intensity of my POIS symptoms (no myalgia). (or is it "Sexual exhaustion"? as B_Jim suggests")

So why am I not celebrating and shouting from rooftops? Where is the champagne??

I'm wary because of the possible "placebo effect" (extremely intense [unconscious?] wishing-for-Levitra-to-work helps somehow to override or mask the actual symptoms).

This placebo effect happened before when I first tried testosterone - upon a Czech sex researcher's recommendation. And it "worked" great!...the FIRST time. But subsequent injections failed to replicate the initial results.

So the same might be true of this first try with Levitra. I will post my continuing results (good or bad) with this drug.
« Last Edit: 18/10/2008 22:25:35 by demografx »

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #12 on: 19/07/2007 10:13:32 »
Hi everone,

I was somewhat pleased to discover that I wasn't the only person to suffer from this infliction. I am a 30 year old male from the UK, who has suffered from this post ejaculation depression for a number of years. The main symptoms I get include extreme tiredness, depression "brain fog" and flushing. It has ruined a number of my relationships and has further increased my depressive state. I too have tried seeking medical advice to no avail.
Conversely, I am upset to see that this condition doesn't seem to be recognised. It is evidently a problem, which is more common than one might suspect.
Out of interest - do those of you who suffer from this also have (clinical) depression? And do you know if any of your family members suffered from the same condition (if you are like me you probably haven't asked)!
How is the medication working out by the way?
Keep in touch everyone - I really feel that we need to explore this further!!

TTFN

Rob  :-\

 
« Last Edit: 17/03/2009 03:31:51 by demografx »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #13 on: 19/07/2007 15:10:05 »
Rob, it seems to continue working (as I suspected not as good as the first time, but still significant improvement). Time will tell. The depression is there and it worsens post-org.

Rob, your problem seems like min..."blank stares" from professionals. It's because it is VERY rare (in my opinion) - I thinl Dr. Waldinger, who is the only one who seems to have studied it, said that as well.
« Last Edit: 18/10/2008 22:26:24 by demografx »

Cox

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #14 on: 24/07/2007 11:56:10 »
That's sounds interesting keep us posted!!

Thanks 

Rob

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15 on: 06/08/2007 06:27:19 »
I'M CAUTIOUSLY OPTIMISTIC! First Day of POIS (less the myalgia) symptoms, popped a Levitra again as an experimental "cure." Also recently resumed testosterone therapy (for months the lab and the doctors had me labeled as "female" (what idiocy!) so naturally my T-readings looked high when they were in fact low.

Levitra (plus testosterone?) seemed to work again! Not the total "cure" that I hoped for, but a significant reduction of POIS symptoms, including reduced recovery time.

I AM NOT A PHYSICIAN...so don't rush out and replicate my experiment...also, I have one anxious eye on the Placebo Effect, although the very encouraging thing is that this is the 3rd try, and the placebo effect normally doesn't last on repeated trials.

It would be great if anyone can shed any theoretical light on this, i.e., why does Levitra seem to work, albeit imperfectly?
Perhaps it speeds up the replacement of lost sperm? Just a wild guess.

Fewer things than POIS have been as misery-making in my life. I hope, for me and others similarly afflicted, that this may be a modest breakthrough.

Can someone contact Dr Waldinger to see what he thinks?
« Last Edit: 18/11/2008 03:20:50 by demografx »

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16 on: 13/08/2007 17:38:55 »
I also find that keeping the mind O-F-F these symptoms of POIS helps. I tend to obsess quite a bit on the symptoms, especially the dry fingertips. Wish me luck, I just started another POIS cycle this morning and I'm not taking Levitra (I'm hoping that the peak testosterone level I'm on will help). But if I don't improve by tomorrow morning I'm taking L. Again, don't copy what I do, let me be the "guinea pig" !

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17 on: 22/08/2007 12:01:36 »
Hi all,
Probably like the rest of you guys I surf the net periodically looking for info about POIS from which I suffer. Well done for being brave enough to post about it. I too was in touch with Dr Waldinger, including filling out a questionaire for his research but have long since lost contact with him as he doesn't reply to emails anymore. My POIS started after I had treatment for an overactive thyroid which then went underactive following radioiodine treatment - I now take thyroxine to correct my underactive thyroid. A therapist I saw managed to actualy speak to Dr Waldinger and he apparently thought the thyroid treatment could possibly have set the condition off. Does that make sense to anyone else? Dr Waldinger said my symptoms do match POIS symptoms. However, I see there seem to be quite a variety of POIS symptoms and I don't have all of them. The most frustrating aspect is the mental fog, extreme tiredness and reduced capacity to think clearly. In the beginning (10+yrs ago) this could last as much as a month after orgasm! I also had a pressure in my head that made it feel like my eyes were bulging out. Over the years it has become less severe (or at least doesn't last as long) and now it takes  around a week to recover. Needless to say this has had a detrimental effect on my social life and my work. I don't get the muscle pain some people describe but I can get loose stools (used to be diarhoea but usually not that bad now) and severe sore throat though generally I don't get that so bad either now. It's mostly the tiredness and diminished mental abiity which decreases confidence when I'm affected. I haven't yet found anything that I can say reduces symptoms but have read all your commments and ideas on this with interest. Two things have helped me. The first was when I learned about Dr Waldinger's research and that there was actually a name for the condition and it was recognised (all be it by few doctors). That makes it easier to talk about and of course there's the knowledge you're not alone. One of the biggest things though has been just remembering that its not my fault I suffer from this and to recognise that I do a pretty amazing job of coping with it, incredibly frustrating as it is. I was used to being a high achiever in life, or at least academically, until POIS hit me. Naturally I get down about it as anyone would. But I also know its not my fault that I have POIS and recognising that has, for me, been an important thing. I'm not sure of the best way to make this condition of ours more widely recognised and researched but I think that is what it needs. Lets try and club together and work towards that.
I'll check back here regularly and post other relevant stuff as I think of it or come across it. Thanks again for starting and contributing to this thread. I hope others who suffer POIS will find it.
all the best to you guys,
stay in touch
« Last Edit: 22/08/2007 12:07:41 by mellivora »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #18 on: 25/08/2007 21:46:27 »
HELLO MELLIVORA,

Thank you for your post. Welcome. And let's keep up the mutual effort, everyone, maybe we'll yet conquer this most annoying syndrome! It was great to see someone else come forward, maybe we'll see more.

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #19 on: 27/08/2007 18:18:48 »
POIS symptom abatement progress. Levitra seems to have a continuing effect. Possibly the testosterone too, but in combination. In the first day or two of symptoms, to combat lethargy: I increased my caffeine consumption (btw, I am a caffeine addict FWIW; I'm also on ADD stimulants; and I just tried a vitamin supplement that seems to work, called "5-HOUR ENERGY" available at convenience stores such as 7-11. If unavailable, their distributor can be reached at 1-888-960-9495. No, this is not a commercial LOL.

Best wishes, everyone, for much success. Please keep posting, telling me you're alive and well!
« Last Edit: 18/10/2008 23:46:11 by demografx »

bobsie

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #20 on: 31/08/2007 21:41:32 »
I am a 57 yo male that has just experienced a very similar episode.

My last two ejaculations created a very strange experience for me.  I became very confused and "punch drunk", similar to what has been described above.  The confusion lasted 4 to 5 hours but eventually dissipated.

The first time this happened was four weeks ago, my wife thought I was having a stroke, and rushed me to the ER in a state of mental confusion.  They kept me overnight for tests; CT, MRI, EEG and Holter Monitor.  Nothing abnormal except my BP was sky high 156/117.  I seemed to come out after 4 or 5 hours. 

I didn't connect the problem with ejaculation until it happened to me again, last weekend.  Both times was I was masterbating.  I have never experienced anything like this before.  Now I'm afraid to have intercourse with my wife and began browsing and found this.  No sure what to do next.   

TracySt

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #21 on: 01/09/2007 02:34:01 »
Hello.

This is my first post, and I really want to thank you for your existence and your discussion. A 43 year old male, I have suffered from what appears to be POIS for the last 24 years (with the symptoms usually lasting 2 to 4 days). There is definite muscle tremor and weakness, along with fever, mental fog and anguish, exhaustion, heightened susceptibility to colds, and pronounced depression. Though I have been treated for depression for the last 23 years, the post-orgasmic depression is so acute that at times it has left me quite desperate and practically suicidal.

As with others who have posted above, this condition is so debilitating that I avoid sexual activity for the most part. And if I do find myself in the throes, I am painstakingly careful not to climax, for fear of facing the resultant condition. (Obviously, one can see how this can take its toll on a relationship.) This may sound strange, but I've even become vigilant in my sleep, avoiding sexual contact in my dreams if possible, so as to avoid the post-orgasmic condition. Further, I have a history of prostatitis and notice that if there is prostatic spillage, I sense the onset of POIS.

Thanks to your postings. I will copy this page (and others referenced here) and discuss this with my doctors. Though I have been on a variety of antidepressants and adjunct meds, I haven't had any relief.

Interestingly, recently my psychiatrist wanted to use an atypical anti-psychotic (Abilify) as an adjunct antidepressant. Unfortunately and apparently, my dopamine level was reduced which resulted in greatly exacerbating the depression. My motor skills were somewhat impaired and my mood plummeted radically to the point of despair. Actually, these symptoms echoed what I feel during the post-orgasmic period. Thus, I can see how dopamine (and other neurotransmitters) may play a role in all of this.

Again, I can't thank you enough for being here and sharing. Before I attributed the peculiar POIS to the general constellation of maladies that can be associated with clinical depression. I now know that this is a distinct condition, I am not alone, and perhaps there is hope.

Best wishes to everyone!

Tracy

jplewin

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #22 on: 04/09/2007 19:51:09 »
If someone wants to contact me, I'd be so grateful knowing I am not alone in this... my e-mail and MSN Messenger is jplewin@hotmail.com

The post above was an e-mail I sent to Dr Marcel Waldinger to several e-mail directions... if someone could help me contact him, I'd be so happy...

I'm very happy to have found this forum... I hope someone answers it jejeje.
I've suffered a lot because of this, nd I hope this can help us find a solution to our problem.

Saludos desde Chile
Juan Pablo
JP

mellivora

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #23 on: 06/09/2007 15:08:59 »
Welcome to the forum jplewin, TracySt, and bobsie. Thanks for sharing your stories with us, itís good to hear from you.
B_Jim you seem to have spent a lot of time researching possible explanations for our syndrome and you have given me renewed inspiration to do the same. I have some scientific/biological  background but not medical. The internet is a wonderful tool for us all.

Demografx, thanks for your continued updates on your Levitra trials etc. Having read a bit about Levitra I canít explain why it might work but Iím definitely no expert and if its  helping you then thatís great! I was interested to read that you are on ADD stimulants since low dopamine may underlie ADD/ADHD and B-Jimís sources suggest dopamine may be at the heart of many of our problems.

I remember reading somewhere that someone suffering POIS or at least sexual exhaustion, had hormone level tests before and after orgasm and was found to have normal hormone levels except for elevated prolactin (permanently elevated not normal post-orgasm refractory period). (I thought it was a post on this forum but now it seems not as I canít seem to find it again at the moment). Anyway this is also interesting because prolactin seems to inhibit dopamine release. Not just that but prolactin could be related to some autoimmune problems (something Iíve only read briefly about so far but there seem to be a lot of references on the internet). So whilst we have these two theories of dopamine/serotonin  deficiency and POIS (autoimmune reaction), they could very well go hand in hand. But Iím just speculating and donít have enough knowledge (yet!).

Personally, Iíve always seen a resemblance between my symptoms and an allergic reaction in the way I get pressure in my head and sinuses  - it just feels like some sort of allergic reaction. So Dr Waldingerís POIS seemed to fit when I found out about it. But I wouldnít really say it feels like flu and  I donít get sweats or muscle ache. One thing I have long noticed is that I feel worse in the mornings than later in afternoon and evening. Our biological clocks are regulated in part by melatonin which interestingly is synthesized from tryptophan via one of our suspects, serotonin. Melatonin also has effects on the immune system.
Iím not suggesting at all that melatonin has much or anything to do with our condition but clearly the roles, interactions and balances between all these things Ė the various neurotransmitters and hormones is complex and there seem to be all sorts of possible knock on effects which are doubtless different in different people.

Iíve just been suffering another episode these past few days which has affected my work. Itís so frustrating. But its great to be able to talk about these things with people who understand what its like so thanks for your continued posts

B_Jim, Coffee and tea donít work for me either in terms of alleviating tiredness. Infact sleep doesnít seem to help much when Iím in a post-orgasm phaseĖ I wake up feeling tired regardless of how much sleep I have.
Iím interested in hearing all you are able to tell about this Zoloft case!

We now have eight people on this forum (including myself) who have come forward with POIS or seemingly related conditions and I think the forum is evolving into a persuasive tool toward gaining wider recognition for our syndrome. I suggest we start (if you haven't already!)to make any sexual medicine professionals that we are in contact with aware of this forum thread to raise awareness. I have included the link to this thread in emails to two doctors well respected in sexual medicine  and I hope you are all ok with me taking this step. It seems to be all of our aims to raise awareness and get our conditions more widely researched. I'll let you know if I hear of any developments.

Best to all,

« Last Edit: 18/11/2008 03:29:15 by demografx »

demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #24 on: 07/09/2007 01:54:07 »
B_JIM I THINK IT IS A COMBINATION:  Levitra, Testosterone injections, ADD supplement (Adderall), Caffeine (B_Jim, instead of coffee/tea try No-Doz tablets?), and now also Cymbalta. Today, POIS DAY #1 but no Levitra. ** And feeling good! ** But yesterday I had an injection of testosterone, so it is fresh in my system. Today lots of caffeine. Plus the two other psych meds I mentioned in the morning. Best wishes to you again.

demografx, your symptoms :
"4 days of extreme exhaustion, depression, foggy cognition, burning FINGERTIPS"

You have effective results with levitra only for these symtoms then ?

What about your ADD supplement ?

Coffee/tea dont work for me (make me crazy and anxious)


« Last Edit: 19/10/2008 00:11:38 by demografx »

 

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