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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6428235 times)

Offline Quasar

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« Reply #14300 on: 12/08/2011 20:07:25 »
Guys i've got some interesting info!

The niacin flush doesn't come from histamine release. I comes from a release of plasma Prostaglandin D2 and Serotonin: http://jpet.aspetjournals.org/content/327/3/665.long

Sustained-Release Niacin for prevention of migraine headaches: http://www.mayoclinicproceedings.com/content/78/6/770.full.pdf

Niacin and its derivatives act as negative feedback regulators on the kynurenine pathway, which is responsible for the conversion of tryptophan (a serotonin precursor) to nicotinic acid (niacin).
Therefore, higher plasma concentrations of niacin may shunt tryptophan into the serotonin pathway, increasing the plasma serotonin level. Low systemic and central nervous system levels of serotonin have been strongly implicated in migraine pathogenesis. During migraine attacks, there is mobilization of serotonin, as evidenced by low platelet serotonin levels and increased urinary excretion of 5-hydroxyindoleacetic acid, its primary metabolite. In addition, serotonin is a pivotal neurotransmitter involved in central antinociception, and the dorsal raphe, which is the central repository for serotonin, has been implicated as a migraine generator on the basis of elegant positron emission tomographic studies of migraine sufferers during attacks.


--> You may ask...then why SSRI and other serotonergic drugs don't work for POIS? Well, i think that even doctors don't know very well how SSRI's work, and where and how they raise serotonin levels.

In fact, i've found this:

To make sense of this divergent body of literature, it is appropriate to divide serotonin into 2 different pools in the body:

1. Peripheral serotonin, which can be measured in the bloodstream and is thought to exert an inhibitory drive on the dorsal raphe nucleus; and
2. Central nervous system serotonin, which activates blood vessels, thus triggering the trigeminal nucleus and leading to headache.
Both of these models of serotonin and headache suggest that the goal of migraine therapy is to maintain high peripheral serotonin levels--and thus high inhibition of the dorsal raphe nucleus pathway--and low central serotonin levels. This goal meshes nicely with the proposed mechanisms of action of most migraine medications. Most acute care medications are thought to work largely at the peripheral serotonin level, while the preventive headache medications and biofeedback and relaxation therapies act as serotonin antagonists at central receptor sites.


So, i really think Niacin raises peripheral serotonin, and exerts an inhibitory drive on the dorsal raphe nucleus (brain).

This does not mean that every drug that raises peripheral serotonin is going to work. Every drug is different.
 
« Last Edit: 12/08/2011 20:42:31 by Quasar »
 

Offline demografx

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« Reply #14301 on: 12/08/2011 20:20:51 »

Quasar, very interesting!
 

Offline Quasar

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« Reply #14302 on: 12/08/2011 20:43:55 »

Quasar, very interesting!

Thanks demografx! I've updated the above Reply some minutes ago with more info!
 

Offline FinalPanic

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« Reply #14303 on: 12/08/2011 22:26:46 »
Could POIS be a severe form of migraine? Next time I may try the anti-sickness tablets for Migraine and see if helps with the awful nausea feelings I get. After four days my POIS has lifted - it is like entering the eye of a storm - all calm and clear, but a bit battered around the edges. It is amazing how it just fades out.
 

Offline daveman

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« Reply #14304 on: 13/08/2011 00:30:45 »
So, it may be that it is OK to take niacin regularly--that is, even if you build up tolerance so that it no longer causes a flush, it might still be able to prevent POIS because it is still 'using up' the histamine.

I don't think POIS is about histamine though.  Have antihistamines worked for anyone? 

Though perhaps it is also depleting other things involved in immune reactions..

I was prescribed antihistamines (Allegra 180mg/day and Cyproheptadine 4 mg/day) and not only didn't they work, but I suffered from suicidal thoughts during POIS.  I am convinced that the serotonin/dopamine levels are significantly suppressed causing the depression/brain fog/anxiety/anti-social symptoms we experience.


About the serotonin/dopamine levels, did anyone get it tested in blood? I think so. It would be interesting to know  serotonin and dopamine blood levels before an O., and after an O.

And also, very important, to have a brain SPECT showing serotonin and dopamine levels. This is crucial. But it is difficult to justify to a doctor such an expensive technique...

The following is almost common knowledge now!

http://www.ncbi.nlm.nih.gov/pubmed/12161024

Depressive-like behavior is the most profound manifestation of autoimmunity-associated behavioral syndrome in lupus-prone MRL-lpr mice. This led to the hypothesis that chronic autoimmunity and inflammation alter the activity of central serotonergic and dopaminergic systems.

........

These results are consistent with the hypothesis that imbalanced neurotransmitter regulation of the hypothalamus-pituitary axis plays an important role in the etiology of behavioral dysfunction induced by systemic autoimmune disease.


« Last Edit: 13/08/2011 01:05:04 by daveman »
 

Offline Quasar

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« Reply #14305 on: 13/08/2011 01:17:07 »
Following the previous argumentation, Niacin seems to work as an "acute" antimigraine medication, in the sense that  because it acts at the peripheral serotonin level, it has a short term effect.

So, Niacin could be included under the family of triptans or NSAIDs. However, triptains are not prophylactic, while NSAIDs and Niacin can be considered prophylactic. I believe Niacin is more effective, at least to us, because it really raises peripheral serotonin levels, while not raising brain serotonin.

So, we should find similar alternatives to Niacin, that is, drugs or supplements that raise the peripheral serotonin level without raising brain serotonin. However, the bad news is that, they also may behave as Niacin in the sense that the effects will be only short-term. But maybe we find some kind of sustained-release forms.

On the other hand, above we have discussed about "acute" antimigraine medications. What can we find similar to Niacin in the "preventive" family of antimigraine medications?

I have found that some beta-blockers, and some serotonin antagonists, have potential to have a similar effect to Niacin:

Some beta-blockers:
The action of migraine preventive drugs is uncertain, but it is believed to result from the inhibition of β1- mediated mechanism. β- blockade results in inhibition of 5-HT release from the monoaminergic nuclei (raphe nuclei) and of the NE from the locus coeruleus to prevent disturbances in vascular control systems. In conclusion, only pure β- blockers (antagonists) will have a prophylactic migraine effect such as propranolol, metoprolol, and Nadolol. The orally given doses of metoprolol for example start with 100 mg 1x a day and can be gradually increased to 2x 100 mg a day.

So, this confirms my theory from yesterday that metoprolol and nebivolol, among others, can be interesting to us.

Some Serotonin Antagonists:
Prophylaxis migraine such as methysergide (Sansert®), methylergonovine (methergine®), cyproheptadine (Periactin®), pizotifen (Pizo- A®), and mianserin (Mianeurin®) are all potent serotonergic antagonists. They are effectively acting on 5-HT2A/B and 5-HT2C receptors. Methysergide and methylergonovine belong to ergot alkaloids family, which will be discussed extensively in section.  Cyproheptadine, pizotifen, and mianserin contain a tricyclic system; two aromatic rings with 7- membered ring in between that has different tethers (figure 18). Serotonin antagonists seem to have the same effect on the raphe nuclei and locus coeruleus as that of the β- blockers.


Has anyone tried some of these Serotonin Antagonists? I find them very interesting (maybe they are even more powerful than beta-blockers) because they act directly on serotonin receptors responsible of migraine in the brain.

Hope this helps!!

I've used this source, among others: www.science.uva.nl/onderwijs/thesis/centraal/files/f446898714124130.doc -------->It's a really interesting article about migraines!
« Last Edit: 13/08/2011 01:24:59 by Quasar »
 

Offline Guthrie

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« Reply #14306 on: 13/08/2011 02:06:44 »
The welcome message contains important information that might be seen for the very first time, and may result in something great!
IMHO, there's no reason to shorten the welcome message.

I suppose I now agree with Demo for the reason that members familiar with the welcome message can simply scroll past it when they see it. It doesn't waste any time since it's not like you have to read the entire message each time you see it. Just takes maybe a second to scroll past it. But more importantly it provides new visitors all the info they need to know about the forum at a glance.

The welcome message is an absolutely fantastic part of the community that has built up here. I speak as someone who spends most of my life in a mental fog in which I find navigating this thread completely overwhelming. The welcome post is a great summary and place to start for people who are like me -- and it should stay that way.

On the other hand, it would be better if it were shorter, for the mere reason that it's pretty overwhelming as it is! Fewer links, for example to the Pyropeach PDF would make it easier to comprehend immediately (the PDF already has loads of other links and info). Try reading it from the perspective of someone who loses track of long sentences, paragraphs beyond 3 lines and skips beyond the post if he gets frustrated :(  (it took me years to realise that this was happening to me)

With regard to the debate over the length of the welcome post, it's probably important to remember that even if the welcome post were shorter, the Naked Scientist thread would still feel pretty 'cluttered' and hard to follow -- simply because it is just one single thread, and lots of different topics get thrown around.  No matter what the welcome message looks like (and we all might have different opinions about how it should look), this will still basically be the case.

So, in terms of the specific issue of things being easier to follow, perhaps the focus should be on the nice, new, organized POIS Forum with lots of lovely divisions between different topics! 

And where is that nice, new, organized forum?  Oh yes, right here: http://www.poiscenter.com/forums/index.php
« Last Edit: 13/08/2011 02:08:47 by Guthrie »
 

Offline apostate801

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« Reply #14307 on: 13/08/2011 05:19:47 »
The welcome message contains important information that might be seen for the very first time, and may result in something great!
IMHO, there's no reason to shorten the welcome message.

I suppose I now agree with Demo for the reason that members familiar with the welcome message can simply scroll past it when they see it. It doesn't waste any time since it's not like you have to read the entire message each time you see it. Just takes maybe a second to scroll past it. But more importantly it provides new visitors all the info they need to know about the forum at a glance.

The welcome message is an absolutely fantastic part of the community that has built up here. I speak as someone who spends most of my life in a mental fog in which I find navigating this thread completely overwhelming. The welcome post is a great summary and place to start for people who are like me -- and it should stay that way.

On the other hand, it would be better if it were shorter, for the mere reason that it's pretty overwhelming as it is! Fewer links, for example to the Pyropeach PDF would make it easier to comprehend immediately (the PDF already has loads of other links and info). Try reading it from the perspective of someone who loses track of long sentences, paragraphs beyond 3 lines and skips beyond the post if he gets frustrated :(  (it took me years to realise that this was happening to me)

With regard to the debate over the length of the welcome post, it's probably important to remember that even if the welcome post were shorter, the Naked Scientist thread would still feel pretty 'cluttered' and hard to follow -- simply because it is just one single thread, and lots of different topics get thrown around.  No matter what the welcome message looks like (and we all might have different opinions about how it should look), this will still basically be the case.

So, in terms of the specific issue of things being easier to follow, perhaps the focus should be on the nice, new, organized POIS Forum with lots of lovely divisions between different topics! 

And where is that nice, new, organized forum?  Oh yes, right here: newbielink:http://www.poiscenter.com/forums/index.php [nonactive]

And that forum seems cluttered too.  Too many categories to look at when there's not enough users/traffic to fill it. 


Not sure how Niacin is helping me, been taking 300 to 400mg of the nicotonic acid kind and can't seem to get the flush (darker skin)?  Get a slight headache like feeling that i usually get when recovering from POIS.  I guess it helps a little bit the lows aren't as low. 
« Last Edit: 13/08/2011 05:24:34 by apostate801 »
 

Offline valtak2610

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« Reply #14308 on: 13/08/2011 05:41:11 »
I've been taking Niacin 200mg 2 times a day and it does help
against the type IV headache disorders - "migraine headaches" that would start 1-2 days after.
It is too early to review it's full impact - I hope it does not loose it's potency with time.

This is the non-time release variety. Tried the Time-Release
500mg - and those did not work.

The other thing that helped for me is Indomethacin 25mg - which postpones the
onset of the headache disorders.

On the triptan note, I have tried Frova 2.5 mg and they alleviate the headache, once a full bout
of head symptoms has commenced, but purely temporarily.
 

Offline Habibou

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« Reply #14309 on: 13/08/2011 14:17:54 »
I also tried Niacin 500 mg but it did not work for me, and I did not get the "flush" everybody is talking about... So I guess I had the "slow release version"! I will try to get the faster one, will update.
 

Offline Counterpoints

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« Reply #14310 on: 13/08/2011 15:23:44 »
And that forum seems cluttered too.  Too many categories to look at when there's not enough users/traffic to fill it. 

Yes, that's what I thought too.
 

Offline rob58

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« Reply #14311 on: 13/08/2011 16:29:08 »
Hi guys. Checking in after a long absence.  Have not had anything to contribute for along while, esp. since my medical knowledge is limited, but I have been reading the posts religiously. Very impressed with the ideas that have come up and with the overall quality of the discussions. Would like to bring up two issues. I have been one of longest sufferers on this forum.  I am now 53 years old and have suffered from pois since I was 14.  What I want to share with you can be good news or bad depending on your expectations, but over my almost 40 years of dealing with POIS it has gotten neither better nor worse, both in terms of intensity and duration. Brain fog, lethargy, aches, etc. all peaking at days two and three, just like they did in 1972.  Second issue is support for the NORD fund. I am committing to donating $50 for every $1000 in the fund until we hit our initial target of around 34K (so far donated $100 ...).  Seems to me that it takes only 20 of us to make a similar commitment, and we are there!  Demo et al., thanks for the support and work in support of the good cause.
Rob
 

Offline daveman

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« Reply #14312 on: 13/08/2011 18:07:30 »
And that forum seems cluttered too.  Too many categories to look at when there's not enough users/traffic to fill it. 


Yes, that's what I thought too.

For those of you who like the free flow, one thread feel, use: http://poiscenter.com/forums/index.php?action=unread

This gives you a list of the latest posted items. You can read them just like they were on THIS forum. It's best for POISers who have trouble adapting to change.

Remember please, the idea at the other forum is to try to have the items more organized into categories for outside researchers and investigators.

 

Offline demografx

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« Reply #14313 on: 13/08/2011 18:27:46 »

For those of you who like the free flow, one thread feel, use: http://poiscenter.com/forums/index.php?action=unread



Thank you, daveman!

I was also concerned about this issue but now I see that the new forum can be viewed quickly.

On behalf of those who think similarly, I really appreciate your strenuous efforts to take our input into account and especially to raise our amateurish  one-thread forum to a very professional alternate discussion venue!



« Last Edit: 13/08/2011 19:48:52 by demografx »
 

Offline demografx

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« Reply #14314 on: 13/08/2011 18:41:50 »

Hi guys. Checking in after a long absence.  Have not had anything to contribute for along while, esp. since my medical knowledge is limited, but I have been reading the posts religiously. Very impressed with the ideas that have come up and with the overall quality of the discussions. Would like to bring up two issues. I have been one of longest sufferers on this forum.  I am now 53 years old and have suffered from pois since I was 14.  What I want to share with you can be good news or bad depending on your expectations, but over my almost 40 years of dealing with POIS it has gotten neither better nor worse, both in terms of intensity and duration. Brain fog, lethargy, aches, etc. all peaking at days two and three, just like they did in 1972.  Second issue is support for the NORD fund. I am committing to donating $50 for every $1000 in the fund until we hit our initial target of around 34K (so far donated $100 ...).  Seems to me that it takes only 20 of us to make a similar commitment, and we are there!  Demo et al., thanks for the support and work in support of the good cause.

Rob



Rob, I am speechless!!! Thank you so very much for brightening this lonely path of ours. You certainly made MY weekend!! :) :) :) :) :) :) :) :) :) :)
 

Offline demografx

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« Reply #14315 on: 13/08/2011 19:46:39 »

Some of you may not know of one of the links to this forum.

This link brings you back to the very last POIS post here at Naked Science Forum:
http://www.thenakedscientists.com/forum/index.php?topic=6576.new#new

Please bookmark it.
« Last Edit: 13/08/2011 19:50:05 by demografx »
 

Offline Habibou

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« Reply #14316 on: 13/08/2011 20:08:16 »
I don't know if it was said but there are 4 types of Niacin : (french website/translation)
-nicotinamide
-hexaniacinate the inositol (also called inositol hexanicotinate or inositol   nicotinate)
-immediate-release niacin = the one we need creates 95% of the time a flush (often simply called niacin or fast-release niacin)
-niacin extended-release (or slow)

I guess I used (Nicobion) = nicotinamide which helped for 30% but no more, going to purchase the faster one definitively !
 

Offline demografx

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« Reply #14317 on: 13/08/2011 21:20:19 »

I don't know if it was said but there are 4 types of Niacin : (french website/translation)
-nicotinamide
-hexaniacinate the inositol (also called inositol hexanicotinate or inositol   nicotinate)
-immediate-release niacin = the one we need creates 95% of the time a flush (often simply called niacin or fast-release niacin)
-niacin extended-release (or slow)

I guess I used (Nicobion) = nicotinamide which helped for 30% but no more, going to purchase the faster one definitively !


Habibou, do you know about Niaspan? (Extended release niacin).

I take 500mg daily for cholesterol.
 

Offline Itsthatskater

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« Reply #14318 on: 14/08/2011 02:31:06 »
Hey Guys Just checking back in with some more of my symptons hopefully to help you and myself!

Ill give you my symptons on a scale of 1 being the least bad to 5 being the worst

Sinus problems-3
Physical Weakness-4
Mental Weakness-5
Brain Fog- (Sometimes in school i felt i could concentrate better but last time I had POIS I had terrible Brain Fog and couldnt remember the day as well as normally when i had it) 4
Lack Of Motivation-5

Those are the worst effects I get on my body with Lack of Motivation and Physical and Mental Weaknesses being the worst.

I am considering asking my doctor about Testosterone Replacement therapy as well.

If anyone has any leads on how to fix any of my problems please let me know. It really feels unfair I cant live my life with a Sex life in it normally.

Let me also say i feel alot more Cardiac Conguestion too
« Last Edit: 14/08/2011 02:37:47 by Itsthatskater »
 

Offline demografx

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« Reply #14319 on: 14/08/2011 05:26:02 »

I am considering asking my doctor about Testosterone Replacement therapy [TRT] as well.


Just in case you don't know my story, TRT has given me 80% POIS relief, after 35 years of POIS torture.
 

Offline demografx

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« Reply #14320 on: 14/08/2011 16:05:53 »






For all our new visitors and friends!


Our new POIS Forum - architectural genius: "daveman" - for detailed subject-by-subject discussion!
http://www.POISCenter.com/forums/index.php


Our 4-year-old POIS thread here at Naked Science Forum will also always remain open for newcomers, for general unstructured discussion, and historical research of the 10,000+ postings here since 2007.


We started a POIS Research Fund to boost our attack on The POIS Monster! Explained here:
http://poiscenter.com/forums/index.php?topic=125.0


We raised $2,150 in just the first 2 weeks, with much more pledged!


And your POIS fund donation is most welcome here:
http://rarediseases.org/about/support/research-donations





 

Offline demografx

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« Reply #14321 on: 14/08/2011 16:50:58 »

Could POIS be a severe form of migraine? Next time I may try the anti-sickness tablets for Migraine and see if helps with the awful nausea feelings I get. After four days my POIS has lifted - it is like entering the eye of a storm - all calm and clear, but a bit battered around the edges. It is amazing how it just fades out.


I agree with your perception of that strange POIS feeling of "fading out amazingly".

 

Offline B_Daniel

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« Reply #14322 on: 14/08/2011 20:44:00 »
Counterpoints, I had forgotten that not everyone has time to read the other forum and I apologize for that.

It seems to me that you think POIS sufferers have at one time in each of their pasts had an above average frequency of orgasms/porn-viewing. I suppose this would have to be explored.

Counterpoints- you say we're addicted to a natural process in our body that is difficult to escape from?  And this is how POIS is similar to an addiction?  An addiction is a psychological or behavioral propensity to an act which makes it difficult to refrain from.  Our internal body functions don't have addictions from what i know.  Like, my eyes are not "addicted" to poor eye-sight.  The shape of my cornea or whatever is wrong.  My former acne was not because my body was addicted to making zits...  is this really what you mean??/

Per the point of POISers having an addiction to porn, etc., there is no doubt.  POIS causes low dopamine, which increases addictive behavior.  We get a rush from masturbation, which temporarily provides relief from feeling shitty.  So we over-do it.  The definition of an addiction is doing something so often that it causes harm on other parts of your life, but you can't stop.  ANY masturbation fits that description for us.  I masturbated once a day, every night, like clock work, for 10 yrs.  Was that an addiction?  Probably.  Did POIS cause that?.. maybe.  Did masturbation cause POIS?... Not the disorder, only the symptoms.  Is POIS an addiction?... (So is my body addicted to having an inflammatory response to orgasms)- I would say categorically no.
 

Offline B_Daniel

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« Reply #14323 on: 14/08/2011 21:30:40 »
 
Hi guys. Checking in after a long absence.  Have not had anything to contribute for along while, esp. since my medical knowledge is limited, but I have been reading the posts religiously. Very impressed with the ideas that have come up and with the overall quality of the discussions. Would like to bring up two issues. I have been one of longest sufferers on this forum.  I am now 53 years old and have suffered from pois since I was 14.  What I want to share with you can be good news or bad depending on your expectations, but over my almost 40 years of dealing with POIS it has gotten neither better nor worse, both in terms of intensity and duration. Brain fog, lethargy, aches, etc. all peaking at days two and three, just like they did in 1972.  Second issue is support for the NORD fund. I am committing to donating $50 for every $1000 in the fund until we hit our initial target of around 34K (so far donated $100 ...).  Seems to me that it takes only 20 of us to make a similar commitment, and we are there!  Demo et al., thanks for the support and work in support of the good cause.
Rob

Rob - 1st of all, thank you thank you thank you!  I can't believe you've gone 39 yrs with pois.  I think about my 14 years in disbelief - what a drag.  And there's no doubt that this thing doesn't go away with age.  We've all been plagued and you totally understand how important this research is.  It's unfortunate to say it this way, but it's your misery, my misery, our collective misery which motivates us so drastically to give so much money to get rid of this.  I want to spend my money on something positive - not getting rid of something negative.  But sometimes fixing the foundation of your house is more important than painting it.  It's time to repair the foundation! 

The other thing I wanted to point out is that you phrased the issue so so well.  I hadn't looked at it in these terms yet:

Quote
Seems to me that it takes only 20 of us to make a similar commitment, and we are there! 

That's exceptionally true.  It shows how close we really are.  And considering how close we are, even smaller donations really do make a difference.  We just need a lot more of them :D  Thanks Rob!

« Last Edit: 14/08/2011 21:45:11 by B_Daniel »
 

Offline daveman

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« Reply #14324 on: 14/08/2011 23:59:11 »
Counterpoints, I had forgotten that not everyone has time to read the other forum and I apologize for that.

It seems to me that you think POIS sufferers have at one time in each of their pasts had an above average frequency of orgasms/porn-viewing. I suppose this would have to be explored.

Counterpoints- you say we're addicted to a natural process in our body that is difficult to escape from?  And this is how POIS is similar to an addiction?  An addiction is a psychological or behavioral propensity to an act which makes it difficult to refrain from.  Our internal body functions don't have addictions from what i know.  Like, my eyes are not "addicted" to poor eye-sight.  The shape of my cornea or whatever is wrong.  My former acne was not because my body was addicted to making zits...  is this really what you mean??/

Per the point of POISers having an addiction to porn, etc., there is no doubt.  POIS causes low dopamine, which increases addictive behavior.  We get a rush from masturbation, which temporarily provides relief from feeling shitty.  So we over-do it.  The definition of an addiction is doing something so often that it causes harm on other parts of your life, but you can't stop.  ANY masturbation fits that description for us.  I masturbated once a day, every night, like clock work, for 10 yrs.  Was that an addiction?  Probably.  Did POIS cause that?.. maybe.  Did masturbation cause POIS?... Not the disorder, only the symptoms.  Is POIS an addiction?... (So is my body addicted to having an inflammatory response to orgasms)- I would say categorically no.


Hi B_Daniel,

I think the whole addiction theory speaks more of withdrawl mechanisms as being the problem than addiction, although I suppose you can't have withdrawl without addiction.

If you think of heroine for instance, something easy to relate to. According to the movies, you see that it causes extreme pleasure, but in a short time, more is required to produce the same effect, and more, until the dose required just makes you sick and doesn't produce any pleasure. So you try to quit. But the withdrawl makes you crazy. So you have to take it just so you don't feel the withdrawl.

This is more than just psychological, it's (neuro)chemical, although in withdrawl, the heroine addicts suffers extreme psychological and physical pain. The addict suffers so much pain of both types that he has to go back to the addiction to stabalize the effect.

I think porn or sex addiction / withdrawl would have a lesser and much more subtle influence, so we might not recognize it as such. So from that point of view, there could be something there, however, in POIS sufferes it would have to be some abnormality, that not only makes normal people addicts, but that could have them suffering for years after any addiction could have passed. Or maybe even, we suffer withdrawl symptoms even if we haven't been addicted, because of some abnormality in the mechanism.

But we should approach this subject very carefully, because it's just too easy to connect the "if you touch it too much your teeth will fall out" stigma with normal sex desires. There are a lot of people here that aren't as outspoken and that are much purer than others, and would slip themselves into the addict slot at the drop of a hat, having them pursue a guilt filled remedy down a completely unproven and undefined path (less so than the more promising  pahs that we are following here).

This shouldn't stop us from investigating, but we must keep in mind that it's very much in its infancy, we're not all addicts, and there just may not be anything at all in it.
 

The Naked Scientists Forum

Post Orgasmic Illness Syndrome (POIS)
« Reply #14324 on: 14/08/2011 23:59:11 »

 

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