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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6460808 times)

Offline Animus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15125 on: 19/12/2011 20:21:14 »
PS- feel free to PM me if you have any questions/ comments- I am open to discuss or explain my surgeries further...
thanks
 

Offline Vandemolen3

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15126 on: 19/12/2011 22:24:15 »
I am back at the turn of the tide. I come with good news.

Desensitization plan works for me. I have 40-50% less symptoms.  I used to have 4 days of POIS. Now it is 2 days. And sometimes only 1 day. I began with a dillution of 1/10.000. Then 1/1000, 1/200, 1/70, 1/50, 1/30, 1/15. And today it was 1/5. The good news is that the max was 1/20. Now there was a meeting with allergists in The Netherlands. They said the dillution can be lower. Now the max is 1/2. Almost pure semen. When I went from 1/50 to 1/30 I had pain in my arms for 6 weeks. And I had a red mark on my arm and under my armpit. I thought it was blood-poisoning, because at another hospital an intern took some blood from my arm and she couldn't do it with 1 shot. But the doctor said this was just the reaction of the desensitization. Last time I had no reaction at all from the injection, no little red mark. So that's why today we went to 1/5. And today my arm really hurts again. :(

The other good news is that the Dutch health insurance are willing to pay for their clients. So that's why a few allergists are willing to do the desensitization. Next week there will be a test of 2 patients of 2 different allergists at the clinic where I go. So hopefully all the POIS-patients in The Netherlands can be helped in 2012 immediately!
« Last Edit: 20/12/2011 23:49:05 by Vandemolen3 »
 

Offline Vandemolen3

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15127 on: 19/12/2011 22:33:18 »
I had a good reason why I avoided this forum. A member insulted and accused me so bad that I said to myself that I will never post again. But the POIS-case is more important! This was trough pm, so I will not give more details. I hoped that this person would apologize, but he didn't. Especially because I am so devoted to get rid of POIS. I took risks, I donated. And then if someone treats me like that, it really hurts. But I don't want to spoil the atmosphere here. So please don't react on this post. I just wanted to give you the reason of my absence. I saw that I had some pm's. I am sorry that I didn't react, but now you know the reason.
 

Offline Vandemolen3

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15128 on: 19/12/2011 22:41:06 »
Today I asked the doctor about Vitamin B3. He said that the reason why some of us find relief is because the flush runs out the histamines in the body. And when you have an O. the body will not spread histamines. And because of the histamines we have this allergy reaction. He said that maybe there is a risk the POIS gets worse because of Niacin. And you have to take a higher dose to get the same effect. And a lot of Niacin brings side effects as liver damage. BUT HE DIDN'T DO ANY RESEARCH ABOUT THIS! This is just his opinion. 

Niacin doesn't help me a lot. Maybe 10 to 20% less symptoms. I use 200 mg Niacin. I get a big flush. I do not dare to take more.
 

Offline Vandemolen3

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15129 on: 19/12/2011 22:47:44 »
There is something I found out about POIS. There are 2 reasons why we catch a cold or get sinusitis:
1. When you have an allergy attack the defense system of your body is very weak. So a small thing will get you sick.
2. Because of the allergy you get a dry mouth and dry nose. And a dry mouth causes a lot of diseases. Just do some Google search and you will find out. So it is very important to drink a lot after an O. And it is very important to bring fresh air in your home. I know that when in POIS you feel cold. But you have to open the window so the air in your room gets more moist. I also bought a humidifier. I think this helps a bit.
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15130 on: 19/12/2011 23:03:25 »
Quote from: badgerstripe
Do users of this forum believe low or high histamine is a cause of POIS? I'm confused. I have always thought high histamine was a problem in allergic reactions.

Many of us including myself believe that POIS is caused by an allergic or auto-immune reaction to some component of our semen. I've found that Claritin and Benadryl, both anti-histamines, relieve the majority of my POIS symptoms when taken about an hour before an orgasm.

Thanks Vincent Marcus and BJim for your comments

I may try Clarytin or Benadryl if the current approach I have started since joining this forum doesn't work. I tried Clarytin a couple of years ago for pollen allergy and it relieved all the nasal and sinus symptoms but the brain fog that i get with pollen allergy and drowsiness persisted.

Since 5 days ago i have taken 3 X 610mg Fenugreek daily along with 100mg of Niacin daily in the morning which causes a flush. I have taken Niacin periodically over the years for pollen allergy and it did seem to make a positive difference. I have taken 15mg Zinc daily for quite a long time as it has noticeably shortened the recovery period from POIS.

It may well be too early to assess the effects of the Fenugreek and regular Niacin but I had an O last night and have to say I felt the worst POIS symptoms today than i have for a while, especially the brain fog and poor memory. Could this be because i took the Niacin half an hour AFTER the O rather than before? I'm going to persevere with the Niacin but intend to take it half an hour BEFORE and see what happens.

On a more general note I am relieved to have found people who understand this debilitating condition. I get really fed up with it, for years having to schedule my life around "O" days - nothing important that requires a sharp mind or physical energy the day after or even two days after in some cases. I usually need a week to recover, there are times when the self discipline required for this is too much and I go for it twice or more a week but this means i spend life in a pretty foggy condition and know that my work suffers and my mood is generally negative.

Meeting others through this forum helps me feel less weird so thanks for all the experiences and knowledge people have shared  :)
 

Yes, it is VITAL that the niacin is taken before the orgasm! Hopefully with a flush. I have had results without a flush, but to a lesser degree. Day 1 and 2 are always cleared, but without the flush, days 3 to 5 can appear and/or be worse.

I previously had 9 day sessions. Now, wit flush, maybe half a day! And NO cognitive symptoms or NO day 1 - 2 POIS yuck!

Great news!

5 days ago I took 100mg of Niacin and had a flush about an hour or so before an O. I had NO POIS symptoms at all afterwards! No Brainfog, muscle weakness, exhaustion etcetera. This very rarely happens at all. I can think of no other variable that has changed from previously, apart from the Fenugreek which i started taking about ten days ago. If this were to be the answer to my particular form of POIS I would be very pleased.

This is in stark contrast to how I felt a couple of weeks ago when I took the Niacin AFTER the O when I had very bad symptoms. Since my "no POIS O" I had another O. This was 2 days after the previous one which is unusually quick for me, I would normally leave it 3 days at the very least so as not to incapacitate myself. This time i took the Niacin just 20 minutes before the O as i had mislaid the tablets. It was interesting to me that this time i had some POIS symptoms - brainfog, memory problems, itchy eyes, muscle weakness but they were quite mild and had passed within 24 hours. I wonder if these symptoms were present because i was still experiencing some flushing while the O happened and the full quota of histamine was not available?  That seems to make sense from what others have said about Niacin  and Histamine. Alternatively 2 days may have been too soon to have another O after the previous one.

Further to kurtosis's post, I read Carl Pfeiffer's book about nutritional treatment of mental illness 20 years ago as a friend of mine's aunt was involved in research and i was involved professionally in the mental health field. I identified with the symptoms of Histadelia, especially the allergies - Histadelia is associated with HIGH histamine levels. (I understand that there seems to be scientific controversy about the very existence of histadelia). After reading this I took Niacin for a while and it seemed to help with pollen allergy relief but i never took it in a timed way in connection with Orgasm and didnt notice any benefit with POIS.

Thank you daveman and all who have contributed to building up this body of knowledge and experience. I will continue to experiment with this and see if I get continued success with a Niacin flush an hour or so before an O. After this I may leave off the Fenugreek for a while to see if that makes any difference to my (hopefully) continued success.

 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15131 on: 20/12/2011 00:00:45 »
PS- feel free to PM me if you have any questions/ comments- I am open to discuss or explain my surgeries further...
thanks

ANIMUS, THANK YOU FOR YOUR KIND AND GENEROUS SPIRIT!

 

Offline gabin

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15132 on: 20/12/2011 09:49:32 »
let's make a poll about the worst possible profession for POIS-sufferer :)
porn-actor must win without a decent rival, i suppose :)
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15133 on: 20/12/2011 10:07:21 »
let's make a poll about the worst possible profession for POIS-sufferer :)
porn-actor must win without a decent rival, i suppose :)

how about air traffic control or brain surgery?

I found this article about prostoglandin and serotonin release with Niacin.

http://jpet.aspetjournals.org/content/327/3/665.long [nofollow]

Its not an easy read!
 

Offline gabin

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15134 on: 20/12/2011 10:42:08 »
let's make a poll about the worst possible profession for POIS-sufferer :)
porn-actor must win without a decent rival, i suppose :)

how about air traffic control or brain surgery?

I found this article about prostoglandin and serotonin release with Niacin.

http://jpet.aspetjournals.org/content/327/3/665.long [nofollow]

Its not an easy read!
Yeap, the worst part of POIS is that it can hit anyone (we haven't found any pattern yet though), independently of the who you are at the moment.. It downgrades you to the the level of partly diabled person, while the environment and expectations of people around you remain the same...
 

Offline daveman

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15135 on: 20/12/2011 10:57:52 »
Badgerstripe.

I think in your second attempt, you took the niacin too soon before the "O". The greatest effect comes with having the "O" just after the peak of the flush. That is about 10 minutes after the skin stops "burning".

Your case reflects my situation as well. "Practically POIS free", better than 90%. There are probably several here who have tried niacin and it didn't work. Some of those may want to try again, but be very specific in taking it according to the schedule that works. Take enough to flush (greatly affected by when you've last eaten), at least 30 min before "O" (waiting for flush to pass).

There are a few who take it according to "all the rules" for which it doesn't work well, but from what I have seen they are the minority.

 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15136 on: 20/12/2011 11:12:29 »
daveman

I thought maybe it was too soon after taking the niacin. I am trying again tonight with the 100mg Niacin about an hour before the O, on an empty stomach. I have to say it felt miraculous the other day with no POIS symptoms at all!

What's your understanding of why Niacin works for many people? I had always thought that i suffered from too high levels of histamine, certainly the tree pollen season in spring has me feeling like my body and brain is full of the stuff. That feels like i am in a POIS state ALL of the time. Antihistamines do not get rid of my cognitive symptoms and replace my sinus symtoms with a headache. I've had some success with homeopathic remedies but these dont seem to work all the time.

gabin, i think i have underestimated the social effects of POIS, other people have noticed my memory problems, difficulty in stringing a sentence together, listlessness and "being an airhead" when in POIS. IT has all added to a feeling of shame that I can well do without as it feels like i should be as sharp as other pople seem to be. I have been successful academically (not on POIS days) so there's nothing wrong with the brain. Lets hope that the Niacin continues to work and that for those it doesnt work for a remedy is found soon.
 

Offline Green

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15137 on: 20/12/2011 16:29:04 »
let's make a poll about the worst possible profession for POIS-sufferer :)
porn-actor must win without a decent rival, i suppose :)

how about air traffic control or brain surgery?

I found this article about prostoglandin and serotonin release with Niacin.

http://jpet.aspetjournals.org/content/327/3/665.long

Its not an easy read!
Yeap, the worst part of POIS is that it can hit anyone (we haven't found any pattern yet though), independently of the who you are at the moment.. It downgrades you to the the level of partly diabled person, while the environment and expectations of people around you remain the same...

Cannot agree more. Even my close family struggle to see the differences in me, in POIS and out of. But to me it's a whole different world.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15138 on: 20/12/2011 17:35:05 »

let's make a poll about the worst possible profession for POIS-sufferer :)
porn-actor must win without a decent rival, i suppose :)








Acrobat   :)
« Last Edit: 20/12/2011 18:35:56 by demografx »
 

Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15139 on: 20/12/2011 17:41:20 »
in my research Ive learned there are very rare cases where a pregnant woman can be allergic to her placenta. In some extraordinary cases woman have flatlined from the autoimmune shock after the water breaks.

I wonder if there could be parallels.
 

Offline Pharaoh

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15140 on: 20/12/2011 18:08:10 »
Hi Guys.  I hope all is well.  Yesterday I became thoroughly convinced that this is an allergic reaction.  Please let me explain.  I was in bed fantasizing and expectedly became sexually aroused.  I did not even attempt to masturbate and did not ejaculate.  I then went to urinate, and afterwards while squeezing out the last drops, I began squeezing out semen.  I did it a couple of times, and the amounts were about 4 cm in circumference.  The symptoms began soon after.  Now I'm in full POIS, without ejaculating.  Interestingly, the semen must have been in my urethra, but only when I squeezed it out, that is, it emitted and exposed, did I begin feeling the symptoms.  I looked up excessive histamine levels and found this:

"‎When released from basophils and tissue mast cells, the biological effects of histamine include increased vascular permeability of small venules; contraction of bronchial and other smooth muscle; increased gastric, nasal, and lacrimal secretions. A function not normally associated with histamine is the role of neurotransmitter in the brain.1,2 Elevated histamine levels may also be related to certain forms of headache and schizophrenia.3,4,5 A list of the characteristics of patients with low or high blood histamine levels are shown in Table 1 (p.237)." Journal of Orthomolecular Medicine, 1998

http://www.orthomolecular.org/library/jom/1998/articles/1998-v13n04-p236.shtml [nofollow]

I'm having an MRI tomorrow to check if there are adenomas, but I think I'm more convinced than ever that this is indeed a severe allergic response. 

What do you guys think?

Happy Holidays!
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15141 on: 20/12/2011 18:24:28 »
Hi Guys.  I hope all is well.  Yesterday I became thoroughly convinced that this is an allergic reaction.  Please let me explain.  I was in bed fantasizing and expectedly became sexually aroused.  I did not even attempt to masturbate and did not ejaculate.  I then went to urinate, and afterwards while squeezing out the last drops, I began squeezing out semen.  I did it a couple of times, and the amounts were about 4 cm in circumference.  The symptoms began soon after.  Now I'm in full POIS, without ejaculating.  Interestingly, the semen must have been in my urethra, but only when I squeezed it out, that is, it emitted and exposed, did I begin feeling the symptoms.  I looked up excessive histamine levels and found this:

"‎When released from basophils and tissue mast cells, the biological effects of histamine include increased vascular permeability of small venules; contraction of bronchial and other smooth muscle; increased gastric, nasal, and lacrimal secretions. A function not normally associated with histamine is the role of neurotransmitter in the brain.1,2 Elevated histamine levels may also be related to certain forms of headache and schizophrenia.3,4,5 A list of the characteristics of patients with low or high blood histamine levels are shown in Table 1 (p.237)." Journal of Orthomolecular Medicine, 1998

http://www.orthomolecular.org/library/jom/1998/articles/1998-v13n04-p236.shtml

I'm having an MRI tomorrow to check if there are adenomas, but I think I'm more convinced than ever that this is indeed a severe allergic response. 

What do you guys think?

Happy Holidays!

Fascinating, Pharaoh! Thank you!
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15142 on: 20/12/2011 18:25:34 »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15143 on: 20/12/2011 18:27:50 »
Quote
He said that the reason why some of us find relief [with niacin] is because the flush runs out the histamines in the body.

Yes, yes, yes he said it  !
 ;D

Quote
I think because the allergy attack is too big. And antihistamines we can take are pills. The only antishistamines that could bring the symptoms down is an injection through the urethra. I talked with my doctor about this, and he said that it could be a solution. But the only problem is, that there is no such thing.

Interresting argument of "local inflammation". But some guys have good results with claritin or others.


Vandermolen, I took the numbers you gave to make a graphic. Once again, if you can have other numbers (like volume injected ;) ) or other protocole details, i'm interrested. But thank you very much and congratulations for all.





B_Jim, thanks for the graphing!
 

Offline Quasar

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15144 on: 20/12/2011 18:34:57 »
Hi all,

I've watched the youtube documentary about the guy who had Pois and undergone a surgery. That indicates the problem is coming from the testicles and/or prostate at the moment (or following) the orgasm.

Anyway, one of my main symptoms, besides the scalp tenderness and mental confusion, is the stomach issue. I think there is some issue with the stomach, which also causes dehydration.

It is impressive that just some seconds/minutes following an orgasm, i can feel my hands getting extremely dry. Is this normal? Could you ask to some non-Pois sufferer if their hands get very dry after having sex?

I also can see my facial skin flushing after having an orgasm (i think this is normal), but afterwards, it gets very dry (this may not be so normal). Maybe is the blood leaving the skin?

But it also could be that Pois does harm to the stomach, and the stomach is the organ which hydrates the body.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15145 on: 20/12/2011 18:47:59 »



It is impressive that just some seconds/minutes following an orgasm, i can feel my hands getting extremely dry. Is this normal?

I also can see my facial skin flushing after having an orgasm (i think this is normal), but afterwards, it gets very dry (this may not be so normal). Maybe is the blood leaving the skin?



I am soooo glad to hear this! (Very few others reported this over 4 years).

My fingertips dry up, leaving me with a terrible feeling I can't explain.

My local "King of Dermatology" (as he liked to call himself)  had no explanation for my postorgasmic dermatitis.

He didn't even believe me, so I had to rush in to see him after sex!!! (no, not with him :)

Quasar, you mentioned blood leaving the skin. I always thought it had to do with "nerve endings".

This is why we need research!!
« Last Edit: 20/12/2011 19:18:01 by demografx »
 

Offline Pharaoh

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15146 on: 20/12/2011 19:32:43 »
Thanks Demo.  I managed to download the full article from our university research port.  Have a look at this:

[nofollow]
 

Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15147 on: 20/12/2011 19:55:25 »



It is impressive that just some seconds/minutes following an orgasm, i can feel my hands getting extremely dry. Is this normal?

I also can see my facial skin flushing after having an orgasm (i think this is normal), but afterwards, it gets very dry (this may not be so normal). Maybe is the blood leaving the skin?



I am soooo glad to hear this! (Very few others reported this over 4 years).

My fingertips dry up, leaving me with a terrible feeling I can't explain.

My local "King of Dermatology" (as he liked to call himself)  had no explanation for my postorgasmic dermatitis.

He didn't even believe me, so I had to rush in to see him after sex!!! (no, not with him :)

Quasar, you mentioned blood leaving the skin. I always thought it had to do with "nerve endings".

This is why we need research!!

When i did a home based two day sublingual rush immunotherapy, the first day i got a wierd facial flush i never get with normal ejaculation. i stopped the first day because of the flush. i didnt get it the second day  though. 
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15148 on: 20/12/2011 21:07:50 »
Thanks Vincent Marcus and BJim for your comments

I may try Clarytin or Benadryl if the current approach I have started since joining this forum doesn't work. I tried Clarytin a couple of years ago for pollen allergy and it relieved all the nasal and sinus symptoms but the brain fog that i get with pollen allergy and drowsiness persisted.

Since 5 days ago i have taken 3 X 610mg Fenugreek daily along with 100mg of Niacin daily in the morning which causes a flush. I have taken Niacin periodically over the years for pollen allergy and it did seem to make a positive difference. I have taken 15mg Zinc daily for quite a long time as it has noticeably shortened the recovery period from POIS.

It may well be too early to assess the effects of the Fenugreek and regular Niacin but I had an O last night and have to say I felt the worst POIS symptoms today than i have for a while, especially the brain fog and poor memory. Could this be because i took the Niacin half an hour AFTER the O rather than before? I'm going to persevere with the Niacin but intend to take it half an hour BEFORE and see what happens.

On a more general note I am relieved to have found people who understand this debilitating condition. I get really fed up with it, for years having to schedule my life around "O" days - nothing important that requires a sharp mind or physical energy the day after or even two days after in some cases. I usually need a week to recover, there are times when the self discipline required for this is too much and I go for it twice or more a week but this means i spend life in a pretty foggy condition and know that my work suffers and my mood is generally negative.

Meeting others through this forum helps me feel less weird so thanks for all the experiences and knowledge people have shared  :)
 

Yes, it is VITAL that the niacin is taken before the orgasm! Hopefully with a flush. I have had results without a flush, but to a lesser degree. Day 1 and 2 are always cleared, but without the flush, days 3 to 5 can appear and/or be worse.

I previously had 9 day sessions. Now, wit flush, maybe half a day! And NO cognitive symptoms or NO day 1 - 2 POIS yuck!

Great news!

5 days ago I took 100mg of Niacin and had a flush about an hour or so before an O. I had NO POIS symptoms at all afterwards! No Brainfog, muscle weakness, exhaustion etcetera. This very rarely happens at all. I can think of no other variable that has changed from previously, apart from the Fenugreek which i started taking about ten days ago. If this were to be the answer to my particular form of POIS I would be very pleased.

This is in stark contrast to how I felt a couple of weeks ago when I took the Niacin AFTER the O when I had very bad symptoms. Since my "no POIS O" I had another O. This was 2 days after the previous one which is unusually quick for me, I would normally leave it 3 days at the very least so as not to incapacitate myself. This time i took the Niacin just 20 minutes before the O as i had mislaid the tablets. It was interesting to me that this time i had some POIS symptoms - brainfog, memory problems, itchy eyes, muscle weakness but they were quite mild and had passed within 24 hours. I wonder if these symptoms were present because i was still experiencing some flushing while the O happened and the full quota of histamine was not available?  That seems to make sense from what others have said about Niacin  and Histamine. Alternatively 2 days may have been too soon to have another O after the previous one.

Further to kurtosis's post, I read Carl Pfeiffer's book about nutritional treatment of mental illness 20 years ago as a friend of mine's aunt was involved in research and i was involved professionally in the mental health field. I identified with the symptoms of Histadelia, especially the allergies - Histadelia is associated with HIGH histamine levels. (I understand that there seems to be scientific controversy about the very existence of histadelia).
It's cool. We can both get better by using treatments deemed medically ineffective for illnesses that don't exist :)
At this stage, I'm beyond caring what the established medical community thinks about illnesses such as histadelia and pyroluria. If my getting better was dependent on changing the attitudes of big pharma and "official medicine" to orthomolecular treatments then I'd just give up now. All I know is the niacin + the pyroluric supplementations are working wonders for me. 
Obviously POIS needs further study but managing the problem asap is important for everybody suffering from this.
People trying different solutions for 20 years are in a better position to evaluate whether something is working than somebody who considers themselves a professional skeptic yet will cite papers with flawed methodologies to further their agenda. Just saying, sometimes it pays to suspend your disbelief  ;)
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15149 on: 21/12/2011 10:32:43 »
Thanks Vincent Marcus and BJim for your comments

I may try Clarytin or Benadryl if the current approach I have started since joining this forum doesn't work. I tried Clarytin a couple of years ago for pollen allergy and it relieved all the nasal and sinus symptoms but the brain fog that i get with pollen allergy and drowsiness persisted.

Since 5 days ago i have taken 3 X 610mg Fenugreek daily along with 100mg of Niacin daily in the morning which causes a flush. I have taken Niacin periodically over the years for pollen allergy and it did seem to make a positive difference. I have taken 15mg Zinc daily for quite a long time as it has noticeably shortened the recovery period from POIS.

It may well be too early to assess the effects of the Fenugreek and regular Niacin but I had an O last night and have to say I felt the worst POIS symptoms today than i have for a while, especially the brain fog and poor memory. Could this be because i took the Niacin half an hour AFTER the O rather than before? I'm going to persevere with the Niacin but intend to take it half an hour BEFORE and see what happens.

On a more general note I am relieved to have found people who understand this debilitating condition. I get really fed up with it, for years having to schedule my life around "O" days - nothing important that requires a sharp mind or physical energy the day after or even two days after in some cases. I usually need a week to recover, there are times when the self discipline required for this is too much and I go for it twice or more a week but this means i spend life in a pretty foggy condition and know that my work suffers and my mood is generally negative.

Meeting others through this forum helps me feel less weird so thanks for all the experiences and knowledge people have shared  :)
 

Yes, it is VITAL that the niacin is taken before the orgasm! Hopefully with a flush. I have had results without a flush, but to a lesser degree. Day 1 and 2 are always cleared, but without the flush, days 3 to 5 can appear and/or be worse.

I previously had 9 day sessions. Now, wit flush, maybe half a day! And NO cognitive symptoms or NO day 1 - 2 POIS yuck!

Great news!

5 days ago I took 100mg of Niacin and had a flush about an hour or so before an O. I had NO POIS symptoms at all afterwards! No Brainfog, muscle weakness, exhaustion etcetera. This very rarely happens at all. I can think of no other variable that has changed from previously, apart from the Fenugreek which i started taking about ten days ago. If this were to be the answer to my particular form of POIS I would be very pleased.

This is in stark contrast to how I felt a couple of weeks ago when I took the Niacin AFTER the O when I had very bad symptoms. Since my "no POIS O" I had another O. This was 2 days after the previous one which is unusually quick for me, I would normally leave it 3 days at the very least so as not to incapacitate myself. This time i took the Niacin just 20 minutes before the O as i had mislaid the tablets. It was interesting to me that this time i had some POIS symptoms - brainfog, memory problems, itchy eyes, muscle weakness but they were quite mild and had passed within 24 hours. I wonder if these symptoms were present because i was still experiencing some flushing while the O happened and the full quota of histamine was not available?  That seems to make sense from what others have said about Niacin  and Histamine. Alternatively 2 days may have been too soon to have another O after the previous one.

Further to kurtosis's post, I read Carl Pfeiffer's book about nutritional treatment of mental illness 20 years ago as a friend of mine's aunt was involved in research and i was involved professionally in the mental health field. I identified with the symptoms of Histadelia, especially the allergies - Histadelia is associated with HIGH histamine levels. (I understand that there seems to be scientific controversy about the very existence of histadelia).
It's cool. We can both get better by using treatments deemed medically ineffective for illnesses that don't exist :)
At this stage, I'm beyond caring what the established medical community thinks about illnesses such as histadelia and pyroluria. If my getting better was dependent on changing the attitudes of big pharma and "official medicine" to orthomolecular treatments then I'd just give up now. All I know is the niacin + the pyroluric supplementations are working wonders for me. 
Obviously POIS needs further study but managing the problem asap is important for everybody suffering from this.
People trying different solutions for 20 years are in a better position to evaluate whether something is working than somebody who considers themselves a professional skeptic yet will cite papers with flawed methodologies to further their agenda. Just saying, sometimes it pays to suspend your disbelief  ;)

I agree Kurtosis. Having suffered from allergies to dairy and gluten which i have been told even recently by medical people don't exist (20 years ago it was even worse) I have little time for those who won't even agree that you are suffering symptoms or that its all in your mind. After 20 years of trial and error it becomes very clear that certain things cause symptoms and other things relieve these symptoms and its patronising and downright insulting when you are told that they "know better" or that you are "just anxious". When it comes to the biochemistry of it there is certainly a debate to be had and research to be undertaken of course.

Sadly I have early experience of the medical profession being very wrong - for the first seven years of my life i had agonising pain periodically from a constricted ureter (between the kidney and bladder). The medics didnt know what was wrong and accused me of making the pain up for attention and my mother of being overprotective. It took a locum General Practitioner to realise what this problem was after i was bent double and continuously vomiting and i was taken into hospital for a total of nine weeks and the ureter replaced with a polythene one. My "imaginary" problem was solved!

I'm trying not to make a career of having unexplained illnesses  :) but after a brief battle with the doctor about allergies I have found it easier to research nutrition, complementary therapies and supplements for myself and this has mostly been effective. I haven't even bothered to report POIS to my G.P. (that's the family doctor for those not familiar with this U.K. term). My level of health and fitness is very good otherwise and medical checkups find BP, cholesterol etc. to be normal and I am generally judged to be 8 - 10 years younger than i am by those who don't know me. I am very glad to have found this forum and learn from the experience of those who actually know what they are talking about  - the people who have the condition themselves.
Phew! I didn't intend to write an essay tonight but there you are! 
 

The Naked Scientists Forum

Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15149 on: 21/12/2011 10:32:43 »

 

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