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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6456975 times)

Offline jferr

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15200 on: 30/12/2011 22:07:46 »
demografx, I too, learned a long time ago not to be too 'nice'. I'm 24 now but from 16 or so up until about 20 I was forced out of many offices. I then got too aggressive for my own good. Finally a couple of years ago I learned how to approach doctors in the right now, Being aggressive when need be. I was able to convince my doctor to do a full range of testing of everything including complete thyroid, prolactin, progesterone, free T, and catecholamines.

If the sophisticated testing you did includes things I somehow haven't tested for it would be greatly appreciated to get a list of the items to present to my doctor, If you wouldn't mind.

I have consistently been weight training since about 18 or 19 years old. Not only because I like to play sports but because it helps my situation. I've only taken a few weeks off in about 6 years because I feel worse without it. I do wonder if it affects my testing levels..

jferr, I can relate to what you said about being paranoid around people.  I guess you can call this social anxiety.  I believe it is probably some guilt-type reaction that your subconscious sets off after orgasm.  Sort of like you sense that people know what you did.  I usually get this after having orgasmed, especially to porn.  That is why I try to stay away from porn.  I don't really get the effects if i just masturbate without any material.  You don't have to look at porn to masturbate, but you can masturbate without looking at porn.  If i do get this feeling,I will have the anxious feeling for that day and maybe the next, the day after that it goes away.  After discovering Niacin I am a lot better too, but I also make the mistake of taking niacin after O because I really do not plan my orgasms.

GoingCrazy, thank you for your response..

My paranoia is part of my constant symptoms.. I explained my issue as best I could a few posts above. I understand what your saying and I'm glad you've conquered it, but my paranoia is not a guilt thing or anything like that. Its really unexplained and I suspect its from a lack of certain neurotransmitters resulting from this problem. My symptoms have been constant with a POIS on top of them making them worse for a few days and the paranoia jumped on the train about  ayear ago after trouble thinking, slurred words, confusion, dulled emotions, fog, and physical symptoms such as short breath, pains, sluggish, and fatigue. These things are always present for me. I am thinking the paranoia has something to do with somewhere in the dopamine or norepinephrine range but I really don't know where to start.

The Niacin has made me a little more alert and has helped everything including the paranoia but not nearly enough. I have been able to think enough for small talk but nothing more than that, but it has given me more energy. I've just recently ordered a bunch of supplements like vma and such to experiment with them. I can only experiment once every couple of weeks because thats how bad my POIS affects me, I always recover different but never fully.

I am also currently seeing a neuropsychiatrist that I may ask for Wellbutrin or Strattera, I tried celexa and it did nothing for me but dull me even further. Everything has felt like an engine 'turn off' from day one so I've always felt like I needed some type of core stimulant, I dont know if that makes sense to those reading this.

Regaurdless, progress is being made. Less than a year ago we found fenugreek and now we are past niacin looking for something better. We will beat this.

Thanks guys,

Jon.
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15201 on: 30/12/2011 22:35:06 »
I just spoke on the phone with the center at Harvard.

http://alzheimersweekly.com/content/alzheimers-disease-research-center-harvard-medical-school [nofollow]

They want me to put together an email describing the correlation between POIS, relatives who have Alzheimers, and the similarity in mental symptoms one gets from POIS to the symptoms one gets from Alzheimers.

This is who I am to send the email to:

http://madrc.mgh.harvard.edu/liang-yap-phd [nofollow]


So I am going to ask one last time, just in case, do any of your relatives, for those who have POIS, have or had Alzheimer's? If you dont know for sure, please check and post here if so. After a few days I will compose the email and send it out.


My paternal grandfather and his daughter, my auntie, had Alzheimers in the couple of years before their deaths, they were both in their 80s. My father died at 57, an age before which Alzheimers is less likely to develop.
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15202 on: 30/12/2011 22:55:06 »
jferr, I can relate to what you said about being paranoid around people.  I guess you can call this social anxiety.  I believe it is probably some guilt-type reaction that your subconscious sets off after orgasm.  Sort of like you sense that people know what you did.  I usually get this after having orgasmed, especially to porn.  That is why I try to stay away from porn.  I don't really get the effects if i just masturbate without any material.  You don't have to look at porn to masturbate, but you can masturbate without looking at porn.  If i do get this feeling,I will have the anxious feeling for that day and maybe the next, the day after that it goes away.  After discovering Niacin I am a lot better too, but I also make the mistake of taking niacin after O because I really do not plan my orgasms.

I too have noticed a mild paranoia that seems to corresponds with the POIS period, most severe the day after O, then fading gradually in the next two or three days. This is nothing like in the psychotic range but it does make me feel more inclined to think people might be talking about me or looking at me strangely and make me defensive. A couple of people close to me have noticed this as well. This could be hormonal but could also be linked to guilt feelings about sex, though i can't really say i have many of those nowadays.
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15203 on: 30/12/2011 23:01:31 »
There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good :), I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15204 on: 31/12/2011 00:50:50 »
jferr, how long have you been battling POIS?  For me the paranoia was also there mostly all the time, but the longer I have battled POIS the less severe my symptoms have been and the shorter duration they have lasted.  I also believe it to be some neurochemical hangover or imbalance.  Over just about 3 years I've managed to bring my POIS down from lasting about a week, to just about a day.  I am saying that maybe if you just realized about POIS that you may need to wait some time before your "constant symptoms" gradually lessen in severity.
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15205 on: 31/12/2011 00:53:31 »
There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good :), I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?

I've been taking Niacin about twice every week, once on Sunday, and once on Wednesday or Thursday.  I still need to see the difference between taking it pre-O versus post-O.  I've only been taking it post-O and that does not do as much as I would like.  I'm pretty sure I have taken it pre-O maybe once on a Thursday morning and I O'd on a Thursday night.  I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?
 

Offline observercenter

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15206 on: 31/12/2011 01:40:59 »
I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?

GoingCrazy, stop taking the niacin after the O. It is useless. You could get relief for 2-3-4 hours - but you are going to get symptoms again after this time passes by.
Niacin pre-O *-1-2-3hour before or 15-20 min after you get the flush* and better in non-full stomach has COMPLETELY blocked my POIS symptoms(No digestive problems, no brain fog, no straw berry shaped hair, no fatigue, no lethargy...). We could discuss why is the reason that it is working, it could be that the histamine release is blocking the later inmune response against semen -misleading your organism- or maybe it is producing the necesary histamine to fight against POIS. We really do not know.
I have found that if i take an anti-histamine(H1) during the day and i take the niacin on this same day and have an Orgasm, it is not going to work completely, maybe i could have a very mild brain fog and slighty fatigue. I think this could be discussed here.
I suggest you to CRUSH the niacin into powder before taking it.
It will be more effective*fast.

Oh... and i nearly forgot:
Happy new year for all of you!! O8)

« Last Edit: 31/12/2011 01:43:19 by observercenter »
 

Offline jferr

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15207 on: 31/12/2011 01:54:19 »
jferr, how long have you been battling POIS?  For me the paranoia was also there mostly all the time, but the longer I have battled POIS the less severe my symptoms have been and the shorter duration they have lasted.  I also believe it to be some neurochemical hangover or imbalance.  Over just about 3 years I've managed to bring my POIS down from lasting about a week, to just about a day.  I am saying that maybe if you just realized about POIS that you may need to wait some time before your "constant symptoms" gradually lessen in severity.

GoingCrazy, I have been battling POIS for 8 years. It started suddenly with dulled emotions one day at orgasm when I was 16 and has not since lifed. Only has gotten worse. Paranoia came about around 2 years ago. I have waited months without orgasm before but only recover to a certain level which has gotten less and less over time. When this suddenly started at that moment when I was 16 it physically felt like an engine turned off in my head, I then developed my POIS on top of it not long after. It has been hell. The symptoms have just become more wide spread. Thankfully since the niacin I have had some minor relief but I am desperately searching for more.

Best wishes.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15208 on: 31/12/2011 02:26:04 »

If the sophisticated testing you did includes things I somehow haven't tested for it would be greatly appreciated to get a list of the items to present to my doctor, If you wouldn't mind.


MY ENDOCRINOLOGIST'S LABWORK ORDERED FOR POIS


Out of reference range

-PROLACTIN

Extremely high (reason for MRI of the pituitary gland - all turned out ok)

-TESTOSTERONE(Bioavailable Testosterone, Free Testosterone, Total Testosterone, Sex Hormone Globulin Binding)

"Free T" is low; others I don't have reference range on summary.

In reference range
-DHEA-SULFATE

-FSH (Follicle Stimulating Hormone)

-LH (Luteinizing Hormone)

-TSH (Thyroid-Stimulating Hormone)

jferr, the "sophisticated testing" meant two things to me: 1. a major university research laboratory vs. my GP's local lab and 2. Working with an endocrinologist vs. urologist or GP.

You probably have covered much of this testing, yours sounds very thorough.
« Last Edit: 31/12/2011 02:28:03 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15209 on: 31/12/2011 02:41:25 »



Best wishes, everyone, for a POIS-free 2012!

  daveman                                   demografx
« Last Edit: 31/12/2011 02:46:04 by demografx »
 

Offline badgerstripe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15210 on: 31/12/2011 08:54:15 »
There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good :), I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?

I've been taking Niacin about twice every week, once on Sunday, and once on Wednesday or Thursday.  I still need to see the difference between taking it pre-O versus post-O.  I've only been taking it post-O and that does not do as much as I would like.  I'm pretty sure I have taken it pre-O maybe once on a Thursday morning and I O'd on a Thursday night.  I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?

My recent experimentation in the last 3 weeks or so has shown me the following.

Niacin:
Post O has made my symptoms worse than ever
1.5 hours before O on an empty stomach with a flush - no symptoms at all!
1 hour before O with a full stomach, barely noticeable flush. Symptoms which were probably half as severe as normal.

There were no other circumstances i can spot which would have effected my symptoms and clearly longer-term experimentation is needed with this but so far it looks promising. I can only speculate on *why* this appears to work and the answers must lie with the sort of testing that demografx and others on this forum have undergone.

The explanation that the Niacin-induced flush is producing the necesary histamine release for an orgasm makes sense to me, especially as my symptoms were so much worse when taking Niacin after an orgasm which suggests over-depletion of histamine but i imagine the process is much more complex than this.

Thankyou for the suggestion of crushing of the Niacin tab observercenter!
 

Online John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15211 on: 31/12/2011 10:44:58 »
I just spoke on the phone with the center at Harvard.

http://alzheimersweekly.com/content/alzheimers-disease-research-center-harvard-medical-school

They want me to put together an email describing the correlation between POIS, relatives who have Alzheimers, and the similarity in mental symptoms one gets from POIS to the symptoms one gets from Alzheimers.

This is who I am to send the email to:

http://madrc.mgh.harvard.edu/liang-yap-phd


So I am going to ask one last time, just in case, do any of your relatives, for those who have POIS, have or had Alzheimer's? If you dont know for sure, please check and post here if so. After a few days I will compose the email and send it out.


My grandmother died with Alzheimers, but a connection to POIS seems improbable to me.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15212 on: 31/12/2011 13:59:32 »
POISers who had parents/grandparents/close family members with Alzheimers:

Kurtosis
martin88
hurray
Defsync

Is there anyone else? This is enough for me to contact an Alzheimers research center at Harvard about this "coincidence" in hopes that some correlation may bring insight to either condition.

Interesting joint study on the testosterone levels of older men with Alzheimers. University of Hong Kong and St. Louis University in Missouri.
http://www.sciencedaily.com/releases/2010/10/101005171202.htm
So saying there might be a relationship between a disease with a set of sexual / hormonal symptoms and alzheimers isn't that much of a stretch. Someone should want to publish about this!

While you're asking the question about Alzheimers, then could you ask the question about Parkisons also?
I'm not aware of any relatives who have had it but it's interesting given some of the treatments people have suggested boost dopamine levels, in theory.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15213 on: 31/12/2011 15:02:43 »
We never know what we can get from having POIS cases studied at Harvard, if it goes till there.
Alzheimer is very frequent with aging so we would have to prove it's more frequent in POIS families.

My experience with niacin months ago was not very long so what I'll say about it might be wrong.
I took 25mg after orgasm --> no effect on POIS but I had a good sleep during the afternoon wich is unusual for me.
I took 100mg before orgasm --> I had premature ejaculation (I usually have a feeling of PE but there it was real PE). This time niacin helped my POIS but not all symptoms. I definitely had improved thinking and focus, less brain fog. However I still had full physical fatigue and exhaustion.

Happy new year to everyone!!!
Hope we'll make some new progress.
 

Offline Starsky

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15214 on: 31/12/2011 15:16:27 »
READ THIS ARTICLE: http://jpet.aspetjournals.org/content/327/3/665.full.pdf

ABOUT HISTAMINE: Methylnicotinate had a weak effect on inducing histamine release from human mast cells,
whereas niacin did not increase rat plasma histamine levels. Moreover, the H1-receptor antagonists brompheniramine,
chlorpheniramine, diphenylhydramine, and ketotifen did not block niacin-induced skin temperature increases. Combined,
these results suggest that histamine is not involved in niacininduced flush



I think Demografx was taking Aspirine to reduce the flush. Aspirie inhibits the effect of prostaglandins, but taking aspirine and niacin didnt make a difference for him so i think prostaglandins are not important. What is left is SEROTONIN. The effect of serotonin can be blocked by taking antihistamines, so i think thats the explanation of Observers case. What my allergist said, histamine and serotonin have the same group of receptors and serotonin can bind to histamine receptors(dont know to which ones) and could work as an antihistamine.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15215 on: 31/12/2011 19:43:52 »

Happy new year !



(Inappropriate   ;D ? )


Perfect, B_Jim! 
« Last Edit: 31/12/2011 19:45:26 by demografx »
 

Offline Omen 30

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15216 on: 31/12/2011 21:38:11 »
Hi kurtosis, my grandmother,her two brothers all are having alczimers and I have always had the feeling that the alczimers has got something to do with my pois...my granny is around 90 years age...
 

Offline daveman

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15217 on: 31/12/2011 21:59:26 »

Happy new year !



(Inappropriate   ;D ? )


Perfect, B_Jim! 


If we can make as much advance this coming year as we have this year, I'll be a happy man. If we can actually reach our donations goal, I'd have to take niacin all year!!

Have a POIS free New Year. I "celebrated" last night, and thanks to niacin, I'll even be enjoying a late New Years party tonight!!

 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15218 on: 31/12/2011 23:19:22 »

Happy new year !



(Inappropriate   ;D ? )


Perfect, B_Jim! 


If we can make as much advance this coming year as we have this year, I'll be a happy man. If we can actually reach our donations goal, I'd have to take niacin all year!!

Have a POIS free New Year. I "celebrated" last night, and thanks to niacin, I'll even be enjoying a late New Years party tonight!!




And I second THAT!!
 

Offline rock27

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15219 on: 01/01/2012 02:38:11 »
HAPPY HAPPY NEW YEAR TO ALL POIS-ERS!

May 2012 bring happiness and health to all. That we will conquer.
I wish all to have a (normal) life and (normal sexual) relations in 2012.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15220 on: 01/01/2012 09:48:45 »

Rock, wonderful New Year's POIS sentiment!!
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15221 on: 01/01/2012 12:09:25 »
Happy new year to you and your families. I haven't been on this forum long but I'm very excited about the progress and the energy displayed by all. If we can do this much with POIS, just imagine how much we can achieve without it.  Let's make that our goal for 2012.
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15222 on: 01/01/2012 18:57:14 »
READ THIS ARTICLE: http://jpet.aspetjournals.org/content/327/3/665.full.pdf

ABOUT HISTAMINE: Methylnicotinate had a weak effect on inducing histamine release from human mast cells,
whereas niacin did not increase rat plasma histamine levels. Moreover, the H1-receptor antagonists brompheniramine,
chlorpheniramine, diphenylhydramine, and ketotifen did not block niacin-induced skin temperature increases. Combined,
these results suggest that histamine is not involved in niacininduced flush



I think Demografx was taking Aspirine to reduce the flush. Aspirie inhibits the effect of prostaglandins, but taking aspirine and niacin didnt make a difference for him so i think prostaglandins are not important. What is left is SEROTONIN. The effect of serotonin can be blocked by taking antihistamines, so i think thats the explanation of Observers case. What my allergist said, histamine and serotonin have the same group of receptors and serotonin can bind to histamine receptors(dont know to which ones) and could work as an antihistamine.

That's quite interesting, and you could be on to something.  I may be stating the obvious here, but ultimately we need data like this to lead to explanation of why Niacin helps us more than the average anti-histamine.     
« Last Edit: 01/01/2012 19:00:31 by B_Daniel »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15223 on: 02/01/2012 06:10:38 »

Happy new year to you and your families. I haven't been on this forum long but I'm very excited about the progress and the energy displayed by all. If we can do this much with POIS, just imagine how much we can achieve without it.  Let's make that our goal for 2012.


kurtosis, many thanks for that upbeat New Year's message!
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15224 on: 02/01/2012 09:49:33 »
Happy new year to everybody also...  I drank last night and usually alcohol makes me feel somewhat better and helps me not to think of symptoms I had a pretty bad headache last night leading into this morning.  Sometimes I feel better the next day after drinking but today I did not.  Perhaps it was because I was drinking hard liquor and not beer.  Probably something in the beer that makes me feel better the next day.

And about Alzheimer's, I have had no family members diagnosed with it, actually most of them seem to have their mind in tact and living late into their 80's and 90's... I only have cancer as a problem within my family.  I also have a close relative that is working in the Alzheimer's field, maybe I could tell him about POIS.
 

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #15224 on: 02/01/2012 09:49:33 »

 

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