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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6462273 times)

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16850 on: 26/06/2012 19:12:51 »
So why would this be related to POIS? Simply because during an O we produce prolactin. Too much or too little would be a problem and would likely indicate a problem with balancing PGE2 levels.

I reviewed the data on prolactin after reading your post kurtosis, and I had to pause:  prolactin has been tied to the refractory period (period of tiredness/relaxation) by *repressing dopamine*.  This caught my attention as dopamine neurotransmission is responsible for so many of the functions we complain are not working well.  What if POIS sufferers have a more powerful prolactin surge than most men?  What if our bodies don't react to the depletion of dopamine like others?

Study on male who presents no prolactin creation upon orgasm, thus able to "O" and stay erect for many ejaculations in a row: http://www.nature.com/ijir/journal/v14/n2/full/3900823a.html

And to tie up more lose ends, what if prolactin could help explain our immune system issues and our successes with that treatment approach?  I feel there is too much evidence in support of an immunological theory to not include it in my thinking.

From the Wiki page on prolactin: "Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system."  Right there.  We have had so many people thinking about histamines and how most allergies the public talk about are being powered by histamines.  Yet, it has been explained that there are different levels of immune response and that POIS probably operates on the cytokine level and out of the reach of anti-histamines.  Well, what if our own hormone is doing double duty, starving our system of the dopamine needed to operate our nervous system well AND is causing the inflammation/flu-like symptoms we have been discussing for so long?

Could Waldinger's desensitization treatments not be calming down an antibody attack, but actually instead be sensitizing his patients to the presence of prolactin so as to buffer against its dopamine fighting actions?

And what about Niacin? Quoting you kurtosis: "Simply because during an O we produce prolactin. Too much or too little would be a problem and would likely indicate a problem with balancing PGE2 levels. "  I didn't see a reference there, but I see it as the only other loose end to tie.  Might the flushing response to niacin somehow set us up for metabolizing prolactin (perhaps less so on our sexual system where it's needed, more so all over the whole body)?

This has got me really interested!
« Last Edit: 26/06/2012 19:14:27 by Nightingale »
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16851 on: 27/06/2012 09:53:54 »
So why would this be related to POIS? Simply because during an O we produce prolactin. Too much or too little would be a problem and would likely indicate a problem with balancing PGE2 levels.

I reviewed the data on prolactin after reading your post kurtosis, and I had to pause:  prolactin has been tied to the refractory period (period of tiredness/relaxation) by *repressing dopamine*.  This caught my attention as dopamine neurotransmission is responsible for so many of the functions we complain are not working well.  What if POIS sufferers have a more powerful prolactin surge than most men?  What if our bodies don't react to the depletion of dopamine like others?

Study on male who presents no prolactin creation upon orgasm, thus able to "O" and stay erect for many ejaculations in a row: http://www.nature.com/ijir/journal/v14/n2/full/3900823a.html

And to tie up more lose ends, what if prolactin could help explain our immune system issues and our successes with that treatment approach?  I feel there is too much evidence in support of an immunological theory to not include it in my thinking.

From the Wiki page on prolactin: "Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system."  Right there.  We have had so many people thinking about histamines and how most allergies the public talk about are being powered by histamines.  Yet, it has been explained that there are different levels of immune response and that POIS probably operates on the cytokine level and out of the reach of anti-histamines.  Well, what if our own hormone is doing double duty, starving our system of the dopamine needed to operate our nervous system well AND is causing the inflammation/flu-like symptoms we have been discussing for so long?

Could Waldinger's desensitization treatments not be calming down an antibody attack, but actually instead be sensitizing his patients to the presence of prolactin so as to buffer against its dopamine fighting actions?

And what about Niacin? Quoting you kurtosis: "Simply because during an O we produce prolactin. Too much or too little would be a problem and would likely indicate a problem with balancing PGE2 levels. "  I didn't see a reference there, but I see it as the only other loose end to tie.  Might the flushing response to niacin somehow set us up for metabolizing prolactin (perhaps less so on our sexual system where it's needed, more so all over the whole body)?

This has got me really interested!
I know it's chickens but PGE2 stimulates prolactin release. http://www.ncbi.nlm.nih.gov/pubmed/6439599
The mechanism by which PGE2 induces prolactin expression in humans is described in the wonderfully detailed http://www.jimmunol.org/content/173/10/5952.full.pdf
What I believe is that flush is important as it induces the production of prostaglandins pgd2 and pge2 in skin langheran cells. I believe that this flush somehow uses up enough of the PGE2 pathway and directs it to the skin (an ancient defence mechanism required to heal cuts) such that when we have an O our bodies don't have so much PGE2 in the CNS and hence don't overload us with prolactin. Prolactin will inhibit some catecholamines and, basically, make us feel dumb and aimless.

The effects of administering PGE2 to pregnant women are well known for example. It's used as a vasodilator, can bring about a skin "flush" and induces labour. Unfortunately, it seems that the niacin flush loses intensity with use and, if the flush is the mechanism that's helping mediate the effects of an overproduction of PGE2, then we'd need to find some better mechanisms of managing this.

I think astaxanthin in krill oil should work (I've been taking it with b6, zinc and magnesium after an O) with some success.
See http://www.ncbi.nlm.nih.gov/pubmed/14503852 for details on how astaxanthing regulates PGE2 production.
However, I've noticed that the quality of some krill oil is rubbish (evidenced by a rancid smell) while others remain odourless and effective (for me anyway).

As to why the PGE2 overproduction, if this hypothesis is correct... I don't know. Vitamin and mineral deficiencies could cause this as the prostaglandins balance themselves. Other dietary problems, nutrition absorption problems, some form of autoimmune disease etc. If anyone else wants to research this I'd be happy to discuss it with them :)
 

Offline tantalus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16852 on: 27/06/2012 14:47:42 »
DRUID,  OBSERVRC, STARSKY, FIDDALGO, NIGHINGALE


I will answer everybody soon. At the moment I still have to re-coffer my progesteron disappointment it was a nearly suicidal psychological disappointment.  My intro letter here took a lot of energy. Also i feel a great responsibility to answer not just out of the shoot.  I have first to haunt al progesterone info, and  bring ithere to quote every sentence and discuss. I feel a great responsibility to  clear the Augias stall  of the progesteron info. Have seen how dangerous it can bee to give senseless hope.  ....... newbielink:http://en.wikipedia.org/wiki/Augeas [nonactive]   

will mail to 'poised' and 'Understanding Pois' on the p.o.i.s. site, but the posts of them are 12 months ago...hmmmm. Bit disappointed other chaps as Daveman and VDMolen on the pois center did not react on my general introletter postscriptum 28/6: I very regret this last sentence got opposite understood. I did intent to say that only Daveman and Vandermolen did react, Daveman did react more times even  but might be do to the spread of so many subjects. But feel warm with he responses I got here. Would be fine to get an exchange there  in more informal matters about pois in general. May bye this takes more time people get accustomed to my stile of openness. 
« Last Edit: 28/06/2012 11:55:22 by tantalus »
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16853 on: 28/06/2012 00:00:20 »
About female Pois, there are strange testimonies describing the same problem... without men.


About astaxanthin,  it should work but it didn't for me . Maybe should i take 3 caps a day during  several weeks.

What else did you take with it? If PGE2 causes some of the cognitive symptoms it doesn't explain what causes the oversupply of PGE2. If it's some kind of problem absorbing b-vitamins then you'd probably need to supplement these too. Also, Astaxanthin with omega 3 would be more effective than it without as it should reduce PGE2 synthesis.

When I say that krill oil improves things for me I mean that when I take 2 caps of the expensive stuff after an O it makes things better. I'd take 2 caps at the start of every day so that's 4 caps some days. Expensive :)
I take GLA and a megadose B complex also with extra magnesium and zinc. My concentration has improved dramatically.
 

Offline tantalus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16854 on: 28/06/2012 12:52:57 »
for the ones that only read the last posts.

I very regret my to literally translated Dutch got reason to misunderstanding. Where I did lift my slight disappointment that missed more re's from the users of the P.o.i.s. centre. I did write "Bit disappointed other chaps as Daveman and VDMolen on the pois center did not react on my general introletter" In Dutch this means that  "only the both named users  did react". 
and the did! Dave man did write me back extensively, with verry good info that helps me to not withdraw. Will need time to get in communication with more poisers . I tried to invite to more openness not to force. I guess I did show  a good example myself.

My stile of openness and humour  might frighten of some at first as to extrovert or on the opposite week, by not hiding my fragility. But I can assure everybody,  It never harmed me, it only brought me friends, that came to see It makes one stronger to give away who you are really. I DID tell most people about my pois. Some did laugh behind myback, and twisted the info, 1 doctor did harm me by twisting  Waldingers diagnosis---I brought it to the judge and won the case. Others did feel invited to tell their secret. so ...if you might feel not man enough because of pois and feel week if you tell....you might just win masculinity by not hide to show who you are. I am also Gay, so I had godthanks already experience choosing not stay living  in the closet  to favour others and approve prejugments !!  others. I never , never got any enemies only respect and [of course envy by the ones not so open] Try it. makes you feel even more masculine even  with pois...

My last real personal words here. Will  exchange  from now on here only professional info. And use the other forum for the 'family feel'  ......hugg.   
 

Offline tantalus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16855 on: 28/06/2012 14:31:14 »


Hello tantalus, my POIS symptoms used to last between 4-5-6 days. I got pretty bad cognitive problems_ Brain fog, lethargy, difficulty concentrating, simple speech and so on... Have you tried niacin? A good use of niacin could block completely my POIS symptoms, and i have been able to overcome this nightmare -> In the sense that is not a -big- problem in my daily life, tough i am going to experience the same POIS symptoms that in the past if i do not take the niacin prior to O.

BTW I am 20 years or more younger than you :P.

Welcome to the forum, i hope you learn more about our initiatives and join us!

Hi, Thank you for your kind and helpfull words. Yes I will try niacin, You, Daveman and others invited me too. I will discuss it with my allergist, no exeriments unguided anymore !! My specialist added vit D already. Did until now nothing with pois, but everybody says to me I got very much more focused, and decisive, maybe will become younger as you even, and with my experience ...wow holland  watch out here comes the pois hulk with his b...
 

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16856 on: 28/06/2012 19:31:19 »
Here is an informative and funny article RE: prolactin and one man's quest for multiple orgasms.  What's also interesting is that he discusses drugs developed to treat Parkinson's disease that inhibit prolactin and boost dopamine:

http://open.salon.com/blog/franklinveaux/2009/03/10/biochemistry_sex_and_hey_multiple_orgasms

Quote
"Cabergoline is another drug that works the same way as bromocriptine; like bromocriptine, cabergoline is used to treat Parkinson's disease and pituitary disease. It, too, blocks prolactin and enhances dopamine, and it has fewer nasty side effects.

One interesting side effect reported in both men and women being treated for things like Parkinson's is multiple orgasms.

Which is a hell of a side effect, if you ask me."

I've heard about interesting benefits after taking anti-Parkinson's meds, I wonder if we might have our own?


tantalus - I'm sorry you've been ignored, I have my own suicide-inducing problems.  But I want you to know, if you have POIS, you are in my family :)
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16857 on: 28/06/2012 20:42:21 »
Here is an informative and funny article RE: prolactin and one man's quest for multiple orgasms.  What's also interesting is that he discusses drugs developed to treat Parkinson's disease that inhibit prolactin and boost dopamine:

http://open.salon.com/blog/franklinveaux/2009/03/10/biochemistry_sex_and_hey_multiple_orgasms

Quote
"Cabergoline is another drug that works the same way as bromocriptine; like bromocriptine, cabergoline is used to treat Parkinson's disease and pituitary disease. It, too, blocks prolactin and enhances dopamine, and it has fewer nasty side effects.

One interesting side effect reported in both men and women being treated for things like Parkinson's is multiple orgasms.

Which is a hell of a side effect, if you ask me."

I've heard about interesting benefits after taking anti-Parkinson's meds, I wonder if we might have our own?


tantalus - I'm sorry you've been ignored, I have my own suicide-inducing problems.  But I want you to know, if you have POIS, you are in my family :)

Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.
 

Offline tantalus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16858 on: 29/06/2012 02:07:25 »
Thank you Nightingale. Mean while  I have been asked to be not  to critical here because you are all volunteers. But I am volunteer too, and as Dutchman I have the blood of Erasmus von Rotterdam in my blood. so I think science is never been  bad serviced by critical notes with a little ironic bite.  I do my best, and who reads my letters here with care will filter the good to be dominant and must admit I do have shown also diplomacy and tact here . I do not know what naked scientist means , but my intuition tells me I am one my right spot here to spread my censire critical comments and my honest possible (likewise) opinion in questions asked to me. In the other forum you wil find me more flat and save ( before I get on toes again, not asked for there!)
« Last Edit: 30/06/2012 12:54:08 by tantalus »
 

Offline Hoping

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16859 on: 29/06/2012 14:25:14 »
Tantalus i have 3 questions:
1. Since when do you have POIS? Since puberty?
2. Did you react to yours partners semen or just your own? Did you get POIS from contact with other males semen?
3. What were your side effects during desensitization?
Interesting tantalus. Thanks for sharing! As far as I can tell, you didn't directly answer #2 and #3. I'm especially interested in your responses to these questions.
--First, do you get POIS reaction from contact with your sexual partner's semen, or only from your own?
--Second, did the desensitization injections from Dr. Waldinger have any side effects? For example, did the injections cause POIS symptoms?
Thanks!
« Last Edit: 30/06/2012 23:56:41 by Hoping »
 

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16860 on: 29/06/2012 17:09:02 »
Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16861 on: 29/06/2012 20:13:46 »
Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!
Do. Ironically, if this hypothesis turns out to have some validity and if Cabergoline works then I'll still have some difficulty in being prescribed it here. I'll end up changing doctors I'd say :)
 

Offline tantalus

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16862 on: 29/06/2012 23:53:39 »
Hi, FiDALGO Sorry you had to wait, but you see I am bussy here to answer everybody as sincerely  possible. Questions are complex /pois is complex. I learnt to mistrust answers given in a few sentences depending pois. Pois is not yes or no. 

Tantalus, I donīt understand well. Do you get better or not with dessensibilization? Do you have a good improve? A cure? Compare how you are now with how you was before the threatment. I'm too curious because I was believing a lot in the dessensibilization...

Depends on the definition of the word 'better'
I am Dutch, it would mean here 'totaly cured'
In english could mean better as before?

I am not cured. Yes, I have less sick days. No I feel not always better as before.   ....you frown with your eyebrows? Well here is no click clack answer to this question, Lesser days sick does not mean you feel lesser sick the day that left over to have still pois. I suffer verry much from this 1 or 2 days or 3 days. This is what I ment with that the cure effect is waving. Most time i am sick the 2th day and 3th day. An other time the first  day and the 2th.
This wave effect makes my social live difficult to plan. Also I suffer in this days 100% pois.
The other side of the story is , I had before 5 til 12 days. So benefit is there sure!
How we, me you,  'mesure',  this  benefit is strongly psychological and personal.
Also the treatment is every generation patients different. I have been treated very slowly. Now the tendency is to do it much faster. We have to invent the wheel...the patients together with the doctors. Which desensitization  frequency, dure  and dilution at the time works best for the average! patient, before 'we' can adapt to the exeptions.  But DO the treatment it might become even THE cure for you.     Benefit you wil have in any case from this treatment I guess in any  case minimal 60%
                                    Wish you luck!
« Last Edit: 30/06/2012 00:19:43 by tantalus »
 

Offline fidalgo

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16863 on: 30/06/2012 01:04:54 »
Hi, FiDALGO Sorry you had to wait, but you see I am bussy here to answer everybody as sincerely  possible. Questions are complex /pois is complex. I learnt to mistrust answers given in a few sentences depending pois. Pois is not yes or no. 

Tantalus, I donīt understand well. Do you get better or not with dessensibilization? Do you have a good improve? A cure? Compare how you are now with how you was before the threatment. I'm too curious because I was believing a lot in the dessensibilization...

Depends on the definition of the word 'better'
I am Dutch, it would mean here 'totaly cured'
In english could mean better as before?

I am not cured. Yes, I have less sick days. No I feel not always better as before.   ....you frown with your eyebrows? Well here is no click clack answer to this question, Lesser days sick does not mean you feel lesser sick the day that left over to have still pois. I suffer verry much from this 1 or 2 days or 3 days. This is what I ment with that the cure effect is waving. Most time i am sick the 2th day and 3th day. An other time the first  day and the 2th.
This wave effect makes my social live difficult to plan. Also I suffer in this days 100% pois.
The other side of the story is , I had before 5 til 12 days. So benefit is there sure!
How we, me you,  'mesure',  this  benefit is strongly psychological and personal.
Also the treatment is every generation patients different. I have been treated very slowly. Now the tendency is to do it much faster. We have to invent the wheel...the patients together with the doctors. Which desensitization  frequency, dure  and dilution at the time works best for the average! patient, before 'we' can adapt to the exeptions.  But DO the treatment it might become even THE cure for you.     Benefit you wil have in any case from this treatment I guess in any  case minimal 60%
                                    Wish you luck!

Thanks for the answer and I understan dall about your english. For me, any improve is good. Less days of Pois will be great for me. Different of the most of you, I never be of POIS. I don't know if I'm what you call contant POIS but I'm never be normal. So, if my POIS come to 'only' 7 days I will be happy. Now I will start to find some doctor that accept do the dessenbilization with me...
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16864 on: 30/06/2012 06:52:52 »
Another update.  This time I "O'd" 4-5 times yesterday and I did feel POIS.  I also put some under my tongue just to see if I could get a reaction and I did.  I woke up last night and my whole body was sweating.  And I got my typical POIS reaction which was a headache from the back to the front of my head.  I think I would like to freeze my semen so when I am not in POIS and can see if this will create a reaction, that way I would know if it was semen or not.  I can "O" every now and then up to a certain amount of times.  Anything over a certain threshold and than I am in POIS.  I could tell yesterday when I passed the threshold.  I was calm and relaxed up to either 3 or 4 O's, but than the next one I felt a surge of adrenaline that I guess did not stop.
« Last Edit: 30/06/2012 06:54:59 by GoingCrazy »
 

Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16865 on: 30/06/2012 07:19:54 »
Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!
cabergoline has the exact opposite effect as antipsychotics.  Antipsychotics block dopamine receptors in the brain.  IF you gave cabergoline to a bipolar patient, it would cause them to go in the wildest manic phase imaginable.  on rare occasions dopamine agonists like cabergoline can cause sex and gambling addictions in otherwise normal and reserved people.   
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16866 on: 30/06/2012 13:05:06 »
Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!
cabergoline has the exact opposite effect as antipsychotics.  Antipsychotics block dopamine receptors in the brain.  IF you gave cabergoline to a bipolar patient, it would cause them to go in the wildest manic phase imaginable.  on rare occasions dopamine agonists like cabergoline can cause sex and gambling addictions in otherwise normal and reserved people.   
Yes, I know. Been doing some research on it. I've also found some studies that link hyperprolactinemia to b6 deficiency.
https://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1013447
http://jcem.endojournals.org/content/42/3/603.long
This should be combined with vitamin E.
http://www.ncbi.nlm.nih.gov/pubmed/1490755
and zinc.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(85)90630-0/abstract

Another supplement that would theoretically reduce prolactin levels is S-adenosylmethionine (also called SAM-e)
See http://www.ncbi.nlm.nih.gov/pubmed/3298421

I'm not sure if anyone else finds this but, for me, if I take enough zinc+b6 to remember my dreams then I'm great the next day. There's no comparison between a day when I can remember my dreams and one where I don't. So I think my POIS has something to do with a vitamin absorption problem that triggers a range of side effects including too much PGe2 and, related to this, prolactin.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16867 on: 30/06/2012 15:29:51 »
Hi Tantalus, it's difficult for me too to write in english, it takes a long time to write posts, and often I can't write exactly what I want to say. I don't always know if people understand me. When I feel it's necessary I'm using these two links but it takes time.
-this one for words: http://www.wordreference.com/
-this one is excellent (hundreds of millions of example sentences translated by real people): http://www.linguee.com/


Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!

Hi Nightingale, some POIS sufferers tried this and reported it was not helpful, but it's good if you make your own experience, everyone is different. I think Hurray and CP took cabergoline without success . Some old posts below:
2nd post relating to Parlodel (Bromocriptine)

Had a try at it again this weekend. This time it did nothing for me, i felt 'hungover' for atleast 3-4 days this time. My first attempt with this drug was very promising, I def thought I had some results there..

Not quite ready to give up on it completely, I will try it for a few more times and post feedback...

I took cabergoline.  It has some risks associated with it that bromocriptine doesn't, and if you consider taking it, consult with a physician.  I don't think it's a good option for more than say, 4 months. HOWEVER, I think for many people cabergoline is a much better drug for these types of tests than bromocriptine.  It has an extremely long half-life.  Taking one 0.5 mg tablet of cabergoline is like taking a significant daily dose of bromocriptine for a week.  You only need to take 1 pill a week.  And generally I think there are fewer side effects.

Also, when you experiment with these types of drugs, I don't think you can expect an immediate cure.  Sometimes the neurotransmitters need to build up for months, before, for instance, your physiological response to orgasm is significantly altered.  For example, someone is not going to cure himself of serious depression by trying a couple SSRI pills now and then.  It needs a dedicated trial.

So I don't know how valuable it is doing 3 or 4 isolated experiments.


« Last Edit: 30/06/2012 17:34:05 by martin88 »
 

Offline fidalgo

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16868 on: 30/06/2012 15:59:13 »
I understand all that you say. I don't think your english is worst than mine and the others no native spoke. And, more you write, better your english will be. So, don't worry about your english.

Only more one question: How much time you have to end the dessensibilization? Do you think you will have more improves?

Thanks for the attenction.
 

Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16869 on: 30/06/2012 19:48:26 »
Yes, I tried Cabergoline, and it didn't provide me with a great deal of relief. I bought the tablets from an online pharmacy which I had not used before, so it is possible that the product I was taking was not genuine. I'd rate my confidence at around 75% that I was taking the real thing.

I've also tried L-Tyrosine (amino acid), selegiline and Bupropion, which are supposed to have a substantial effect on dopamine levels, but didn't help my POIS very much. The deservedly-reviled cigarette is my best dopamine-based weapon against POIS - nicotine is supposed to raise dopamine levels, but it doesn't work particularly well. I would never ever recommend somebody started smoking to help their POIS.

Fenugreek is still my best aid for POIS, although the B6 I tried was giving good results until I ran out of tablets. It's  difficult to buy in my current location.
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16870 on: 01/07/2012 05:18:17 »
I will follow the average opinion about  quality of my English.
Therefore I need yours also. Otherwise I remove better my replies.
 thank you. Please reed                        http://poiscenter.com/forums/index.php?topic=426.msg4911#msg4911

tantalus, I can understand most of what you write, but it's true that it would help if you could try to clear up your english a little if that's possible for you. But if it's not possible then I still want you to keep posting. Also I think there was some sort of misunderstanding between you and another member here. I just want to let you know that you are very welcome here. I found your posts interesting and helpful to our cause : )
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16871 on: 01/07/2012 08:30:34 »
I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16872 on: 01/07/2012 08:45:35 »
I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.

Wellbutrin is sometimes called Bupropion, just in case anybody is wondering what it is and how it works.  http://en.wikipedia.org/wiki/Bupropion
 

Offline Scribblz

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16873 on: 02/07/2012 02:42:14 »
As a new member, I am relieved to know I'm not the only person inflicted by this disorder. I ama 20 year old Irish lad, currently afflicted by POIS, and its disrupting my work life and causing me to avoid masturbation and sex.

This started when I was 14, when I masturbated for the first time. I was scared stiff at what was happening at first, and I couldnt sleep for that night. Over the next few weeks, I felt nauseous, unwilling to eat, a strange sensation in my testicles which caused them to harden  which freaked me out immensely, and a fever.
I was constantly unfocused and unable to sleep.

Since then, I masturbate regularly and have occasional sex. Now its happened again and I feel downright awful. This time around though, I'm suffering from constipation, leading to the inability to urinate properly and vomiting, as well as dizzy spells and lack of sleep. I have avoided masturbation and sexual intercourse until the symptoms subside completely because I'm scared it may happen again. I'm too embarrassed to tell anyone, or go to a doctor about it, so I came here seeking guidance and a possible remedy to this problem.

Can anyone help me out?
 

Offline Hoping

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16874 on: 02/07/2012 05:38:49 »
I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.

Wellbutrin is sometimes called Bupropion, just in case anybody is wondering what it is and how it works.  http://en.wikipedia.org/wiki/Bupropion
I've been taking Wellbutrin/Bupropion for the last few years and upped my dosage fairly recently. B_Daniel, I'll send you a PM.
 

The Naked Scientists Forum

Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16874 on: 02/07/2012 05:38:49 »

 

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