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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6450824 times)

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16975 on: 18/07/2012 08:34:19 »
How much of the B complex are you taking?  That would be my last dosage question.

Also, are you still taking Magnesium and Zinc

With B6, B12, Krill, Magnesium and Zing I have definitely felt different.  I have been abstaining for the past 2 weeks because I became quite depressed and needed to back off the sexual activity, so I can't tell you if I have reduced POIS symptoms.  As far as my other health issues go, I had a very interesting few experiences where I was able to feel anger and act on it.  For the majority of my life, I have been very passive and felt like I had become numb to my anger in order to avoid conflict.  This has been a bad thing, but the past week I have been able to act upon subtle feelings of anger with positive results.  Some people might not see this as positive but I definitely do lol!  I have had such an issue expressing my anger thus resulting in depression.

This has been the main positive effect.  Other than that, I have felt "different" in ways I can't quite describe, which is why I'm wondering if I need to increase my dosing to really see what is being effected.

Bottom line is it has given me desire to keep it up!

I am taking medications for my psychiatric issues which could be making this hard for me to figure out what is going on.  I want to pick up those Coenzymated vitamins.  I'll let you know how I do!

P.S.: Join poiscenter.com/forums!  Demo will make sure you get thru the spam filter :)

I still take ZMA most nights. If I don't, then I don't remember my dreams. I've said before that, for whatever reason, when I have dream recall I'm much more productive the next day. I'll PM you with a link to the b-supplement I take.  It has CoQ10 and ALA as well as b vitamins. It's available from some "major online retailers" :)

Querctin and bilobalide have been shown to have neurogenic effects (not in people as yet I think) but my understanding is that people who get a boost from ginkgo have generally being using it for quite a while. A relative of mine said it took 6 months for a really dramatic improvement in memory. I don't think it's a good idea to just take lots of ginkgo or huperzine (>200mcg for instance) as there are reports on internet fora of people becoming quite manic when they did that. Steady consumption with some days off are best.

Ideally, I'd just keep taking the B's, add the ginkgo every day and take some huperzine A every time my eyes bother me. I wish I had just 1 pill to deliver the improvement I want but I've found 1 website where you can do this and I'd have to test whatever they shipped to know it was what I asked for.
 
I have joined poiscenter forums. However, I only check there once a week. I'm sorry I haven't posted much.  I have a lot to do and I look at other NSF threads so this is 1 that I stop by every day or so.
 

Offline FireCat

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16976 on: 19/07/2012 00:02:27 »
So, I've been on Niacin and B12 for a week now.

I do say that Niacin works great on me, but I'm not sure whether this can be a total cure.
I have flush on my skin for the first time today, and I have to adjust the amount I take.

Otherwise, they reduced back and neck pains after orgasm, and I appreciated the effect.
The downside seems to be that they seem to raise sexual appetite, and it was hard for me to go without some ejaculation during the week. I was gradually getting dull when I beared from it for several days.

Hopefully, I can soon find a point to comporomise.
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16977 on: 19/07/2012 06:02:40 »
I'd like to re-post and say that Wellbutrin, taking one 150mg XR pill every 3 days, works quite well.  I feel 50-75% better and am more productive than ever.  To those of you with Constant POIS, this is a game-changer.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16978 on: 19/07/2012 10:41:18 »
I'd like to re-post and say that Wellbutrin, taking one 150mg XR pill every 3 days, works quite well.  I feel 50-75% better and am more productive than ever.  To those of you with Constant POIS, this is a game-changer.
As it's mentioned in the study below, if you're taking testosterone at the same time it can help. T participates in the antidepressant action of a noradrenaline reuptake inhibitor (Wellbutrin is also a NRI).
http://www.ncbi.nlm.nih.gov/pubmed/15301926
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16979 on: 19/07/2012 15:39:03 »
I'd like to re-post and say that Wellbutrin, taking one 150mg XR pill every 3 days, works quite well.  I feel 50-75% better and am more productive than ever.  To those of you with Constant POIS, this is a game-changer.
As it's mentioned in the study below, if you're taking testosterone at the same time it can help. T participates in the antidepressant action of a noradrenaline reuptake inhibitor (Wellbutrin is also a NRI).
http://www.ncbi.nlm.nih.gov/pubmed/15301926

Perhaps that's so, but I stopped taking Testosterone 2 months ago and the Wellbutrin, only taken 1 per 3 days, still helps a lot.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16980 on: 19/07/2012 19:00:08 »
I'd like to re-post and say that Wellbutrin, taking one 150mg XR pill every 3 days, works quite well.  I feel 50-75% better and am more productive than ever.  To those of you with Constant POIS, this is a game-changer.
As it's mentioned in the study below, if you're taking testosterone at the same time it can help. T participates in the antidepressant action of a noradrenaline reuptake inhibitor (Wellbutrin is also a NRI).
http://www.ncbi.nlm.nih.gov/pubmed/15301926
noradrenaline and dopamine reuptake inhibitor.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16981 on: 20/07/2012 08:35:29 »
Krill Oil.
I have in the past taken fish oil capsules (good quality brand) and never noticed anything for the better while on them, so was off and on them over the years. Recently I have started taking a good quality distilled artic cod liver oil which has DHA/EPA/Omega3.
I have been reading good things about krill oil, but then I have also read other articles that say that while its is a great supplement it is over hyped and over priced compared to regular fish oils. I realise its hard to isolate a specific item, when one is taking multiple supplements, but for those that are taking Krill oil, do you think it is any better than fish oil, just from personal experience?

I think it's better BUT it tends to be very expensive (2-3 times what other many fish oils cost) and I'm not convinced of the freshness of all KO supplements I've taken. The ones that help reduce POIS don't smell rancid. The slightly rancid smell (if that's possible) seems to indicate that key ingredients have degraded, perhaps the astaxanthin.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16982 on: 20/07/2012 08:51:33 »
How much of the B complex are you taking?  That would be my last dosage question.

Also, are you still taking Magnesium and Zinc

With B6, B12, Krill, Magnesium and Zing I have definitely felt different.  I have been abstaining for the past 2 weeks because I became quite depressed and needed to back off the sexual activity, so I can't tell you if I have reduced POIS symptoms.  As far as my other health issues go, I had a very interesting few experiences where I was able to feel anger and act on it.  For the majority of my life, I have been very passive and felt like I had become numb to my anger in order to avoid conflict.  This has been a bad thing, but the past week I have been able to act upon subtle feelings of anger with positive results.  Some people might not see this as positive but I definitely do lol!  I have had such an issue expressing my anger thus resulting in depression.

This has been the main positive effect.  Other than that, I have felt "different" in ways I can't quite describe, which is why I'm wondering if I need to increase my dosing to really see what is being effected.

Bottom line is it has given me desire to keep it up!

I am taking medications for my psychiatric issues which could be making this hard for me to figure out what is going on.  I want to pick up those Coenzymated vitamins.  I'll let you know how I do!

P.S.: Join poiscenter.com/forums!  Demo will make sure you get thru the spam filter :)

I still take ZMA most nights. If I don't, then I don't remember my dreams. I've said before that, for whatever reason, when I have dream recall I'm much more productive the next day. I'll PM you with a link to the b-supplement I take.  It has CoQ10 and ALA as well as b vitamins. It's available from some "major online retailers" :)

Querctin and bilobalide have been shown to have neurogenic effects (not in people as yet I think) but my understanding is that people who get a boost from ginkgo have generally being using it for quite a while. A relative of mine said it took 6 months for a really dramatic improvement in memory. I don't think it's a good idea to just take lots of ginkgo or huperzine (>200mcg for instance) as there are reports on internet fora of people becoming quite manic when they did that. Steady consumption with some days off are best.

Ideally, I'd just keep taking the B's, add the ginkgo every day and take some huperzine A every time my eyes bother me. I wish I had just 1 pill to deliver the improvement I want but I've found 1 website where you can do this and I'd have to test whatever they shipped to know it was what I asked for.
 
I have joined poiscenter forums. However, I only check there once a week. I'm sorry I haven't posted much.  I have a lot to do and I look at other NSF threads so this is 1 that I stop by every day or so.

It's still working :) Feel great.
I priced up an all-in-1 formula, less the fish oil, on vitaganic.com but the cost was steep. An average of around $45 month. I'll going to keep trying the individual supplements for a few more weeks and make 100% sure that I still feel as great then as I do now before making that kind of investment.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16983 on: 20/07/2012 13:22:06 »
Perhaps that's so, but I stopped taking Testosterone 2 months ago and the Wellbutrin, only taken 1 per 3 days, still helps a lot.
Thanks for reporting. 3 POIS cases (old members) (or more) tried Wellbutrin, I don't know the dosage. One had a bad reaction and had to stop, an other had no effect on his POIS, and the third had a positive effect but not enough. An other example that everyone must do his own experience. Hope you'll keep us updated.

 

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16984 on: 21/07/2012 00:08:55 »

It's still working :) Feel great.
I priced up an all-in-1 formula, less the fish oil, on vitaganic.com but the cost was steep. An average of around $45 month. I'll going to keep trying the individual supplements for a few more weeks and make 100% sure that I still feel as great then as I do now before making that kind of investment.

So far so good for me, I'm feeling better physically for sure, and mentally pretty sure...  I have experienced something I'll call "mental numbness" after taking something, probably Magnesium Zinc or B6.  I wonder if Lithium is suppressing my cognitive improvement off these supplements.  Lithium is known to cause confusion.  I take Seroquel which causes somnolence and generally fatigues me on both physical and mental levels.
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16985 on: 21/07/2012 01:10:03 »
B_Daniel, I read that wellbutrin has an effect similar to that of amphetamine type stimulants and I was wondering how your experience with wellbutrin compares to the effects you got from ritalin.

The fact that Wellbutrin is a norepinephrine reuptake inhibitor makes me weary of considering taking it since Effexor, also a norepinephrine reuptake inhibitor, gave me so many bad side effects.

I'm glad that it's helping you though.
 

Offline fidalgo

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16986 on: 21/07/2012 02:51:46 »
Good Night. I am with a doubt. I see a lot of you saying about Constant POIS but I don't understand if i have it or not.

My case is that my symptoms improve a lot without ejaculation but I never feel normal. When you say that your POIS is over after 7 days, are you saying that the most symptoms improve or that you are normal after 7 days? I have a wonderful improve after 7 days but I never seem to be normal. My problem with food, for example, never ends. This is constant POIS?
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16987 on: 21/07/2012 08:15:42 »
B_Daniel, I read that wellbutrin has an effect similar to that of amphetamine type stimulants and I was wondering how your experience with wellbutrin compares to the effects you got from ritalin.

The fact that Wellbutrin is a norepinephrine reuptake inhibitor makes me weary of considering taking it since Effexor, also a norepinephrine reuptake inhibitor, gave me so many bad side effects.

I'm glad that it's helping you though.

Thanks Vincent M.  I think the benefit I get from Wellbutrin is similar in many ways to that which I've gotten from Ritalin.  Here's the difference - Ritalin I get scared to take.   It's like a commitment.  It only lasts 6 hours and even at very low doses it's too intense for me.  Also, Ritalin sometimes clears my head and other times doesn't.  I take 1 Wellbutrin and I feel the effect for 3 days.  It works every time, and I never get scared to take it but rather excited to soon feel pretty good again.  Also, I don't know a ton about wellbutrin, but i've heard it's chemically very different from anything else out there - so I wouldn't paint it with the same brush as all norepinephrine reuptake inhibitor.  In regards to your 3rd point, the Effexor having bad side effects, I address that below.   

Martin - There are mixed reviews of Wellbutrin.  Demo took it for one day and it didn't agree with his body.  But on the whole, the ppl that don't speak highly of it are those that took it for 6+ weeks.  I'd venture to guess very few of us have tried to take it in the method I suggest.  By taking it 1 day on, 3 days off, you shouldn't see the same side effects.  Also, you can always stop taking it very easily, with no withdrawal period, as by taking it so infrequently you never allow the drug to build up in your body. 

I'll repeat this 100 times, Wellbutrin isn't perfect, but for the first time, I'm beginning to feel like I'm getting my life back. 
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16988 on: 21/07/2012 11:06:22 »
B_Daniel, I read that wellbutrin has an effect similar to that of amphetamine type stimulants and I was wondering how your experience with wellbutrin compares to the effects you got from ritalin.

The fact that Wellbutrin is a norepinephrine reuptake inhibitor makes me weary of considering taking it since Effexor, also a norepinephrine reuptake inhibitor, gave me so many bad side effects.

I'm glad that it's helping you though.

Thanks Vincent M.  I think the benefit I get from Wellbutrin is similar in many ways to that which I've gotten from Ritalin.  Here's the difference - Ritalin I get scared to take.   It's like a commitment.  It only lasts 6 hours and even at very low doses it's too intense for me.  Also, Ritalin sometimes clears my head and other times doesn't.  I take 1 Wellbutrin and I feel the effect for 3 days.  It works every time, and I never get scared to take it but rather excited to soon feel pretty good again.  Also, I don't know a ton about wellbutrin, but i've heard it's chemically very different from anything else out there - so I wouldn't paint it with the same brush as all norepinephrine reuptake inhibitor.  In regards to your 3rd point, the Effexor having bad side effects, I address that below.   

Martin - There are mixed reviews of Wellbutrin.  Demo took it for one day and it didn't agree with his body.  But on the whole, the ppl that don't speak highly of it are those that took it for 6+ weeks.  I'd venture to guess very few of us have tried to take it in the method I suggest.  By taking it 1 day on, 3 days off, you shouldn't see the same side effects.  Also, you can always stop taking it very easily, with no withdrawal period, as by taking it so infrequently you never allow the drug to build up in your body. 

I'll repeat this 100 times, Wellbutrin isn't perfect, but for the first time, I'm beginning to feel like I'm getting my life back. 

Hi,
Just like to make a few points on this.
1) Wellbutrin will increase your dopamine levels. That makes it a very different treatment to the SSRI anti-depressants most of us have been prescribed for POIS. It's also very different to ritalin and will have very different long term side effects from its use. Even if someone told me ritalin would cure POIS I'd be very worried about taking it long term.

In all the technical details I posted about prostaglandins etc. it appears plausible that dopamine and other catecholamines are out of balance and wellbutrin would help fix that. If anybody has been sent to a psychiatrist to treat their POIS then they could do a lot worse than asking them if they could try wellbutrin.

2) Anyone who has a severe neurochemical balance problem (which an O might be triggering in POIS) could suffer a really bad reaction the first time they take a treatment that may work very well in the long run. One of the big problems is that the number of receptors for neurotransmitters in the brain reduces when there's too little of the neurotransmitter in the brain. The brain strives for efficiency and tries to do more with less but it can't work miracles so the sufferer feels flat, depressed, slow-thinking etc. The treatment increases the levels of neurotransmitters which floods your brain initially. Psychiatrists do their best to vary doses to find the right level but it's not exact and everyone is different.

This is a known problem with some other anti-depressants where someone can experience severe mood swings and may feel physically sick in the first few days. It's not a reason to stop taking it and you should consult the psychiatrist who prescribed it immediately.

I don't think anybody could write off the benefit of wellbutrin to them without trying it first _under medical supervision_
 

Offline msl

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16989 on: 21/07/2012 14:29:27 »
Hey everyone,

I'd like to introduce myself. I have actually been on and off visiting and reading the posts on this forum for many years. Well, I found it a while back but then stopped visiting for a period. I first noticed POIS when I was about 15. At first I would be perhaps at most 2 days ill afterward... but then over time this grew to the present 7 days. My complaints are exclusively cognitive. I feel very very slow mentally with difficulty concentrating.... well actually no... I can concentrate but everything requires much much more effort mentally than usual and sometimes I am unable to accomplish what would normally be trivial. Recalling information becomes hard. I have difficulty speaking and recalling words. This was particularly frustrating when I had a nocturnal emission before my german oral exams at school. My behaviour becomes completely different. I am admittedly a bastard to everyone around me. I first shared it with my parents when I become extremely bitter/angry/depressed when I had a nocturnal emission very shortly before a large chemistry A-level exam. As you have probably guessed, I do not masturbate and have no partner, hence why I have these nocturnal emissions from time to time. I shared it with my parents back then but they were largely skeptical and even to this day they think it is all in my head and accuse me of being a hypochondriac. I went to the Doctor and he gave me Prozac primarily because of the side-effect which decreases libido, for the purpose that this would lower the frequency of NEs. I took that for a while and then stopped. I revisited the doctor then at university to try and push this all further and was met with scepticism and disbelief. I guess I visited two more doctors at this stage. I had my first year exams at university and I had more NEs due to the stress. I complained to my parents but all they said was "Well its just the stress" "Its the stress thats doing this...". I visited the mental health counsellor at university and she was the first to take me seriously. She referred me to a genitourinary specialist at the erectile dysfunction place at the hospital who gave me a physical exam and quickly passed me on to another specialist, namely a sexual psychotherapist. He again tried to tell me that this is all in my head. At this point, even I was beginning to question my own judgement and sanity. I figured... maybe I should just lighten up and have sex.. for fun. But obviously this did not work. At this point, I was so fed up and despairing with all of the doctors I had seen (I had visited other GPs in between), so I gave up. I dont engage in any sexual activity whatsoever. I gave up on the hope of a relationship with a girl. I accepted that I would be alone in life. And what is more, I would even be happy in this life, if it were not for these NEs happening still. I went back to prozac and then went off it again. I distinctly remember a very ill week in my 3rd year of university, on the week when my first exams would begin. I worked so hard for these exams and then an NE, I was incensed. I stopped reading this forum at a point because there were really so many different "remedies" that people had come up with that it was becoming a bit ridiculous (i don't mean to offend). It seems everyone was clutching at straws and out of desperation latching on to something which claimed to help. If a medical practitioner saw this and didn't give it any credibility, I would forgive him for that. It seems anything from wheat-grass to herbs to anticonvulsants to antihistamines to hormone injections are helping people. This does not give our condition any credibility, in fact, it makes it lose credibility. That there are so many different remedies suggests that this is a psychological condition, when everyone here knows that it certainly is not! I think that peoples judgement on something helping is biased by their absolute desperation and hope that it will help.  If this is a real objective condition then there is an absolute etiology for these symptoms and hence there must exist a definite mechanism by which a medication would help, they cannot all be working.

I have been in touch with two guys, namely, victor and juan-pablo. They have been very supportive and from them I have learned about Niacin and the recent papers. I am curious about the autoimmune hypothesis proposed by Waldinger. However, I am still sceptical. Firstly, symptoms are supposed to alleviate with desensitization treatment. But I've already been exposing my body to my own semen for years, without it getting better! This does not agree with Waldinger. Secondly, there was no control group in his work, he explicitly mentions this in his paper:

"Although the current study supports our
hypothesis of an immunogenic reactivity against
autologous semen, the current study contains an
important limitation due to the current prelimi-
nary observational design. One of the main ques-
tions that still needs answering is whether clinical
and immunogenic responses post-ejaculation are
different in two intentionally recruited groups,
e.g., individuals with POIS criteria vs. a control
group. In other words, the current study does not
provide data on sensitivity and specificity of skin-
***** testing in POIS. Another intriguing question
is whether hyperreactivity against autologous
semen is confined to POIS or to a common phe-
nomenon in the general population.
"

Put it this way, what would a skin-test show on a normal person with no POIS symptoms? It would not surprise me if they too had a reaction, afterall, semen is not meant to be injected directly into the bloodstream. Moreover, he concludes that it is a semen allergy because men to stopped before ejaculating did not experience the symptoms. For me personally, ejaculation coincides with orgasm. So why could it not in fact be the orgasm that is causing POIS and not the ejaculation?

I am personally worried about the auto-immune hypothesis. Auto-immune responses are always to do with inflammation. I would be very worried if it were the brain that is becoming inflamed and is causing these cognitive defects. I would like to ask if anyone has had an MRI scan WHILST IN POIS to see if there is anything abnormal. In Waldingers papers with the two case studies it says that nothing normal is observed in the MRI, but it does not say whether the patient is in a POIS episode or not.

I scored the highest mark in A-level chemistry in the end, I was also given the sixth form prize for mathematics and performance in A-levels. I recently got a masters in physics and was awarded the departmental prize for performance in examinations. Now I have a fellowship to do a PhD in the US. As I gave up on a regular life and relationship, my mind is my most treasured asset. Recently a dangerous idea has began to grow in my mind, that these POIS symptoms might cause damage and that it is not 100% reversible after 7 days (again, symptoms peak in 2 days). I cannot seem to shake this idea and it is really troubling me, as I don't feel as sharp as I used to be...
 

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16990 on: 21/07/2012 15:28:16 »
IT WORKS.

That in short is the message I am saying today about the vitamin regimin that our friend *kurtosis* has been working on and taking himself.  After taking the supplements he has been recommending for 2-3 weeks, I decided to have an orgasm *without niacin* and there were VIRTUALLY NO SYMPTOMS.  I'd say I was safely 90 to 95% better then after an "O" without any treatment!

I've been moving more towards the vitamin deficiency/absorption hypothesis after trying to figure out why the niacin flush helps us, and kurtosis has provided a coherent theory and treatment that works for me.  You should try it and see if it works for you.

kurtosis and myself both believe that the post-orgasm symptoms are not the only symptoms we face from this issue, and that there might be more benefit in the future with continued use of these vitamins/herbs.  I will be continuing my supplementation and I will be happy to answer more about this to anyone interested!
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16991 on: 21/07/2012 20:00:36 »
IT WORKS.

That in short is the message I am saying today about the vitamin regimin that our friend *kurtosis* has been working on and taking himself.  After taking the supplements he has been recommending for 2-3 weeks, I decided to have an orgasm *without niacin* and there were VIRTUALLY NO SYMPTOMS.  I'd say I was safely 90 to 95% better then after an "O" without any treatment!

I've been moving more towards the vitamin deficiency/absorption hypothesis after trying to figure out why the niacin flush helps us, and kurtosis has provided a coherent theory and treatment that works for me.  You should try it and see if it works for you.

kurtosis and myself both believe that the post-orgasm symptoms are not the only symptoms we face from this issue, and that there might be more benefit in the future with continued use of these vitamins/herbs.  I will be continuing my supplementation and I will be happy to answer more about this to anyone interested!

That is the best news I've heard this month!  Congratulations Nightingale!
 

Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16992 on: 21/07/2012 20:26:12 »
I know! Kurtosis, you rock for figuring that recipe out! :) I'm anxious to try it out and am ordering the ingredients now. I hope it works for me and for many others, but one never knows because everyone's different. Still gonna try out it though. Niacin doesn't work that well for me, even at 600mg.
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16993 on: 22/07/2012 00:53:08 »
I know! Kurtosis, you rock for figuring that recipe out! :) I'm anxious to try it out and am ordering the ingredients now. I hope it works for me and for many others, but one never knows because everyone's different. Still gonna try out it though. Niacin doesn't work that well for me, even at 600mg.

I can't promise it will work guys. However, can I suggest 2 things if you're going to go down this route.
1) don't give up on the supplements after a few days. If you buy them, take each for the month or so of capsules in the bottle (as directed) and don't expect an overnight cure.
2) get some aerobic exercise (long walks is enough) and try to calm some of your anxiety about POIS. I know this is incredibly difficult but you have give your brain some time to heal and cortisol from anxiety and stress will, in itself, prevent you from getting over POIS.

The stress of knowing that you have an illness that's affecting your cognitive ability will _itself_ harm you. You have to somehow deal with it and exercise like brisk walking can help reduce your cortisol levels. 
 

Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16994 on: 22/07/2012 08:35:55 »
I tracked down all the ingredients today - with the exception of huperzine which i'll find tomorrow or order online- and i'm going to give your recipe a real shot, Kurtosis.  I have a lot of respect for both you and Nightingale, so I'm hopeful that this helps!  I'll keep everyone posted.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16995 on: 22/07/2012 13:24:39 »
I complained to my parents but all they said was "Well its just the stress" "Its the stress thats doing this...". I visited the mental health counsellor at university and she was the first to take me seriously. She referred me to a genitourinary specialist at the erectile dysfunction place at the hospital who gave me a physical exam and quickly passed me on to another specialist, namely a sexual psychotherapist.
He again tried to tell me that this is all in my head.
Hi, I think they say it's stress because it's stress, but they're missing the whole picture, the problem is our tolerance to stress, and this is a physical part in my opinion. To illustrate what I'm saying: women will cry easily while men won't for the same thing. When this is happening, is it psychological? Yes there's always a triggering event , but still women are crying more often than men and there's obviously something hormonal behind it.

I gave up on the hope of a relationship with a girl. I accepted that I would be alone in life.
Don't give up! There's a woman for each possible kind of men in this world.

If a medical practitioner saw this and didn't give it any credibility, I would forgive him for that. It seems anything from wheat-grass to herbs to anticonvulsants to antihistamines to hormone injections are helping people. This does not give our condition any credibility, in fact, it makes it lose credibility.
That there are so many different remedies suggests that this is a psychological condition, when everyone here knows that it certainly is not! I think that peoples judgement on something helping is biased by their absolute desperation and hope that it will help.  If this is a real objective condition then there is an absolute etiology for these symptoms and hence there must exist a definite mechanism by which a medication would help, they cannot all be working.
I tought the same thing after reading some posts. I think some people are constantly in a state "very close from the cure" like an heart arrhythmia would come and go. When I was around 25 I could have frequent cure by just doing exercise or eating something but it was temporary. Now that I'm older I'm a lot more constant (never cured). At least you'll admit that some remedies are working better and more often than others. Stats are important for us. About credibility a lot of us didn't have some even before this forum anyway.

For me personally, ejaculation coincides with orgasm. So why could it not in fact be the orgasm that is causing POIS and not the ejaculation?
We don't know. I have a short and mild POIS from sexual activity without orgasm although that means nothing since there could be (for example) some neurons firing using energy in both cases.
« Last Edit: 22/07/2012 18:07:00 by martin88 »
 

Offline Nightingale

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16996 on: 22/07/2012 15:58:16 »
kurtosis, I've found the ZMA on a "major online retailer" :)  Says serving size is 3 capsules.  Is that how much you take?
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16997 on: 22/07/2012 16:08:05 »
kurtosis, I've found the ZMA on a "major online retailer" :)  Says serving size is 3 capsules.  Is that how much you take?
I take 750mg a night.  It's not necessary to take more ZMA when you're taking the b-co-enzymes.
You could also just buy zinc & magnesium and take these with a 2nd co-enzyme capsule. I've done this and it worked also (as in I remembered my dreams and felt good the next day). It's up to you.
 

Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16998 on: 22/07/2012 16:37:47 »
Hey everyone,

I'd like to introduce myself. I have actually been on and off visiting and reading the posts on this forum for many years. Well, I found it a while back but then stopped visiting for a period. I first noticed POIS when I was about 15. At first I would be perhaps at most 2 days ill afterward... but then over time this grew to the present 7 days. My complaints are exclusively cognitive. I feel very very slow mentally with difficulty concentrating.... well actually no... I can concentrate but everything requires much much more effort mentally than usual and sometimes I am unable to accomplish what would normally be trivial. Recalling information becomes hard. I have difficulty speaking and recalling words. This was particularly frustrating when I had a nocturnal emission before my german oral exams at school. My behaviour becomes completely different. I am admittedly a bastard to everyone around me. I first shared it with my parents when I become extremely bitter/angry/depressed when I had a nocturnal emission very shortly before a large chemistry A-level exam. As you have probably guessed, I do not masturbate and have no partner, hence why I have these nocturnal emissions from time to time. I shared it with my parents back then but they were largely skeptical and even to this day they think it is all in my head and accuse me of being a hypochondriac. I went to the Doctor and he gave me Prozac primarily because of the side-effect which decreases libido, for the purpose that this would lower the frequency of NEs. I took that for a while and then stopped. I revisited the doctor then at university to try and push this all further and was met with scepticism and disbelief. I guess I visited two more doctors at this stage. I had my first year exams at university and I had more NEs due to the stress. I complained to my parents but all they said was "Well its just the stress" "Its the stress thats doing this...". I visited the mental health counsellor at university and she was the first to take me seriously. She referred me to a genitourinary specialist at the erectile dysfunction place at the hospital who gave me a physical exam and quickly passed me on to another specialist, namely a sexual psychotherapist. He again tried to tell me that this is all in my head. At this point, even I was beginning to question my own judgement and sanity. I figured... maybe I should just lighten up and have sex.. for fun. But obviously this did not work. At this point, I was so fed up and despairing with all of the doctors I had seen (I had visited other GPs in between), so I gave up. I dont engage in any sexual activity whatsoever. I gave up on the hope of a relationship with a girl. I accepted that I would be alone in life. And what is more, I would even be happy in this life, if it were not for these NEs happening still. I went back to prozac and then went off it again. I distinctly remember a very ill week in my 3rd year of university, on the week when my first exams would begin. I worked so hard for these exams and then an NE, I was incensed. I stopped reading this forum at a point because there were really so many different "remedies" that people had come up with that it was becoming a bit ridiculous (i don't mean to offend). It seems everyone was clutching at straws and out of desperation latching on to something which claimed to help. If a medical practitioner saw this and didn't give it any credibility, I would forgive him for that. It seems anything from wheat-grass to herbs to anticonvulsants to antihistamines to hormone injections are helping people. This does not give our condition any credibility, in fact, it makes it lose credibility. That there are so many different remedies suggests that this is a psychological condition, when everyone here knows that it certainly is not! I think that peoples judgement on something helping is biased by their absolute desperation and hope that it will help.  If this is a real objective condition then there is an absolute etiology for these symptoms and hence there must exist a definite mechanism by which a medication would help, they cannot all be working.

I have been in touch with two guys, namely, victor and juan-pablo. They have been very supportive and from them I have learned about Niacin and the recent papers. I am curious about the autoimmune hypothesis proposed by Waldinger. However, I am still sceptical. Firstly, symptoms are supposed to alleviate with desensitization treatment. But I've already been exposing my body to my own semen for years, without it getting better! This does not agree with Waldinger. Secondly, there was no control group in his work, he explicitly mentions this in his paper:

"Although the current study supports our
hypothesis of an immunogenic reactivity against
autologous semen, the current study contains an
important limitation due to the current prelimi-
nary observational design. One of the main ques-
tions that still needs answering is whether clinical
and immunogenic responses post-ejaculation are
different in two intentionally recruited groups,
e.g., individuals with POIS criteria vs. a control
group. In other words, the current study does not
provide data on sensitivity and specificity of skin-
***** testing in POIS. Another intriguing question
is whether hyperreactivity against autologous
semen is confined to POIS or to a common phe-
nomenon in the general population.
"

Put it this way, what would a skin-test show on a normal person with no POIS symptoms? It would not surprise me if they too had a reaction, afterall, semen is not meant to be injected directly into the bloodstream. Moreover, he concludes that it is a semen allergy because men to stopped before ejaculating did not experience the symptoms. For me personally, ejaculation coincides with orgasm. So why could it not in fact be the orgasm that is causing POIS and not the ejaculation?

I am personally worried about the auto-immune hypothesis. Auto-immune responses are always to do with inflammation. I would be very worried if it were the brain that is becoming inflamed and is causing these cognitive defects. I would like to ask if anyone has had an MRI scan WHILST IN POIS to see if there is anything abnormal. In Waldingers papers with the two case studies it says that nothing normal is observed in the MRI, but it does not say whether the patient is in a POIS episode or not.

I scored the highest mark in A-level chemistry in the end, I was also given the sixth form prize for mathematics and performance in A-levels. I recently got a masters in physics and was awarded the departmental prize for performance in examinations. Now I have a fellowship to do a PhD in the US. As I gave up on a regular life and relationship, my mind is my most treasured asset. Recently a dangerous idea has began to grow in my mind, that these POIS symptoms might cause damage and that it is not 100% reversible after 7 days (again, symptoms peak in 2 days). I cannot seem to shake this idea and it is really troubling me, as I don't feel as sharp as I used to be...

I know what you mean that it must look chaotic for an outsider reading this site, and how it must appear that we have all bought into a myth that allows us to understand our difficuties in a more acceptable way. But the truth is, that isn't the truth. POIS, or whatever it is called that I have had all my life is very real, and maybe it is something a person can't imagine unless they have it. But until it is understood better we will always have a psychological illness in the minds of most health care providers. That shouldn't anger us, as we might have difficulty believing it if we didn't have it.

And yes desperate people will search high and low for answers. I think we have made some real progress finding things that will help us, and these will hopefully shed light on the cause of the problem, eventually. I have personally been helped by an anti-inflammatory diet, and fenugreek has also helped.
 

Offline tonytwoton

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16999 on: 22/07/2012 20:45:58 »
Just a quick update guys. After the initial period of extreme fatigue from taking b12 cyanocobalamin as well as oral methylcobalamin and adenosylcobalamin, I have suddenly noticed a large uptick in energy and cognitive performance as well as a small increase in libido. I think I am making progress because mentally, I have not felt this good in a long time. Still have not tried to have an O because still not strong enough yet. Nerves take a long time to heal so will keep you updated.
 

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #16999 on: 22/07/2012 20:45:58 »

 

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