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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6435941 times)

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17575 on: 08/01/2013 17:20:31 »
so basiciallly    in    the normal POIS,   thyroid  makes your  adrenal  pump harder.  And   cortisol is usually high ,  since cortisol  is pumped to  create RT3 hormone to stop   the thryoid affect... This  the  ratio of dopamine/serotonin is   not right and also  conversion  of noradrenaline  into  adrenaline.    That is why  naicin works,   it grabs methyl   and  inhibits conversion of noradrenaline to adrenaline.

Herman
 

Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17576 on: 08/01/2013 17:22:08 »
We allowed to post here if we keep it scientific. Keeping it scientific means providing evidence.
If you did not just come up with this theory out of nowhere then you should past evidence you can easily provide.
nobody is competing or trying to attack you, we just want evidence.

I'm not even sure there's a moderator any more. Like Elvis, they may have left the building :)
 

Offline Gbolduev

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Offline Gbolduev

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Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17579 on: 08/01/2013 17:50:09 »
Interesting, Kurtosis. I have read a bit about H3 receptor inverse agonists and they do seem to have a lot of potential. It'd be interesting to see how they'll do when they hit the market.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17580 on: 08/01/2013 17:54:18 »
Norepinephrine
Also known as:   NE;  Noradrenaline;  Levarterenol
Description
Catecholamine Stimulatory Neurotransmitter that is chemically similar to Adrenaline.
Beneficial Biological Functions of Norepinephrine
Norepinephrine possesses Life Extension potential:
-   A high ratio of Serotonin/NE accelerates the Aging Process.
-   A low ratio of Serotonin/NE slows down the Aging Process.
Immune System
NE stimulates the release of Hormones that provide the Thymus Gland with correct instructions.
Metabolism
NE alleviates Obesity (by stimulating the body's Brown Adipose Tissue to utilize other Adipose Tissue in the production of Energy).
Nervous System
Norepinephrine is produced and secreted by the Adrenal Medulla.
   Norepinephrine controls the Adrenergic Nervous System (a component of the Autonomic Nervous System).
   Age related decline in NE levels are associated with Age Related Memory Decline.
   Persons afflicted with Alzheimer's Disease usually have insufficient Norepinephrine in their Brains [scientific research - humans].
NE depletion can cause Apathy.
   NE suppresses Appetite.
   NE stimulates Beta-1 Adrenergic Receptors.
   NE stimulates Beta-2 Adrenergic Receptors (although NE has less affinity with these Receptors than does Adrenaline).
NE is involved in Moods (due to its central role in the excitatory drives associated with mood and Emotion).
   NE deficiency is a major cause of Depression.
   NE enhances Learning.
   NE enhances Memory.
Norepinephrine helps to minimize the sensation of Pain:
-   Norepinephrine travels via a descending pathway that originates in the Locus Coeruleus of the Medulla of the Brain and terminates in the Dorsal Horn of the Spinal Cord to inhibit the release of Substance P (the Neuropeptide that initiates Nerve Impulses relating to Pain).
Sexual System
NE increases Sexual Desire.
Norepinephrine Enhances the Function of these Substances
Hormones
NE is the immediate precursor of Adrenaline:
NE is required for the release of human Growth Hormone (hGH).
   Norepinephrine stimulates the release of Luteinising Hormone Releasing Hormone (LHRH) from the Hypothalamus.
   The nightly production of Melatonin occurs primarily as a result of NE release from postganglionic sympathetic Neurons that terminate in the Pineal Gland:
-   Following its release from these Neurons, Norepinephrine interacts with Adrenergic Receptors which (via a specific G-Protein) in turn activate Adenyl Cyclase in the Membrane of Pinealocytes (Cells of the Pineal Gland).
-   Activation of Adenyl Cyclase in the Pineal Gland increases the intracellular production of Cyclic AMP (cAMP) which then activates the N-
acetyl Transferase (NAT) enzyme (a precursor for Melatonin synthesis from N-acetyl Serotonin).
-   Approximately 85% of Melatonin produced in the Pineal Gland occurs as a result of Norepinephrine activating Beta-Adrenergic Receptors and approximately 15% occurs as a result of activation of Alpha-Adrenergic Receptors.
These Substances Enhance the Production or Release of Norepinephrine
Coenzymes - Electron Transport System
Nicotinamide Adenine Dinucleotide (NAD) is essential for maintaining proper levels of Norepinephrine in the Synapses of Neurons:
-   After Norepinephrine crosses the Neuron's Synapses it loses one electron to form oxidized Norepinephrine.  In the presence of NAD, this oxidized Norepinephrine then re-converts back to active Norepinephrine.  If there is a deficiency of NAD, the oxidized Norepinephrine loses another electron to irreversibly form Noradrenochrome.
-   NADH increases the production of Norepinephrine within the Brain.
Enzymes
Decarboxylases are required for the manufacture of NE.
Alkaloids
Yohimbine increases blood levels of Norepinephrine [scientific research - Yohimbine increases serum NE levels by up to 66%].
Amino Acids
Phenylalanine is a precursor for the endogenous production of Norepinephrine.
   Tyrosine is a precursor for the endogenous production of Norepinephrine.
Environmental Factors
Regular Exercise increases the production of Norepinephrine.
Methylxanthines
Caffeine increases Norepinephrine synthesis and release within the Brain [scientific research - animals].
Minerals
Calcium affects the function of NE.
   Copper is a cofactor for the Dopamine Beta-Hydroxylase enzyme (that catalyzes the conversion of Dopamine to Norepinephrine).
Organic Acids
Fumaric Acid stimulates the activity of the Dopamine Beta-Hydroxylase (that catalyzes the conversion of Dopamine to Norepinephrine).
Pharmaceutical Drugs
Many Tricyclic Antidepressants (including Amitryptiline, Desipramine and Imipramine) increase Norepinephrine levels within the Brain by blocking the reuptake of Norepinephrine into Alpha-1 Adrenergic Receptors (i.e. by functioning as Norepinephrine Reuptake Inhibitors), thereby increasing the availability and effects of NE [caution:  Tricyclic Antidepressants have numerous potentially toxic side-effects and contraindications].
Sibutramine inhibits the reuptake of Norepinephrine.
   Venlafaxine (a relatively new type of Pharmaceutical Antidepressant) inhibits the reuptake of Norepinephrine into Neurons.
Smart Drugs
Deprenyl totally inhibits the destruction of Norepinephrine by Monoamine Oxidase Type B (MAO-B):
-   Deprenyl blocks the re-uptake of NE from the Synapses between Neurons into the Storage Sites within Neurons (thereby increasing the level of Norepinephrine in its active state within the Synapes) - Deprenyl could therefore be described as a Norepinephrine Re-Uptake Inhibitor.
Idebenone enhances the endogenous production of Norepinephrine (by facilitating the cellular uptake of Tyrosine).
   Vinpocetine increases the Brain's turnover of Norepinephrine.
Vitamins
Vitamin C is a cofactor for the conversion of Dopamine to Norepinephrine by Dopamine Beta-Hydroxylase (it is converted to its Dehydroascorbic Acid form during this metabolic process).
These Herbs Enhance the Function of Norepinephrine
Ginkgo biloba stimulates the release of Norepinephrine within the body [scientific research].
   Ginsengs increase the body's Norepinephrine production when the body is under Stress [scientific research].
These Substances Interfere with or Block Norepinephrine
Enzymes
Monoamine Oxidase Type A (MAO-A) causes the breakdown (oxidation) of Norepinephrine to Dihydroxymendalic Acid [this activity is essential to keep Norepinephrine levels in check, however excessive MAO production can over-deplete Norepinephrine].
Flavoproteins
If Nicotinamide Adenine Dinucleotide (NAD) deficiency exists, Norepinephrine is oxidized to irreversibly form Noradrenochrome.
Neurotoxins
DSP-4 causes long-lasting depletion of Norepinephrine by damaging Noradrenergic Neurons.
Neurotransmitters
Gamma Aminobutyric Acid (GABA) inhibits the release of Norepinephrine (by binding to and activating GABAb Receptors).
Alkaloids
Cocaine causes depletion of Norepinephrine due to its over-stimulation of the Central Nervous System causing the sudden release and non-replacement of the body's reserves of NE.



Amino Acids
Tyramine causes over-stimulation of the Adrenal Glands, resulting in depletion of the body's Norepinephrine reserves.
Pharmaceutical Drugs - Amphetamine Derivatives
GABAb Receptor Agonists inhibit the release of Norepinephrine (by binding to and activating GABAb Receptors).
   Ritalin causes the sudden release of stores of NE and subsequent depletion and deficiency.
Recreational Drugs
Amphetamine causes the Brain to release NE and to block the recycling of NE, resulting in the high concentration of NE in the Synapses between Neurons that is responsible for the stimulatory effects of Amphetamine [however long term or excessive usage of Amphetamine causes NE depletion due to the large amounts of NE that are released but not replaced].
These Ailments Cause the Depletion of Norepinephrine
Adrenal Glands
Continual Stress causes the over-production of NE and its subsequent depletion.
Aging Process
The body's supplies of Norepinephrine decline in tandem with the Aging Process:
-   The number of Neuron Receptors for NE decline with the progression of the Aging Process.
-   The conversion of nutrients into NE declines with Age.
Metabolism
Hypoglycaemia causes NE deficiency.
Toxic Effects of Excessive NE Production
Cardiovascular System
Chronically elevated Norepinephrine levels can induce abnormal Blood Clotting (increasing the possibility of Thrombosis and Heart Attack).
Nervous System
Excessive NE production causes Schizophrenia.

Copyright 1997 In-Tele-Health
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17581 on: 08/01/2013 17:55:33 »
Kurtosis, notice the ratio of  serotonin to  noradernaline.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17582 on: 08/01/2013 18:17:31 »
Orgasm-Induced Catecholamine Imbalance via Pituitary Dysfunction
The psychiatric symptoms of dopamine depletion closely match those of POIS.  In a recent study, dopamine depletion was found to cause lessened fluency of speech, mental fatigue, confusion, loss of control over ideas, and poor concentration.  Given these close similarities between symptoms as well as dopamine’s essential role in the synthesis of catecholamines, which will be further discussed, it is arguable that an orgasm-induced deficiency of this neurotransmitter is significantly responsible for causing the psychiatric symptoms of POIS.

The physiological symptoms of excess norepinephrine, epinephrine, and cortisol also closely match those of POIS.  Abnormally high levels of the two catecholamines, norepinephrine and epinephrine, have been found to cause palpitations, insomnia, heightened blood pressure, feeling of uneasiness, heat, and sweating.  Overproduction of these catecholamines could potentially over-consume dopamine to abnormally low levels, and be the primary cause of the physiological symptoms of this syndrome.  Likewise, excess cortisol is known to aggravate these symptoms.

Immediately subsequent to orgasm, prolactin levels significantly increase and remain elevated for an extended period[ii].  It has been recently hypothesized that prolactin may modify the dopaminergic neurons in the nigrostriatal and mesolimbocoritcal system and the medial preoptic area as a means to alter sexual behavior (T.H. Kruger et al., 2003).  Animal studies have shown these sites are responsible for the regulation of genital responses, appetitive behavior, and motor activity (T.H. Kruger et al., 2003).  Although the inhibition of dopaminergic neurons by prolactin in these regions do not explain the psychiatric symptoms of POIS, it may clarify why some POIS sufferers experience light muscle tremors as the result of a potential overproduction of prolactin.  However, motor control is not significantly affected by POIS as people can still perform tasks requiring high dexterity and agility (i.e. playing piano). Blood testing has revealed abnormally high levels of prolactin in several of those known to have POIS.  So far, one of these individuals has attributed these elevated levels to a pituitary microadenoma located on the anterior lobe revealed by MRI scan.  The cause of high prolactin in others has not yet been determined.  However, it is evidence that suggest the pituitary gland is not properly functioning.

Similarly, norepinephrine and epinephrine levels peak upon orgasm and then return to basal levels (T.H. Kruger et al., 2003).  The synthesis of these catecholamines is accelerated by adrenocorticotropic hormone (ACTH) that is also secreted by the anterior lobe of the pituitary.  As a result, ACTH enhances the activity of two enzymes: tyrosine hydroxylase and dopamine β-hydroxylase.  Figure 1 below shows these enzymes in the biochemical pathway by which norepinephrine and epinephrine are synthesized.  If the anterior lobe of the pituitary is overproducing prolactin, then, by extension, ACTH might also be produced to abnormally elevated levels.  The only evidence supporting this contention is several POIS sufferers have reported having high ACTH levels.  ACTH also stimulates the release of cortisol to increase the expression of phenylethanolamine N­-methytransferase (PNMT) to enhance epinephrine synthesis (see Figure 1).

The potential overproduction or prolonged secretion of ACTH induced by orgasm may result in abnormally elevated levels of norepinephrine, epinephrine, and cortisol that could all give rise to the physiological symptoms.  So long as ACTH is present, dopamine is converted into norepinephrine at accelerated rates, which could potentially deplete this neurotransmitter and cause the psychological symptoms.  Moreover, the actions of prolactin during the post-orgasm stage is still largely unknown, making it more than possible for prolactin to directly inhibit dopamine secretion in the same manner dopamine inhibits prolactin secretion.


L. de HAAN, J. BOOIJ, J. LAVALYE, T. van AMELSVOORT, and D. LINSZEN,

“Subjective Experiences During Dopamine Depletion,” Am J Psychiatry, vol. 162, 2005, pp. 1755-. 

[ii] T.H. Kruger, P. Haake, D. Chereath, W. Knapp, O.E. Janssen, M.S. Exton, M. Schedlowski, and U. Hartmann, “Specificity of the neuroendocrine response to orgasm during sexual arousal in men,” J Endocrinol, vol. 177, 2003, pp. 57-64. 
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17583 on: 08/01/2013 18:25:24 »
I hope this helps ,



Kurtosis,  the way you balanced  your body chemistry  is the way it is done by  any knowledgable nutritionist.
In USA   the creators  of mineral analysis  spent 50 more years researching  this stuff, and  they were fixing this imbalance  left and right, I dont understand why you think this is  something new..  and  somepeople   are collecting  money for  this research..  This research was done  years ago. .  People just  make up new names for imbalances,   which is silly. POIS, CFD  and stuff like that. 
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17584 on: 08/01/2013 18:26:57 »
The actualy research is done  in the lab  with patients   and  big population, not  the internet or providing  abstacrts from wikepedia.
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17585 on: 08/01/2013 19:33:49 »
Since we're reiterating old information I'll re-post an interesting thing in the news about chemo brain that CertainlyPOIS posted recently.

"Using brain scans, scientists in the US have uncovered physiological evidence for "chemo brain", a common and often debilitating side effect of cancer chemotherapy treatment that patients often describe as a "mental fog". With the help of positron emission tomography combined with computed tomography (PET/CT), the team found that following chemotherapy, areas of the brain involved with planning and decision-making use less energy."

http://www.medicalnewstoday.com/articles/253277.php

I find this study inspiring because it means there is hope for us to someday obtain evidence that will convince doctors that our POIS symptoms are not psychosomatic.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17586 on: 08/01/2013 19:46:51 »
serotonin/Ne is old info?   

this was the info in which RT3  is  addressed,  which takes to balance  3 months. and  this info   also provides the logic pattern to what I have said.   Including niacin possibly  influencing  conversion of NE to adrenaline.  High cortisol in POIS sufferers,    stress of the adrenal caused by  thyroid...  What new information do you need?  another miracle  herb?
This is sistemic problem  and understanding how  the system  works is the key , not the research of  new components,   ALL of the components of the  system are known and researched for many many years.  POIS is just an imbalance,  I dont know why you dont go get your body  chemistry balanced and get it over with.\\
Kurtosis   mentioned  for this forum to be scientific but  discussing    separate parts of the system  as  a problem  does not make any scientific sense.
Let
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17587 on: 08/01/2013 19:50:53 »
You keep on saying "scientific" and yet you didn't provide a scientific source for your serotonin/NE post.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17588 on: 08/01/2013 19:57:51 »
every column in  noradrenaline  piece is the   research  based  on  the  studies.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17589 on: 08/01/2013 20:00:52 »
Vincent,

I think  scientific does not apply to POIS,   

it is a  metabolic imbalance. You can go fix that   at 1000s of practioners  in the US.
It is like  taking   the results and trying to find a cause of a results  with many different things..   The cause of this  POIS is your  lifestyle or lifestyle of your parents  if you were born with it.   
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17590 on: 08/01/2013 20:02:35 »
every column in  noradrenaline  piece is the   research  based  on  the  studies.

Which studies? Give us links.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17591 on: 08/01/2013 20:06:12 »
I dont have links for every column .Sorry.

Good luck , Herman
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17592 on: 08/01/2013 20:07:41 »
serotonin.>NE ratio  conclusion  comes from  another piece anyway.  if you read carefully.
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17593 on: 08/01/2013 20:10:31 »
serotonin.>NE ratio  conclusion  comes from  another piece anyway.  if you read carefully.

I'm sure you don't happen to have a scientific source for that piece either.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17594 on: 08/01/2013 20:12:42 »
Vincent M, 

I want to help you, and I will . But  trust me on this,   orgasming  every day, you will never  let RT3 come down,  and cortisol  would not come down  until   you burn out.
Even if you have  perfect regimen for your imbalance.
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17595 on: 08/01/2013 20:14:35 »
Okay. I trust you. I trust you with my life. lol. This is just making me laugh at this point.
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17596 on: 08/01/2013 20:17:02 »
Scientific source for the ratio?   Dude, you are something.    Serotonin   devided  by noradrenaline .   Yeah , I guess  somwhere   in China  they  studied what happens when you devide one neurotransmiter on another.   OR  you want me to prove that serotonin/ Ne is the life  ratio.   I think it is quite obvious, isnt it?
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17597 on: 08/01/2013 20:18:52 »
laughing  will  calm you down  , I am glad I can do  good for you ...

Herman
 

Offline Gbolduev

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17598 on: 08/01/2013 20:24:24 »
if you  dont want to  give me tests,  go   find a practioner who will balance your body chemestry , they are 1000s of them  an d stop yo ur  guessing and shooting in the dark thing..  POIS is just  an imbalance  in 3 months you  wont have it.  I cant beilive people research this.   I guess I can ,  internet people do that.   Nothing is new here.  Your imbalance was  cured  for more than 40 years.   
 

Offline Vincent M

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17599 on: 08/01/2013 20:44:54 »
Herman, if you would just stop claiming to know everything about POIS then I would have no problem with you.
 

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Re: Post Orgasmic Illness Syndrome (POIS)
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