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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6444805 times)

Offline girlwind

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3375 on: 08/02/2009 02:50:47 »
Does anyone here have a history of using cortisone creams? e.g. elocom, etc.  Anything with hydrocortisone in it?
Last week I did a 24 hr urine cortisol test, and the results were really alarming (high)... more than twice the upper reference.  I haven't used cortisone creams very much for a couple years now, but I used to use them regularly (daily)... before POIS started too.

Also, T3 measured high again (above upper reference).  Twice in a row now.  T4 and TSH both quite normal though.

It's really quite interesting to see that your diagnostic test results are the EXACT OPPOSITE of mine. I'm always on the low
end of normal with cortisol, especially the evening one. (I do the 4 saliva cortisol tests.) My T3 is too low, my T4 normal.

The only hydrocortisone cream I ever used was in 2003, when I had a hideous oozing bout of poison oak. I only used
it once, and it worked like a miracle. The itch stopped instantly and all the poison oak was gone in 3 days. I was appa-
rently VERY sensitive to it, maybe because I hadn't ever used it in my life before that time.

 

Offline underwater

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3376 on: 08/02/2009 03:42:03 »
If Dr. Waldinger is correct, and there is a type of inflammatory response to orgasm

I always get a mild stuffed nose during POIS. Could that be an allergic response?

 

So many of the theories put forward seem plausible to me. I certainly have had serious allergy problems during my life.  To both indoor and outdoor allergents.  POIS makes me more susceptible.  I do get a stuffed nose, my asthma gets worse. Also my arthritis and tendonitis problems get worse.

Has anybody systematically taken their body temperature before and after orgasm?

Hi Rob--
I haven't taken my temp systematically after orgasm, but I can tell you that during  a POIS episode I usually feel colder than normal, especially in the morning. My normal body temperature is around 97---- Interesting; allergies, tendonitis, arthritis?? My arthritis and joint pain discomfort gets worse too. For us it appears that there is definitely an inflammatory component to POIS. But whether this is autoallergic or not is unclear. For me, one of my theories is that there is a hyperexcitatory condition that triggers an overwhelming cascade of catecholamines without the counterbalancing inhibitory neurotransmitters, leaving me for a few nights with residual nocturnal catecholamine excretion and insomnia. I get this also with an anxiety flare up. Although this isn't an autoallergic reaction, it comes close. Without a "shut off valve", it may create the same issues as an autoallergic response; thus arthritis, tendonitis flareups etc.

I also find the depletion theory you mention as quite plausible. Have you ever skipped a POIS episode after orgasm? Quite a few members here have reported (luckily) missing post orgasmic symptoms. Some of their percentages are quite high. For me, I can remember maybe skipping them twice. I find this fascinating, because it may indicate that there are times when the body is prepared to deal with the chemistry and not suffer a rebound reaction i.e. POIS.

 

Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3377 on: 08/02/2009 04:09:31 »

Rob, thanks for your theory, It's hard to say if it's caused by fluid loss or orgasm itself.
Maybe the two are causing problems (?)
About higher volume of ejaculation It's a possibility for me too but I never tried to scientifically measure this. I tought it could be caused by sexual abstinence.


I certainly used to believe that the body's desperation to replenish lost fluids was key to POIS. I still have a lot of success with eating a large protein-heavy meal following orgasm.

However, when I wake up aroused in the morning (no fluids involved), it usually leads to a mild POIS episode (brain-fog for 1-2 days). So a mere erection can cause me problems.

Does this mean that POIS and fluid-loss are unconnected? I don't think it does, but I do think there is more than one factor that throw the brain into POIS - possibly several.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3378 on: 08/02/2009 06:24:55 »

I always get a mild stuffed nose during POIS. Could that be an allergic response?
 

Yes, I used a tiny shot of Afrin (powerful but addictive stuff, careful!) this AM to clear it.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3379 on: 08/02/2009 06:56:40 »

FIRST TRIAL LEVITRA AND TESTOSTERONE PATCH COMBO

Since several hours ago......very few POIS symptoms! First time with the patches. I'm cautiously optimistic and on guard for the placebo effect.

As scientific research demands, I'm keeping my toes and fingers crossed! :)


The above was yesterday. It is now the end of a first full and GOOD day and it feels like last year's 75%+ cure!

This forum forces added awareness of POIS-variables for me. After 1+ years' declining Levitra effectiveness, I "gave up" hope and assumed Levitra no longer worked WELL, but now realize that the testosterone/Levitra combination may have been most significant. Perhaps neither work well alone (for me, that is).

Rob and others who weren't here: with early months' Levitra success, the possible POIS-effect of nitric oxide (NO) in Levitra stirred some discussion, if you are interested, please see link below:
http://www.google.com/search?hl=en&q=POIS+nitric+oxide+NO+site%3Ahttp%3A%2F%2Fthenakedscientists.com&btnG=Search

CAUTION: This is not medical advice, only my personal exerience. Only you and your physician can decide if this is right for you.
« Last Edit: 08/02/2009 07:14:31 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3380 on: 08/02/2009 07:07:31 »

Thanks for the encouragement demografx, fenugreek really does seem to have nailed POIS for me!


Hurray, sorry if I missed a more recent post, but what is the latest status with your experiments? Thanks again!
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3381 on: 08/02/2009 07:55:21 »

Theory: Depletion and replacement problems.  Several have mentioned this on this forum and to me this seems the most likely candidate. From an evolutionary perspective it is important for men to replace sperm relatively quickly once it is lost. Most can do so but this requires the endocrine system to work hard and take "resources" away from other activities (like brain function and physical fitness). POIS sufferers may have more problems than others because their body is not as efficient in replacing sperm.  One example may be those with low testosterone production or tolerance.


Thanks, Rob. This theory would nicely explain one of my success components (success to be re-validated [from 2007-8 days] over time) with testosterone replacement therapy.

I wonder what role Levitra might play, if any, along the lines of a depletion/replacement theory.

In one of my desperate search attempts for professional help over the years (30+ years of POIS!), I contacted a highly recommended Czechoslovakian sexuality research psychologist - who was firmly convinced that my POIS was due to low testosterone. In 2007, Depotestosterone/cypionate (injectables) miraculously "cured" my POIS upon first trial, but not in repeat trials (perhaps placebo effect). I'm now on 10mg daily T-patches after blood tests with endocrinologist.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3382 on: 08/02/2009 14:02:19 »
I certainly used to believe that the body's desperation to replenish lost fluids was key to POIS. I still have a lot of success with eating a large protein-heavy meal following orgasm.

However, when I wake up aroused in the morning (no fluids involved), it usually leads to a mild POIS episode (brain-fog for 1-2 days). So a mere erection can cause me problems.

Does this mean that POIS and fluid-loss are unconnected? I don't think it does, but I do think there is more than one factor that throw the brain into POIS - possibly several.

Hurray, I hope you're still doing well on fenugreek.

Like you and with the recent developments I think there could be several causes to pois. (For many reasons I still believe fluids are involved.)

I can't explain why a simple erection could cause pois symptoms for 1-2 days. I don't think this has been reported before, but I find this interesting. Perhaps something with relaxation. When I'm aroused there is usually a small loss of fluids but I understand it's not your case.

Concerning the heavy meal it seems to be a constant, a lot of pois sufferers including me are reporting a faster recovery with enhanced nutrition. (Unfortunately this is not a proof that fluid loss is involved.) On an other side my experience is that anything that can give you energy will eventually exhaust you after a while. That's why when I don't try to stimulate my body I can have more energy ultimately.
I'm sometimes wondering if pois could be caused by excessive intake of food.(enlarged digestive organs...)
 

Offline deloun

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3383 on: 08/02/2009 15:29:56 »
I've added some things, added things are green:

POIS catecholamines theory

The theory that I have about POIS, is that the symptoms may be caused by a deficiency of one or more of the catecholamines of which noradrenaline may be of most significance.

There are several points that may lead into this direction.

Possible links between POIS and catecholamines:

- During sexual activity noradrenaline levels increase and afterwards they decrease. (1)
- Having a shower with alternating hot and cold water and the sauna including cooling down with a cold water bath / shower both help reducing the symptoms. Noradrenaline and adrenaline levels rise significantly when the body is subjected to cold stress. (2) (3)
- During a period in which POIS symptoms occur, I can have an enlarged / swollen penis. Continuous release of noradrenaline is necessary to keep the penis in a non-erectile state. (4)
- Human semen contains high levels of catecholamines. (5)
- The symptoms of a depletion of catecholamines are similar to many symptoms related to POIS. In the scientific research linked as reference a depletion of dopamine is induced, though this is likely to cause a depletion of noradrenaline and adrenaline besides dopamine alone, as a consequence. Since noradrenaline and adrenaline are produced from dopamine in the body. (6)
- PDE4 inhibits the cyclic AMP (cAMP), which has an inhibition of noradrenaline and adrenaline as a consequence. Therefore, a PDE4-inhibitor has the opposite effect, an increase of cAMP and noradrenaline levels. (7) (8)
- Among other areas in the body, PDE4 has also been found in male and female sexual organs. I'm not sure if this is relevant. (9) (10)
- Sceletium Tortuosum helps reducing POIS symptoms. It's a herb of which the main active alkaloid is mesembrine, which is a PDE4 inhibitor with a mechanism in a way similar to rolipram (11) that raises levels of noradrenaline. (7) (8)
- Thinking back about it, I remember that recreational use of amphetamines (speed) in the past showed a reduction of symptoms and after the effects wore off, an increase of the severity of the symptoms was noticed for up until about a week, possibly because of a depletion of noradrenaline. I already had POIS long before I had used any amphetamines, by the way. Amphetamines are known to increase levels of noradrenaline and a temporary depletion of noradrenaline after use is possible.
- Garlic has been reported to help reducing POIS symptoms. Garlic can increase noradrenaline and adrenaline levels. (12)
- Fenugreek has been reported to help reducing POIS symptoms. Fenugreek contains diosgenin, which can produce an oxytocin-like effect. Oxytocin can increase noradrenaline levels. (13)
- Celtic salt has been reported to help reducing POIS symptoms. That person might be sensitive to salt-induced hypertension, which can cause an increase in plasma noradrenaline and adrenaline levels. (14) Another possibility is that the level of oxytocin increases by the salt. (15) Oxytocin can increase noradrenaline levels. (13)
- Heavy physical exercise can reduce POIS symptoms. Heavy physical exercise can increase catecholamines. (16)
- The combination of testosterone and Levitra (vardenafil) has been reported to reduce POIS symptoms. Testosterone may increase noradrenaline. (17) Vardenafil also inhibits PDE4 besides PDE5, although relatively weak. (18) Vardenafil also increases nitric oxide. Nitric oxide can increase dopamine. (19) (20) An increase of dopamine may lead to an increase of the other catecholamines as well. Testosterone and vardenafil can have a synergistic effect. (21)


- Blood test results showed a deficiency of noradrenaline and adrenaline. During the collection of blood for the tests, only mild POIS symptoms were experienced, during a period of more severe symptoms there may be an even greater deficiency. (22)


(1) Plasma noradrenaline and dopamine-beta-hydroxylase during sexual activity Link to full text (PDF) is also available at that website.
(2) The Influence of Cold Stress on Catecholamine Excretion and Oxygen Uptake of Normal Person
(3) Interrelations between Sympathoadrenal System and Hypothalamo-Pituitary-Adrenocortical/Thyroid Systems in Rats Exposed to Cold Stress
(4) Physiological significance of nitrergic transmission in human penile erection
(5) High levels of catecholamines in human semen: a preliminary study
(6) Subjective Experiences During Dopamine Depletion
(7) Rolipram, an Antidepressant That Increases the Availability of cAMP, Transiently Enhances Wakefulness in Rats
(8) The antidepressant and antiinflammatory effects of rolipram in the central nervous system
(9) Immunohistochemical Distribution of cAMP- and cGMP-Phosphodiesterase (PDE) Isoenzymes in the Human Prostate
(10) Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora
(11) Mesembrine is an inhibitor of PDE4 that follows structure-activity relationship of rolipram
(12) Allyl-Containing Sulfides in Garlic Increase Uncoupling Protein Content in Brown Adipose Tissue, and Noradrenaline and Adrenaline Secretion in Rats  ("Administration of diallyldisulfide, diallyltrisulfide and alliin, organosulfur compounds present in garlic, significantly increased plasma noradrenaline and adrenaline concentrations")
(13) Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus
(14) Genetic influence on brain catecholamines: high brain noradrenaline in salt-sensitive rats
(15) Release of oxytocin induced by salt loading and its influence on renal excretion in the male rat
(16) FREE AND CONJUGATED CATECHOLAMINES IN HUMAN PLASMA DURING PHYSICAL EXERCISE
(17) Effects of testosterone and ethinyloestradiol on the synthesis and uptake of noradrenaline and 5-hydroxytryptamine in rat hindbrain: evidence for a presynaptic regulation of monoamine synthesis?
(18) The inhibitory selectivity of vardenafil on bovine and human recombinant phosphodiesterase isoenzymes
(19) Nitric oxide inhibits [3H]dopamine uptake
(20) Effect of Nitroprusside (Nitric Oxide) on Endogenous Dopamine Release from Rat Striatal Slices
(21) Hypogonadism and erectile dysfunction: the role for testosterone therapy

(22) Test results of neurotransmitters, hormones, etc.
« Last Edit: 08/02/2009 15:48:27 by deloun »
 

Offline underwater

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3384 on: 08/02/2009 16:21:57 »
Wow! So much news/ideas this A.M.----

Demo, let's keep our fingers crossed that you get continued positive responses during this POIS episode---

I submit that various POIS theories are not mutually exclusive e.g. depletion, catecholamine and autoimmune etc. In all of these we're still dealing with the Hypothalamus, Pituitary, Adrenal Axis--They all involve, somehow, responses to and by hormones, whether we identify them as "hormones" (e.g. prolactin, cortisol), catecholamines (e.g. noradrenaline, dopamine) or immune messengers (e.g. prostoglandins, cytokines). For me, in the last 24 hours, I seem to find that the catecholamine and autoimmune ideas are merging!! I hope the next 48 hours will be positive in this regard.

The problem I have, is that I don't have near enough knowledge in chemistry or physiology to properly articulate my ideas and physiological responses. However, I'm not going to let that stop me.

To help me with my personal experimentation and theories, are there any others out there who have classical inflammatory responses to POIS or anxiety flare up? I have back and hip flare ups, Rob has arthritis and tendon flare ups, Demo has fingertips flare ups, etc. Any burning eyes? other myalgias? sneezing? skin issues? I'm asking these questions because I might see a connection between our regularly discussed neurotransmitters and the inflammatory messengers that modulate them (e.g. prostoglandins). This may point to a synthesis of theories: Hormone/neurotransmitter imbalance triggers autoallergic reaction, perhaps allowing multiple therapeutic responses such as: balancing out hormones and/or disabling or countering the autoallergic response from the immune system. At minimum, the research "I do" clearly tells me what my supplements are "intended" to do.  I am able to monitor my mood and physical response based on my supplement experiments. Then I am able to research into how the chemistry of the supplements (active components) may impact on the endocrine/nervous system. I have two major problems I monitor, anxiety and pelvic inflammation. They are connected at the hip! How's that for a pun? If I fix one, the other is gone, gone, gone!!! (90% of the time). Until last night, I never looked at GAD as a possible autoallergic reacation. Now I do, and now I look at POIS and GAD as possibly being both an autoallergic and hormone imbalance together. It may give me TWO methods to attack each problem, OR are they both really part of the same imbalances in ME (and some of us)?
 

Offline deloun

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3385 on: 08/02/2009 16:29:50 »
I certainly used to believe that the body's desperation to replenish lost fluids was key to POIS. I still have a lot of success with eating a large protein-heavy meal following orgasm.

However, when I wake up aroused in the morning (no fluids involved), it usually leads to a mild POIS episode (brain-fog for 1-2 days). So a mere erection can cause me problems.

Does this mean that POIS and fluid-loss are unconnected? I don't think it does, but I do think there is more than one factor that throw the brain into POIS - possibly several.

Hurray, I hope you're still doing well on fenugreek.

Like you and with the recent developments I think there could be several causes to pois. (For many reasons I still believe fluids are involved.)

I can't explain why a simple erection could cause pois symptoms for 1-2 days. I don't think this has been reported before, but I find this interesting. Perhaps something with relaxation. When I'm aroused there is usually a small loss of fluids but I understand it's not your case.

Concerning the heavy meal it seems to be a constant, a lot of pois sufferers including me are reporting a faster recovery with enhanced nutrition. (Unfortunately this is not a proof that fluid loss is involved.) On an other side my experience is that anything that can give you energy will eventually exhaust you after a while. That's why when I don't try to stimulate my body I can have more energy ultimately.
I'm sometimes wondering if pois could be caused by excessive intake of food.(enlarged digestive organs...)

I've also noticed that sexual arousal alone can cause mild POIS symptoms, at least after sexual activity without orgasm. I remember I've heard it before here on the forum, that others experience that too.

The scientific research that I mention in reference number one in my post about the POIS catecholamines theory shows something interesting that may be relevant:

Quote from: Plasma Noradrenaline and Dopamine-Beta-Hydroxylase During Sexual Activity
In each study sexual arousal and erection correlated positively with noradrenaline concentration. Interruption of arousal in roughly the middle of each study is reflected consistently by a decrease in plasma noradrenaline levels.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3386 on: 08/02/2009 17:09:33 »
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Just posting this again in case someone missed it - demo


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« Last Edit: 08/02/2009 18:39:44 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3387 on: 08/02/2009 17:58:01 »

Demo, let's keep our fingers crossed that you get continued positive responses during this POIS episode---


Many thanks, Underwater (great name, I even can envision the goggles!).

I woke up this morning clearheaded and refreshed! (Last POIS episode, morning of Day 2, even after sleeping 300+ hours straight, I woke up feeling like I'd been sledgehammered!).

But I must admit, stimulant meds and caffeine...and a little sugar...also play a part. (Junior role, though). Oh yes, and in moderation. I can hear the naturopaths breaking down my front door :).

Underwater, the silly comment above about goggles: in my last (and usual) POIS episode that 'extraneous' thought simply would not have occurred. Don't laugh, I know it's hardly creative, but it's a strong sign to me of "cognitive repair".

Can you tell I'm excited??? ;D And it was Double-O to boot: normally, a   k i l l e r ,  as in 'lock him up, throw away the keys.'

Thanks, UW and everyone!

ps - kidding aside, I do have respect for competent naturopaths...as I do for competent physicians...or competent anythings for that matter!

Well, maybe not competent house burglars....
« Last Edit: 08/02/2009 19:07:36 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3388 on: 08/02/2009 18:33:46 »

To help me with my personal experimentation and theories, are there any others out there who have classical inflammatory responses to POIS or anxiety flare up?...Demo has fingertips flare ups, etc.


Last night, I ran across an old post from a POISer (can someone please come up with a better name??;D) with "strange sensations in fingers".

I did a forum history search on "burning" and "sneezing" and came up with zip. Here's how I search the forum with Google. Try different words?

type in Google box:
burning sneezing POIS site:http://thenakedscientists.com

[UW, be careful with space/no space and colon-placement]
« Last Edit: 08/02/2009 18:53:54 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3389 on: 08/02/2009 18:47:41 »
Quote from: Plasma Noradrenaline and Dopamine-Beta-Hydroxylase During
Sexual Activity

In each study sexual arousal and erection correlated positively with noradrenaline concentration. Interruption of arousal in roughly the middle of each study is reflected consistently by a decrease in plasma noradrenaline levels.


Deloun, this is very interesting. I hope it can contribute to the chemistry of a POIS cure.

I'm lucky that neither state triggers POIS for me, and it confirms why I stay there - - unfortunately, with the frightening thought that the next step crosses the line into enemy territory!
« Last Edit: 08/02/2009 18:49:54 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3390 on: 08/02/2009 19:24:56 »

I've added some things, added things are green:

POIS catecholamines theory


Deloun, fascinating compilation! And it explains/makes sense of my success with Levitra/testosterone/stimulants, so thank you.
 

Offline girlwind

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3391 on: 08/02/2009 19:46:36 »
I submit that various POIS theories are not mutually exclusive e.g. depletion, catecholamine and autoimmune etc. In all of these we're still
dealing with the Hypothalamus, Pituitary, Adrenal Axis--They all involve, somehow, responses to and by hormones, whether we identify
them as "hormones" (e.g. prolactin, cortisol), catecholamines (e.g. noradrenaline, dopamine) or immune messengers (e.g. prostoglandins,
cytokines).

To help me with my personal experimentation and theories, are there any others out there who have classical inflammatory responses to
POIS or anxiety flare up? I have back and hip flare ups, Rob has arthritis and tendon flare ups, Demo has fingertips flare ups, etc. Any burning
eyes? other myalgias? sneezing? skin issues? I'm asking these questions because I might see a connection between our regularly discussed
neurotransmitters and the inflammatory messengers that modulate them (e.g. prostoglandins).

Until last night, I never looked at GAD as a possible autoallergic reacation. Now I do, and now I look at POIS and GAD as possibly being both
an autoallergic and hormone imbalance together. It may give me TWO methods to attack each problem, OR are they both really part of the
same imbalances in ME (and some of us)?


Yes, Underwater--I definitely have had all of the above: 1) depletion--as in loss of energy to function normally physically
and mentally, due to lowered levels of many hormones; 2) inflammatory response--higher levels of sensitivity to allergens
with resulting body aches, itchy eyes, sinus congestion; 3) neurotransmitter disruption and/or depletion--causing both
insomnia and hyperactivity. So I concur with your idea that there is a CONNECTION btwn all three.

I've noticed, for many years, that when my energy is down (when my adrenals are stressed and tired), I am more likely to feel
allergic and become ill with infections more easily. And of course, the low energy affects my mood. At those time both my CFS
and POIS symptoms are NOTICEABLY WORSE. When my energy picks up, my mood does as well, and then my allergies and my
tendency twds chronic infections diminishes. 

I would also add that some allergies, like those to petrochemicals, cigarette smoke and car exhaust CLEARLY affect my mood,
my brain, and my emotions in a very adverse way. I can get both depressed and anxious from exposures to all of these. When
the allergic response clears, then likewise my mood "clears" back to a calm place as well. Some people I know with various
food allergies can have pretty severe mood changes from those, but fortunately that's ONE thing I actually don't have.
« Last Edit: 08/02/2009 22:25:22 by girlwind »
 

Offline underwater

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3392 on: 08/02/2009 20:51:35 »
Girlwind--
I'm sorry that you are having a down mood right now. I am also in that roller coaster car right behind you. For the last 21 months, the longest I have felt really great is approx. 18-24 hours; very cyclical. I'm trying to work on getting over that hump. If I can get over that hump, I'll have hard info. to share.
 

Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3393 on: 08/02/2009 21:37:34 »
demografx
   I was just  wondering while symptoms improving is recovery period reducing.
 

Offline girlwind

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3394 on: 08/02/2009 22:23:17 »
Girlwind--
I'm sorry that you are having a down mood right now. I am also in that roller coaster car right behind you. For the last 21 months, the longest I have felt really great is approx. 18-24 hours; very cyclical. I'm trying to work on getting over that hump. If I can get over that hump, I'll have hard info. to share.

Actually I'm feeling much better right now, since I began that cortisol treatment. And I wish the same for you.
What I meant in my previous post is that IN GENERAL those issues of: depletion, inflammatory response, and
neurotransmitter disruption are problems that I HAVE suffered from, which are aggravated by POIS and by CFS.
I was agreeing with the connection between those three kinds of physiological responses, which you too have
noticed. I will change my prior post to clarify that.
« Last Edit: 08/02/2009 22:30:12 by girlwind »
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3395 on: 09/02/2009 02:06:33 »
Has anybody tried 5 hour energy? I would say it releives a bit of the pois, i tried some yesterday, but only a couple sips not even half of the bottle.
 

Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3396 on: 09/02/2009 06:16:43 »
Has anybody tried 5 hour energy? I would say it releives a bit of the pois, i tried some yesterday, but only a couple sips not even half of the bottle.

used the decaf 5-hour energy did nothing for me. But also reap off.
 

Offline rob58

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3397 on: 09/02/2009 11:52:53 »
Underwater:
That makes sense, that either an auto-allergic response or a hyper excitation of the adrenal system that leads to an adverse reaction (am I summarizing your view here?) could cause an inflammatory/allergic reaction.

Seems to me that in either view we should expect specific variations in body temperature over the POIS cycle. I would be thrilled if, as a group, we could agree to do a simple experiment:  take body temperature, say sublingually, for 30 days in a row (including hopefully ::) one or more POIS episodes) each morning. Write down three things for each day: the temperature, your day in the POIS cycle, and whether at the time you are aware of having an illness unrelated to POIS. If we had 20 of us do this for 30 days or more we would likely be able to say something quite definite, ruling out or supporting theories that imply inflammation.  There are many other tests we can do, of course, many of which have been mentioned, but this one seems to be the easiest: can be done at home without cost.
 

Offline rob58

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3398 on: 09/02/2009 12:20:38 »
Deloun:

Intrigued by the connection between catecholamines and POIS that you present although I am not sure I understand the whole story. (Over)simplified view would probably be that catecholamines are lost with semen. Then body is short of dopamine and adrenaline.

What strikes a chord with me is that I do feel that I have a dopamine shortage during POIS.  Not much scientific backing for this except the book/movie "Awakenings".  Oliver Sachs there realizes that certain catatonic patients are dopamine deprived.  He theorizes they feel like they have no will from inside themselves even though they can react to outside stimuli.  For instance, the patients come alive (sort of) to catch a tennis ball thrown at them.  This is how I feel during POIS plus I become quite good at catching tennisballs, not kidding.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3399 on: 09/02/2009 13:08:31 »

demografx
   I was just  wondering while symptoms improving is recovery period reducing.


CC, the recovery period is definitely reducing. Subjectively, recovery feels immediate. Compared to weeks of recovery with no treatment as I am currently undergoing.
 

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #3399 on: 09/02/2009 13:08:31 »

 

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