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Author Topic: Post Orgasmic Illness Syndrome (POIS)  (Read 6461971 times)

Offline Counterpoints

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5675 on: 26/09/2009 10:48:36 »
Drinking a lot of orange juice throughout the day would make me feel horrible. 

One thing I think nearly all of us have in common, is that the duration and intensity of POIS varies from orgasm to orgasm.  Some people talk about feeling great after one NE, and then this not being repeated.  After the results of the first NE, the reasoning is that NEs are better than other types of orgasm.  Then if this is not repeated, this reasoning is adjusted: maybe it was an NE in combination with something else?

Many of us are trying to figure out WHY one orgasm may have fewer effects than the other.  And sometimes it's easy to pin it on something we did specifically that day: and since we are all trying different things, we come to the conclusion that we are feeling better, or worse, for these very different reasons.  But perhaps we would be feeling better, or worse, regardless.

Many times I've thought I've had a treatment, to be dissapointed.  But here are some things I believe have consistently affected my POIS, and may generalize to some of us:

1) Frequency.  If I have waited a long time since the last ejaculation, it will make a difference.  I am not sure whether this means the result will be better or worse.  For example, if I just had an orgasm 5 minutes ago, and then I have another one, it will probably not make me feel as different, than if I had waited a few weeks.  I have found that my body copes with certain frequencies better than others.  Perhaps I was feeling best when my body regulated itself, through nocturnal emissions. (Although if I am feeling really bad, I still find a subsequent orgasm to often be helpful.  This may not be true for all here).

2) What happens (internally) during orgasm.  As I've mentioned, and others have also, sometimes an orgasm can actually alleviate symptoms, when not feeling well.  In a sense, MOST (but not all) of the symptoms of POIS, can be switched ON or OFF.  This is what I mean by ON/OFF:
- When I have POIS symptoms, these symptoms CAN vary in intensity and duration
- HOWEVER, the process of getting these symptoms, is very discrete, and the process of them leaving can seem very discrete (in most respects).
- For example, I can keep having orgasm until I know that a certain set of symptoms is relieved; once this happens, I know that further orgasm will quite likely be of no help. But sometimes there will still be residual symptoms that will get better (or worse and then better) over time... e.g. a sort of dazed/druggy feeling.
oms that will get better (or worse and then better) over time (e.g. a sort of dazed/druggy feeling).

(Aside: sometimes a particular orgasm will make me feel dizzy, thick-headed, disoriented, visual disturbances etc.  My symptoms are much much greater than normal, and in this case, can be usually (somewhat) corrected by a subsequent orgasm.)

3) Pornography.  For me, POIS is somewhat like an addiction.  At times there are intense cravings, which could in fact be seen as POIS symptoms.  Just looking at pornography is unlikely to put me in POIS (it is a very "ON/OFF" process), but viewing is likely to change my response to orgasm -- usually, for the worse.  It also seems to change the "cycle" of POIS (symptom duration, intensity, etc.).  This might explain why an NE cycle could be better; it is more driven by the body's needs, than your own choices (which could be driven by addiction).

4) Diet.  This is more peripheral.  I don't think having a bad diet, or a good diet, for one day, will make much of a difference to post-orgasm symptoms.  But a long term, healthy, balanced diet, for me (low on sugar!!!), seems to lessen the overall intensity of POIS.
 
5) Alcohol.  Perhaps mostly beer?  This seems to have a consistent effect of some sort.

Sorry if this is somewhat rambling... just a few thoughts.

Thanks for the welcome, Demografx! 
« Last Edit: 26/09/2009 16:55:11 by Counterpoints »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5676 on: 27/09/2009 01:53:55 »

I think taking naps has been one of the most effective POIS-alleviators for me. Anyone else?
 

Offline Limejuice

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5677 on: 27/09/2009 05:04:27 »
Naps definately help  Unfortunately I don't sleep well that night if I nap, so I don't nap.

Question - does anyone get a runny nose after eating?

I found out my mother and aunt do which are similar symptoms of POIS.  I'm interested in knowing if you do to.  Google research shows a runny nose after eating is common but the cause is not known, nor the solution.  Some speculate a mild allergy to all food.  Could we have an allergy to O'ing?
« Last Edit: 27/09/2009 05:06:58 by Limejuice »
 

Offline Limejuice

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5678 on: 27/09/2009 14:59:51 »
I agree with all of CP's points except subsequent O's. Each O digs me further underground.
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5679 on: 28/09/2009 00:38:02 »
I asked my endo how to improve my 75% POIS cure. He said to test Estradiol and other hormones.

As another POIS experiment today (sparked by the usual in-POIS carbs-craving) I drank a "ton" of orange juice throughout the day. That, plus doubling the Rx stimulant-dose(again, with psychiatric approval) as mentioned in the first post at the top of this page, shortened the time of POIS symptoms significantly.

I know this goes counter to some people who studiously avoid carbs. But we're all built differently and, I think, have different forms of POIS.
for the good effect with orange it can be naringenin in it (or vitamin c!).
This substance is a natural aromatase inhibitor which prevent the conversion of testosterone into estradiol(which is anti testosterone).

from wiki:
Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. It is the predominant flavanone in grapefruit.[1]

Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2

Sources and bioavailability:
Grapefruit, Oranges, and Tomato (skin).


Also I heard that grapefruit juice is prohibited to avoid overdosing with some prescriptions drugs including some antidepressants. (this is very serious!). Not sure if naringenin is involved :
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1873672

Maybe aromatase inhibitors can help us with POIS:
-chrysin (passiflora)
-naringenin(grapefruit)
-resveratrol(grape)
http://en.wikipedia.org/wiki/Resveratrol
Resveratrol also significantly increases natural testosterone production from being both a selective estrogen receptor modulator[73][74] and an aromatase inhibitor.[75][76]
« Last Edit: 28/09/2009 00:44:56 by martin88 »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5680 on: 28/09/2009 03:36:45 »

Each O digs me further underground.


DITTO!!
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5681 on: 28/09/2009 03:40:25 »
I asked my endo how to improve my 75% POIS cure. He said to test Estradiol and other hormones.

As another POIS experiment today (sparked by the usual in-POIS carbs-craving) I drank a "ton" of orange juice throughout the day. That, plus doubling the Rx stimulant-dose(again, with psychiatric approval) as mentioned in the first post at the top of this page, shortened the time of POIS symptoms significantly.

I know this goes counter to some people who studiously avoid carbs. But we're all built differently and, I think, have different forms of POIS.
for the good effect with orange it can be naringenin in it (or vitamin c!).
This substance is a natural aromatase inhibitor which prevent the conversion of testosterone into estradiol(which is anti testosterone).

from wiki:
Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. It is the predominant flavanone in grapefruit.[1]

Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2

Sources and bioavailability:
Grapefruit, Oranges, and Tomato (skin).


Also I heard that grapefruit juice is prohibited to avoid overdosing with some prescriptions drugs including some antidepressants. (this is very serious!). Not sure if naringenin is involved :
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1873672

Maybe aromatase inhibitors can help us with POIS:
-chrysin (passiflora)
-naringenin(grapefruit)
-resveratrol(grape)
http://en.wikipedia.org/wiki/Resveratrol
Resveratrol also significantly increases natural testosterone production from being both a selective estrogen receptor modulator[73][74] and an aromatase inhibitor.[75][76]


Thanks, Martin. I simply thought my heavy dose of orange was only a "sugar rush", but the aromatose inhibition seems very logical!
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5682 on: 28/09/2009 03:47:57 »

Martin, you've researched testosterone extensively and have a lot of knowledge in this area: do you think it's possible for someone to take testosterone and not have their body shut down its own natural production of testosterone?

If so, I would like to approach a testosterone manufacturer to see if they can do a clinical trial on us for POIS. For motivation, there is potentially a new worldwide market for them!
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5683 on: 28/09/2009 14:14:59 »
Martin, you've researched testosterone extensively and have a lot of knowledge in this area: do you think it's possible for someone to take testosterone and not have their body shut down its own natural production of testosterone?
I have no experience with T, like you I'm curious to know the answer. I heard about clomid, HCG, novaldex to restart the natural T production. Also there is andriol (T pills) which is a weak androgen less likely to do this.


Thanks, Martin. I simply thought my heavy dose of orange was only a "sugar rush", but the aromatose inhibition seems very logical!
Sugar rush is also a possibility .. :)

 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5684 on: 28/09/2009 14:26:39 »
just to report my trials with 100% pure cranberry juice. I couldn't find whole fruits. Unfortunately I had no success for POIS. More than 3 glasses in a row slightly increased my anxiety. But it's probably good to drink in long term for antioxydants. One funny thing, cranberry juice mixed with orange juice taste a bit like grapefruit.

the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...
« Last Edit: 28/09/2009 14:31:07 by martin88 »
 

Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5685 on: 28/09/2009 19:38:52 »

Martin, you've researched testosterone extensively and have a lot of knowledge in this area: do you think it's possible for someone to take testosterone and not have their body shut down its own natural production of testosterone?

If so, I would like to approach a testosterone manufacturer to see if they can do a clinical trial on us for POIS. For motivation, there is potentially a new worldwide market for them!

Isnt that why body builders have smaller testicles.
 

Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5686 on: 28/09/2009 19:40:28 »
just to report my trials with 100% pure cranberry juice. I couldn't find whole fruits. Unfortunately I had no success for POIS. More than 3 glasses in a row slightly increased my anxiety. But it's probably good to drink in long term for antioxydants. One funny thing, cranberry juice mixed with orange juice taste a bit like grapefruit.

the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...

With cortisol like that it is going to be hard to get a doctor to check your high ACTH.     

Is urine the most precise way to test 24/7 cortisol.   
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5687 on: 28/09/2009 19:53:09 »

Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.
« Last Edit: 28/09/2009 20:01:25 by demografx »
 

Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5688 on: 29/09/2009 00:24:04 »
demo,
it sounds interesting, but there are not very many people with pois, their future sales from us(mostly forum memeber of this site)probably would not pay for their study. i just tied .5 cc injection of T in my but, 5 minutes after an o.  i am worried about down regualting natural t production and t receptor sites from continued use. 1 am only 28, and very hesitant to use t on a continual basis, except for, 4 0r 5 experiments where i have taken injections during bad pois symptoms.  a drug that naturally stimulates t sounds good, but anabolic steroids severly increase chances of getting cancer. 
 

Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5689 on: 29/09/2009 13:52:02 »
the result of my 24h urine cortisol pois day 3 was 103nmol/d (28-276)...
With cortisol like that it is going to be hard to get a doctor to check your high ACTH.    
nothing new :)


Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.
I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.
 

Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5690 on: 30/09/2009 04:12:04 »
Does anybody else get these "rushes" now.  My last 2 O's were characterized by extreme rushes of energy, I couldn't sit still and had to move around.  This rush lasted for about a few days, I didnt get any usual symptoms of POIS, such as depression, but I felt really energetic, as in an over-adrenalized state.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5691 on: 30/09/2009 20:13:44 »

demo,

it sounds interesting, but there are not very many people with pois, their future sales from us(mostly forum members of this site) probably would not pay for their study.


Thanks, laurac. I thought POIS was rare too, but others have disagreed. Some even think it's a HUGE problem, but just that it goes unreported. It's taken many people (including me) years to connect the dots between sex and POIS symptoms. There's also the embarrassment factor: it took me (and others) a long time to get the courage to tell my POIS story to a physician for the first time. Each lack of understanding made me withdraw even further into privacy.

An awareness campaign might make a difference, even though it may take years. For example, Bob Dole and others spoke out about erectile dysfunction, others spoke out about alcoholism, drug addiction, breast cancer, etc.

We have had nearly 500,000 hits on this POIS thread. Surely those can't be all me double-checking my grammar :)


anabolic steroids severely increase chances of getting cancer. 


Although a cancer link was thought to be true by many people for a long time, A Harvard review of 72 studies found no link to cancer:
http://www.harvardscience.harvard.edu/medicine-health/articles/study-finds-no-direct-links-between-testosterone-therapy-diseases

It was my concern too, until I consulted some leading practitioners.
« Last Edit: 30/09/2009 22:40:56 by demografx »
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5692 on: 30/09/2009 20:24:40 »

Harvard article shows testosterone relieves depression:
http://www.harvardscience.harvard.edu/medicine-health/articles/testosterone-drives-away-blues

This has been certainly true in my case.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5693 on: 30/09/2009 21:51:47 »

Quote from: demografx on 28/09/2009 19:53:09
Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.



I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.


Thanks, Martin!

OK, if I understand the response to my post correctly, there are only two (2) people here who are possibly interested in a clinical trial/research study of POIS and testosterone. Which is not enough for me to approach Watson Pharmaceuticals, Inc. If I'm wrong, and you are interested, please let me know by posting your interest here or by PM! Thank you.
« Last Edit: 01/10/2009 03:05:26 by demografx »
 

Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5694 on: 01/10/2009 23:23:40 »
 demo, you said, We have had nearly 500,000 hits on this POIS thread. Surely those can't be all me double-checking my grammar.  we have the words: sex. orgasm, and ejaculation, amoung other things all over this forum that are picked out by earch engines.  these people are looking for porn, the site our forum is on is called "the naked scientists".

you are right, i think there are more people out there ,but not a half million.  i think we should take advatage of the 500,000 hits for the purpose of convincing big pharma that there are tons of people out there with pois and the they can make a lot of money.
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5695 on: 02/10/2009 03:57:24 »

I think we should take advantage of the 500,000 hits for the purpose of convincing big pharma that there are tons of people out there with pois and that they can make a lot of money.


That was exactly what I intended, laurac. But if they ever read the earlier part of your post they could then accuse us of deception. :)
« Last Edit: 02/10/2009 04:00:05 by demografx »
 

Offline Paulrx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5696 on: 02/10/2009 17:19:38 »
Hello guys,

I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.
I encourage you to visit a board called newbielink:http://www.malemultiple.org [nonactive] where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.
I truly believe that this is the way to go to combat this awful POIS!

Paul
« Last Edit: 02/10/2009 18:52:18 by Paulrx »
 

Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5697 on: 02/10/2009 21:41:07 »

Quote from: demografx on 28/09/2009 19:53:09
Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.



I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.


Thanks, Martin!

OK, if I understand the response to my post correctly, there are only two (2) people here who are possibly interested in a clinical trial/research study of POIS and testosterone. Which is not enough for me to approach Watson Pharmaceuticals, Inc. If I'm wrong, and you are interested, please let me know by posting your interest here or by PM! Thank you.

I am interested.

Hell i'll be their guinea pig if they want to try solutions that have a moderate % to kill me even. Anything to find a REAL viable consistent solution.
 

Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5698 on: 02/10/2009 21:41:54 »
Hello guys,

I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.
I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.
I truly believe that this is the way to go to combat this awful POIS!

Paul

yeah i can do that but it doesnt work for me, as i've stated before whatever causes the "feel good" sensation, with or without ejac, causes my POIS
 

Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5699 on: 03/10/2009 02:52:36 »
Hello guys,

I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.
I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.
I truly believe that this is the way to go to combat this awful POIS!
Paul

Previous forum posts on orgasm without ejaculation:
http://www.google.com/search?hl=en&q=orgasm+without+ejaculation+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&oq=&aqi=

Previous forum posts on Mantak Chia:
http://www.google.com/search?hl=en&q=mantak+chia+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&oq=&aqi=

I, and others, have pursued this avenue for years and "succeeded", but POIS still ravaged. Discussed in more detail above.
 

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5699 on: 03/10/2009 02:52:36 »

 

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