[martin88]

Hi Tantalus, it's difficult for me too to write in english, it takes a long time to write posts, and often I can't write exactly what I want to say. I don't always know if people understand me. When I feel it's necessary I'm using these two links but it takes time.
-this one for words: http://www.wordreference.com/
-this one is excellent (hundreds of millions of example sentences translated by real people): http://www.linguee.com/

Looks promising. I'm not sure I'd have any success in getting prescribed Cabergoline but if you can find a doctor who'll prescribe it then let us know how you get on.

I've been seeing an open-minded endocrinologist for metabolic syndrome that I developed while taking antipsychotics, he has prescribed me testosterone gel before on speculation it might help my PIOS.  He's one of the few docs who has given me the benefit of the doubt.  I have a well documented medical history, and it might make him feel secure enough to go with the cabergoline.  I will get an appointment soon!

Hi Nightingale, some POIS sufferers tried this and reported it was not helpful, but it's good if you make your own experience, everyone is different. I think Hurray and CP took cabergoline without success . Some old posts below:

2nd post relating to Parlodel (Bromocriptine)

Had a try at it again this weekend. This time it did nothing for me, i felt 'hungover' for atleast 3-4 days this time. My first attempt with this drug was very promising, I def thought I had some results there..

Not quite ready to give up on it completely, I will try it for a few more times and post feedback...

I took cabergoline.  It has some risks associated with it that bromocriptine doesn't, and if you consider taking it, consult with a physician.  I don't think it's a good option for more than say, 4 months. HOWEVER, I think for many people cabergoline is a much better drug for these types of tests than bromocriptine.  It has an extremely long half-life.  Taking one 0.5 mg tablet of cabergoline is like taking a significant daily dose of bromocriptine for a week.  You only need to take 1 pill a week.  And generally I think there are fewer side effects.

Also, when you experiment with these types of drugs, I don't think you can expect an immediate cure.  Sometimes the neurotransmitters need to build up for months, before, for instance, your physiological response to orgasm is significantly altered.  For example, someone is not going to cure himself of serious depression by trying a couple SSRI pills now and then.  It needs a dedicated trial.

So I don't know how valuable it is doing 3 or 4 isolated experiments.

[fidalgo]

I understand all that you say. I don't think your english is worst than mine and the others no native spoke. And, more you write, better your english will be. So, don't worry about your english.

Only more one question: How much time you have to end the dessensibilization? Do you think you will have more improves?

Thanks for the attenction.

[hurray]

Yes, I tried Cabergoline, and it didn't provide me with a great deal of relief. I bought the tablets from an online pharmacy which I had not used before, so it is possible that the product I was taking was not genuine. I'd rate my confidence at around 75% that I was taking the real thing.

I've also tried L-Tyrosine (amino acid), selegiline and Bupropion, which are supposed to have a substantial effect on dopamine levels, but didn't help my POIS very much. The deservedly-reviled cigarette is my best dopamine-based weapon against POIS - nicotine is supposed to raise dopamine levels, but it doesn't work particularly well. I would never ever recommend somebody started smoking to help their POIS.

Fenugreek is still my best aid for POIS, although the B6 I tried was giving good results until I ran out of tablets. It's  difficult to buy in my current location.

[Vincent M]

I will follow the average opinion about  quality of my English.
Therefore I need yours also. Otherwise I remove better my replies.
 thank you. Please reed                        http://poiscenter.com/forums/index.php?topic=426.msg4911#msg4911

tantalus, I can understand most of what you write, but it's true that it would help if you could try to clear up your english a little if that's possible for you. But if it's not possible then I still want you to keep posting. Also I think there was some sort of misunderstanding between you and another member here. I just want to let you know that you are very welcome here. I found your posts interesting and helpful to our cause : )

[B_Daniel]

I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.

[kurtosis]

I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.

Wellbutrin is sometimes called Bupropion, just in case anybody is wondering what it is and how it works.  http://en.wikipedia.org/wiki/Bupropion

[Scribblz]

As a new member, I am relieved to know I'm not the only person inflicted by this disorder. I ama 20 year old Irish lad, currently afflicted by POIS, and its disrupting my work life and causing me to avoid masturbation and sex.

This started when I was 14, when I masturbated for the first time. I was scared stiff at what was happening at first, and I couldnt sleep for that night. Over the next few weeks, I felt nauseous, unwilling to eat, a strange sensation in my testicles which caused them to harden  which freaked me out immensely, and a fever.
I was constantly unfocused and unable to sleep.

Since then, I masturbate regularly and have occasional sex. Now its happened again and I feel downright awful. This time around though, I'm suffering from constipation, leading to the inability to urinate properly and vomiting, as well as dizzy spells and lack of sleep. I have avoided masturbation and sexual intercourse until the symptoms subside completely because I'm scared it may happen again. I'm too embarrassed to tell anyone, or go to a doctor about it, so I came here seeking guidance and a possible remedy to this problem.

Can anyone help me out?

[Hoping]

I've had some success lately by taking Wellbutrin for 2 days on, 2 days off.  The initial effects of the drug add some type of stimulant to my body which overrides a lot of my pois.  I then take 2 days off to let it clear from my system so I can repeat the 2 good days.  I've done this successfully for about 2 weeks now, so way too early to recommend and say for sure.  I also haven't discussed this yet with my doctor, who likely won't be very pleased.  I'm not recommending anyone try this, but if anyone already has, or has taken wellbutrin on and off, please PM me because I'm curious about it.

Wellbutrin is sometimes called Bupropion, just in case anybody is wondering what it is and how it works.  http://en.wikipedia.org/wiki/Bupropion

I've been taking Wellbutrin/Bupropion for the last few years and upped my dosage fairly recently. B_Daniel, I'll send you a PM.

[kurtosis]

As a new member, I am relieved to know I'm not the only person inflicted by this disorder. I ama 20 year old Irish lad, currently afflicted by POIS, and its disrupting my work life and causing me to avoid masturbation and sex.

This started when I was 14, when I masturbated for the first time. I was scared stiff at what was happening at first, and I couldnt sleep for that night. Over the next few weeks, I felt nauseous, unwilling to eat, a strange sensation in my testicles which caused them to harden  which freaked me out immensely, and a fever.
I was constantly unfocused and unable to sleep.

Since then, I masturbate regularly and have occasional sex. Now its happened again and I feel downright awful. This time around though, I'm suffering from constipation, leading to the inability to urinate properly and vomiting, as well as dizzy spells and lack of sleep. I have avoided masturbation and sexual intercourse until the symptoms subside completely because I'm scared it may happen again. I'm too embarrassed to tell anyone, or go to a doctor about it, so I came here seeking guidance and a possible remedy to this problem.

Can anyone help me out?

Hi Scribblz,
You have to tell your doctor about it. If you're not comfortable talking to your current doctor then consider getting a new one. Ask friends to see if they'd recommend a good GP. The problem with POIS is, there's no way you can pretend it's not happening as it affects relationships, work, education etc. So you have to try and tell a medical professional what's going on. At the minimum they'll understand that there's something wrong with you and you may need them to vouch for that fact later.

[Nightingale]

cabergoline has the exact opposite effect as antipsychotics.  Antipsychotics block dopamine receptors in the brain.  IF you gave cabergoline to a bipolar patient, it would cause them to go in the wildest manic phase imaginable.  on rare occasions dopamine agonists like cabergoline can cause sex and gambling addictions in otherwise normal and reserved people.   

Ok, thanks for bringing this up.  I searched through the thread and found a good few posts about people's trials with cabergoline and the other similar drug.  It seems to have only had a minimal positive effect, if any, so I don't think it's worth it!

But regarding use of cabergoline with people with psychiatric issues:  Antipsychotics reverse some of the effect of cabergoilne, too.  I looked at suggested procedures with people who are being treated for psychosis/mania.  It isn't totally thrown out, but all suggest being careful with adding cabergoline.  A psychiatrist would be wise to increase the dosage of antipsychotics if their patient were to try a dopamine agonist, but they could still try it.  I'm not going to though, it doesn't seem like prolactin is the best target for POIS treatment.  Treating the endocrine system is such a messy affair, all drugs that effect it have serious side effects...

[Nightingale]

Hi Scribblz, glad you found us!

Go here and read about Niacin and how most all of us have found relief by taking it according to the method described: http://poiscenter.com/forums/index.php?topic=319.0

And while you are there, please register and post at those forums!  It is better than this one giant forum thread.

[Nightingale]

I decided to give kurtosis' vitamin regimen a try: krill oil, magnesium, and zinc

Results: short-live but significant improvement!

I had a bad attempt at a niacin treatment last night for a planned "O".  I have been having trouble getting the full effect even with 4 hours of fasting.  Really frustrating.  So I went to my local health foods store and got the vitamins/supplements.  After 1 hour, I got excited!  I was having very poor concentration and I couldn't put together a coherent sentence, but that improved by 80%.  I didn't have as many physical problems, but they improved too.

This only lasted about 2-3 hours, though.  I am almost all the way back to the way I felt this morning before taking the supplements.  I took them again just 15 minutes ago, lets see what happens.

Exact doses:

Brand (for all 3): Nature's Way

Krill oil - 1 gram
  amount of astaxanthin in it - 1.25 mg

Magnesium (as citrate/oxide)- 500 mg

Zinc (as amino acid chelate) - 30 mg

Krill oil is sooo expensive...

[Nightingale]

I decided to give kurtosis' vitamin regimen a try: krill oil, magnesium, and zinc

Results: short-live but significant improvement!

I had a bad attempt at a niacin treatment last night for a planned "O".  I have been having trouble getting the full effect even with 4 hours of fasting.  Really frustrating.  So I went to my local health foods store and got the vitamins/supplements.  After 1 hour, I got excited!  I was having very poor concentration and I couldn't put together a coherent sentence, but that improved by 80%.  I didn't have as many physical problems, but they improved too.

This only lasted about 2-3 hours, though.  I am almost all the way back to the way I felt this morning before taking the supplements.  I took them again just 15 minutes ago, lets see what happens.

Exact doses:

Brand (for all 3): Nature's Way

Krill oil - 1 gram
  amount of astaxanthin in it - 1.25 mg

Magnesium (as citrate/oxide)- 500 mg

Zinc (as amino acid chelate) - 30 mg

Krill oil is sooo expensive...

2nd time not nearly so effective, maybe 30%.  Still, this is quite interesting.  This really helped me feel better in a pinch

UPDATE: I went to the store about 1 1/2 hours after my dose.  I was looking around for some items and I noticed my ability to pay attention to details had dramatically improved.  Almost like something you'd expect an ADHD medication to do.  I was able to see each sign located above the products and scan around them much more easily.  Otherwise, it was back to feeling "in a fog"

[Habibou]

I made a blood test and an urina test about candida and indoxyl :
candida is negative
indoxyl is : 4+ (the maximum)
It means my bowel is full of bacteria and the indoxyl is eating the tryptophan in the bowel...
The tryptophan is essential to product serotonin.
If the serotonin is low, dopamin (and noradrenalin) is also low and it leads to depression and other weird reations.

Did someone make this kind of test and what did you do then?

[kurtosis]

I decided to give kurtosis' vitamin regimen a try: krill oil, magnesium, and zinc

Results: short-live but significant improvement!

I had a bad attempt at a niacin treatment last night for a planned "O".  I have been having trouble getting the full effect even with 4 hours of fasting.  Really frustrating.  So I went to my local health foods store and got the vitamins/supplements.  After 1 hour, I got excited!  I was having very poor concentration and I couldn't put together a coherent sentence, but that improved by 80%.  I didn't have as many physical problems, but they improved too.

This only lasted about 2-3 hours, though.  I am almost all the way back to the way I felt this morning before taking the supplements.  I took them again just 15 minutes ago, lets see what happens.

Exact doses:

Brand (for all 3): Nature's Way

Krill oil - 1 gram
  amount of astaxanthin in it - 1.25 mg

Magnesium (as citrate/oxide)- 500 mg

Zinc (as amino acid chelate) - 30 mg

Krill oil is sooo expensive...

2nd time not nearly so effective, maybe 30%.  Still, this is quite interesting.  This really helped me feel better in a pinch

UPDATE: I went to the store about 1 1/2 hours after my dose.  I was looking around for some items and I noticed my ability to pay attention to details had dramatically improved.  Almost like something you'd expect an ADHD medication to do.  I was able to see each sign located above the products and scan around them much more easily.  Otherwise, it was back to feeling "in a fog"

Sounds like it's having an effect though. I take zinc, magnesium and b6 every night.
Over the course of a day I probably take double the amount of the supplements you've listed and I have to do it every day.
Although I've noticed that the requirement for supplementation is getting less the longer I take it.
Maybe something is correcting itself.

You missed 2 important ingredients.
1) b6 and b12. I either get the a conezymated b-complex or buy these separately as p5p and methylcobalamin. I take the b12 every morning.
2) Complete proteins and reduce sugar. For protein sources I like liver, eggs and spirulina. I'm lactose intolerant so I only take whey when its hydrolysed with almost no lactose. You need protein to make neurotransmitters and too much sugar or carbohydrates will exacerbate nutrient absorption problems. It's tough to reduce sugar because it gives us a kick when we're down but in the long run, reducing my sugar intake by 50% (one desert / day) has improved my POIS immensely.

I agree that Krill Oil is wickedly expensive and so variable in price and quality it seems. A months's supply ranges from €18 to €35. Go figure...

[Nightingale]

I neglected to mention I take a B complex pill each day, and have separate B6 supplements.  I have not been taking the B6 at night, morning instead.  I will start taking supplementary B12 too.

[nathan123]

I just sharing my experience expecting it may be the cause for POIS.

Hi,  Last month I have posted about my Vita B 12 deficiency and Vitamin D severe deficiency.  After that, I contacted the best doctor in my state and told about my symptoms and problems.  After a careful study and diagnosis, he concluded that what I am suffering is a  muscle weakness. 

As per his explanation, during orgasm many muscles in the body are involved and this will be contracted.  Hence, due to autoimmune reaction during orgasm, autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors throughout neuromuscular junctions.

Further, he added after orgasm I will have a illness of same symptoms like mild Myasthenia gravis where there will be burning eyes, slurred speech, fatigue, shortness of breath due to muscular weakness in nose and around head region. 

Now he has prescribed me a Homeopothic medicine for 3 months and also advised to eat more and more vegetables and Finger millet as it help to strengthen our muscle and it gives a ability to face orgasm for our muscles. 

Further, he also added that during wet dreams there will be very less involvement of muscle contraction and hence, there will be no POIS symtoms for us.  Similarly, if I do more exercises, dips, this will result in muscle restlessness and due to this POIS symptoms will occur. 

Finally, to conclude as per him it is a muscle weakness due to auto immune reaction in the body. 

Also see the symptoms of Myasthenia gravis, you will see some of the symptoms face by POIS people. 

Hoping for best in this new treatment. 

[Nightingale]

I've been studying prostaglandins lately since they are responsible for the "niacin flush."  Prostaglandin D2 is the specific one responsible, and I found that it has also been found to cause male pattern baldness:

http://www.nature.com/news/clues-to-the-cause-of-male-pattern-baldness-1.10277#/b1

I don't think this is totally new to us, but I was interested in one line in particular: "The authors also found that, in mice, PGD2 expression peaks during the hair-growth cycle stage in which the follicle begins regressing."

Just as a poll, what's everyone's hair status?  I have quite a lot of hair covering my body.  It is dark brown and I still have a lot of it on my head at 26.  I wonder, since hair growth spikes during puberty if PDG2 starts to behave differently afterwards??

Otherwise, there are drugs in development that are targeting PGD2 because it has also been found to be a major cause of asthma.  Perhaps it is worth contacting these scientists to tell them how niacin is helping us by using PGD2 for our flush?

Here's a company working on a PGD2 receptor antagonist for COPD: http://mcpharmacol.com/index.php/Journals/article/viewFile/92/89

You can find the email here for a consultant who writes about PGD2 antagonists: http://www.ncbi.nlm.nih.gov/pubmed/20615077

And more meds discovered for trial.  Emails next to the researcher's names: http://www.sciencedirect.com/science/article/pii/S0960894X06006093

"Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases."

I'll be working on a letter today to send out by tomorrow.  Let me know if you want to coordinate :)

[kurtosis]

I just sharing my experience expecting it may be the cause for POIS.

Hi,  Last month I have posted about my Vita B 12 deficiency and Vitamin D severe deficiency.  After that, I contacted the best doctor in my state and told about my symptoms and problems.  After a careful study and diagnosis, he concluded that what I am suffering is a  muscle weakness. 

As per his explanation, during orgasm many muscles in the body are involved and this will be contracted.  Hence, due to autoimmune reaction during orgasm, autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors throughout neuromuscular junctions.

Further, he added after orgasm I will have a illness of same symptoms like mild Myasthenia gravis where there will be burning eyes, slurred speech, fatigue, shortness of breath due to muscular weakness in nose and around head region. 

Now he has prescribed me a Homeopothic medicine for 3 months and also advised to eat more and more vegetables and Finger millet as it help to strengthen our muscle and it gives a ability to face orgasm for our muscles. 

Further, he also added that during wet dreams there will be very less involvement of muscle contraction and hence, there will be no POIS symtoms for us.  Similarly, if I do more exercises, dips, this will result in muscle restlessness and due to this POIS symptoms will occur. 

Finally, to conclude as per him it is a muscle weakness due to auto immune reaction in the body. 

Also see the symptoms of Myasthenia gravis, you will see some of the symptoms face by POIS people. 

Hoping for best in this new treatment. 

Fascinating. I have an eye muscle problem too and I always assumed that had nothing to do with the POIS but it's been getting progressively worse. One thing I'm wondering about. Why did he prescribe you a homeopathic remedy? There are quite a few cholinesterase inhibitors available. Huperzine-A for instance.

[jferr]

Guys, hope all is well with you all.

My pois is constant, only have an orgasm once or twice a month. In the first few days after sex, i have red/itchy/light sensitive eyes. These eye symptoms seem to councide with all my symptoms, extreme cognitive to fatigue. Niqcin before sex and spirulina + vitamin c after sex worked for a few months for my symptoms. Eye problems, fatigue and cognitive symptoms would subside and I was able to wake up in the morning and be alert. Lately these medications have stopped working for me an my symptoms are taking over.

Is there anyone else with these symptoms and if so what is working for you ? I really need help. It feels as if ive tried everything.

PS I do plan to follow through on my $1,000 donations.

We will beat this,

Jon.

[Starsky]

I just sharing my experience expecting it may be the cause for POIS.

Hi,  Last month I have posted about my Vita B 12 deficiency and Vitamin D severe deficiency.  After that, I contacted the best doctor in my state and told about my symptoms and problems.  After a careful study and diagnosis, he concluded that what I am suffering is a  muscle weakness. 

As per his explanation, during orgasm many muscles in the body are involved and this will be contracted.  Hence, due to autoimmune reaction during orgasm, autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors throughout neuromuscular junctions.

Further, he added after orgasm I will have a illness of same symptoms like mild Myasthenia gravis where there will be burning eyes, slurred speech, fatigue, shortness of breath due to muscular weakness in nose and around head region. 

Now he has prescribed me a Homeopothic medicine for 3 months and also advised to eat more and more vegetables and Finger millet as it help to strengthen our muscle and it gives a ability to face orgasm for our muscles. 

Further, he also added that during wet dreams there will be very less involvement of muscle contraction and hence, there will be no POIS symtoms for us.  Similarly, if I do more exercises, dips, this will result in muscle restlessness and due to this POIS symptoms will occur. 

Finally, to conclude as per him it is a muscle weakness due to auto immune reaction in the body. 

Also see the symptoms of Myasthenia gravis, you will see some of the symptoms face by POIS people. 

Hoping for best in this new treatment. 

Fascinating. I have an eye muscle problem too and I always assumed that had nothing to do with the POIS but it's been getting progressively worse. One thing I'm wondering about. Why did he prescribe you a homeopathic remedy? There are quite a few cholinesterase inhibitors available. Huperzine-A for instance.

If myasthenia is suspected a Tensilon test should be performed!

But the whole acetycholine link is very interesting, because vitamin B1, vitamin B6 and vitamin B12, all of which are critical to the synthesis of acetylcholine and some of us claimed he was cured by taking Hydroxil.

[B_Daniel]

.................... I'm too embarrassed to tell anyone, or go to a doctor about it, so I came here seeking guidance and a possible remedy to this problem......

Hi Scribblz,
You have to tell your doctor about it. If you're not comfortable talking to your current doctor then consider getting a new one. Ask friends to see if they'd recommend a good GP. The problem with POIS is, there's no way you can pretend it's not happening as it affects relationships, work, education etc. So you have to try and tell a medical professional what's going on. At the minimum they'll understand that there's something wrong with you and you may need them to vouch for that fact later.

Well put, Kurtosis.  The first couple doctors I told about my POIS, I remember nervously explaining the problem.  I've done it so many times now, that my last doctor even remarked how surprising it was that I talked about all of it so comfortably.  I don't see doctors that are family friends anymore, but I do tell this problem to male and female doctors alike.  Also, I typically try to put it within the first 2 sentences of meeting them.  "Hi, nice to meet you, I'm Daniel.  So the reason I'm coming in today is that I incur a range of symptoms after I have Orgasms.  The typical symptoms are ____(fill in the blanks here)... Have you heard of POIS?...."   

[Prancer]

I'm having trouble signing up on the other forum. I'm not getting my approval email. :( Does anyone have any suggestions? Thanks!

[jferr]

Guys, hope all is well with you all.

My pois is constant, only have an orgasm once or twice a month. In the first few days after sex, i have red/itchy/light sensitive eyes. These eye symptoms seem to councide with all my symptoms, extreme cognitive to fatigue. Niqcin before sex and spirulina + vitamin c after sex worked for a few months for my symptoms. Eye problems, fatigue and cognitive symptoms would subside and I was able to wake up in the morning and be alert. Lately these medications have stopped working for me an my symptoms are taking over.

Is there anyone else with these symptoms and if so what is working for you ? I really need help. It feels as if ive tried everything.

PS I do plan to follow through on my $1,000 donations.

We will beat this,

Jon.

PS. I would like to thank Kurtosis for helping me time and time again without hesitation. He has given me tons of info from medications that have helped me to ideas that could be related to my issue. People like you make this forum great.

Thank you.

[tantalus]

"  "Hi, nice to meet you, I'm Daniel.  So the reason I'm coming in today is that I incur a range of symptoms after I have Orgasms.  The typical symptoms are ____(fill in the blanks here)... Have you heard of POIS?...."

Hi,  B_Daniel...your message of: 04/07/2012 22:04:00.........I like to compliment you with your brilliant intro words when visiting a doctor. Great!.....every doctor will skip the (autopilot)idea that a neurotic patient is sitting in front of him, when telling about pois. i advise everybody to start talking like that, during the first visit .  (you made me giggle too)

your smart;>)   good to have you here