The Naked Scientists

The Naked Scientists Forum

Author Topic: Can Pyriproxyfen cause microencephaly?  (Read 1464 times)

Offline syhprum

  • Neilep Level Member
  • ******
  • Posts: 3822
  • Thanked: 19 times
    • View Profile
Can Pyriproxyfen cause microencephaly?
« on: 15/02/2016 11:22:22 »
It has been reported that there is an overlap between the areas where many cases of microcephaly have been reported and where Pyriproxyfen has been used.
« Last Edit: 15/02/2016 17:09:21 by chris »


 

Offline chris

  • Neilep Level Member
  • ******
  • Posts: 5339
  • Thanked: 65 times
  • The Naked Scientist
    • View Profile
    • The Naked Scientists
Re: Can Pyriproxyfen cause microencephaly?
« Reply #1 on: 15/02/2016 17:12:58 »
Pyriproxifen is a larvicidal chemical added to water to prevent mosquitoes breeding. It has been added to water supplies in Brazil for about the last 18 months. Some have claimed that the presence of this chemical can cause microcephaly, although the Brazilian government have refuted this claim.

Here's an update on the story: http://www.telegraph.co.uk/news/worldnews/zika/12157747/Zika-virus-Brazil-dismisses-link-between-larvicide-and-microcephaly.html
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: Can Pyriproxyfen cause microencephaly?
« Reply #2 on: 15/02/2016 22:34:16 »
From a pharmacodynamic standpoint.... I'm thinking it's merely coincidental, as the mutagenicity/teratogenicity profile of pyriproxyfen clearly indicates it's not the culprit.

Principles and Methods of Toxicology, Fifth Edition
A. Wallace Hayes - 2007 - ‎Medical
Harvard School of Public Health
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: Can Pyriproxyfen cause microencephaly?
« Reply #3 on: 15/02/2016 23:20:18 »
More non-mutagenic/teratogenic data:

WHO SPECIFICATIONS AND EVALUATIONS FOR PUBLIC HEALTH PESTICIDES
PYRIPROXYFEN
phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether


webcache.googleusercontent.com/search?q=cache:aVHmqULYTRQJ:www.who.int/whopes/quality/en/pyriproxyfen_eval_specs_WHO_jul2006.pdf+&cd=1&hl=en&ct=clnk&gl=us
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: Can Pyriproxyfen cause microencephaly?
« Reply #4 on: 16/02/2016 00:05:07 »
In terms of the etiology of microcephaly, new research has identified pathogenic mutations in the MCPH1 & CASC5 genes, as well as mutations in SPATA5.

MCPH1 mutation
ncbi.nlm.nih.gov/pubmed/26192461

CASC5 mutation
ncbi.nlm.nih.gov/pubmed/26626498

SPATA5 mutation
ncbi.nlm.nih.gov/pubmed/26299366
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 920
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: Can Pyriproxyfen cause microencephaly?
« Reply #5 on: 16/02/2016 12:12:47 »
Sounds like a diversion to create confusion about the origins of the microencephaly...

Taking antidepressants during pregnancy can cause delayed fetal head growth: http://www.thenakedscientists.com/forum/index.php?topic=65724.0
 

The Naked Scientists Forum

Re: Can Pyriproxyfen cause microencephaly?
« Reply #5 on: 16/02/2016 12:12:47 »

 

SMF 2.0.10 | SMF © 2015, Simple Machines
SMFAds for Free Forums