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Author Topic: What are the effects of THC tolerance?  (Read 767 times)

Offline tkadm30

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What are the effects of THC tolerance?
« on: 25/02/2016 18:10:37 »
The positive effects of THC tolerance seems misunderstood. CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. The synthesis of endogenous cannabinoids may promote adult hippocampal neurogenesis in vivo:

"In in vivo experiments, Rueda et al. demonstrated that chronic administration of endogenous cannabinoid for 2 weeks increased the number of newborn (BrdU-immunopositive), non-neuronal (NeuN-immunonegative) cells in the rat dentate gyrus without affecting the total number of BrdU-labeled cells (25), which was interpreted as evidence for a CB1-mediated impairment in neurogenesis. We observed, however, a significant increase in the hippocampal newborn neurons following twice-daily HU210 injection for 10 days. The differing regulatory effects of endocannabinoid shown in Rueda et al.ís study and exocannabinoid HU210 shown in this study on hippocampal neurogenesis may be produced by the different pharmacology of exo- and endocannabinoids in the brain, i.e., the full and partial agonist actions of exo- and endocannabinoids on CB1 receptors, respectively (11); or the different intracellular signaling pathways induced by exo- and endocannabinoids as speculated by Martin et al"


Thus, the different pharmacology between endocannabinoids and exocannabinoids (THC) on CB1 receptors expression may explain a positive effect of THC tolerance on hippocampal neurogenesis. Cannabis pharmacology research should explore further the differential aspect of THC tolerance on the neuropsychology of cannabis smoking.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
« Last Edit: 25/02/2016 18:19:24 by tkadm30 »


 

Offline tkadm30

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Re: What are the effects of THC tolerance?
« Reply #1 on: 25/02/2016 19:45:40 »
Quote
"The architects of marijuana prohibition have long maintained that tolerance to cannabis means the same thing as tolerance to addictive drugs like cocaine and heroin - that users need more and more to get high, driving them to crime and desperation. Now, the federal government's own research indicates that precisely the opposite is true. Science has finally caught on to what tokers have known all along: With marijuana tolerance, you have to smoke less to get high! High Times correspondent Jon Gettman explains the latest findings and how they discredit the government's drug policy...
An alternative hypothesis about how dynamic tolerance to marijuana operates involves receptor "down-regulation," in which the body adjusts to chronic exposure to a drug by reducing the number of receptor sites available for binding. A 1993 paper published in Brain Research by Angelica Oviedo, John Glowa and Herkenham indicates that tolerance to cannabinoids results from receptor down-regulation. This, as we shall see, is good news. It means that marijuana tolerance is actually the brain's mechanism to maintain equilibrium. "

THC tolerance may help maintain the brain homeostasis through endocannabinoid mobilization. Thus, maintaining the brain energetic homeostasis is perhaps a positive effect of THC tolerance and a potential therapy for metabolic disorders.

Source: http://www.marijuanalibrary.org/brain2.html

 

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Re: What are the effects of THC tolerance?
« Reply #1 on: 25/02/2016 19:45:40 »

 

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