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Author Topic: Could cannabis use normalize dopamine function?  (Read 1743 times)

Online tkadm30

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Could cannabis use normalize dopamine function?
« on: 18/03/2016 20:43:47 »
The effects of cannabinoids on dopamine function are poorly understood. Does THC and anandamide act as dopamine system stabilizers (DSS) ?
« Last Edit: 18/03/2016 20:48:16 by tkadm30 »


 

Online tkadm30

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Re: Could cannabis use normalize dopamine function?
« Reply #1 on: 19/03/2016 10:15:25 »
The antipsychotic properties of CBD can prevent psychosis:

http://www.ncbi.nlm.nih.gov/pubmed/22716160

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CBD appears to have pharmacological profile similar to that of atypical antipsychotic drugs as seem using behavioral and neurochemical techniques in animal models. Additionally, CBD prevented human experimental psychosis and was effective in open case reports and clinical trials in patients with schizophrenia with a remarkable safety profile.

Is CBD a partial dopamine receptors agonist ?

https://www.ncbi.nlm.nih.gov/pubmed/16258853

« Last Edit: 19/03/2016 10:17:36 by tkadm30 »
 

Offline exothermic

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Re: Could cannabis use normalize dopamine function?
« Reply #2 on: 19/03/2016 20:49:08 »
Could cannabis use normalize dopamine function?

In individuals with presynaptic striatal dopamine dysfunction? .... Not likely.


The antipsychotic properties of CBD can prevent psychosis:

That may be the case with intracerebral microinjections of CBD in the animal model, but it hasn't been replicated by any appreciable degree in humans, despite various attempts. 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531/table/RSTB20110389TB3/?report=objectonly
 

Offline exothermic

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Re: Could cannabis use normalize dopamine function?
« Reply #3 on: 20/03/2016 00:18:25 »
Is CBD a partial dopamine receptors agonist ?

https://www.ncbi.nlm.nih.gov/pubmed/16258853

I'm not sure what the Ki values were, but either way.... there can't be much affinity based on that citation:

"cloned rat 5-HT2a receptor suggesting that CBD is active, but less so, relative to the human 5-HT1a receptor, in binding analyses"
 

Online tkadm30

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Re: Could cannabis use normalize dopamine function?
« Reply #4 on: 20/03/2016 11:11:04 »
Could cannabis use normalize dopamine function?
In individuals with presynaptic striatal dopamine dysfunction? .... Not likely.

Atypical antipsychotics such as aripiprazole binds on dopamine D2 receptor. I was thinking aripiprazole and CBD affinity for dopamine D2 receptor could stimulate dopamine release:

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What are the implications of D2 partial agonism? Aripiprazole binds to the D2 receptor with the same affinity than dopamine, but has a lower intrinsic efficacy, so the response it triggers is lower than dopamine but higher than an antagonist.

http://psychopharmacologyinstitute.com/antipsychotics/aripiprazole/mechanism-of-action-aripiprazole/

Thus, how may aripirazole affect cannabinoid-induced dopamine signaling? The role of DSS in monoaminergic neurotransmission need investigation. Is D2 partial agonism enhancing dopaminergic activity through binding of cannabinoid receptors ? 
 

Offline Thebox

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Re: Could cannabis use normalize dopamine function?
« Reply #5 on: 20/03/2016 14:13:10 »
The effects of cannabinoids on dopamine function are poorly understood. Does THC and anandamide act as dopamine system stabilizers (DSS) ?


I will have a go at answering for you, if the amount of dopamine released is released at the same magnitude because it is being induced by the smoker, is that not  the rate the body gets use to in being a stable rate?

 

Online tkadm30

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Re: Could cannabis use normalize dopamine function?
« Reply #6 on: 20/03/2016 18:48:27 »
The effects of cannabinoids on dopamine function are poorly understood. Does THC and anandamide act as dopamine system stabilizers (DSS) ?
I will have a go at answering for you, if the amount of dopamine released is released at the same magnitude because it is being induced by the smoker, is that not  the rate the body gets use to in being a stable rate?

I think atypical antipsychotics may modulate and regulate dopamine release. For aripiprazole, the stable rate of dopamine neurotransmission depends on D2 partial agonism. Cannabis use may increase striatal D2/D3 receptor availability.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532956/
 

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Re: Could cannabis use normalize dopamine function?
« Reply #7 on: 20/11/2016 10:58:59 »
Dopamine stimulation via exogenous THC administration may promote neurogenesis (proliferation) in the subventricular zone (SVZ):

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Dopamine-mediated stimulation of proliferation is dependent on ciliary neurotrophic factor (CNTF), which is known to promote proliferation in the SVZ (Emsley and Hagg, 2003; Yang et al., 2008). A recent study has proposed that dopamine induces proliferation through Akt and extracellular signal-regulated kinase 1/2 signaling, whereas other studies suggest that dopamine stimulates the release of epidermal growth factor (EGF), which is known to promote proliferation of neural stem cells (Reynolds and Weiss, 1996; O'Keeffe et al., 2009; Lao et al., 2013).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666382/
 

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Re: Could cannabis use normalize dopamine function?
« Reply #7 on: 20/11/2016 10:58:59 »

 

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