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Author Topic: Can uric acid cause cancer?  (Read 1193 times)

Offline Thebox

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Can uric acid cause cancer?
« on: 16/04/2016 12:45:36 »
Like a ''splinter'' in the foot of gout, doe' s uric acid ''splinter'' in the lipid bilayers to cause tumours?
« Last Edit: 16/04/2016 14:04:11 by chris »


 

Offline Colin2B

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Re: Doe's Uric aid cause cancer?
« Reply #1 on: 16/04/2016 13:42:29 »
A high level in the blood can be a result of chemotherapy.
However, you might want to read this http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560981/#!po=2.58621
 

Offline chris

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Re: Can uric acid cause cancer?
« Reply #2 on: 16/04/2016 14:09:51 »
Hyperuricaemia (high blood urate) is sometimes a consequence of "tumour lysis syndrome" when drugs or radiotherapy are administered to cancer patients. The rapid disintegration of the tumour mass releases large amounts of nucleic acid, which is metabolised to uric acid. This can crystallise in the kidney causing tubular damage. Some people, usually in response to dietary factors, also have elevated uric acid levels in the blood. This partitions into the fluid inside joints where it can nucleate, producing gout attacks. Urate is thus a normal component of metabolism that can occasionally have pathological consequences if present in large amounts, but cancer is not regarded as one of them.
 

Offline Bored chemist

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Re: Can uric acid cause cancer?
« Reply #3 on: 17/04/2016 16:33:10 »
It seems unlikely that uric acid is a carcinogen- even when the levels are high enough to cause gout.
http://www.ncbi.nlm.nih.gov/pubmed/19337060
People whose lifestyles lead to gout may also have a raised risk of cancer; things like smoking and drinking alcohol contribute to the risk of both.
But there don't seem to be raised incidences of cancers of the joints.
 

Offline Thebox

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Re: Can uric acid cause cancer?
« Reply #4 on: 23/04/2016 23:06:08 »
Thank you for the very interesting links which I have bookmarked as they will take a while to read and understand.   


Is Uric acid in anyway related to electrolytes when in solution form or ''splinter'' form?
 

Offline chris

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Re: Can uric acid cause cancer?
« Reply #5 on: 24/04/2016 09:33:55 »
Uric acid is one of many dissolved electrolytes that can precipitate out of solution when the conditions dictate. Calcium can do the same thing and deposit into joints giving rise to an inflammatory state called "pesudogout".
 

Offline Thebox

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Re: Can uric acid cause cancer?
« Reply #6 on: 24/04/2016 15:09:57 »
Uric acid is one of many dissolved electrolytes that can precipitate out of solution when the conditions dictate. Calcium can do the same thing and deposit into joints giving rise to an inflammatory state called "pesudogout".


Thank you Chris, I do not want to really cross chemistry and physics, but surely if electrolytes were to ''sediment'' , these sediments would be more radiated by thermodynamics and the area becomes more radiated on a micro scale causing the inflammation and this more radiated micro area a possible concern for mutation and cancer?

I sort of imagine a filter becoming clogged and my hoover motor overheats and burns out. The hoover motor being ''sediments'' of electrolytes that gain entropy .



 
 

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Re: Can uric acid cause cancer?
« Reply #6 on: 24/04/2016 15:09:57 »

 

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