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Author Topic: Is synaptogenesis implicated in the neuromodulation of consciousness?  (Read 1573 times)

Offline tkadm30

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The role of synaptogenesis and retrograde signaling in the neuromodulation of consciousness is poorly understood. Could β-neurexin-neuroligin junctions mediate interneuronal quantum coherence in the discrete computations of conscious activity and synaptic function?

Is synaptic hypercomputation an evidence of quantum coherence in the entanglement of β-neurexin-neuroligin complexes?

http://arxiv.org/vc/quant-ph/papers/0207/0207093v2.pdf

http://www.thenakedscientists.com/forum/index.php?topic=67550.0
« Last Edit: 08/07/2016 14:48:39 by tkadm30 »


 

Offline tkadm30

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Is synaptogenesis an evidence of homeostatic endocannabinoid transport?
 

Offline dlorde

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Is synaptogenesis an evidence of homeostatic endocannabinoid transport?
What makes you think synaptogenesis has anything to do with endocannabinoid transport - is it reduced when endocannabinoid transporters are inhibited? why, in particular, should homeostasis be relevant to synaptogenesis?


« Last Edit: 10/07/2016 22:06:16 by dlorde »
 

Offline tkadm30

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What makes you think synaptogenesis has anything to do with endocannabinoid transport - is it reduced when endocannabinoid transporters are inhibited? why, in particular, should homeostasis be relevant to synaptogenesis?

Endocannabinoid transport may under the scene traffick synaptic homeostasis by regulating synaptogenesis.
 
See:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633430/
http://www.ncbi.nlm.nih.gov/pubmed/25740514

Quote
Together, these results indicate that the CB1 receptor signaling system both on inhibitory and excitatory neurons controls functional and structural synaptic plasticity of pyramidal neurons in the hippocampal CA1 region to maintain an appropriate homeostatic state upon neuronal activation.
 

Offline dlorde

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Endocannabinoid transport may under the scene traffick synaptic homeostasis by regulating synaptogenesis.
 
See:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633430/
http://www.ncbi.nlm.nih.gov/pubmed/25740514

Quote
Together, these results indicate that the CB1 receptor signaling system both on inhibitory and excitatory neurons controls functional and structural synaptic plasticity of pyramidal neurons in the hippocampal CA1 region to maintain an appropriate homeostatic state upon neuronal activation.
OK; those articles are certainly less opaque than what you post about them. So the CB1 pathway may help control synaptic density in the hippocampus; so what? Presumably it helps keep memory processes consistent over time, which is important. How is this relatively long term synaptic density modulation relevant to consciousness?

What makes this of particular interest to a general science forum - what's the hook? 
« Last Edit: 11/07/2016 13:19:17 by dlorde »
 

Offline tkadm30

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OK; those articles are certainly less opaque than what you post about them. So the CB1 pathway may help control synaptic density in the hippocampus; so what? Presumably it helps keep memory processes consistent over time, which is important. How is this relatively long term synaptic density modulation relevant to consciousness?

What makes this of particular interest to a general science forum - what's the hook?

Understanding how synaptogenesis and retrograde signaling control synaptic hypercomputation may provide evidences that the neuromodulation of consciousness is nonlocal and depends on synaptic function. Feel free to comment on my "synaptic hypercomputation" hypothesis if you like the topic of biological hypercomputation. :)

http://www.thenakedscientists.com/forum/index.php?topic=67550.0
 

Offline Alan McDougall

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OK; those articles are certainly less opaque than what you post about them. So the CB1 pathway may help control synaptic density in the hippocampus; so what? Presumably it helps keep memory processes consistent over time, which is important. How is this relatively long term synaptic density modulation relevant to consciousness?

What makes this of particular interest to a general science forum - what's the hook?

Understanding how synaptogenesis and retrograde signaling control synaptic hypercomputation may provide evidences that the neuromodulation of consciousness is nonlocal and depends on synaptic function. Feel free to comment on my "synaptic hypercomputation" hypothesis if you like the topic of biological hypercomputation. :)

http://www.thenakedscientists.com/forum/index.php?topic=67550.0

What a lot of convoluted incomprehensible load of garbage is this.

Maybe you should cut out the cannabis somewhat?

This is a joke!!

I think the answer lies in that the unknown known facts far outweigh those who weigh modality out of nonexistence leading maybe into the void of absolute nothingness which continued and was full of empty concrete, nothing something's, that was other than emptiness that did not proved that it existed because it spoke to me in a loud deep very quiet voice, but did exist when tests had proved that it did not to exist when in fact it did exist, as a very real concrete material object both soft to touch and as hard as the hardest diamond that hurt when I touched it with my one toe. It was so real that it was invisible even though it was very visible before it really existed when it affected all of the non-reality dimensional nothingness in the most profound way, not possible.

This led to the absolute proof that the absolute proof was wrong which proved that the proof was right before scientific methods proved the opposite that the proof was wrong, making in into the actuality of non-positive emptiness with concrete reality which should have been what it should have been when in fact, the fact was that it was not real although it was proved to be very real and the positive side of the negative, In fact, it was both positive and negative at many places momentarily but in just absolute confined to just one place within the set boundaries of the infinite finite cosmos.

Alan
 

Offline tkadm30

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I think the answer lies in that the unknown known facts far outweigh those who weigh modality out of nonexistence leading maybe into the void of absolute nothingness which continued and was full of empty concrete, nothing something's, that was other than emptiness that did not proved that it existed because it spoke to me in a loud deep very quiet voice, but did exist when tests had proved that it did not to exist when in fact it did exist, as a very real concrete material object both soft to touch and as hard as the hardest diamond that hurt when I touched it with my one toe. It was so real that it was invisible even though it was very visible before it really existed when it affected all of the non-reality dimensional nothingness in the most profound way, not possible.

This led to the absolute proof that the absolute proof was wrong which proved that the proof was right before scientific methods proved the opposite that the proof was wrong, making in into the actuality of non-positive emptiness with concrete reality which should have been what it should have been when in fact, the fact was that it was not real although it was proved to be very real and the positive side of the negative, In fact, it was both positive and negative at many places momentarily but in just absolute confined to just one place within the set boundaries of the infinite finite cosmos.

Alan

I don't understand anything from this nonsense quackery. Drop your rage perhaps...

One love!
 

Offline Alan McDougall

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I think the answer lies in that the unknown known facts far outweigh those who weigh modality out of nonexistence leading maybe into the void of absolute nothingness which continued and was full of empty concrete, nothing something's, that was other than emptiness that did not proved that it existed because it spoke to me in a loud deep very quiet voice, but did exist when tests had proved that it did not to exist when in fact it did exist, as a very real concrete material object both soft to touch and as hard as the hardest diamond that hurt when I touched it with my one toe. It was so real that it was invisible even though it was very visible before it really existed when it affected all of the non-reality dimensional nothingness in the most profound way, not possible.

This led to the absolute proof that the absolute proof was wrong which proved that the proof was right before scientific methods proved the opposite that the proof was wrong, making in into the actuality of non-positive emptiness with concrete reality which should have been what it should have been when in fact, the fact was that it was not real although it was proved to be very real and the positive side of the negative, In fact, it was both positive and negative at many places momentarily but in just absolute confined to just one place within the set boundaries of the infinite finite cosmos.

Alan

I don't understand anything from this nonsense quackery. Drop your rage perhaps...

One love!

You are the on sprouting quackery with you anti-psychiatric garbage and cannabis delusion.

I do not need your love! Of course, you do not understand it was a joke get a sense of humor
 

Offline tkadm30

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You are the on sprouting quackery with you anti-psychiatric garbage and cannabis delusion.

I do not need your love! Of course, you do not understand it was a joke get a sense of humor

Quit trolling...

We all need love.

 

Offline dlorde

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Understanding how synaptogenesis and retrograde signaling control synaptic hypercomputation may provide evidences that the neuromodulation of consciousness is nonlocal and depends on synaptic function.
How?

Quote
Feel free to comment on my "synaptic hypercomputation" hypothesis if you like the topic of biological hypercomputation. :)

http://www.thenakedscientists.com/forum/index.php?topic=67550.0
Feel free to provide some evidence that hypercomputation actually occurs in the brain.
 

Offline dlorde

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What a lot of convoluted incomprehensible load of garbage is this.

Maybe you should cut out the cannabis somewhat?

This is a joke!!
I can understand your scepticism, but it's not all gibberish; he's using published research on cannabinoid receptor neuroscience to support some highly speculative ideas about consciousness without explaining just how it does so.

It's unfortunate that he seems unable to present it clearly. I suspect the jargon is used to reinforce the impression of scientific solidity, because it's not necessary and doesn't always make sense.
 

Offline tkadm30

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Understanding how synaptogenesis and retrograde signaling control synaptic hypercomputation may provide evidences that the neuromodulation of consciousness is nonlocal and depends on synaptic function.
How?

Quote
Feel free to comment on my "synaptic hypercomputation" hypothesis if you like the topic of biological hypercomputation. :)

http://www.thenakedscientists.com/forum/index.php?topic=67550.0
Feel free to provide some evidence that hypercomputation actually occurs in the brain.

Synaptic activity is instantaneous... The biological nonlocality of consciousness might refer to the transfer potential of synaptic hypercomputation to remotely compute neural energy from retrograde signaling and synaptogenesis. Therefore could the CB1 receptor be involved in the biological utilization of nonlocality to hypercompute remote synaptic activity?
 
« Last Edit: 11/07/2016 20:06:31 by tkadm30 »
 

Offline dlorde

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Synaptic activity is instantaneous...
Evidence? neurotransmitters take a finite time to diffuse across a synapse (1-5ms for cerebro-cortical synapses).
Quote
The biological nonlocality of consciousness might refer to the transfer potential of synaptic hypercomputation to remotely compute neural energy from retrograde signaling and synaptogenesis.
What do you mean by 'biological nonlocality'?

You didn't answer the question you replied to - please provide some evidence that hypercomputation actually occurs in the brain (or anywhere, for that matter). I'm aware of theoretical arguments for hypercomputation, but I'm keen to see the evidence for it that you seem to take for granted.
 

Offline tkadm30

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Evidence? neurotransmitters take a finite time to diffuse across a synapse (1-5ms for cerebro-cortical synapses).

Electrical synapses allow virtually instantaneous transmission: "Another important feature of the electrical synapse is that transmission is extraordinarily fast: Because passive current flow across the gap junction is virtually instantaneous, communication can occur without the delay that is characteristic of chemical synapses."

http://www.ncbi.nlm.nih.gov/books/NBK11164/

Quote from: dlorde
What do you mean by 'biological nonlocality? 

You didn't answer the question you replied to - please provide some evidence that hypercomputation actually occurs in the brain (or anywhere, for that matter). I'm aware of theoretical arguments for hypercomputation, but I'm keen to see the evidence for it that you seem to take for granted.

The biological nonlocality of consciousness is the hypothesis that neural energy transfer may occur through nonlocal synaptic activity, allowing virtually instant neurotransmission across excitatory synapses.

Synaptogenesis and endocannabinoid transport are evidences of interneuronal hypercomputation by regulating phase coherence of exocytosis at the macroscopic level.   
« Last Edit: 27/07/2016 01:24:56 by tkadm30 »
 

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